{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:33:29Z","timestamp":1771338809640,"version":"3.50.1"},"reference-count":61,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sato Fund, Dental Research Center, Nihon University School of Dentistry","award":["no"],"award-info":[{"award-number":["no"]}]},{"name":"Uemura Fund, Dental Research Center, Nihon University School of Dentistry","award":["no"],"award-info":[{"award-number":["no"]}]},{"name":"KAKENHI (Grant-in-Aid for Scientific Research (C))","award":["18K09732"],"award-info":[{"award-number":["18K09732"]}]},{"name":"KAKENHI (Grant-in-Aid for Scientific Research (C))","award":["19K19178"],"award-info":[{"award-number":["19K19178"]}]},{"name":"KAKENHI (Grant-in-Aid for Scientific Research (C))","award":["19K10049"],"award-info":[{"award-number":["19K10049"]}]},{"name":"Nihon University Multidisciplinary Research Grant","award":["18-014"],"award-info":[{"award-number":["18-014"]}]},{"name":"Nihon University Chairman of the Board of Trustees Grant","award":["2019-2020"],"award-info":[{"award-number":["2019-2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We evaluated the mechanisms underlying the oxytocin (OXT)-induced analgesic effect on orofacial neuropathic pain following infraorbital nerve injury (IONI). IONI was established through tight ligation of one-third of the infraorbital nerve thickness. Subsequently, the head withdrawal threshold for mechanical stimulation (MHWT) of the whisker pad skin was measured using a von Frey filament. Trigeminal ganglion (TG) neurons innervating the whisker pad skin were identified using a retrograde labeling technique. OXT receptor-immunoreactive (IR), transient receptor potential vanilloid 1 (TRPV1)-IR, and TRPV4-IR TG neurons innervating the whisker pad skin were examined on post-IONI day 5. The MHWT remarkably decreased from post-IONI day 1 onward. OXT application to the nerve-injured site attenuated the decrease in MHWT from day 5 onward. TRPV1 or TRPV4 antagonism significantly suppressed the decrement of MHWT following IONI. OXT receptors were expressed in the uninjured and Fluoro-Gold (FG)-labeled TG neurons. Furthermore, there was an increase in the number of FG-labeled TRPV1-IR and TRPV4-IR TG neurons, which was inhibited by administering OXT. This inhibition was suppressed by co-administration with an OXT receptor antagonist. These findings suggest that OXT application inhibits the increase in TRPV1-IR and TRPV4-IR TG neurons innervating the whisker pad skin, which attenuates post-IONI orofacial mechanical allodynia.<\/jats:p>","DOI":"10.3390\/ijms21239173","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T20:06:09Z","timestamp":1606853169000},"page":"9173","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Oxytocin-Dependent Regulation of TRPs Expression in Trigeminal Ganglion Neurons Attenuates Orofacial Neuropathic Pain following Infraorbital Nerve Injury in Rats"],"prefix":"10.3390","volume":"21","author":[{"given":"Masatoshi","family":"Ando","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-0674","authenticated-orcid":false,"given":"Yoshinori","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzuro","family":"Hitomi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuko","family":"Shibuta","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuki","family":"Oto","sequence":"additional","affiliation":[{"name":"Department of Complete Denture Prosthodontics, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Inada","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo 142-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikashi","family":"Fukaya","sequence":"additional","affiliation":[{"name":"Division of Applied System Neuroscience, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Noma","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostic Sciences, Nihon University School of Dentistry Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Removable Prosthodontics, Nihon University School of Dentistry at Matsudo, Matsudo 271-8587, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Yonehara","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadayoshi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-9237","authenticated-orcid":false,"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0965-6498","authenticated-orcid":false,"given":"Masamichi","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lin, C.S., Wu, S.Y., Huang, H.Y., and Lai, Y.L. 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