{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:08:10Z","timestamp":1771636090462,"version":"3.50.1"},"reference-count":102,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Extracellular vesicles (EVs) are a heterogeneous group of cell-derived submicron vesicles released under physiological or pathological conditions. EVs mediate the cellular crosstalk, thus contributing to defining the tumor microenvironment, including in epithelial ovarian cancer (EOC). The available literature investigating the role of EVs in EOC has been reviewed following PRISMA guidelines, focusing on the role of EVs in early disease diagnosis, metastatic spread, and the development of chemoresistance in EOC. Data were identified from searches of Medline, Current Contents, PubMed, and from references in relevant articles from 2010 to 1 April 2020. The research yielded 194 results. Of these, a total of 36 papers, 9 reviews, and 27 original types of research were retained and analyzed. The literature findings demonstrate that a panel of EV-derived circulating miRNAs may be useful for early diagnosis of EOC. Furthermore, it appears clear that EVs are involved in mediating two crucial processes for metastatic and chemoresistance development: the epithelial\u2013mesenchymal transition, and tumor escape from the immune system response. Further studies, more focused on in vivo evidence, are urgently needed to clarify the role of EV assessment in the clinical management of EOC patients.<\/jats:p>","DOI":"10.3390\/ijms21228762","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T02:09:07Z","timestamp":1605838147000},"page":"8762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Role of Extracellular Vesicles in Epithelial Ovarian Cancer: A Systematic Review"],"prefix":"10.3390","volume":"21","author":[{"given":"Alessandro","family":"Lucidi","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Clinic, University of Chieti, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-7407","authenticated-orcid":false,"given":"Danilo","family":"Buca","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Clinic, University of Chieti, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-282X","authenticated-orcid":false,"given":"Carlo","family":"Ronsini","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Clinic, University of Chieti, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Tinari","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Clinic, University of Chieti, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Bologna","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences, University \u201cG. d\u2019Annunzio\u201d, Chieti\u2014Pescara, 66100 Chieti, Italy"},{"name":"Center for Advanced Studies and Technology (C.A.S.T.), University \u201cG. d\u2019Annunzio\u201d, Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Buca","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences, University \u201cG. d\u2019Annunzio\u201d, Chieti\u2014Pescara, 66100 Chieti, Italy"},{"name":"Center for Advanced Studies and Technology (C.A.S.T.), University \u201cG. d\u2019Annunzio\u201d, Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Leombroni","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Clinic, University of Chieti, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-0973","authenticated-orcid":false,"given":"Marco","family":"Liberati","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Clinic, University of Chieti, 66100 Chieti, Italy"},{"name":"Department of Medicine and Aging Sciences, University \u201cG. d\u2019Annunzio\u201d, Chieti\u2014Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Clinic, University of Chieti, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health, IRCCS Fondazione Policlinico Agostino Gemelli, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Lanuti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences, University \u201cG. d\u2019Annunzio\u201d, Chieti\u2014Pescara, 66100 Chieti, Italy"},{"name":"Center for Advanced Studies and Technology (C.A.S.T.), University \u201cG. d\u2019Annunzio\u201d, Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-4328","authenticated-orcid":false,"given":"Marco","family":"Petrillo","sequence":"additional","affiliation":[{"name":"Department of Medical, Gynecologic and Obstetric Unit, University of Sassari, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00280-017-3501-8","article-title":"Advances in ovarian cancer therapy","volume":"81","author":"Cortez","year":"2018","journal-title":"Cancer Chemother. 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