{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:03:36Z","timestamp":1791846216241,"version":"4.3.4"},"reference-count":147,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","award":["016\/RID\/2018\/19"],"award-info":[{"award-number":["016\/RID\/2018\/19"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In various diseases, there is an increased production of the free radicals needed to carry out certain physiological processes but their excessive amounts can cause oxidative stress and cell damage. Enzymes play a major role in the transformations associated with free radicals. One of them is nitric oxide synthase (NOS), which catalyzes the formation of nitric oxide (NO). This enzyme exists in three forms (NOS1, NOS2, NOS3), each encoded by a different gene. The following work presents the most important information on the NOS isoforms and their role in the human body, including NO synthesis in various tissues and cells, intercellular signaling and activities supporting the immune system and regulating blood vessel functions. The role of NOS in pathological conditions such as obesity, diabetes and heart disease is considered. Attention is also paid to the influence of the polymorphisms of these genes, encoding particular isoforms, on the development of these pathologies and the role of NOS inhibitors in the treatment of patients.<\/jats:p>","DOI":"10.3390\/ijms22010056","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T08:38:43Z","timestamp":1608712723000},"page":"56","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":177,"title":["Human Nitric Oxide Synthase\u2014Its Functions, Polymorphisms, and Inhibitors in the Context of Inflammation, Diabetes and Cardiovascular Diseases"],"prefix":"10.3390","volume":"22","author":[{"given":"Magdalena","family":"Kr\u00f3l","sequence":"first","affiliation":[{"name":"Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-5663","authenticated-orcid":false,"given":"Marta","family":"Kepinska","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Togliatto, G., Lombardo, G., and Brizzi, M.F. (2017). The future challenge of reactive oxygen species (ros) in hypertension: From bench to bed side. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091988"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nm.3624","article-title":"Unraveling the truth about antioxidants: Mitohormesis explains ros-induced health benefits","volume":"20","author":"Ristow","year":"2014","journal-title":"Nat. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1007\/s12274-018-2092-y","article-title":"Scavenging of reactive oxygen and nitrogen species with nanomaterials","volume":"10","author":"Ferreira","year":"2018","journal-title":"Nano Res."},{"key":"ref_4","unstructured":"Ganten, D., and Ruckpaul, K. (2005). Nitrosative Stress. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine, Springer."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Torres, I., Manzano-Pech, L., Rubio-Ru\u00edz, M.E., Soto, M.E., and Guarner-Lans, V. (2020). Nitrosative stress and its association with cardiometabolic disorders. Molecules, 25.","DOI":"10.3390\/molecules25112555"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: Regulation and function","volume":"33","author":"Sessa","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1475-097X.1990.tb00443.x","article-title":"Endothelium-Derived relaxing factor (EDRF) and nitric oxide (NO). II. Physiology, pharmacology and pathophysiological implications","volume":"10","author":"Feng","year":"1990","journal-title":"Clin. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mam.2004.09.003","article-title":"The role of nitric oxide in cardiovascular diseases","volume":"26","author":"Naseem","year":"2005","journal-title":"Mol. Asp. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1073\/pnas.98.1.355","article-title":"The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O2","volume":"98","author":"Thomas","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1023\/A:1006431309841","article-title":"Nitric oxide and angiogenesis","volume":"50","author":"Ziche","year":"2000","journal-title":"J. Neurooncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ana.21555","article-title":"Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy","volume":"65","author":"Ji","year":"2009","journal-title":"Ann. Neurol."},{"key":"ref_12","first-page":"313","article-title":"Reaktywne formy tlenu i azotu","volume":"185","author":"Saczko","year":"2011","journal-title":"Pol. Merk. Lek."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2004.10.011","article-title":"Mitochondrial proteomics in free radical research","volume":"38","author":"Bailey","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"ref_14","unstructured":"(2020, December 18). PubChem Substance and Compound Databases\u2014NCBI\u2014NIH, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Nitrilooxonium."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1021\/cr000074t","article-title":"Coordination and organometallic chemistry of metal-NO complexes","volume":"102","author":"Hayton","year":"2002","journal-title":"Chem. Rev."},{"key":"ref_16","unstructured":"(2020, December 18). PubChem Substance and Compound Databases\u2014NCBI\u2014NIH, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Nitrogen-dioxide."},{"key":"ref_17","unstructured":"(2020, December 18). PubChem Substance and Compound Databases\u2014NCBI\u2014NIH, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Dinitrogen-trioxide."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0076-6879(08)36004-2","article-title":"The chemistry of peroxynitrite: Implications for biological activity","volume":"436","author":"Goldstein","year":"2008","journal-title":"Methods Enzymol."},{"key":"ref_19","unstructured":"(2020, December 18). PubChem Substance and Compound Databases\u2014NCBI\u2014NIH, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Nitrite."},{"key":"ref_20","unstructured":"(2020, December 18). PubChem Substance and Compound Databases\u2014NCBI\u2014NIH, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Nitrate."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.abb.2016.08.014","article-title":"The chemical biology of HNO signaling","volume":"617","author":"Bianco","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"113793","DOI":"10.1016\/j.bcp.2020.113793","article-title":"Historical origins of the discovery of mammalian nitric oxide (nitrogen monoxide) production\/physiology\/pathophysiology","volume":"176","author":"Lancaster","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_23","first-page":"227","article-title":"Nitric oxide as a unique bioactive signaling messenger in physiology and pathophysiology","volume":"4","author":"Tuteja","year":"2004","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s10540-005-2741-8","article-title":"Discovery of some of the biological effects of nitric oxide and its role in cell signaling","volume":"24","author":"Murad","year":"2004","journal-title":"Biosci. Rep."},{"key":"ref_25","first-page":"43","article-title":"Nitric oxide signaling: Would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone?","volume":"53","author":"Murad","year":"1998","journal-title":"Recent Prog. Horm. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0005-2728(99)00028-6","article-title":"Biological aspects of reactive nitrogen species","volume":"1411","author":"Patel","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-4757-9480-9_21","article-title":"The importance of superoxide in nitric oxide-dependent toxicity: Evidence for peroxynitrite-mediated injury","volume":"387","author":"Crow","year":"1996","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12937-016-0186-5","article-title":"The importance of antioxidants which play the role in cellular response against oxidative\/nitrosative stress: Current state","volume":"15","author":"Kurutas","year":"2016","journal-title":"Nutr J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/0006-291X(91)92093-Y","article-title":"Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes","volume":"181","author":"Rubanyi","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.87.4.1620","article-title":"Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide","volume":"87","author":"Beckman","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1021\/tx980207u","article-title":"Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ion","volume":"12","author":"Eiserich","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1021\/tx00031a003","article-title":"Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the NO\/O2 reaction","volume":"6","author":"Wink","year":"1993","journal-title":"Chem. Res. Toxicol."},{"key":"ref_33","first-page":"315","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Psychol. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.ph.57.030195.003423","article-title":"Nitric oxide synthases: Properties and catalytic mechanism","volume":"57","author":"Griffith","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"ref_35","unstructured":"(2020, December 04). GeneCards\u2014Human Genes|Gene Database|Gene Search. Available online: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=NOS1."},{"key":"ref_36","unstructured":"(2020, December 04). GeneCards\u2014Human Genes|Gene Database|Gene Search. Available online: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=NOS3."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1089\/ars.2008.2234","article-title":"Nitric oxide in health and disease of the nervous system","volume":"11","author":"Knott","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00018-005-5421-8","article-title":"Endothelial nitric oxide synthase: Insight into cell-specific gene regulation in the vascular endothelium","volume":"63","author":"Fish","year":"2006","journal-title":"Cell Mol. Life Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/S1357-2725(02)00075-4","article-title":"Cells in focus: Endothelial cell","volume":"34","author":"Sumpio","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/CIRCULATIONAHA.105.602532","article-title":"Endothelial nitric oxide synthase in vascular disease: From marvel to menace","volume":"113","year":"2006","journal-title":"Circulation"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"22789","DOI":"10.1016\/S0021-9258(18)54421-5","article-title":"Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein","volume":"266","author":"Hevel","year":"1991","journal-title":"J. Biol. Cherm."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1126\/science.7690156","article-title":"Inhibition of viral replication by interferon-y-induced nitric oxide synthase","volume":"261","author":"Karupiah","year":"1993","journal-title":"Science"},{"key":"ref_43","unstructured":"(2020, December 04). GeneCards\u2014Human Genes|Gene Database|Gene Search. Available online: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=NOS2."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.semcancer.2005.04.004","article-title":"Inducible nitric oxide synthase (iNOS) in tumor biology: The two sides of the same coin","volume":"15","author":"Lechner","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.redox.2015.08.009","article-title":"The dual role of iNOS in cancer","volume":"6","author":"Vanninia","year":"2015","journal-title":"Redox Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/6675","article-title":"Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation","volume":"6","author":"Fischmann","year":"1999","journal-title":"Nat. Struct. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/niox.1999.0217","article-title":"Peroxynitrite reaction with heme proteins","volume":"3","author":"Mehl","year":"1999","journal-title":"Nitric Oxide"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1021\/cr000661e","article-title":"Intrinsic and extrinsic modulation of nitric oxide synthase activity","volume":"102","author":"Roman","year":"2002","journal-title":"Chem. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"37918","DOI":"10.1074\/jbc.M406204200","article-title":"Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase","volume":"279","author":"Garcin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1242\/jcs.01166","article-title":"iNOS (NOS2) at a glance","volume":"117","author":"Lowenstein","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1089\/ars.2012.4744","article-title":"S-Nitrosothiols and the S-nitrosoproteome of the cardiovascular system","volume":"18","author":"Maron","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bbagen.2011.07.010","article-title":"Protein S-nitrosylation: Role for nitric oxide signaling in neuronal death","volume":"1820","author":"Shahani","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"22997","DOI":"10.1074\/jbc.270.39.22997","article-title":"Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis","volume":"270","author":"Wang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2743S","DOI":"10.1093\/jn\/134.10.2743S","article-title":"Enzymes of arginine metabolism","volume":"134","author":"Morris","year":"2004","journal-title":"J. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"14101","DOI":"10.1074\/jbc.M609237200","article-title":"Activation of peroxynitrite by inducible nitric-oxide synthase. A direct source of nitrative stress","volume":"282","author":"Mattioli","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"24694","DOI":"10.1074\/jbc.274.35.24694","article-title":"Geminate recombination of nitric oxide to endothelial nitric oxide-synthase and mechanistic implications","volume":"274","author":"Negrerie","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_57","unstructured":"Centers for Disease Control and Prevention (US), National Center for Chronic Disease Prevention and Health Promotion (US), and Office on Smoking and Health (US) (2010). How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1021\/bi00016a012","article-title":"Inhibition of ribonucleotide reductase by nitric oxide derived from thionitrites: Reversible modifications of both subunits","volume":"34","author":"Roy","year":"1995","journal-title":"Biochemistry"},{"key":"ref_59","first-page":"147","article-title":"Inducible nitric oxide synthase in human diseases","volume":"113","author":"Fehsel","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.niox.2009.03.001","article-title":"Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications","volume":"20","author":"Zhou","year":"2009","journal-title":"Nitric. Oxide"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1073\/pnas.91.6.2046","article-title":"Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation","volume":"91","author":"Vane","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/S1567-5769(01)00086-8","article-title":"Nitric oxide in immunity and inflammation","volume":"1","author":"Coleman","year":"2001","journal-title":"Int. Immunopharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fonc.2018.00160","article-title":"Phosphoinositide 3-Kinase\/Akt signaling and redox metabolism in cancer","volume":"8","author":"Koundouros","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1742-7843.2011.00785.x","article-title":"Reactive oxygen species and endothelial function--role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases","volume":"110","author":"Montezano","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cca.2003.08.009","article-title":"Nitric oxide inhibits mitochondrial monoamine oxidase activity and decreases outer mitochondria membrane fluidity","volume":"136","author":"Muriel","year":"2003","journal-title":"Comp. Biochem. Physiol. Toxicol. Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1093\/rheumatology\/39.9.1004","article-title":"Nitric oxide is a mediator of apoptosis in the rheumatoid joint","volume":"39","author":"Hocking","year":"2000","journal-title":"Rheumatology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-0036-1597577","article-title":"Nitric oxide: Link between inflammation and endothelial dysfunction in rheumatoid arthritis","volume":"26","author":"Garg","year":"2017","journal-title":"Int. J. Angiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0022-2275(20)33432-5","article-title":"Expression of nitric oxide synthases in subcutaneous adipose tissue of nonobese and obese humans","volume":"41","author":"Elizalde","year":"2000","journal-title":"J. Lipid Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1113\/JP276894","article-title":"Inducible nitric oxide synthase-derived nitric oxide reduces vagal satiety signalling in obese mice","volume":"597","author":"Yu","year":"2019","journal-title":"J. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/bph.14849","article-title":"Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease","volume":"177","author":"Udi","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000506160","article-title":"NOS3 gene rs1799983 and rs2070744 polymorphisms in patients with unstable angina","volume":"57","author":"Pawlik","year":"2020","journal-title":"J. Vasc. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11010-012-1456-y","article-title":"eNOS polymorphism associated with metabolic syndrome in children and adolescents","volume":"372","author":"Miranda","year":"2013","journal-title":"Mol. Cell Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/cpf.12255","article-title":"Endothelial nitric oxide synthase Glu298Asp gene polymorphism influences body composition and biochemical parameters but not the nitric oxide response to eccentric resistance exercise in elderly obese women","volume":"36","author":"Teixeira","year":"2016","journal-title":"Clin. Physiol. Funct. Imaging."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1007\/s00125-011-2264-8","article-title":"Increased neuronal nitric oxide synthase dimerisation is involved in rat and human pancreatic beta cell hyperactivity in obesity","volume":"54","author":"Mezghenna","year":"2011","journal-title":"Diabetologia"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"C296","DOI":"10.1152\/ajpcell.00537.2001","article-title":"Role of nitric oxide synthase isoforms in glucose-stimulated insulin release","volume":"283","author":"Henningsson","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00441-004-1013-4","article-title":"Glucose stimulates the expression and activities of nitric oxide synthases in incubated rat islets: An effect counteracted by GLP-1 through the cyclic AMP\/PKA pathway","volume":"319","author":"Lundquist","year":"2005","journal-title":"Cell Tissue Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11154-012-9229-1","article-title":"Role of insulin resistance in endothelial dysfunction","volume":"14","author":"Muniyappa","year":"2013","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1254\/jphs.13R10CP","article-title":"Dual role of nitric oxide in pancreatic \u03b2-cells","volume":"123","author":"Kaneko","year":"2013","journal-title":"J. Pharmacol. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1432-1033.1997.00710.x","article-title":"Modulation of the mitochondrial permeability transition by nitric oxide","volume":"246","author":"Balakirev","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/15216540310001639652","article-title":"Mitochondria as targets of apoptosis regulation by nitric oxide","volume":"55","author":"Vieira","year":"2003","journal-title":"IUBMB Life"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/EC-14-0092","article-title":"Mitochondrial dysfunction and insulin resistance: An update","volume":"4","author":"Montgomery","year":"2015","journal-title":"Endocr. Connect."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"165838","DOI":"10.1016\/j.bbadis.2020.165838","article-title":"Mitochondrial dysfunction in metabolic syndrome","volume":"1866","author":"Prasun","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Belosludtsev, K.N., Belosludtseva, N.V., and Dubinin, M.V. (2020). Diabetes mellitus, mitochondrial dysfunction and Ca2+-dependent permeability transition pore. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186559"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.regpep.2008.07.002","article-title":"Impaired glucose-stimulated insulin secretion in the GK rat is associated with abnormalities in islet nitric oxide production","volume":"151","author":"Ostenson","year":"2008","journal-title":"Regul. Pept."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1210\/me.2009-0138","article-title":"Naturally occurring glucokinase mutations are associated with defects in posttranslational S-nitrosylation","volume":"24","author":"Ding","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00424-003-1176-y","article-title":"Constitutive nitric oxide synthases in rat pancreatic islets: Direct imaging of glucose-induced nitric oxide production in beta-cells","volume":"447","author":"Nakada","year":"2003","journal-title":"Pflugers Arch."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1085\/jgp.104.6.1079","article-title":"Nitric oxide opens ATP-sensitive K+ channels through suppression of phosphofructokinase activity and inhibits glucose-induced insulin release in pancreatic beta cells","volume":"104","author":"Tsuura","year":"1994","journal-title":"J. Gen. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"11374","DOI":"10.1016\/S0021-9258(19)49920-1","article-title":"Ca2+\/calmodulin-dependent cytochrome c reductase activity of brain nitric oxide synthase","volume":"267","author":"Klatt","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_89","first-page":"1227","article-title":"Insulin secretion: The nitric oxide controversy","volume":"19","author":"Gheibi","year":"2020","journal-title":"EXCLI J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1463-1326.2012.01632.x","article-title":"Pancreatic \u03b2-cell dysfunction, expression of iNOS and the effect of phosphodiesterase inhibitors in human pancreatic islets of type 2 diabetes","volume":"14","author":"Muhammed","year":"2012","journal-title":"Diabetes Obes. Metab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tem.2019.10.001","article-title":"Role of nitric oxide in insulin secretion and glucose metabolism","volume":"31","author":"Bahadoran","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1073\/pnas.90.5.1731","article-title":"Nitric oxide mediatescytokine-induced inhibition of insulin secretion byhuman islets of Langerhans","volume":"90","author":"Corbett","year":"1993","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1476-5381.1995.tb13225.x","article-title":"Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues","volume":"114","author":"Panagiotidis","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"37251","DOI":"10.1074\/jbc.M110.142315","article-title":"Chronic ethanol consumption-induced pancreaticb-cell dysfunction and apoptosisthrough glucokinase nitration and its down-regulation","volume":"285","author":"Kim","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2337\/db09-0421","article-title":"Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation","volume":"59","author":"Fioramonti","year":"2010","journal-title":"Diabetes"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1172\/JCI3030","article-title":"Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action","volume":"102","author":"Shankar","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1159\/000455865","article-title":"Hypothalamic insulin resistance in obesity: Effects on glucose homeostasis","volume":"104","author":"Chen","year":"2017","journal-title":"Neuroendocrinology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s12291-015-0516-y","article-title":"Endothelial dysfunction in type 2 diabetes mellitus","volume":"31","author":"Dhananjayan","year":"2016","journal-title":"Indian. J. Clin. Biochem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/MCA.0000000000000178","article-title":"Endothelial dysfunction and coronary artery disease: Assessment, prognosis, and treatment","volume":"25","author":"Matsuzawa","year":"2014","journal-title":"Coron. Artery Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.freeradbiomed.2014.05.016","article-title":"Regulation of obesity and insulin resistance by nitric oxide","volume":"73","author":"Sansbury","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s00125-003-1046-3","article-title":"Nitric oxide synthase gene polymorphisms and diabetic nephropathy","volume":"46","author":"Rippin","year":"2003","journal-title":"Diabetologia"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1089\/gtmb.2011.0218","article-title":"Endothelial nitric oxide synthase gene polymorphisms and the risk of diabetic nephropathy in type 2 diabetes mellitus","volume":"16","author":"Shoukry","year":"2012","journal-title":"Genet. Test Mol. Biomark."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1161\/01.RES.0000064585.95749.6D","article-title":"Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling","volume":"92","author":"Sears","year":"2003","journal-title":"Circ. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/CIRCRESAHA.107.164798","article-title":"Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice","volume":"102","author":"Zhang","year":"2008","journal-title":"Circ. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1161\/CIRCULATIONAHA.108.846402","article-title":"Neuronal nitric oxide synthase protects against myocardial infarction-induced ventricular arrhythmia and mortality in mice","volume":"120","author":"Burger","year":"2009","journal-title":"Circulation"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/nm1119","article-title":"S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide","volume":"10","author":"Adachi","year":"2004","journal-title":"Nat. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1042\/bj3120169","article-title":"Inhibition of cytochrome c oxidase in turnover by nitric oxide: Mechanism and implications for control of respiration","volume":"312","author":"Torres","year":"1995","journal-title":"Biochem. J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/abbi.1996.0276","article-title":"The effects of nitric oxide on electron transport complexes","volume":"331","author":"Welter","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nm.3212","article-title":"Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I","volume":"19","author":"Chouchani","year":"2013","journal-title":"Nat. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tcm.2012.03.001","article-title":"Role of nNOS in cardiac ischemia-reperfusion injury","volume":"21","author":"Strasen","year":"2011","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1161\/CIRCULATIONAHA.105.557892","article-title":"Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: Role of nitroso-redox equilibrium","volume":"112","author":"Saraiva","year":"2005","journal-title":"Circulation"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(04)16048-0","article-title":"Increased neuronal nitric oxide synthase-derived NO production in the failing human heart","volume":"363","author":"Damy","year":"2004","journal-title":"Lancet"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1089\/ars.2012.4824","article-title":"Nitric oxide synthases in heart failure","volume":"18","author":"Carnicer","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1113\/jphysiol.2013.270306","article-title":"Molecular mechanisms of neuronal nitric oxide synthase in cardiac function and pathophysiology","volume":"592","author":"Zhang","year":"2014","journal-title":"J. Physiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bbrc.2015.02.113","article-title":"Oxidative stress induces phosphorylation of neuronal NOS in cardiomyocytes through AMP-activated protein kinase (AMPK)","volume":"459","author":"Kar","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/cvr\/cvr087","article-title":"Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology","volume":"91","author":"Nishijima","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/eurheartj\/ehs306","article-title":"Nitric oxide synthase-3 deficiency results in hypoplastic coronary arteries and postnatal myocardial infarction","volume":"35","author":"Liu","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2014.03.164","article-title":"Nitric oxide synthase (NOS) single nucleotide polymorphisms are associated with coronary heart disease and hypertension in the INTERGENE study","volume":"39","author":"Levinsson","year":"2014","journal-title":"Nitric. Oxide"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2143\/AC.63.2.2029533","article-title":"Lack of evidence for contribution of intron4a\/b polymorphism of endothelial nitric oxide synthase (NOS3) gene to plasma nitric oxide levels","volume":"63","author":"Salimi","year":"2008","journal-title":"Acta Cardiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/iub.1513","article-title":"Association of NOS2 and NOS3 gene polymorphisms with susceptibility to type 2 diabetes mellitus and diabetic nephropathy in the Chinese Han population","volume":"68","author":"Chen","year":"2016","journal-title":"IUBMB Life"},{"key":"ref_121","first-page":"1734","article-title":"Nitric oxide synthase 2 polymorphisms (rs2779248T\/C and rs1137933C\/T) and the risk of type 2 diabetes in zahedan, southeastern iran","volume":"47","author":"Garme","year":"2018","journal-title":"Iran J. Public Health"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/07853890600969213","article-title":"Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy","volume":"38","author":"Wessman","year":"2006","journal-title":"Ann. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/2047487318780748","article-title":"Associations between endothelial nitric oxide synthase gene polymorphisms and the risk of coronary artery disease: A systematic review and meta-analysis of 132 case-control studies","volume":"26","author":"Li","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Zhang, X., Lynch, A.I., Davis, B.R., Ford, C.E., Boerwinkle, E., Eckfeldt, J.H., Leiendecker-Foster, C., and Arnett, D.K. (2012). Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: The GenHAT study. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034217"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"26669","DOI":"10.1016\/S0021-9258(18)47071-8","article-title":"Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas","volume":"269","author":"Garvey","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3570593","article-title":"Nitric oxide synthases: Structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1074\/jbc.272.8.4959","article-title":"1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo","volume":"272","author":"Garvey","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1021\/ar800201v","article-title":"Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases","volume":"42","author":"Silverman","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1021\/acs.jmedchem.5b00057","article-title":"Cell-Permeable inhibitors of neuronal nitric oxide synthase open new prospects for the treatment of neurological disorders","volume":"58","author":"Annedi","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2174\/156802607779318253","article-title":"Pharmacologic manipulation of nitric oxide signaling: Targeting NOS dimerization and protein-protein interactions","volume":"7","author":"Paige","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1021\/ar300175n","article-title":"Structural basis for isoform-selective inhibition in nitric oxide synthase","volume":"46","author":"Poulos","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nrd960","article-title":"Blocking NO synthesis: How, where and why?","volume":"1","author":"Vallance","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1001\/jama.297.15.joc70035","article-title":"Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: The TRIUMPH randomized controlled trial","volume":"297","author":"Alexander","year":"2007","journal-title":"J. Am. Med Assoc."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"FSO35","DOI":"10.4155\/fso.15.35","article-title":"Nitric oxide inhibition strategies","volume":"1","author":"Wong","year":"2015","journal-title":"Future Sci. OA"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/eurheartj\/ehm075","article-title":"Should we inhibit nitric Oxide synthase in Cardiogenic shocK 2 (SHOCK-2) investigators. Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: A phase II dose-ranging study","volume":"28","author":"Cotter","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0195-668X(03)00193-3","article-title":"LINCS: L-NAME (a NO synthase inhibitor) in the treatment of refractory cardiogenic shock: A prospective randomized study","volume":"24","author":"Cottera","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.0001-6772.2003.01254.x","article-title":"Effects of N-nitro l-arginine methyl ester (l-NAME), a potent nitric oxide synthase inhibitor, on visual evoked potentials of rats exposed to different experimental stress models","volume":"180","author":"Agar","year":"2004","journal-title":"Acta Physiol. Scand."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/157340310791162659","article-title":"The role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease","volume":"6","author":"Sibal","year":"2010","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1177\/1358836X0501000104","article-title":"Asymmetric dimethylarginine (ADMA) and cardiovascular disease: Insights from prospective clinical trials","volume":"10","year":"2005","journal-title":"Vasc. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/00003246-199905000-00025","article-title":"An open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group","volume":"27","author":"Grover","year":"1999","journal-title":"Crit. Care Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1213\/01.ANE.0000177117.80058.4D","article-title":"Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studies","volume":"101","author":"Hauser","year":"2005","journal-title":"Anesth. Analg."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0006-8993(99)01749-7","article-title":"7-Nitroindazole, a selective inhibitor of nNOS, increases hippocampal extracellular glutamate concentration in status epilepticus induced by kainic acid in rats","volume":"839","author":"Thibault","year":"1999","journal-title":"Brain Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1023\/A:1013042817281","article-title":"Pharmacokinetics and pharmacodynamics of 7-nitroindazole, a selective nitric oxide synthase inhibitor, in the rat hippocampus","volume":"18","author":"Bush","year":"2001","journal-title":"Pharm. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/0974-2700.136864","article-title":"Effects of aminoguanidine, a potent nitric oxide synthase inhibitor, on myocardial and organ structure in a rat model of hemorrhagic shock","volume":"7","author":"Soliman","year":"2014","journal-title":"J. Emerg. Trauma. Shock."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jneuroim.2016.12.007","article-title":"Nitric oxide synthase inhibitor, aminoguanidine reduces intracerebroventricular colchicine induced neurodegeneration, memory impairments and changes of systemic immune responses in rats","volume":"303","author":"Sil","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/cc5925","article-title":"Nitric oxide inhibition rapidly increases blood pressure with no change in outcome in cardiogenic shock: The TRIUMPH trial","volume":"11","author":"Salem","year":"2007","journal-title":"Crit. 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