{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:49:06Z","timestamp":1790272146657,"version":"4.1.0"},"reference-count":104,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Drug discovery efforts largely depend on access to structural diversity. Multicomponent reactions allow for time-efficient chemical transformations and provide advanced intermediates with three or four points of diversification for further expansion to a structural variety of organic molecules. This review is aimed at solid-phase syntheses of small molecules involving isocyanide-based multicomponent reactions. The majority of all reported syntheses employ the Ugi four-component reaction. The review also covers the Passerini and Groebke-Blackburn-Bienaym\u00e9 reactions. To date, the main advantages of the solid-phase approach are the ability to prepare chemical libraries intended for biological screening and elimination of the isocyanide odor. However, the potential of multicomponent reactions has not been fully exploited. The unexplored avenues of these reactions, including chiral frameworks, DNA-encoded libraries, eco-friendly synthesis, and chiral auxiliary reactions, are briefly outlined.<\/jats:p>","DOI":"10.3390\/ijms21239160","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T20:06:09Z","timestamp":1606853169000},"page":"9160","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Isocyanide Multicomponent Reactions on Solid Phase: State of the Art and Future Application"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2963-1194","authenticated-orcid":false,"given":"Nad\u011b\u017eda","family":"Canka\u0159ov\u00e1","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Science, Palack\u00fd University, 17. listopadu 12, 779 00 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5688-4069","authenticated-orcid":false,"given":"Viktor","family":"Krch\u0148\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Science, Palack\u00fd University, 17. listopadu 12, 779 00 Olomouc, Czech Republic"},{"name":"Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/S0040-4039(00)00052-6","article-title":"Novel applications of convertible isonitriles for the synthesis of mono and bicyclic \u03b3-lactams via a UDC strategy","volume":"41","author":"Hulme","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6993","DOI":"10.1016\/S0040-4039(98)01547-0","article-title":"Construction of combinatorial chemical libraries using a rapid and efficient solid phase synthesis based on a multicomponent condensation reaction","volume":"39","author":"Kim","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1021\/ol005574n","article-title":"Pairwise Use of Complexity-Generating Reactions in Diversity-Oriented Organic Synthesis","volume":"2","author":"Lee","year":"2000","journal-title":"Org. 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