{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:53:55Z","timestamp":1784192035241,"version":"3.55.0"},"reference-count":144,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The Gram-negative diplococcus Neisseria meningitidis, also called meningococcus, exclusively infects humans and can cause meningitis, a severe disease that can lead to the death of the afflicted individuals. To cause meningitis, the bacteria have to enter the central nervous system (CNS) by crossing one of the barriers protecting the CNS from entry by pathogens. These barriers are represented by the blood\u2013brain barrier separating the blood from the brain parenchyma and the blood\u2013cerebrospinal fluid (CSF) barriers at the choroid plexus and the meninges. During the course of meningococcal disease resulting in meningitis, the bacteria undergo several interactions with host cells, including the pharyngeal epithelium and the cells constituting the barriers between the blood and the CSF. These interactions are required to initiate signal transduction pathways that are involved during the crossing of the meningococci into the blood stream and CNS entry, as well as in the host cell response to infection. In this review we summarize the interactions and pathways involved in these processes, whose understanding could help to better understand the pathogenesis of meningococcal meningitis.<\/jats:p>","DOI":"10.3390\/ijms21228788","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T09:46:18Z","timestamp":1605865578000},"page":"8788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Interactions and Signal Transduction Pathways Involved during Central Nervous System Entry by Neisseria meningitidis across the Blood\u2013Brain Barriers"],"prefix":"10.3390","volume":"21","author":[{"given":"Julia","family":"Borkowski","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Schroten","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-0259","authenticated-orcid":false,"given":"Christian","family":"Schwerk","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-61779-346-2_1","article-title":"Neisseria meningitidis: Biology, microbiology, and epidemiology","volume":"799","author":"Rouphael","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Coureuil, M., Jamet, A., Bille, E., Lecuyer, H., Bourdoulous, S., and Nassif, X. (2019). Molecular interactions between Neisseria meningitidis and its human host. Cell. Microbiol., 21.","DOI":"10.1111\/cmi.13063"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Adriani, K.S., Brouwer, M.C., Baas, F., Zwinderman, A.H., van der Ende, A., and van de Beek, D. (2012). Genetic variation in the \u03b22-adrenocepter gene is associated with susceptibility to bacterial meningitis in adults. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037618"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1473-3099(08)70261-5","article-title":"Host genetic susceptibility to pneumococcal and meningococcal disease: A systematic review and meta-analysis","volume":"9","author":"Brouwer","year":"2009","journal-title":"Lancet Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1073\/pnas.95.6.3140","article-title":"Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms","volume":"95","author":"Maiden","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bille, E., Meyer, J., Jamet, A., Euphrasie, D., Barnier, J.P., Brissac, T., Larsen, A., Pelissier, P., and Nassif, X. (2017). A virulence-associated filamentous bacteriophage of Neisseria meningitidis increases host-cell colonisation. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006495"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1084\/jem.20050112","article-title":"A chromosomally integrated bacteriophage in invasive meningococci","volume":"201","author":"Bille","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1574-6976.2006.00052.x","article-title":"Lessons from meningococcal carriage studies","volume":"31","author":"Caugant","year":"2007","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1042\/CS20090513","article-title":"Cellular and molecular biology of Neisseria meningitidis colonization and invasive disease","volume":"118","author":"Hill","year":"2010","journal-title":"Clin. Sci. (London, England: 1979)"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Peterson, M.E., Li, Y., Bita, A., Moureau, A., Nair, H., Kyaw, M.H., Meningococcal Surveillance, G., Abad, R., Bailey, F., and Garcia, I.F. (2019). Meningococcal serogroups and surveillance: A systematic review and survey. J. Glob. Health, 9.","DOI":"10.7189\/jogh.09.010409"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.yapd.2020.03.007","article-title":"Meningococcal Infections in Children and Adolescents: Update and Prevention","volume":"67","author":"Brady","year":"2020","journal-title":"Adv. Pediatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00401-018-1809-z","article-title":"The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS","volume":"135","author":"Weller","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00401-018-1807-1","article-title":"Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease","volume":"135","author":"Strazielle","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1113\/JP275376","article-title":"Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain","volume":"596","author":"Saunders","year":"2018","journal-title":"J. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1124\/pr.117.014647","article-title":"Neuroimmune Axes of the Blood-Brain Barriers and Blood-Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions","volume":"70","author":"Erickson","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Castro Dias, M., Mapunda, J.A., Vladymyrov, M., and Engelhardt, B. (2019). Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215372"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1113\/jphysiol.1990.sp018243","article-title":"Electrical resistance across the blood-brain barrier in anaesthetized rats: A developmental study","volume":"429","author":"Butt","year":"1990","journal-title":"J. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Join-Lambert, O., Morand, P.C., Carbonnelle, E., Coureuil, M., Bille, E., Bourdoulous, S., and Nassif, X. (2010). Mechanisms of meningeal invasion by a bacterial extracellular pathogen, the example of Neisseria meningitidis. Prog. Neurobiol., 130\u2013139.","DOI":"10.1016\/j.pneurobio.2009.12.004"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1128\/IAI.70.8.4035-4044.2002","article-title":"Interaction of Neisseria meningitidis with human meningeal cells induces the secretion of a distinct group of chemotactic, proinflammatory, and growth-factor cytokines","volume":"70","author":"Christodoulides","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.molmed.2018.04.003","article-title":"Advances in Meningeal Immunity","volume":"24","author":"Rua","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1126\/science.1200729","article-title":"Posttranslational modification of pili upon cell contact triggers N. meningitidis dissemination","volume":"331","author":"Mikaty","year":"2011","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1128\/iai.65.11.4836-4842.1997","article-title":"Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells","volume":"65","author":"Pujol","year":"1997","journal-title":"Infect. Immun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1073\/pnas.91.9.3769","article-title":"Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells","volume":"91","author":"Nassif","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1128\/IAI.00968-08","article-title":"Identification of meningococcal genes necessary for colonization of human upper airway tissue","volume":"77","author":"Exley","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/infdis\/143.4.525","article-title":"Attachment of Neisseria meningitidis to human mucosal surfaces: Influence of pili and type of receptor cell","volume":"143","author":"Stephens","year":"1981","journal-title":"J. Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/BF03401658","article-title":"Traversal of a polarized epithelium by pathogenic Neisseriae: Facilitation by type IV pili and maintenance of epithelial barrier function","volume":"2","author":"Merz","year":"1996","journal-title":"Mol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1046\/j.1365-2958.1997.4841857.x","article-title":"Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria","volume":"25","author":"Kallstrom","year":"1997","journal-title":"Mol. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1086476","article-title":"CD46 in meningococcal disease","volume":"301","author":"Johansson","year":"2003","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"19979","DOI":"10.1074\/jbc.274.28.19979","article-title":"Importance of the carboxyl-terminal FTSL motif of membrane cofactor protein for basolateral sorting and endocytosis. Positive and negative modulation by signals inside and outside the cytoplasmic tail","volume":"274","author":"Teuchert","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"18853","DOI":"10.1074\/jbc.271.31.18853","article-title":"Two different cytoplasmic tails direct isoforms of the membrane cofactor protein (CD46) to the basolateral surface of Madin-Darby canine kidney cells","volume":"271","author":"Maisner","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.molmed.2004.07.002","article-title":"CD46 in Neisseria pathogenesis","volume":"10","author":"Gill","year":"2004","journal-title":"Trends Mol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1128\/IAI.73.5.3072-3082.2005","article-title":"CD46-independent binding of neisserial type IV pili and the major pilus adhesin, PilC, to human epithelial cells","volume":"73","author":"Kirchner","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1365-2958.2005.04600.x","article-title":"The PilC adhesin of the Neisseria type IV pilus-binding specificities and new insights into the nature of the host cell receptor","volume":"56","author":"Kirchner","year":"2005","journal-title":"Mol. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1128\/IAI.01377-09","article-title":"Transcellular passage of Neisseria meningitidis across a polarized respiratory epithelium","volume":"78","author":"Sutherland","year":"2010","journal-title":"Infect. Immun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1046\/j.1365-2958.1999.01459.x","article-title":"Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cells","volume":"32","author":"Merz","year":"1999","journal-title":"Mol. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1128\/iai.65.10.4341-4349.1997","article-title":"Attachment of piliated, Opa- and Opc- gonococci and meningococci to epithelial cells elicits cortical actin rearrangements and clustering of tyrosine-phosphorylated proteins","volume":"65","author":"Merz","year":"1997","journal-title":"Infect. Immun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/infdis\/148.3.369","article-title":"Interaction of Neisseria meningitidis with human nasopharyngeal mucosa: Attachment and entry into columnar epithelial cells","volume":"148","author":"Stephens","year":"1983","journal-title":"J. Infect. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1046\/j.1365-2958.2002.02838.x","article-title":"Down-regulation of pili and capsule of Neisseria meningitidis upon contact with epithelial cells is mediated by CrgA regulatory protein","volume":"43","author":"Deghmane","year":"2002","journal-title":"Mol. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1128\/IAI.01945-06","article-title":"The Neisseria meningitidis capsule is important for intracellular survival in human cells","volume":"75","author":"Spinosa","year":"2007","journal-title":"Infect. Immun."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sj\u00f6linder, H., and Jonsson, A.B. (2010). Olfactory nerve--a novel invasion route of Neisseria meningitidis to reach the meninges. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0014034"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/cmi.12417","article-title":"Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters","volume":"17","author":"Khairalla","year":"2015","journal-title":"Cell. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1574-6976.2010.00260.x","article-title":"Opa proteins and CEACAMs: Pathways of immune engagement for pathogenic Neisseria","volume":"35","author":"Sadarangani","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Johswich, K.O., McCaw, S.E., Islam, E., Sintsova, A., Gu, A., Shively, J.E., and Gray-Owen, S.D. (2013). In vivo adaptation and persistence of Neisseria meningitidis within the nasopharyngeal mucosa. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003509"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/ni.1661","article-title":"CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells","volume":"9","author":"Slevogt","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1046\/j.1365-2958.1998.00763.x","article-title":"Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptors","volume":"27","author":"Cole","year":"1998","journal-title":"Mol. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-2958.1993.tb00922.x","article-title":"Meningococcal Opa and Opc proteins: Their role in colonization and invasion of human epithelial and endothelial cells","volume":"10","author":"Virji","year":"1993","journal-title":"Mol. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1111\/j.1365-2958.1992.tb01458.x","article-title":"Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidis","volume":"6","author":"Virji","year":"1992","journal-title":"Mol. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1128\/IAI.03134-14","article-title":"Resistance of Neisseria meningitidis to human serum depends on T and B cell stimulating protein B","volume":"83","author":"Moe","year":"2015","journal-title":"Infect. Immun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0923-2508(98)80320-3","article-title":"Cooperation between the components of the meningococcal transferrin receptor, TbpA and TbpB, in the uptake of transferrin iron by the 37-kDa ferric-binding protein (FbpA)","volume":"149","author":"Criado","year":"1998","journal-title":"Res. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/mpat.1994.1085","article-title":"Molecular characterization of the structural gene for the lactoferrin receptor of the meningococcal strain H44\/76","volume":"17","author":"Pettersson","year":"1994","journal-title":"Microb. Pathog."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1128\/iai.56.5.1144-1149.1988","article-title":"Identification and characterization of the human lactoferrin-binding protein from Neisseria meningitidis","volume":"56","author":"Schryvers","year":"1988","journal-title":"Infect. Immun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1128\/jb.177.5.1299-1306.1995","article-title":"Identification of an iron-regulated outer membrane protein of Neisseria meningitidis involved in the utilization of hemoglobin complexed to haptoglobin","volume":"177","author":"Lewis","year":"1995","journal-title":"J. Bacteriol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2958.1995.tb02266.x","article-title":"The Neisseria meningitidis haemoglobin receptor: Its role in iron utilization and virulence","volume":"15","author":"Stojiljkovic","year":"1995","journal-title":"Mol. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1073\/pnas.0915162107","article-title":"Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans","volume":"107","author":"Serruto","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1126\/science.810892","article-title":"Neisseria gonorrhoeae and neisseria meningitidis: Extracellular enzyme cleaves human immunoglobulin A","volume":"190","author":"Plaut","year":"1975","journal-title":"Science"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.4049\/jimmunol.174.10.6299","article-title":"Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis","volume":"174","author":"Jarva","year":"2005","journal-title":"J. Immunol. (Baltimore, Md. 1950)"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1128\/IAI.02984-14","article-title":"Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity","volume":"83","author":"Giuntini","year":"2015","journal-title":"Infect. Immun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1586\/14760584.2015.1016915","article-title":"Neisseria meningitidis factor H-binding protein fHbp: A key virulence factor and vaccine antigen","volume":"14","author":"Seib","year":"2015","journal-title":"Expert Rev. Vaccines"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/mpat.1993.1085","article-title":"Demonstration of lipooligosaccharide immunotype and capsule as virulence factors for Neisseria meningitidis using an infant mouse intranasal infection model","volume":"15","author":"Mackinnon","year":"1993","journal-title":"Microb. Pathog."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1101\/gr.664303","article-title":"Large-scale analysis of the meningococcus genome by gene disruption: Resistance to complement-mediated lysis","volume":"13","author":"Geoffroy","year":"2003","journal-title":"Genome Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1128\/IAI.00181-09","article-title":"Evidence for capsule switching between carried and disease-causing Neisseria meningitidis strains","volume":"77","author":"Beddek","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1073\/pnas.94.1.271","article-title":"Capsule switching of Neisseria meningitidis","volume":"94","author":"Swartley","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1155\/2005\/216369","article-title":"Potential capsule switching from serogroup Y to B: The characterization of three such Neisseria meningitidis isolates causing invasive meningococcal disease in Canada","volume":"16","author":"Tsang","year":"2005","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1126\/science.287.5459.1809","article-title":"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58","volume":"287","author":"Tettelin","year":"2000","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35006655","article-title":"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491","volume":"404","author":"Parkhill","year":"2000","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0092-8674(86)90489-7","article-title":"The repertoire of silent pilus genes in Neisseria gonorrhoeae: Evidence for gene conversion","volume":"44","author":"Haas","year":"1986","journal-title":"Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1073\/pnas.83.7.2177","article-title":"Antigenic variation of gonococcal pilus involves assembly of separated silent gene segments","volume":"83","author":"Segal","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2958.1994.tb00416.x","article-title":"Variable expression of the Opc outer membrane protein in Neisseria meningitidis is caused by size variation of a promoter containing poly-cytidine","volume":"13","author":"Sarkari","year":"1994","journal-title":"Mol. Microbiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0966-842X(00)88918-0","article-title":"Epidemic spread and antigenic variability of Neisseria meningitidis","volume":"3","author":"Achtman","year":"1995","journal-title":"Trends Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/j.1365-2958.1996.tb02641.x","article-title":"Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): Correlation with bacterial invasion and the outbreak of meningococcal disease","volume":"20","author":"Hammerschmidt","year":"1996","journal-title":"Mol. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1099\/00221287-145-11-3013","article-title":"The genetic basis of the phase variation repertoire of lipopolysaccharide immunotypes in Neisseria meningitidis","volume":"145","author":"Jennings","year":"1999","journal-title":"Microbiology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0092-8674(86)90366-1","article-title":"Opacity genes in Neisseria gonorrhoeae: Control of phase and antigenic variation","volume":"47","author":"Stern","year":"1986","journal-title":"Cell"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Frosch, M., and Maiden, M.C.J. (2006). Structure and Genetics of the Meningococcal Capsule. Handbook of Meningococcal Disease, Wiley-VCH.","DOI":"10.1002\/3527608508"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/10408419891294216","article-title":"Genetic basis for biosynthesis, structure, and function of meningococcal lipooligosaccharide (endotoxin)","volume":"24","author":"Kahler","year":"1998","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/978-1-4615-1267-7_35","article-title":"Molecular mimicry of host structures by lipooligosaccharides of Neisseria meningitidis: Characterization of sialylated and nonsialylated lacto-N-neotetraose (Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc) structures in lipooligosaccharides using monoclonal antibodies and specific lectins","volume":"491","author":"Tsai","year":"2001","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1128\/IAI.05837-11","article-title":"Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells","volume":"80","author":"Nassif","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm.3563","article-title":"Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization","volume":"20","author":"Bernard","year":"2014","journal-title":"Nat. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1093\/infdis\/jit301","article-title":"Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans","volume":"208","author":"Lecuyer","year":"2013","journal-title":"J. Infect. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Melican, K., Michea Veloso, P., Martin, T., Bruneval, P., and Dum\u00e9nil, G. (2013). Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003139"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Coureuil, M., L\u00e9cuyer, H., Bourdoulous, S., and Nassif, X. (2017). A journey into the brain: Insight into how bacterial pathogens cross blood\u2013brain barriers. Microbiology, 15.","DOI":"10.1038\/nrmicro.2016.178"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-4939-9202-7_10","article-title":"In Vitro Models for Studying the Interaction of Neisseria meningitidis with Human Brain Endothelial Cells","volume":"Volume 1969","author":"Kim","year":"2019","journal-title":"Neisseria Meningitidis"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Melican, K., Aubey, F., and Dum\u00e9nil, G. (2014). Humanized mouse model to study bacterial infections targeting the microvasculature. J. Vis. Exp. JoVE.","DOI":"10.3791\/51134-v"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1172\/JCI36759","article-title":"Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models","volume":"119","author":"Orihuela","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Jen, F.E., Warren, M.J., Schulz, B.L., Power, P.M., Swords, W.E., Weiser, J.N., Apicella, M.A., Edwards, J.L., and Jennings, M.P. (2013). Dual pili post-translational modifications synergize to mediate meningococcal adherence to platelet activating factor receptor on human airway cells. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003377"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Martins Gomes, S.F., Westermann, A.J., Sauerwein, T., Hertlein, T., Forstner, K.U., Ohlsen, K., Metzger, M., Shusta, E.V., Kim, B.J., and Appelt-Menzel, A. (2019). Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Neisseria meningitidis Infection. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01181"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Ma\u00efssa, N., Covarelli, V., Janel, S., Durel, B., Simpson, N., Bernard, S.C., Pardo-Lopez, L., Bouzinba-S\u00e9gard, H., Faure, C., and Scott, M.G.H. (2017). Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147\/\u03b2(2)-adrenoceptor clusters assembled by alpha-actinin-4. Nat. Commun., 8.","DOI":"10.1038\/ncomms15764"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1242\/jcs.115.6.1231","article-title":"Microvilli-like structures are associated with the internalization of virulent capsulated Neisseria meningitidis into vascular endothelial cells","volume":"115","author":"Eugene","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.cell.2010.11.035","article-title":"Meningococcus Hijacks a \u03b22-adrenoceptor\/\u03b2-Arrestin pathway to cross brain microvasculature endothelium","volume":"143","author":"Coureuil","year":"2010","journal-title":"Cell"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1126\/science.283.5402.655","article-title":"Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes","volume":"283","author":"Luttrell","year":"1999","journal-title":"Science"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Mikaty, G., Soyer, M., Mairey, E., Henry, N., Dyer, D., Forest, K.T., Morand, P., Guadagnini, S., Prevost, M.C., and Nassif, X. (2009). Extracellular bacterial pathogen induces host cell surface reorganization to resist shear stress. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000314"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1083\/jcb.200507128","article-title":"Neisseria meningitidis infection of human endothelial cells interferes with leukocyte transmigration by preventing the formation of endothelial docking structures","volume":"173","author":"Doulet","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1128\/IAI.01346-13","article-title":"Role of epidermal growth factor receptor signaling in the interaction of Neisseria meningitidis with endothelial cells","volume":"82","author":"Slanina","year":"2014","journal-title":"Infect. Immun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1083\/jcb.200106148","article-title":"Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis","volume":"155","author":"Hoffmann","year":"2001","journal-title":"J. Cell Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1083\/jcb.148.6.1267","article-title":"beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1\/2","volume":"148","author":"DeFea","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1073\/pnas.041604898","article-title":"Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds","volume":"98","author":"Luttrell","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1462-5822.2004.00422.x","article-title":"Interaction of Neisseria meningitidis with human brain microvascular endothelial cells: Role of MAP- and tyrosine kinases in invasion and inflammatory cytokine release","volume":"6","author":"Sokolova","year":"2004","journal-title":"Cell. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1242\/jcs.02514","article-title":"Invasion of endothelial cells by Neisseria meningitidis requires cortactin recruitment by a phosphoinositide-3-kinase\/Rac1 signalling pathway triggered by the lipo-oligosaccharide","volume":"118","author":"Lambotin","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ijmm.2006.06.006","article-title":"Intracellular survival and replication of Neisseria meningitidis in human brain microvascular endothelial cells","volume":"296","author":"Nikulin","year":"2006","journal-title":"Int. J. Med Microbiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1173196","article-title":"Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium","volume":"325","author":"Coureuil","year":"2009","journal-title":"Science"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Schubert-Unkmeir, A., Konrad, C., Slanina, H., Czapek, F., Hebling, S., and Frosch, M. (2010). Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: A role for MMP-8. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000874"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1128\/IAI.01508-06","article-title":"Gene expression pattern in human brain endothelial cells in response to Neisseria meningitidis","volume":"75","author":"Sokolova","year":"2007","journal-title":"Infect. Immun."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1084\/jem.20060482","article-title":"Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood-brain barrier","volume":"203","author":"Mairey","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"K\u00e1, E., Jim\u00e9nez-Mungu\u00eda, I., Majerov\u00e1, P., Tk\u00e1\u010dov\u00e1, Z., Bhide, K., Mertinkov\u00e1, P., Pulzov\u00e1, L., Kov\u00e1\u010d, A., and Bhide, M. (2018). Deciphering the Interactome of Neisseria meningitidis With Human Brain Microvascular Endothelial Cells. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.02294"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1046\/j.1365-2958.2000.01923.x","article-title":"Interactions of Neisseria meningitidis with cells of the human meninges","volume":"36","author":"Hardy","year":"2000","journal-title":"Mol. Microbiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1046\/j.1365-2958.2002.03222.x","article-title":"Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cells","volume":"46","author":"Unkmeir","year":"2002","journal-title":"Mol. Microbiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/j.1462-5822.2005.00572.x","article-title":"Critical determinants of the interactions of capsule-expressing Neisseria meningitidis with host cells: The role of receptor density in increased cellular targeting via the outer membrane Opa proteins","volume":"7","author":"Bradley","year":"2005","journal-title":"Cell. Microbiol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Schubert-Unkmeir, A. (2017). Molecular mechanisms involved in the interaction of Neisseria meningitidis with cells of the human blood\u2013cerebrospinal fluid barrier. Pathog. Dis.","DOI":"10.1093\/femspd\/ftx023"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1046\/j.1365-2958.1996.01551.x","article-title":"Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae","volume":"22","author":"Virji","year":"1996","journal-title":"Mol. Microbiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1365-2958.1994.tb01277.x","article-title":"Distinct mechanisms of interactions of Opc-expressing meningococci at apical and basolateral surfaces of human endothelial cells; the role of integrins in apical interactions","volume":"14","author":"Virji","year":"1994","journal-title":"Mol. Microbiol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Sa, E.C.C., Griffiths, N.J., and Virji, M. (2010). Neisseria meningitidis Opc invasin binds to the sulphated tyrosines of activated vitronectin to attach to and invade human brain endothelial cells. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000911"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1126\/science.285.5430.1028","article-title":"Integrin signaling","volume":"285","author":"Giancotti","year":"1999","journal-title":"Science"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1128\/IAI.01267-09","article-title":"Entry of Neisseria meningitidis into mammalian cells requires the Src family protein tyrosine kinases","volume":"78","author":"Slanina","year":"2010","journal-title":"Infect. Immun."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Slanina, H., Hebling, S., Hauck, C.R., and Schubert-Unkmeir, A. (2012). Cell invasion by Neisseria meningitidis requires a functional interplay between the focal adhesion kinase, Src and cortactin. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039613"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1462-5822.2008.01262.x","article-title":"Neisseria meningitidis Opc invasin binds to the cytoskeletal protein alpha-actinin","volume":"11","author":"Sa","year":"2009","journal-title":"Cell. Microbiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1046\/j.1365-2958.1996.437970.x","article-title":"Allelic polymorphism and site-specific recombination in the opc locus of Neisseria meningitidis","volume":"19","author":"Seiler","year":"1996","journal-title":"Mol. Microbiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1017\/S0950268800058568","article-title":"Targeted vaccination with meningococcal polysaccharide vaccine in one district of the Czech Republic","volume":"115","author":"Kriz","year":"1995","journal-title":"Epidemiol. Infect."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1001\/jama.1995.03520290042027","article-title":"The changing epidemiology of invasive meningococcal disease in Canada, 1985 through 1992. Emergence of a virulent clone of Neisseria meningitidis","volume":"273","author":"Whalen","year":"1995","journal-title":"JAMA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/cmi.12482","article-title":"Neisseria meningitidis causes cell cycle arrest of human brain microvascular endothelial cells at S phase via p21 and cyclin G2","volume":"18","author":"Oosthuysen","year":"2016","journal-title":"Cell. Microbiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1128\/IAI.00296-16","article-title":"Disease and Carrier Isolates of Neisseria meningitidis Cause G1 Cell Cycle Arrest in Human Epithelial Cells","volume":"84","author":"Oosthuysen","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Simonis, A., Hebling, S., Gulbins, E., Schneider-Schaulies, S., and Schubert-Unkmeir, A. (2014). Differential activation of acid sphingomyelinase and ceramide release determines invasiveness of Neisseria meningitidis into brain endothelial cells. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004160"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1086\/514124","article-title":"Interaction of Neisseria maningitidis with the components of the blood-brain barrier correlates with an increased expression of PilC","volume":"176","author":"Pron","year":"1997","journal-title":"J. Infect. Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0966-842X(02)02349-1","article-title":"How do extracellular pathogens cross the blood-brain barrier?","volume":"10","author":"Nassif","year":"2002","journal-title":"Trends Microbiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1309\/3489075U03LMK9AE","article-title":"Pathogenesis and diagnosis of human meningococcal disease using immunohistochemical and PCR assays","volume":"122","author":"Guarner","year":"2004","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jinf.2014.10.018","article-title":"Pneumococcal meningitis-associated pyogenic ventriculitis","volume":"70","author":"Woehrl","year":"2015","journal-title":"J. Infect."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Schwerk, C., Papandreou, T., Schuhmann, D., Nickol, L., Borkowski, J., Steinmann, U., Quednau, N., Stump, C., Weiss, C., and Berger, J. (2012). Polar Invasion and Translocation of Neisseria meningitidis and Streptococcus suis in a Novel Human Model of the Blood-Cerebrospinal Fluid Barrier. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030069"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Dinner, S., Borkowski, J., Stump-Guthier, C., Ishikawa, H., Tenenbaum, T., Schroten, H., and Schwerk, C. (2016). A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side. J. Vis. Exp. Jove.","DOI":"10.3791\/54061"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Borkowski, J., Li, L., Steinmann, U., Quednau, N., Stump-Guthier, C., Weiss, C., Findeisen, P., Gretz, N., Ishikawa, H., and Tenenbaum, T. (2014). Neisseria meningitidis elicits a pro-inflammatory response involving I\u03baB\u03b6 in a human blood-cerebrospinal fluid barrier model. J. Neuroinflamm., 11.","DOI":"10.1186\/s12974-014-0163-x"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/NEN.0b013e3182909f2f","article-title":"How does the brain limit the severity of inflammation and tissue injury during bacterial meningitis?","volume":"72","author":"Neal","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Steinmann, U., Borkowski, J., Wolburg, H., Schr\u00f6ppel, B., Findeisen, P., Weiss, C., Ishikawa, H., Schwerk, C., Schroten, H., and Tenenbaum, T. (2013). Transmigration of polymorphnuclear neutrophils and monocytes through the human blood-cerebrospinal fluid barrier after bacterial infection in vitro. J. Neuroinflamm., 10.","DOI":"10.1186\/1742-2094-10-31"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.micinf.2011.05.012","article-title":"In vitro transcriptome analysis of porcine choroid plexus epithelial cells in response to Streptococcus suis: Release of pro-inflammatory cytokines and chemokines","volume":"13","author":"Schwerk","year":"2011","journal-title":"Microbes Infect. Inst. Pasteur"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.micinf.2016.06.001","article-title":"Neisseriae internalization by epithelial cells is enhanced by TLR2 stimulation","volume":"18","author":"Toussi","year":"2016","journal-title":"Microbes Infect."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.4049\/jimmunol.176.4.2373","article-title":"Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling","volume":"176","author":"Massari","year":"2006","journal-title":"J. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.4049\/jimmunol.168.4.1533","article-title":"Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent","volume":"168","author":"Massari","year":"2002","journal-title":"J. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0966-842X(02)00037-9","article-title":"The role of porins in neisserial pathogenesis and immunity","volume":"11","author":"Massari","year":"2003","journal-title":"Trends Microbiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature02738","article-title":"Regulation of Toll\/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta","volume":"430","author":"Yamamoto","year":"2004","journal-title":"Nature"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1189\/jlb.0610369","article-title":"Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2","volume":"89","author":"Zughaier","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1096\/fj.00-0339com","article-title":"Toll-like receptor 4: The missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components","volume":"15","author":"Laflamme","year":"2001","journal-title":"FASEB J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1046\/j.1471-4159.2001.00603.x","article-title":"Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS","volume":"79","author":"Laflamme","year":"2001","journal-title":"J. Neurochem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/nature07924","article-title":"Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay","volume":"458","author":"Matsushita","year":"2009","journal-title":"Nature"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2990.1991.tb00739.x","article-title":"Barrier functions of the leptomeninges: A study of normal meninges and meningiomas in tissue culture","volume":"17","author":"Feurer","year":"1991","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1462-5822.2004.00471.x","article-title":"Activation of human meningeal cells is modulated by lipopolysaccharide (LPS) and non-LPS components of Neisseria meningitidis and is independent of Toll-like receptor (TLR)4 and TLR2 signalling","volume":"7","author":"Humphries","year":"2005","journal-title":"Cell. Microbiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1128\/IAI.69.4.2718-2722.2001","article-title":"Differential gene expression during meningeal-meningococcal interaction: Evidence for self-defense and early release of cytokines and chemokines","volume":"69","author":"Wells","year":"2001","journal-title":"Infect. Immun."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1462-5822.2004.00382.x","article-title":"Different meningitis-causing bacteria induce distinct inflammatory responses on interaction with cells of the human meninges","volume":"6","author":"Fowler","year":"2004","journal-title":"Cell. Microbiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1462-5822.2004.00410.x","article-title":"Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation","volume":"6","author":"Robinson","year":"2004","journal-title":"Cell. Microbiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/22\/8788\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:34:59Z","timestamp":1760178899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/22\/8788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,20]]},"references-count":144,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["ijms21228788"],"URL":"https:\/\/doi.org\/10.3390\/ijms21228788","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,20]]}}}