{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T02:57:57Z","timestamp":1776394677629,"version":"3.51.2"},"reference-count":73,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Community\u2019s Seventh Framework Programme","award":["115009"],"award-info":[{"award-number":["115009"]}]},{"name":"Italian Ministry of Health","award":["Ricerca Corrente"],"award-info":[{"award-number":["Ricerca Corrente"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Objective. In this exploratory study, we tested whether electroencephalographic (EEG) rhythms may reflect the effects of a chronic administration (4 weeks) of an anti-amyloid \u03b2-site amyloid precursor protein (APP) cleaving enzyme 1 inhibitor (BACE-1; ER-901356; Eisai Co., Ltd., Tokyo, Japan) in TASTPM (double mutation in APP KM670\/671NL and PSEN1 M146V) producing Alzheimer\u2019s disease (AD) amyloid neuropathology as compared to wild type (WT) mice. Methods. Ongoing EEG rhythms were recorded from a bipolar frontoparietal and two monopolar frontomedial (prelimbic) and hippocampal channels in 11 WT Vehicle, 10 WT BACE-1, 10 TASTPM Vehicle, and 11 TASTPM BACE-1 mice (males; aged 8\/9 months old at the beginning of treatment). Normalized EEG power (density) was compared between the first day (Day 0) and after 4 weeks (Week 4) of the BACE-1 inhibitor (10 mg\/Kg) or vehicle administration in the 4 mouse groups. Frequency and magnitude of individual EEG delta and theta frequency peaks (IDF and ITF) were considered during animal conditions of behaviorally passive and active wakefulness. Cognitive status was not tested. Results. Compared with the WT group, the TASTPM group generally showed a significantly lower reactivity in frontoparietal ITF power during the active over the passive condition (p &lt; 0.05). Notably, there was no other statistically significant effect (e.g., additional electrodes, recording time, and BACE-1 inhibitor). Conclusions. The above EEG biomarkers reflected differences between the WT and TASTPM groups, but no BACE-1 inhibitor effect. The results suggest an enhanced experimental design with the use of younger mice, longer drug administrations, an effective control drug, and neuropathological amyloid markers.<\/jats:p>","DOI":"10.3390\/ijms21239072","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T21:00:57Z","timestamp":1606683657000},"page":"9072","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic BACE-1 Inhibitor Administration in TASTPM Mice (APP KM670\/671NL and PSEN1 M146V Mutation): An EEG Study"],"prefix":"10.3390","volume":"21","author":[{"given":"Susanna","family":"Lopez","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV Erspamer\u201d, Sapienza University of Rome, 00185 Rome, Italy"},{"name":"Department of Emergency and Organ Transplantation - Nephrology, Dialysis and Transplantation Unit, Aldo Moro University of Bari, 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Del Percio","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV Erspamer\u201d, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Forloni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelisa","family":"Frasca","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelmus","family":"Drinkenburg","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, Pharmaceutical Companies of J&amp;J, B-2340 Beerse, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-3689","authenticated-orcid":false,"given":"Roberta","family":"Lizio","sequence":"additional","affiliation":[{"name":"IRCCS SDN, 80143 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Noce","sequence":"additional","affiliation":[{"name":"IRCCS SDN, 80143 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-3065","authenticated-orcid":false,"given":"Raffaele","family":"Ferri","sequence":"additional","affiliation":[{"name":"Oasi Research Institute - IRCCS, 94018 Troina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-7667","authenticated-orcid":false,"given":"Andrea","family":"Soricelli","sequence":"additional","affiliation":[{"name":"IRCCS SDN, 80143 Naples, Italy"},{"name":"Department of Motor Sciences and Healthiness, University of Naples Parthenope, 80133 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Stocchi","sequence":"additional","affiliation":[{"name":"Institute for Research and Medical Care, IRCCS San Raffaele Pisana, 00163 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Vacca","sequence":"additional","affiliation":[{"name":"Institute for Research and Medical Care, IRCCS San Raffaele Pisana, 00163 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e8gis","family":"Bordet","sequence":"additional","affiliation":[{"name":"University of Lille, Inserm, CHU, 59000 Lille, France"},{"name":"U1171 - Degenerative and Vascular Cognitive Disorders, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Richardson","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline R&amp;D Neuroscience Therapeutic Area UK, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-9839","authenticated-orcid":false,"given":"Claudio","family":"Babiloni","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV Erspamer\u201d, Sapienza University of Rome, 00185 Rome, Italy"},{"name":"San Raffaele Cassino, 03043 Cassino (FR), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of PharmaCog Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Braak, H., and Braak, E. 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