{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T11:01:58Z","timestamp":1775300518129,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["18-29-04023"],"award-info":[{"award-number":["18-29-04023"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3n S\u00e9neca de la Regi\u00f3n de Murcia","award":["20988\/PI\/18"],"award-info":[{"award-number":["20988\/PI\/18"]}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["CTQ2017-87974-R"],"award-info":[{"award-number":["CTQ2017-87974-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The selectivity of encapsulation of leflunomide and teriflunomide by native \u03b1-, \u03b2- and \u03b3-cyclodextrins was investigated through 1H NMR and molecular modeling. Thermodynamic analysis revealed the main driving forces involved in the binding. For \u03b1-cyclodextrin, the partial encapsulation was obtained while deep penetration was characterized for the other two cyclodextrins, where the remaining polar fragment of the molecule is located outside the macrocyclic cavity. The interactions via hydrogen bonding are responsible for high negative enthalpy and entropy changes accompanying the complexation of cyclodextrins with teriflunomide. These results were in agreement with the molecular modeling calculations, which provide a clearer picture of the involved interactions at the atomic level.<\/jats:p>","DOI":"10.3390\/ijms21239102","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T10:26:12Z","timestamp":1606731972000},"page":"9102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Selective Binding of Cyclodextrins with Leflunomide and Its Pharmacologically Active Metabolite Teriflunomide"],"prefix":"10.3390","volume":"21","author":[{"given":"Irina","family":"Terekhova","sequence":"first","affiliation":[{"name":"G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 153045 Ivanovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6936-4545","authenticated-orcid":false,"given":"Iliya","family":"Kritskiy","sequence":"additional","affiliation":[{"name":"G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 153045 Ivanovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Agafonov","sequence":"additional","affiliation":[{"name":"G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 153045 Ivanovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Kumeev","sequence":"additional","affiliation":[{"name":"G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 153045 Ivanovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Mart\u00ednez-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Structural Bioinformatics and High Performance Computing Research Group (BIO-HPC), Universidad Cat\u00f3lica de Murcia (UCAM), 30107 Guadalupe, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-7898","authenticated-orcid":false,"given":"Horacio","family":"P\u00e9rez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Structural Bioinformatics and High Performance Computing Research Group (BIO-HPC), Universidad Cat\u00f3lica de Murcia (UCAM), 30107 Guadalupe, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.autrev.2006.12.001","article-title":"Leflunomide in psoriatic arthritis","volume":"6","author":"Kaltwasser","year":"2007","journal-title":"Autoimmun. 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