{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:41:35Z","timestamp":1788352895925,"version":"build-2803163510"},"reference-count":83,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Japanese Society for the Promotion of Science (JSPS)\/Grant-in-Aid for Young Scientists","award":["20K17283"],"award-info":[{"award-number":["20K17283"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nephrotic syndrome represents the clinical situation characterized by presence of massive proteinuria and low serum protein caused by a variety of diseases, including minimal change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS) and membranous glomerulonephropathy. Differentiating between diagnoses requires invasive renal biopsies in general. Even with the biopsy, we encounter difficulties to differentiate MCNS and FSGS in some cases. There is no other better option currently available for the diagnosis other than renal biopsy. MicroRNAs (miRNAs) are no-coding RNAs of approximately 20 nucleotides in length, which regulate target genes in the post-transcriptional processes and have essential roles in many diseases. MiRNAs in serum and urine have been shown as non-invasive biomarkers in multiple diseases, including renal diseases. In this article, we summarize the current knowledge of miRNAs as the promising biomarkers for nephrotic syndrome.<\/jats:p>","DOI":"10.3390\/ijms22010088","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T12:19:51Z","timestamp":1608725991000},"page":"88","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["MicroRNAs as Biomarkers for Nephrotic Syndrome"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5442-7008","authenticated-orcid":false,"given":"Kenji","family":"Tsuji","sequence":"first","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4535-8092","authenticated-orcid":false,"given":"Shinji","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.12688\/f1000research.10165.1","article-title":"Recent advances in understanding and treating nephrotic syndrome","volume":"6","author":"Bierzynska","year":"2017","journal-title":"F1000Research"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/0971-4065.41289","article-title":"Revised guidelines for management of steroid-sensitive nephrotic syndrome","volume":"18","author":"Bagga","year":"2008","journal-title":"Indian J. Nephrol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0272-6386(97)90485-6","article-title":"Changing etiologies of unexplained adult nephrotic syndrome: A comparison of renal biopsy findings from 1976\u20131979 and 1995\u20131997","volume":"30","author":"Haas","year":"1997","journal-title":"Am. J. Kidney Dis."},{"key":"ref_4","first-page":"319","article-title":"Nephrotic syndrome in the elderly","volume":"16","author":"Cameron","year":"1996","journal-title":"Semin. Nephrol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3345\/kjp.2016.59.5.205","article-title":"Pathogenesis of minimal change nephrotic syndrome: An immunological concept","volume":"59","author":"Kim","year":"2016","journal-title":"Korean J. Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.2215\/CJN.03800609","article-title":"Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis","volume":"5","author":"McCarthy","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00007890-200202150-00009","article-title":"Proteinuria after injection of human focal segmental glomerulosclerosis factor","volume":"73","author":"Sharma","year":"2002","journal-title":"Transplantation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm.2411","article-title":"Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis","volume":"17","author":"Wei","year":"2011","journal-title":"Nat. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature07228","article-title":"Widespread changes in protein synthesis induced by microRNAs","volume":"455","author":"Selbach","year":"2008","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output","volume":"455","author":"Baek","year":"2008","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/eci.12676","article-title":"Primary focal segmental glomerulosclerosis: miRNAs and targeted therapies","volume":"46","author":"Leierer","year":"2016","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-1-62703-748-8_3","article-title":"The role of microRNAs in human diseases","volume":"1107","author":"Tufekci","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3390\/diagnostics10110891","article-title":"MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers","volume":"10","author":"Kipkeeva","year":"2020","journal-title":"Diagnostics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7893","DOI":"10.3390\/ijms21217893","article-title":"MicroRNA Biomarkers in IBD-Differential Diagnosis and Prediction of Colitis-Associated Cancer","volume":"21","author":"James","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6738","DOI":"10.3390\/ijms21186738","article-title":"MicroRNAs as Biomarkers and Therapeutic Targets in Inflammation- and Ischemia-Reperfusion-Related Acute Renal Injury","volume":"21","author":"Wu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ramanathan, K., and Padmanabhan, G. (2020). MiRNAs as potential biomarker of kidney diseases: A review. Cell. Biochem. Funct.","DOI":"10.1002\/cbf.3555"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1373\/clinchem.2012.195297","article-title":"Increased serum and urinary microRNAs in children with idiopathic nephrotic syndrome","volume":"59","author":"Luo","year":"2013","journal-title":"Clin. Chem."},{"key":"ref_19","first-page":"958","article-title":"Role of microRNA-17-5p in the pathogenesis of pediatric nephrotic syndrome and related mechanisms","volume":"22","author":"Zhang","year":"2020","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ebiom.2018.11.018","article-title":"Increased urinary exosomal microRNAs in children with idiopathic nephrotic syndrome","volume":"39","author":"Chen","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.7754\/Clin.Lab.2015.150407","article-title":"Decreased Serum miR-503 Level in Children with Nephrotic Syndrome","volume":"61","author":"Wang","year":"2015","journal-title":"Clin. Lab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.yexmp.2015.10.003","article-title":"Differentially expressed microRNAs in kidney biopsies from various subtypes of nephrotic children","volume":"99","author":"Lu","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cca.2012.12.011","article-title":"Urinary sediment miRNA levels in adult nephrotic syndrome","volume":"418","author":"Wang","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"ref_24","first-page":"9531074","article-title":"Cytoplasmic Localization of WT1 and Decrease of miRNA-16-1 in Nephrotic Syndrome","volume":"2017","author":"Bollain","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"ref_25","first-page":"7282","article-title":"Differential microRNA expression in the serum of patients with nephrotic syndrome and clinical correlation analysis","volume":"8","author":"Teng","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_26","first-page":"371","article-title":"Circulating microRNAs as potential biomarkers for nephrotic syndrome","volume":"8","author":"Sui","year":"2014","journal-title":"Iran J. Kidney Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1681\/ASN.2016101117","article-title":"MicroRNAs as Master Regulators of Glomerular Function in Health and Disease","volume":"28","author":"Trionfini","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa0810457","article-title":"M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy","volume":"361","author":"Beck","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.kint.2019.09.014","article-title":"Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy","volume":"97","author":"Sethi","year":"2020","journal-title":"Kidney Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMoa1409354","article-title":"Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy","volume":"371","author":"Tomas","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9364","DOI":"10.12659\/MSM.917732","article-title":"Anti-Phospholipase A2 Receptor (Anti-PLA2R) Antibody in Diagnosis and Treatment of Idiopathic Membranous Nephropathy: A Single-Center Observational Study in China","volume":"25","author":"Guo","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3892\/ijmm.2013.1554","article-title":"Integrated profiling of microRNA expression in membranous nephropathy using high-throughput sequencing technology","volume":"33","author":"Chen","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_33","first-page":"2168767","article-title":"miR-217 is a Useful Diagnostic Biomarker and Regulates Human Podocyte Cells Apoptosis via Targeting TNFSF11 in Membranous Nephropathy","volume":"2017","author":"Li","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.biopha.2015.07.021","article-title":"Down-regulation of miR-186 contributes to podocytes apoptosis in membranous nephropathy","volume":"75","author":"Sha","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/IJNRD.S258624","article-title":"Expression Levels of miR-30c and miR-186 in Adult Patients with Membranous Glomerulonephritis and Focal Segmental Glomerulosclerosis","volume":"13","author":"Hejazian","year":"2020","journal-title":"Int. J. Nephrol. Renovasc. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Rahbar Saadat, Y., Hejazian, S.M., Nariman-Saleh-Fam, Z., Bastami, M., Poursheikhani, A., Shoja, M.M., Ardalan, M., and Zununi Vahed, S. (2020). Glucocorticoid receptors and their upstream epigenetic regulators in adults with steroid-resistant nephrotic syndrome. Biofactors.","DOI":"10.1002\/biof.1680"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1080\/15384101.2018.1542901","article-title":"MiR-130a-5p prevents angiotensin II-induced podocyte apoptosis by modulating M-type phospholipase A2 receptor","volume":"17","author":"Liu","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1080\/0886022X.2019.1642210","article-title":"Application of miR-193a\/WT1\/PODXL axis to estimate risk and prognosis of idiopathic membranous nephropathy","volume":"41","author":"Zhang","year":"2019","journal-title":"Ren. Fail."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.12659\/MSM.913057","article-title":"Both Peripheral Blood and Urinary miR-195-5p, miR-192-3p, miR-328-5p and Their Target Genes PPM1A, RAB1A and BRSK1 May Be Potential Biomarkers for Membranous Nephropathy","volume":"25","author":"Zhou","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"12625","DOI":"10.1002\/jcp.27851","article-title":"Upregulated microRNAs in membranous glomerulonephropathy are associated with significant downregulation of IL6 and MYC mRNAs","volume":"234","author":"Barbagallo","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2147\/IJNRD.S132980","article-title":"The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome","volume":"10","author":"Kitamura","year":"2017","journal-title":"Int. J. Nephrol. Renovasc. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Sang, Y., Tsuji, K., Inoue-Torii, A., Fukushima, K., Kitamura, S., and Wada, J. (2020). Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114099"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev.immunol.23.021704.115611","article-title":"The B7 family revisited","volume":"23","author":"Greenwald","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00467-013-2498-4","article-title":"Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes","volume":"28","author":"Ishimoto","year":"2013","journal-title":"Pediatr. Nephrol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/ki.2010.143","article-title":"Urinary CD80 is elevated in minimal change disease but not in focal segmental glomerulosclerosis","volume":"78","author":"Garin","year":"2010","journal-title":"Kidney Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1172\/JCI20402","article-title":"Induction of B7-1 in podocytes is associated with nephrotic syndrome","volume":"113","author":"Reiser","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1681\/ASN.V103529","article-title":"Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: Evidence for increased IL-13 mRNA expression in relapse","volume":"10","author":"Yap","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/tropej\/fmu040","article-title":"Serum immunoglobulin E and interleukin-13 levels in children with idiopathic nephrotic syndrome","volume":"60","author":"Mishra","year":"2014","journal-title":"J. Trop. Pediatr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1681\/ASN.V113413","article-title":"Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells","volume":"11","author":"Aten","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1681\/ASN.2006070710","article-title":"Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats","volume":"18","author":"Lai","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1007\/s00467-005-1936-3","article-title":"Altered activity of plasma hemopexin in patients with minimal change disease in relapse","volume":"20","author":"Bakker","year":"2005","journal-title":"Pediatr. Nephrol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1681\/ASN.2007080940","article-title":"Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes","volume":"19","author":"Lennon","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nm.2261","article-title":"Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome","volume":"17","author":"Clement","year":"2011","journal-title":"Nat. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.3892\/ol.2020.11768","article-title":"ANGPTL4 overexpression is associated with progression and poor prognosis in breast cancer","volume":"20","author":"Zhao","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3396","article-title":"Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome","volume":"20","author":"Clement","year":"2014","journal-title":"Nat. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2215\/CJN.05960616","article-title":"Focal Segmental Glomerulosclerosis","volume":"12","author":"Rosenberg","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00467-013-2452-5","article-title":"Serum suPAR in patients with FSGS: Trash or treasure?","volume":"28","author":"Maas","year":"2013","journal-title":"Pediatr. Nephrol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e031812","DOI":"10.1136\/bmjopen-2019-031812","article-title":"Serum soluble urokinase type plasminogen activated receptor and focal segmental glomerulosclerosis: A systematic review and meta-analysis","volume":"9","author":"Shuai","year":"2019","journal-title":"BMJ Open"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5679518","DOI":"10.1155\/2019\/5679518","article-title":"Increased Serum Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels in FSGS: A Meta-Analysis","volume":"2019","author":"Lee","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1056\/NEJMe1512997","article-title":"A suPAR Biomarker for Chronic Kidney Disease","volume":"373","author":"Skorecki","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ki.2013.505","article-title":"The soluble urokinase receptor is not a clinical marker for focal segmental glomerulosclerosis","volume":"85","author":"Meijers","year":"2014","journal-title":"Kidney Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/TP.0b013e3182977ab1","article-title":"Urine but not serum soluble urokinase receptor (suPAR) may identify cases of recurrent FSGS in kidney transplant candidates","volume":"96","author":"Lieske","year":"2013","journal-title":"Transplantation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/eci.12420","article-title":"Circulating and urinary microRNA profile in focal segmental glomerulosclerosis: A pilot study","volume":"45","author":"Ramezani","year":"2015","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3892\/ijmm.2017.3152","article-title":"MicroRNA-135a is involved in podocyte injury in a transient receptor potential channel 1-dependent manner","volume":"40","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1053\/j.ajkd.2014.07.013","article-title":"Plasma microRNA-186 and proteinuria in focal segmental glomerulosclerosis","volume":"65","author":"Zhang","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1681\/ASN.2012111101","article-title":"Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids","volume":"25","author":"Wu","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.bbrc.2019.11.096","article-title":"miR-150 inhibitor ameliorates adriamycin-induced focal segmental glomerulosclerosis","volume":"522","author":"Qi","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41419-018-0569-y","article-title":"Plasma microRNA panel is a novel biomarker for focal segmental glomerulosclerosis and associated with podocyte apoptosis","volume":"9","author":"Xiao","year":"2018","journal-title":"Cell. Death Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.2215\/CJN.11561113","article-title":"Evaluation of microRNAs miR-196a, miR-30a-5P, and miR-490 as biomarkers of disease activity among patients with FSGS","volume":"9","author":"Zhang","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nm.3142","article-title":"Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1","volume":"19","author":"Gebeshuber","year":"2013","journal-title":"Nat. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s00467-013-2434-7","article-title":"Serum microRNAs levels in primary focal segmental glomerulosclerosis","volume":"28","author":"Cai","year":"2013","journal-title":"Pediatr. Nephrol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Wang, N., Zhou, Y., Jiang, L., Li, D., Yang, J., Zhang, C.Y., and Zen, K. (2012). Urinary microRNA-10a and microRNA-30d serve as novel, sensitive and specific biomarkers for kidney injury. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051140"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Tsuji, K., Kitamura, S., and Wada, J. (2020). Immunomodulatory and Regenerative Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Renal Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030756"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"24032","DOI":"10.3390\/ijms161024032","article-title":"MiR-30a Inhibits the Epithelial--Mesenchymal Transition of Podocytes through Downregulation of NFATc3","volume":"16","author":"Peng","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI81061","article-title":"MicroRNA-30 family members regulate calcium\/calcineurin signaling in podocytes","volume":"125","author":"Wu","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41419-019-1625-y","article-title":"MiR-30 family prevents uPAR-ITGB3 signaling activation through calcineurin-NFATC pathway to protect podocytes","volume":"10","author":"Lang","year":"2019","journal-title":"Cell. Death Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"F589","DOI":"10.1152\/ajprenal.00486.2016","article-title":"MicroRNA-30e targets BNIP3L to protect against aldosterone-induced podocyte apoptosis and mitochondrial dysfunction","volume":"312","author":"Guo","year":"2017","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1101\/gad.1884710","article-title":"Mammalian microRNAs: Experimental evaluation of novel and previously annotated genes","volume":"24","author":"Chiang","year":"2010","journal-title":"Genes Dev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/ncb2690","article-title":"miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis","volume":"15","author":"Zhang","year":"2013","journal-title":"Nat. Cell. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1158\/0008-5472.CAN-10-2345","article-title":"MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI\/SNF to generate a double-negative feedback loop in a variety of human cancers","volume":"71","author":"Sakurai","year":"2011","journal-title":"Cancer Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1002\/art.34505","article-title":"Decreased microRNA-142-3p\/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus","volume":"64","author":"Ding","year":"2012","journal-title":"Arthritis Rheumatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1038\/s41467-019-12292-5","article-title":"microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat. 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