{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:52:21Z","timestamp":1790189541108,"version":"4.1.0"},"reference-count":52,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T00:00:00Z","timestamp":1608940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Arbovirus infections represent a global public health problem, and recent epidemics of yellow fever, dengue, and Zika have shown their critical importance in Brazil and worldwide. Whilst a major effort for vaccination programs has been in the spotlight, a number of aptamer approaches have been proposed in a complementary manner, offering the possibility of differential diagnosis between these arboviruses, which often present similar clinical symptoms, as well as the potential for a treatment option when no other alternative is available. In this review, we aim to provide a background on arbovirus, with a basic description of the main viral classes and the disease they cause, using the Brazilian context to build a comprehensive understanding of their role on a global scale. Subsequently, we offer an exhaustive revision of the diagnostic and therapeutic approaches offered by aptamers against arboviruses. We demonstrate how these promising reagents could help in the clinical diagnosis of this group of viruses, their use in a range of diagnostic formats, from biosensors to serological testing, and we give a short review on the potential approaches for novel aptamer-based antiviral treatment options against different arboviral diseases.<\/jats:p>","DOI":"10.3390\/ijms22010159","type":"journal-article","created":{"date-parts":[[2020,12,27]],"date-time":"2020-12-27T20:04:58Z","timestamp":1609099498000},"page":"159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Application of Aptamer-Based Assays to the Diagnosis of Arboviruses Important for Public Health in Brazil"],"prefix":"10.3390","volume":"22","author":[{"given":"Ana Paula Corr\u00eaa","family":"Argondizzo","sequence":"first","affiliation":[{"name":"Instituto de Tecnologia em Imunobiol\u00f3gicos (Bio-Manguinhos), Funda\u00e7\u00e3o Oswaldo Cruz, Av. Brasil, 4365-Rio de Janeiro\/RJ CEP 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9726-2442","authenticated-orcid":false,"given":"Dilson","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia em Imunobiol\u00f3gicos (Bio-Manguinhos), Funda\u00e7\u00e3o Oswaldo Cruz, Av. Brasil, 4365-Rio de Janeiro\/RJ CEP 21040-900, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas da Universidade do Estado do Rio de Janeiro, Rua S\u00e3o Francisco Xavier, 255-Rio de Janeiro\/RJ-CEP 22783-127, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiris","family":"Missailidis","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia em Imunobiol\u00f3gicos (Bio-Manguinhos), Funda\u00e7\u00e3o Oswaldo Cruz, Av. Brasil, 4365-Rio de Janeiro\/RJ CEP 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2009.10.008","article-title":"Present and Future Arboviral Threats","volume":"85","author":"Weaver","year":"2010","journal-title":"Antiviral. Res."},{"key":"ref_2","first-page":"55","article-title":"General features and epidemiology of emerging arboviruses in Brazil","volume":"5","author":"Lopes","year":"2014","journal-title":"Rev. Pan-Amaz. Saude"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3201\/eid0704.017431","article-title":"Identification of Arboviruses and Certain Rodent-Borne Viruses: Reevaluation of the Paradigm","volume":"7","author":"Calisher","year":"2001","journal-title":"Emerg. Infect. Dis."},{"key":"ref_4","unstructured":"Karabatsos, N. (1985). 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