{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:48:20Z","timestamp":1771019300003,"version":"3.50.1"},"reference-count":52,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H03818"],"award-info":[{"award-number":["19H03818"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K19652"],"award-info":[{"award-number":["18K19652"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K12050"],"award-info":[{"award-number":["17K12050"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09523"],"award-info":[{"award-number":["18K09523"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007369","name":"Fukuoka Foundation for Sound Health","doi-asserted-by":"publisher","award":["Cancer Research Fund"],"award-info":[{"award-number":["Cancer Research Fund"]}],"id":[{"id":"10.13039\/501100007369","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Taste disorders are common adverse effects of cancer chemotherapy that can reduce quality of life and impair nutritional status. However, the molecular mechanisms underlying chemotherapy-induced taste disorders remain largely unknown. Furthermore, there are no effective preventive measures for chemotherapy-induced taste disorders. We investigated the effects of a combination of three anticancer drugs (TPF: docetaxel, cisplatin and 5-fluorouracil) on the structure and function of mouse taste tissues and examined whether the drinking of ice-cold water after TPF administration would attenuate these effects. TPF administration significantly increased the number of cells expressing apoptotic and proliferative markers. Furthermore, TPF administration significantly reduced the number of cells expressing taste cell markers and the magnitudes of the responses of taste nerves to tastants. The above results suggest that anticancer drug-induced taste dysfunction may be due to a reduction in the number of taste cells expressing taste-related molecules. The suppressive effects of TPF on taste cell marker expression and taste perception were reduced by the drinking of ice-cold water. We speculate that oral cryotherapy with an ice cube might be useful for prophylaxis against anticancer drug-induced taste disorders in humans.<\/jats:p>","DOI":"10.3390\/ijms21238958","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T20:48:12Z","timestamp":1606337292000},"page":"8958","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Drinking Ice-Cold Water Reduces the Severity of Anticancer Drug-Induced Taste Dysfunction in Mice"],"prefix":"10.3390","volume":"21","author":[{"given":"Ayana","family":"Osaki","sequence":"first","affiliation":[{"name":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"},{"name":"Division of General Dentistry, Kyushu University Hospital, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8532-7429","authenticated-orcid":false,"given":"Keisuke","family":"Sanematsu","sequence":"additional","affiliation":[{"name":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"},{"name":"Oral Health\/Brain Health\/Total Health Research Center, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"},{"name":"Research and Development Center for Five-Sense Devices, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-0615","authenticated-orcid":false,"given":"Junichi","family":"Yamazoe","sequence":"additional","affiliation":[{"name":"Section of Oral Healthcare and Dentistry Cooperation, Division of Maxillofacial Diagnostic and Surgical 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Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"},{"name":"Research and Development Center for Five-Sense Devices, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Takai","sequence":"additional","affiliation":[{"name":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohisa","family":"Wada","sequence":"additional","affiliation":[{"name":"Division of General Dentistry, Kyushu University Hospital, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, 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Motil."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMoa070956","article-title":"Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer","volume":"357","author":"Posner","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_3","first-page":"697","article-title":"Taste changes experienced by patients receiving chemotherapy","volume":"26","author":"Wickham","year":"1999","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3109\/0284186X.2011.633554","article-title":"Taste alterations in breast and gynaecological cancer patients receiving chemotherapy: Prevalence, course of severity, and quality of life correlates","volume":"51","author":"Gamper","year":"2012","journal-title":"Acta Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00520-004-0589-2","article-title":"Decreased taste sensitivity in cancer patients under chemotherapy","volume":"12","author":"Berteretche","year":"2004","journal-title":"Support. Care Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s005200100279","article-title":"Taste and smell dysfunction in patients receiving chemotherapy: A review of current knowledge","volume":"9","author":"Comeau","year":"2001","journal-title":"Support. Care Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/sj.bmt.1703716","article-title":"Quality of life, taste, olfactory and oral function following high-dose chemotherapy and allogeneic hematopoietic cell transplantation","volume":"30","author":"Epstein","year":"2002","journal-title":"Bone Marrow Transplant."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/annonc\/mdx018","article-title":"Subjective and objective taste and smell changes in cancer","volume":"28","author":"Spotten","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fphys.2017.00134","article-title":"Alteration in taste perception in cancer: Causes and strategies of treatment","volume":"8","author":"Murtaza","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/35093032","article-title":"Receptors and transduction in taste","volume":"413","author":"Lindemann","year":"2001","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1126\/science.aao3264","article-title":"An evolutionarily conserved gene family encodes proton-selective ion channels","volume":"359","author":"Tu","year":"2018","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/bs.ircmb.2015.12.004","article-title":"Recent advances in molecular mechanisms of taste signaling and modifying","volume":"323","author":"Shigemura","year":"2016","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_13","first-page":"1","article-title":"Functional cell types in taste buds have distinct longevities","volume":"8","author":"Nagai","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1200\/JCO.1991.9.3.449","article-title":"Inhibition of fluorouracil-induced stomatitis by oral cryotherapy","volume":"9","author":"Mahood","year":"1991","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"E340","DOI":"10.1188\/12.ONF.E340-E345","article-title":"Malnutrition and chemotherapy-induced nausea and vomiting: Implications for practice","volume":"39","author":"Davidson","year":"2012","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tice.2014.04.005","article-title":"Effects of anticancer drug docetaxel on the structure and function of the rabbit olfactory mucosa","volume":"46","author":"Kavoi","year":"2014","journal-title":"Tissue Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.biopha.2018.07.029","article-title":"Assessment of dose-response relationship of 5-fluorouracil to murine intestinal injury","volume":"106","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.oraloncology.2011.07.028","article-title":"Antitumor activity of cetuximab associated with the taxotere\u2013cisplatin\u2013fluorouracil (TPF) combination on an orthotopic head and neck cancer model","volume":"47","author":"Bozec","year":"2011","journal-title":"Oral Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e552","DOI":"10.1161\/STROKEAHA.110.589010","article-title":"Isolation of locally derived stem\/progenitor cells from the peri-infarct area that do not migrate from the lateral ventricle after cortical stroke","volume":"41","author":"Shimada","year":"2010","journal-title":"Stroke"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/chemse\/bjh248","article-title":"A strong nerve dependence of Sonic hedgehog expression in basal cells in mouse taste bud and an autonomous transcriptional control of genes in differentiated taste cells","volume":"29","author":"Miura","year":"2004","journal-title":"Chem. Senses"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa071028","article-title":"Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer","volume":"357","author":"Vermorken","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0012-1606(02)00048-9","article-title":"Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae","volume":"255","author":"Hall","year":"2003","journal-title":"Dev. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1634\/theoncologist.2009-0333","article-title":"Taste alterations in cancer patients receiving chemotherapy: A neglected side effect?","volume":"15","author":"Zabernigg","year":"2010","journal-title":"Oncologist"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.2174\/1381612822666160216150812","article-title":"Smell and taste disorders resulting from cancer and chemotherapy","volume":"22","author":"Cohen","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/01635581.2016.1144075","article-title":"Value: Changes in the detection and recognition thresholds of three basic tastes in lung cancer patients receiving cisplatin and paclitaxel and its association with nutritional and quality of life parameters","volume":"68","author":"Turcott","year":"2016","journal-title":"Nutr. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e12633","DOI":"10.1111\/ecc.12633","article-title":"Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: A cross-sectional study","volume":"26","author":"Ponticelli","year":"2017","journal-title":"Eur. J. Cancer Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s00520-016-3545-z","article-title":"Symptom clusters during palliative chemotherapy and their influence on functioning and quality of life","volume":"25","author":"Rha","year":"2017","journal-title":"Support. Care Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.clnu.2016.10.013","article-title":"Changes in taste and smell function, dietary intake, food preference, and body composition in testicular cancer patients treated with cisplatin-based chemotherapy","volume":"36","author":"IJpma","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jpainsymman.2006.12.010","article-title":"Chemosensory changes experienced by patients undergoing cancer chemotherapy: A qualitative interview study","volume":"34","author":"Bernhardson","year":"2007","journal-title":"J. Pain Symptom Manag."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00520-007-0319-7","article-title":"Self-reported taste and smell changes during cancer chemotherapy","volume":"16","author":"Bernhardson","year":"2008","journal-title":"Support. Care Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00404-012-2307-5","article-title":"Effect of platinum-containing chemotherapy on olfactory, gustatory, and hearing function in ovarian cancer patients","volume":"286","author":"Steinbach","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Boltong, A., Aranda, S., Keast, R., Wynne, R., Francis, P.A., Chirgwin, J., and Gough, K. (2014). A prospective cohort study of the effects of adjuvant breast cancer chemotherapy on taste function, food liking, appetite and associated nutritional outcomes. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0103512"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1242\/jcs.111.19.2867","article-title":"Strategies of epithelial repair: Modulation of stem cell and transit amplifying cell proliferation","volume":"111","author":"Lehrer","year":"1998","journal-title":"J. Cell Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1523\/JNEUROSCI.4167-11.2012","article-title":"Mechanisms of taste bud cell loss after head and neck irradiation","volume":"32","author":"Nguyen","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nature05084","article-title":"The cells and logic for mammalian sour taste detection","volume":"442","author":"Huang","year":"2006","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/chemse\/bjx048","article-title":"Genetic labeling of Car4-expressing cells reveals subpopulations of type III taste cells","volume":"42","author":"Lossow","year":"2017","journal-title":"Chem. Senses"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Mukherjee, N., Pal Choudhuri, S., Delay, R.J., and Delay, E.R. (2017). Cellular mechanisms of cyclophosphamide-induced taste loss in mice. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0185473"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Mukherjee, N., Carroll, B.L., Spees, J.L., and Delay, E.R. (2013). Pre-Treatment with amifostine protects against cyclophosphamide-induced disruption of taste in mice. PLoS ONE, 8.","DOI":"10.1371\/annotation\/5487e265-8175-47cb-b9a4-d85862a4a96f"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0214890","article-title":"Cyclophosphamide and the taste system: Effects of dose fractionation and amifostine on taste cell renewal","volume":"14","author":"Delay","year":"2019","journal-title":"PLoS ONE"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ydbio.2004.07.042","article-title":"Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development","volume":"276","author":"Liu","year":"2004","journal-title":"Dev. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/cam4.350","article-title":"Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds","volume":"4","author":"Yang","year":"2015","journal-title":"Cancer Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"E10369","DOI":"10.1073\/pnas.1712881114","article-title":"Recovery of taste organs and sensory function after severe loss from Hedgehog\/Smoothened inhibition with cancer drug sonidegib","volume":"114","author":"Kumari","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/stem.1338","article-title":"Lgr5-EGFP marks taste bud stem\/progenitor cells in posterior tongue","volume":"31","author":"Yee","year":"2013","journal-title":"Stem Cells"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nn.2820","article-title":"Skn-1a (Pou2f3) specifies taste receptor cell lineage","volume":"14","author":"Matsumoto","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00280-008-0715-9","article-title":"Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolution","volume":"63","author":"Soares","year":"2008","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejon.2011.07.008","article-title":"Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy\u2014A randomized controlled trial","volume":"16","author":"Katranci","year":"2012","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejon.2013.11.001","article-title":"The impact of oral cryotherapy and oral and gastrointestinal mucositis after autologous stem cell transplantation","volume":"18","author":"Vokurka","year":"2014","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/jop.12696","article-title":"Cooling of the oral mucosa to prevent adverse effects of chemotherapeutic agents: An in vitro study","volume":"47","author":"Walladbegi","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"358","DOI":"10.6004\/jnccn.2018.7110","article-title":"Efficacy of oral cryotherapy during oxaliplatin infusion in preventing oral thermal hyperalgesia: A randomized trial","volume":"17","author":"Bauman","year":"2019","journal-title":"Natl. Compr. Canc. Netw."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/jnci\/djx178","article-title":"Effects of cryotherapy on objective and subjective symptoms of paclitaxel-induced neuropathy: Prospective self-controlled trial","volume":"110","author":"Hanai","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1073\/pnas.0912048107","article-title":"Endocannabinoids selectively enhance sweet taste","volume":"107","author":"Yoshida","year":"2010","journal-title":"Proc. Natl. Acad. Sci. 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