{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:32:05Z","timestamp":1790418725672,"version":"4.1.0"},"reference-count":84,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Gangliosides constitute a subgroup of glycosphingolipids characterized by the presence of sialic acid residues in their structure. As constituents of cellular membranes, in particular of raft microdomains, they exert multiple functions, some of them capital in cell homeostasis. Their presence in cells is tightly regulated by a balanced expression and function of the enzymes responsible for their biosynthesis, ganglioside synthases, and their degradation, glycosidases. The dysregulation of their abundance results in rare and common diseases. In this review, we make a point on the relevance of gangliosides and some of their metabolic precursors, such as ceramides, in the function of podocytes, the main cellular component of the glomerular filtration barrier, as well as their implications in podocytopathies. The results presented in this review suggest the pertinence of clinical lipidomic studies targeting these metabolites.<\/jats:p>","DOI":"10.3390\/ijms21249645","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T21:21:49Z","timestamp":1608240109000},"page":"9645","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Gangliosides in Podocyte Biology and Disease"],"prefix":"10.3390","volume":"21","author":[{"given":"Berkan","family":"Savas","sequence":"first","affiliation":[{"name":"INSERM, IMRB, Univ Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6700-301X","authenticated-orcid":false,"given":"Giuseppe","family":"Astarita","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular &amp; Cellular Biology, Georgetown University, 20007 Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Aureli","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology and Translational Medicine, University of Milano, Milano Italy, 20090 Segrate (Milano), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dil","family":"Sahali","sequence":"additional","affiliation":[{"name":"INSERM, IMRB, Univ Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"},{"name":"Service N\u00e9phrologie, AP-HP, H\u00f4pital Henri Mondor, F-94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-706X","authenticated-orcid":false,"given":"Mario","family":"Ollero","sequence":"additional","affiliation":[{"name":"INSERM, IMRB, Univ Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-8552-4_1","article-title":"Chemical and physicochemical properties of gangliosides","volume":"Volume 1804","author":"Mauri","year":"2018","journal-title":"Gangliosides"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ncb1103","article-title":"Lipid raft proteins have a random distribution during localized activation of the T-cell receptor","volume":"6","author":"Glebov","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/bs.pmbts.2017.10.004","article-title":"Biology of GM3 ganglioside","volume":"156","author":"Inokuchi","year":"2018","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrm2977","article-title":"Revitalizing membrane rafts: New tools and insights","volume":"11","author":"Simons","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3390\/cells2040751","article-title":"How do gangliosides regulate RTKs signaling?","volume":"2","author":"Julien","year":"2013","journal-title":"Cells"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.cell.2012.08.037","article-title":"Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function","volume":"151","author":"Jin","year":"2012","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/s41423-019-0266-5","article-title":"CMIP is a negative regulator of T cell signaling","volume":"17","author":"Oniszczuk","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10719-020-09944-w","article-title":"APOL1 polymorphism modulates sphingolipid profile of human podocytes","volume":"37","author":"Valsecchi","year":"2020","journal-title":"Glycoconj. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1679\/aohc.53.371","article-title":"A cytochemical study of glycocalyx and the membrane cholesterol of rat glomerular podocytes","volume":"53","author":"Nishi","year":"1990","journal-title":"Arch. Histol. Cytol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1681\/ASN.2008070694","article-title":"Lipid-protein interactions along the slit diaphragm of podocytes","volume":"20","author":"Schermer","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1159\/000101789","article-title":"Podocin organizes ion channel-lipid supercomplexes: Implications for mechanosensation at the slit diaphragm","volume":"106","author":"Huber","year":"2007","journal-title":"Nephron Exp. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0002-9440(10)61782-8","article-title":"Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm","volume":"159","author":"Simons","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1172\/JCI200112849","article-title":"Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin","volume":"108","author":"Schwarz","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"F585","DOI":"10.1152\/ajprenal.00290.2001","article-title":"Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton","volume":"282","author":"Yuan","year":"2002","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1093\/hmg\/ddg360","article-title":"Molecular basis of the functional podocin-nephrin complex: Mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains","volume":"12","author":"Huber","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1600-0854.2003.00148.x","article-title":"Plasma membrane targeting of Podocin through the classical exocytic pathway: Effect of NPHS2 mutations","volume":"5","author":"Roselli","year":"2003","journal-title":"Traffic"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"C960","DOI":"10.1152\/ajpcell.00191.2013","article-title":"NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: Essential role of podocin in formation of this complex","volume":"305","author":"Kim","year":"2013","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fendo.2014.00127","article-title":"Podocyte pathology and nephropathy\u2014Sphingolipids in glomerular diseases","volume":"5","author":"Merscher","year":"2014","journal-title":"Front. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrneph.2014.87","article-title":"Lipid biology of the podocyte--new perspectives offer new opportunities","volume":"10","author":"Fornoni","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ki.1994.14","article-title":"Nephron segment and cell-type specific expression of gangliosides in the developing and adult kidney","volume":"45","author":"Holthofer","year":"1994","journal-title":"Kidney Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/ki.1992.327","article-title":"A cell-type specific ganglioside of glomerular podocytes in rat kidney: An O-acetylated GD3","volume":"42","author":"Reivinen","year":"1992","journal-title":"Kidney Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/ki.1992.236","article-title":"Expression of a monoclonal antibody (3G5) defined ganglioside antigen in the renal cortex","volume":"41","author":"Nayak","year":"1992","journal-title":"Kidney Int."},{"key":"ref_23","first-page":"184","article-title":"Characterization of a rat glomerular visceral epithelial cell line","volume":"4","author":"Coers","year":"1996","journal-title":"Exp. Nephrol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4939-8552-4_5","article-title":"Ganglioside metabolism and its inherited diseases","volume":"1804","author":"Breiden","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jat.1256","article-title":"Renal gangliosides are involved in lead intoxication","volume":"28","author":"Aguilar","year":"2008","journal-title":"J. Appl. Toxicol."},{"key":"ref_26","first-page":"1009","article-title":"Decrease of glomerular disialogangliosides in puromycin nephrosis of the rat","volume":"149","author":"Reivinen","year":"1996","journal-title":"Am. J. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Pereira, R.L., Reis, V.O., Semedo, P., Buscariollo, B.N., Donizetti-Oliveira, C., Cenedeze, M.A., Soares, M.F., Pacheco-Silva, A., Savage, P.B., and C\u00e2mara, N.O. (2012). Invariant natural killer T cell agonist modulates experimental focal and segmental glomerulosclerosis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032454"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10157-014-1003-0","article-title":"Histochemical and immunoelectron microscopic analysis of ganglioside GM3 in human kidney","volume":"19","author":"Kaneko","year":"2014","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1084\/jem.20030566","article-title":"Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization","volume":"198","author":"Grimbert","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10719-013-9516-4","article-title":"GM3 and diabetes","volume":"31","author":"Inokuchi","year":"2014","journal-title":"Glycoconj. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1074\/jbc.M103705200","article-title":"Ganglioside GM3 participates in the pathological conditions of insulin resistance","volume":"277","author":"Tagami","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"18987","DOI":"10.1073\/pnas.0609281103","article-title":"Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor","volume":"103","author":"Yoon","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"13678","DOI":"10.1073\/pnas.0703650104","article-title":"Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance","volume":"104","author":"Kabayama","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/15321819.2015.1050107","article-title":"Monitoring diabetic nephropathy by circulating gangliosides","volume":"37","author":"Ene","year":"2015","journal-title":"J. Immunoass. Immunochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000368506","article-title":"The missing link\u2014Likely pathogenetic role of GM3 and other gangliosides in the development of diabetic nephropathy","volume":"40","author":"Vukovic","year":"2015","journal-title":"Kidney Blood Press. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1172\/JCI116299","article-title":"A role for glycosphingolipid accumulation in the renal hypertrophy of streptozotocin-induced diabetes mellitus","volume":"91","author":"Zador","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/S0024-3205(03)00090-0","article-title":"Decreases of ganglioside GM3 in streptozotocin-induced diabetic glomeruli of rats","volume":"72","author":"Kwak","year":"2003","journal-title":"Life Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s13105-013-0249-4","article-title":"Renal distribution of ganglioside GM3 in rat models of types 1 and 2 diabetes","volume":"69","author":"Novak","year":"2013","journal-title":"J. Physiol. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1194\/jlr.M049189","article-title":"Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles","volume":"55","author":"Grove","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1681\/ASN.2014050508","article-title":"Renal glycosphingolipid metabolism is dysfunctional in lupus nephritis","volume":"26","author":"Nowling","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Nowling, T.K., Rodgers, J., Thiyagarajan, T., Wolf, B., Bruner, E., Sundararaj, K., Molano, I., and Gilkeson, G. (2020). Targeting glycosphingolipid metabolism as a potential therapeutic approach for treating disease in female MRL\/lpr lupus mice. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0230499"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1073\/pnas.0635898100","article-title":"Enhanced insulin sensitivity in mice lacking ganglioside GM3","volume":"100","author":"Yamashita","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e1811","DOI":"10.6061\/clinics\/2020\/e1811","article-title":"Unexpectedly high prevalence of low alpha-galactosidase A enzyme activity in patients with focal segmental glomerulosclerosis","volume":"75","author":"Hasbal","year":"2020","journal-title":"Clinics"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Ryckman, A.E., Brockhausen, I., and Walia, J.S. (2020). Metabolism of glycosphingolipids and their role in the pathophysiology of lysosomal storage disorders. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186881"},{"key":"ref_45","first-page":"503","article-title":"Sandhoff disease","volume":"31","author":"Tatematsu","year":"1981","journal-title":"Pathol. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ki.2010.484","article-title":"Progressive podocyte injury and globotriaosylceramide (GL-3) accumulation in young patients with Fabry disease","volume":"79","author":"Najafian","year":"2011","journal-title":"Kidney Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/BJ20041506","article-title":"Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: Implication of gangliosides","volume":"388","author":"Masson","year":"2005","journal-title":"Biochem. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/j.dsx.2020.10.017","article-title":"Identification of biomarkers for early diagnosis of diabetic nephropathy disease using direct flow through mass spectrometry","volume":"14","author":"Nilavan","year":"2020","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1038\/s41598-019-39376-y","article-title":"Disruption of APOL1-miR193a axis induces disorganization of podocyte actin cytoskeleton","volume":"9","author":"Kumar","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"F326","DOI":"10.1152\/ajprenal.00647.2013","article-title":"APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability","volume":"307","author":"Lan","year":"2014","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.ajpath.2020.02.008","article-title":"Podocytopathy and nephrotic syndrome in mice with podocyte-specific deletion of the Asah1 gene: Role of ceramide accumulation in glomeruli","volume":"190","author":"Li","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"ra39","DOI":"10.1126\/scisignal.2000678","article-title":"c-mip impairs podocyte proximal signaling and induces heavy proteinuria","volume":"3","author":"Zhang","year":"2010","journal-title":"Sci. Signal"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/j.bbamem.2006.08.019","article-title":"Acid ceramidase and human disease","volume":"1758","author":"Park","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/humu.23192","article-title":"Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications","volume":"38","author":"Janecke","year":"2017","journal-title":"Hum. Mutat."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1172\/JCI89626","article-title":"Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency","volume":"127","author":"Lovric","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1172\/JCI90171","article-title":"Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome","volume":"127","author":"Prasad","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1177\/0192623314565650","article-title":"Reduced activity of sphingosine-1-phosphate lyase induces podocyte-related glomerular proteinuria, skin irritation, and platelet activation","volume":"43","author":"Grevot","year":"2015","journal-title":"Toxicol. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.metabol.2018.02.004","article-title":"Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy","volume":"85","author":"Choi","year":"2018","journal-title":"Metabolism"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Boini, K.M., Xia, M., Abais, J.M., Xu, M., Li, C.X., and Li, P.L. (2012). Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-beta-synthase. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045020"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1681\/ASN.2013111213","article-title":"Sphingomyelinase-like phosphodiesterase 3b expression levels determine podocyte injury phenotypes in glomerular disease","volume":"26","author":"Yoo","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"85ra46","DOI":"10.1126\/scitranslmed.3002231","article-title":"Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis","volume":"3","author":"Fornoni","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00281-013-0415-3","article-title":"Immunopathogenesis of idiopathic nephrotic syndrome with relapse","volume":"36","author":"Sahali","year":"2014","journal-title":"Semin. Immunopathol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-4939-8552-4_4","article-title":"Gangliosides in the immune system: Role of glycosphingolipids and glycosphingolipid-enriched lipid rafts in immunological functions","volume":"1804","author":"Iwabuchi","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fimmu.2019.00090","article-title":"The role of glycosphingolipids in immune cell functions","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1007\/s00018-012-1208-x","article-title":"Heterogeneity of gangliosides among T cell subsets","volume":"70","author":"Inokuchi","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbalip.2014.07.013","article-title":"Distinct selectivity of gangliosides required for CD4+ T and CD8+ T cell activation","volume":"1851","author":"Inokuchi","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"E336","DOI":"10.1073\/pnas.1114965109","article-title":"CD4 and CD8 T cells require different membrane gangliosides for activation","volume":"109","author":"Nagafuku","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/glycob\/cwj103","article-title":"Endogenously produced ganglioside GM3 endows etoposide and doxorubicin resistance by up-regulating Bcl-2 expression in 3LL Lewis lung carcinoma cells","volume":"16","author":"Noguchi","year":"2006","journal-title":"Glycobiology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/cei.12312","article-title":"Desialylation of dying cells with catalytically active antibodies possessing sialidase activity facilitate their clearance by human macrophages","volume":"179","author":"Tomin","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"ref_70","first-page":"135","article-title":"Anti-ganglioside antibodies in a large cohort of European patients with systemic lupus erythematosus: Clinical, serological, and HLA class II gene associations. European concerted action on the immunogenetics of SLE","volume":"27","author":"Galeazzi","year":"2000","journal-title":"J. Rheumatol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1177\/0961203312436856","article-title":"Anti-ganglioside antibodies in patients with systemic lupus erythematosus and neurological manifestations","volume":"21","author":"Gallardo","year":"2012","journal-title":"Lupus"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"569053","DOI":"10.1155\/2010\/569053","article-title":"Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in systemic Lupus Erythematosus patients","volume":"2010","author":"Dong","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1172\/JCI200420345","article-title":"Altered lipid raft\u2013associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus","volume":"113","author":"Jury","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.4049\/jimmunol.172.12.7821","article-title":"Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus","volume":"172","author":"Krishnan","year":"2004","journal-title":"J. Immunol."},{"key":"ref_75","first-page":"107","article-title":"Studies on Hanganutziu-Deicher antibodies in renal diseases","volume":"34","author":"Seki","year":"1992","journal-title":"Nihon Jinzo Gakkai"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1507\/endocrj1954.34.587","article-title":"Thyroid antigen-antibody nephritis: Possible involvement of Fucosyl-GM1 as the antigen","volume":"34","author":"Matsuura","year":"1987","journal-title":"Endocrinol. Jpn."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"7748","DOI":"10.3390\/ijms16047748","article-title":"Lipidomics: An evolving discipline in molecular sciences","volume":"16","author":"Astarita","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s10719-008-9145-5","article-title":"Thin layer chromatography of gangliosides","volume":"26","author":"Scandroglio","year":"2009","journal-title":"Glycoconj. J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-4939-3170-5_16","article-title":"Analysis of sphingolipid synthesis and transport by metabolic labeling of cultured cells with [(3)H] Serine","volume":"1376","author":"Ridgway","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5166","DOI":"10.1021\/acs.analchem.6b00155","article-title":"Electrospray ionization ion mobility mass spectrometry of human brain gangliosides","volume":"88","author":"Sarbu","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1039\/C0AN00732C","article-title":"Gangliosides\u2019 analysis by MALDI-ion mobility MS","volume":"136","author":"Jackson","year":"2011","journal-title":"Analyst"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Abbas, I., Noun, M., Touboul, D., Sahali, D., Brunelle, A., and Ollero, M. (2019). Kidney lipidomics by mass spectrometry imaging: A focus on the glomerulus. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071623"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"9483","DOI":"10.1073\/pnas.0903279106","article-title":"Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti","volume":"106","author":"Yoshikawa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1093\/hmg\/dds172","article-title":"Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease","volume":"21","author":"Natoli","year":"2012","journal-title":"Hum. Mol. Genet."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/24\/9645\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:46:38Z","timestamp":1760179598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/24\/9645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,17]]},"references-count":84,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["ijms21249645"],"URL":"https:\/\/doi.org\/10.3390\/ijms21249645","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,17]]}}}