{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:46:33Z","timestamp":1790786793620,"version":"4.1.0"},"reference-count":165,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health, Czech Republic (Conceptual development of research organization, General University Hospital in Prague)","award":["VFN64165"],"award-info":[{"award-number":["VFN64165"]}]},{"name":"Ministry of Health, Czech Republic (Conceptual development of research organization, Thomayer Hospital in Prague)","award":["TN64190"],"award-info":[{"award-number":["TN64190"]}]},{"name":"Grants Agency of the Ministry of Health","award":["NV19-04-00090"],"award-info":[{"award-number":["NV19-04-00090"]}]},{"name":"Grants Agency of the Ministry of Health","award":["NV18-04-00179"],"award-info":[{"award-number":["NV18-04-00179"]}]},{"name":"Charles University - Project Progress","award":["Q27\/LF1"],"award-info":[{"award-number":["Q27\/LF1"]}]},{"name":"Charles University (Project GAUK)","award":["142120"],"award-info":[{"award-number":["142120"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neurodegenerative diseases are characterized by the deposition of specific protein aggregates, both intracellularly and\/or extracellularly, depending on the type of disease. The extracellular occurrence of tridimensional structures formed by amyloidogenic proteins defines Alzheimer\u2019s disease, in which plaques are composed of amyloid \u03b2-protein, while in prionoses, the same term \u201camyloid\u201d refers to the amyloid prion protein. In this review, we focused on providing a detailed didactic description and differentiation of diffuse, neuritic, and burnt-out plaques found in Alzheimer\u2019s disease and kuru-like, florid, multicentric, and neuritic plaques in human transmissible spongiform encephalopathies, followed by a systematic classification of the morphological similarities and differences between the extracellular amyloid deposits in these disorders. Both conditions are accompanied by the extracellular deposits that share certain signs, including neuritic degeneration, suggesting a particular role for amyloid protein toxicity.<\/jats:p>","DOI":"10.3390\/ijms22010007","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T20:39:29Z","timestamp":1608669569000},"page":"7","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Extracellular Amyloid Deposits in Alzheimer\u2019s and Creutzfeldt\u2013Jakob Disease: Similar Behavior of Different Proteins?"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-2628","authenticated-orcid":false,"given":"Nikol","family":"Jankovska","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer Hospital, 100 00 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-5029","authenticated-orcid":false,"given":"Tomas","family":"Olejar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer Hospital, 100 00 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6152-6343","authenticated-orcid":false,"given":"Radoslav","family":"Matej","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer Hospital, 100 00 Prague, Czech Republic"},{"name":"Department of Pathology, First Faculty of Medicine, Charles University, and General University Hospital, 100 00 Prague, Czech Republic"},{"name":"Department of Pathology, Third Faculty of Medicine, Charles University, and University Hospital Kralovske Vinohrady, 100 00 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-0039-1683445","article-title":"An Overview of Primary Dementias as Clinicopathological Entities","volume":"39","author":"Salardini","year":"2019","journal-title":"Semin. 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