{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:12:19Z","timestamp":1788307939977,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the R\u00e9gion Poitou Charentes, the CHU de Poitiers, the University of Poitiers and the Inserm","award":["."],"award-info":[{"award-number":["."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The current organ shortage in hepatic transplantation leads to increased use of marginal livers. New organ sources are needed, and deceased after circulatory death (DCD) donors present an interesting possibility. However, many unknown remains on these donors and their pathophysiology regarding ischemia reperfusion injury (IRI). Our hypothesis was that DCD combined with abdominal normothermic regional recirculation (ANOR) is not inferior to deceased after brain death (DBD) donors. We performed a mechanistic comparison between livers from DBD and DCD donors in a highly reproducible pig model, closely mimicking donor conditions encountered in the clinic. DCD donors were conditioned by ANOR. We determined that from the start of storage, pro-lesion pathways such as oxidative stress and cell death were induced in both donor types, but to a higher extent in DBD organs. Furthermore, pro-survival pathways, such as resistance to hypoxia and regeneration showed activation levels closer to healthy livers in DCD-ANOR rather than in DBD organs. These data highlight critical differences between DBD and DCD-ANOR livers, with an apparent superiority of DCD in terms of quality. This confirms our hypothesis and further confirms previously demonstrated benefits of ANOR. This encourages the expended use of DCD organs, particularly with ANOR preconditioning.<\/jats:p>","DOI":"10.3390\/ijms21239040","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T03:51:16Z","timestamp":1606535476000},"page":"9040","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Liver Quality after Circulatory Death versus Brain Death: A Comparative Preclinical Pig Model Study"],"prefix":"10.3390","volume":"21","author":[{"given":"J\u00e9r\u00f4me","family":"Danion","sequence":"first","affiliation":[{"name":"Inserm U1082, F-86000 Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie, Universit\u00e9 de Poitiers, F-86000 Poitiers, France"},{"name":"CHU de Poitiers, Service de Chirurgie G\u00e9n\u00e9rale et Endocrinienne, F-86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Thuillier","sequence":"additional","affiliation":[{"name":"Inserm U1082, F-86000 Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie, Universit\u00e9 de Poitiers, F-86000 Poitiers, France"},{"name":"CHU Poitiers, Service de Biochimie, F-86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Allain","sequence":"additional","affiliation":[{"name":"Inserm U1082, F-86000 Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie, Universit\u00e9 de Poitiers, F-86000 Poitiers, France"},{"name":"CHU Poitiers, Service de Chirurgie Cardiothoracique et Vasculaire, F-86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-2914","authenticated-orcid":false,"given":"Patrick","family":"Bruneval","sequence":"additional","affiliation":[{"name":"H\u00f4pital Europ\u00e9en Georges Pompidou, Service D\u2019anatomie Pathologique, F-75015 Paris, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris-Descartes, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Tomasi","sequence":"additional","affiliation":[{"name":"CHU Poitiers, Service de Chirurgie Cardiothoracique et Vasculaire, F-86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Pinsard","sequence":"additional","affiliation":[{"name":"CHU Poitiers, Service de R\u00e9animation Chirurgie Cardio-Thoracique et Vasculaire, Coordination des P.M.O., F-86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-071X","authenticated-orcid":false,"given":"Thierry","family":"Hauet","sequence":"additional","affiliation":[{"name":"Inserm U1082, F-86000 Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie, Universit\u00e9 de Poitiers, F-86000 Poitiers, France"},{"name":"CHU Poitiers, Service de Biochimie, F-86021 Poitiers, France"},{"name":"F\u00e9d\u00e9ration Hospitalo-Universitaire SUPORT, F-86000 Poitiers, France"},{"name":"IBiSA Plateforme \u2018Plate-Forme MOd\u00e9lisation Pr\u00e9clinique\u2014Innovation Chirurgicale et Technologique (MOPICT)\u2019, Domaine Exp\u00e9rimental du Magneraud, F-17700 Surg\u00e8res, France"},{"name":"Pr. Thierry HAUET, INSERM U1082, CHU de Poitiers, 2 rue de la Miletrie, CEDEX BP 577, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kerforne","sequence":"additional","affiliation":[{"name":"Inserm U1082, F-86000 Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie, Universit\u00e9 de Poitiers, F-86000 Poitiers, France"},{"name":"CHU Poitiers, Service de R\u00e9animation Chirurgie Cardio-Thoracique et Vasculaire, Coordination des P.M.O., F-86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/00015458.2008.11680168","article-title":"Abdominal Transplant Surgery and Transplant Coordination University Hospitals Leuven 1997\u20132007: An overview","volume":"108","author":"Pirenne","year":"2008","journal-title":"Acta Chir. 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