{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:26:19Z","timestamp":1780529179848,"version":"3.54.1"},"reference-count":131,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["6905"],"award-info":[{"award-number":["6905"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ocular melanoma consists of posterior uveal melanoma, iris melanoma and conjunctival melanoma. These malignancies derive from melanocytes in the uveal tract or conjunctiva. The genetic profiles of these different entities differ from each other. In uveal melanoma, GNAQ and GNA11 gene mutations are frequently found and prognosis is based on mutation status of BAP1, SF3B1 and EIF1AX genes. Iris melanoma, also originating from the uvea, has similarities to the genetic makeups of both posterior uveal melanoma (UM) and conjunctival melanoma since mutations in GNAQ and GNA11 are less common and genes involved in conjunctival melanoma such as BRAF have been described. The genetic spectrum of conjunctival melanoma, however, includes frequent mutations in the BRAF, NRAS and TERT promoter genes, which are found in cutaneous melanoma as well. The BRAF status of the tumor is not correlated to prognosis, whereas the TERT promoter gene mutations are. Clinical presentation, histopathological characteristics and copy number alterations are associated with survival in ocular melanoma. Tissue material is needed to classify ocular melanoma in the different subgroups, which creates a need for the use of noninvasive techniques to prognosticate patients who underwent eye preserving treatment.<\/jats:p>","DOI":"10.3390\/ijms22010336","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T20:13:41Z","timestamp":1609359221000},"page":"336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Genetics of Ocular Melanoma: Insights into Genetics, Inheritance and Testing"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-9997","authenticated-orcid":false,"given":"Natasha M.","family":"van Poppelen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"},{"name":"Department of Clinical Genetics, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00ebl P.","family":"de Bruyn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"},{"name":"Department of Clinical Genetics, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-7876","authenticated-orcid":false,"given":"Tolga","family":"Bicer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"},{"name":"Department of Ophthalmology, University of Health Sciences Diskapi Training and Research Hospital, Ankara 06330, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-214X","authenticated-orcid":false,"given":"Rob","family":"Verdijk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"},{"name":"Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Naus","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"Mensink","sequence":"additional","affiliation":[{"name":"Department of Ophthalmic Oncology, The Rotterdam Eye Hospital, 3011 BH Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6762-3614","authenticated-orcid":false,"given":"Dion","family":"Paridaens","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"},{"name":"Department of Ophthalmic Oncology, The Rotterdam Eye Hospital, 3011 BH Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"de Klein","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8235-4010","authenticated-orcid":false,"given":"Erwin","family":"Brosens","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Kili\u04ab","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/aos.13535","article-title":"The first description of the complete natural history of uveal melanoma by two Scottish surgeons, Allan Burns and James Wardrop","volume":"96","author":"Kivela","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"ref_2","first-page":"1563","article-title":"The distinguished Austrian ophthalmologist Ernst Fuchs (1851\u20131930) and the \u201csarcom des uvealtractus\u201d","volume":"23","author":"Zozolou","year":"2018","journal-title":"J. BUON"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/cncr.20866","article-title":"Incidence of noncutaneous melanomas in the U.S","volume":"103","author":"McLaughlin","year":"2005","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2147\/OPTH.S120530","article-title":"Ocular melanoma-when you have seen one, you have not seen them all: A clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973\u20132012)","volume":"11","author":"Mahendraraj","year":"2017","journal-title":"Clin. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/09286580591000836","article-title":"Uveal and conjunctival malignant melanoma in Denmark, 1943\u20131997: Incidence and validation study","volume":"12","author":"Isager","year":"2005","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/02713683.2016.1245422","article-title":"Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up","volume":"42","author":"Yue","year":"2017","journal-title":"Curr. Eye Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.2147\/OPTH.S113623","article-title":"Trends in incidence, survival, and management of uveal melanoma: A population-based study of 7516 patients from the Surveillance, Epidemiology, and End Results database (1973\u20132012)","volume":"10","author":"Mahendraraj","year":"2016","journal-title":"Clin. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1097\/IAE.0b013e31824d09a8","article-title":"Clinical spectrum and prognosis of uveal melanoma based on age at presentation in 8033 cases","volume":"32","author":"Shields","year":"2012","journal-title":"Retina"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/09286580600553330","article-title":"Uveal and conjunctival malignant melanoma in denmark 1943-97: Observed and relative survival of patients followed through 2002","volume":"13","author":"Isager","year":"2006","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1038\/s41433-019-0622-9","article-title":"Uveal melanoma-associated survival in Scotland","volume":"33","author":"Jamison","year":"2019","journal-title":"Eye (London)"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.ophtha.2017.11.040","article-title":"Iris Melanoma Outcomes Based on the American Joint Committee on Cancer Classification (Eighth Edition) in 432 Patients","volume":"125","author":"Shields","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1001\/jamaophthalmol.2018.2466","article-title":"Survival Rates in Patients After Treatment for Metastasis From Uveal Melanoma","volume":"136","author":"Lane","year":"2018","journal-title":"JAMA Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.5114\/jcb.2017.70986","article-title":"Patterns of care and survival outcomes after treatment for uveal melanoma in the post-coms era (2004\u20132013): A surveillance, epidemiology, and end results analysis","volume":"9","author":"Rao","year":"2017","journal-title":"J. Contemp. Brachyther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1001\/archopht.124.12.1684","article-title":"The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognostic factors: COMS report No. 28","volume":"124","year":"2006","journal-title":"Arch. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00066-017-1203-0","article-title":"Surgery vs. radiotherapy in patients with uveal melanoma: Analysis of the SEER database using propensity score matching and weighting Chirurgie vs. Strahlentherapie bei Patienten mit Uveamelanom: Analyse der SEER-Datenbank mithilfe von Propensity-Score-Matching und -Gewichtung","volume":"193","author":"Jang","year":"2017","journal-title":"Strahlenther. Onkol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00262-019-02352-6","article-title":"Pembrolizumab as first-line treatment for metastatic uveal melanoma","volume":"68","author":"Rossi","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1056\/NEJMoa1000584","article-title":"Mutations in GNA11 in uveal melanoma","volume":"363","author":"Griewank","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1158\/1078-0432.CCR-19-1223","article-title":"Randomized phase II trial and tumor mutational spectrum analysis from cabozantinib versus chemotherapy in metastatic uveal melanoma (Alliance A091201)","volume":"26","author":"Luke","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1200\/JCO.2017.74.1090","article-title":"Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT)","volume":"36","author":"Carvajal","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/gcc.22541","article-title":"Prognostic value of chromosomal imbalances, gene mutations, and BAP1 expression in uveal melanoma","volume":"57","author":"Patrone","year":"2018","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.ophtha.2016.01.023","article-title":"Uveal Melanomas with SF3B1 Mutations: A Distinct Subclass Associated with Late-Onset Metastases","volume":"123","author":"Yavuzyigitoglu","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/aos.13452","article-title":"Prognostic impact of chromosomal aberrations and GNAQ, GNA11 and BAP1 mutations in uveal melanoma","volume":"96","author":"Staby","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1097\/IAE.0b013e3181cfdfad","article-title":"Posterior uveal melanoma in young patients treated with proton beam therapy","volume":"30","author":"Vavvas","year":"2010","journal-title":"Retina"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ophtha.2013.10.032","article-title":"Proton therapy for uveal melanoma in 43 juvenile patients: Long-term results","volume":"121","author":"Petrovic","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1001\/jamaophthalmol.2018.5132","article-title":"Clinical Features, Metastasis, and Survival in Patients Younger Than 21 Years With Posterior Uveal Melanoma","volume":"137","author":"Fry","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.sjopt.2013.06.013","article-title":"Uveal melanoma in children and teenagers","volume":"27","author":"Shields","year":"2013","journal-title":"Saudi J. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ophtha.2015.12.024","article-title":"The Pediatric Choroidal and Ciliary Body Melanoma Study: A Survey by the European Ophthalmic Oncology Group","volume":"123","author":"Cassoux","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jaapos.2013.11.006","article-title":"Uveal melanoma among Finnish children and young adults","volume":"18","author":"Kivela","year":"2014","journal-title":"J. AAPOS"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1001\/archopht.1981.03930021009003","article-title":"Uveal melanoma in children and adolescents","volume":"99","author":"Barr","year":"1981","journal-title":"Arch. Ophthalmol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5301\/ejo.5000200","article-title":"Influence of age on prognosis of young patients with uveal melanoma: A matched retrospective cohort study","volume":"23","author":"Kaliki","year":"2013","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1136\/bjophthalmol-2017-311530","article-title":"Population-based incidence of conjunctival tumours in Olmsted County, Minnesota","volume":"102","author":"Dalvin","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/aos.13207","article-title":"Conjunctival malignant melanoma in Denmark: Epidemiology, treatment and prognosis with special emphasis on tumorigenesis and genetic profile","volume":"94","author":"Larsen","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ajo.2016.09.034","article-title":"Conjunctival Tumors in 5002 Cases. Comparative Analysis of Benign Versus Malignant Counterparts. The 2016 James D. Allen Lecture","volume":"173","author":"Shields","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/aos.13007","article-title":"BRAF mutations in conjunctival melanoma: Investigation of incidence, clinicopathological features, prognosis and paired premalignant lesions","volume":"94","author":"Larsen","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/s41416-018-0046-5","article-title":"NF1 mutations in conjunctival melanoma","volume":"118","author":"Scholz","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1159\/000497813","article-title":"Conjunctival Melanoma in Childhood and Adolescence: A Systematic Review","volume":"5","author":"Balzer","year":"2019","journal-title":"Ocul. Oncol. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1097\/PAS.0000000000001344","article-title":"Greater Tumor Thickness, Ulceration, and Positive Sentinel Lymph Node Are Associated With Worse Prognosis in Patients With Conjunctival Melanoma: Implications for Future AJCC Classifications","volume":"43","author":"Esmaeli","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1136\/bjophthalmol-2017-311082","article-title":"Treatment of conjunctival melanoma in a Dutch referral centre","volume":"102","author":"Brouwer","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/pcmr.12767","article-title":"Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features, and clinical outcome","volume":"32","author":"Kenawy","year":"2019","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40425-019-0555-7","article-title":"Checkpoint inhibition immunotherapy for advanced local and systemic conjunctival melanoma: A clinical case series","volume":"7","author":"Finger","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1001\/jamaophthalmol.2018.3488","article-title":"Immunotherapy With Programmed Cell Death 1 Inhibitors for 5 Patients With Conjunctival Melanoma","volume":"136","author":"Sagiv","year":"2018","journal-title":"JAMA Ophthalmol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0140-6736(96)90736-9","article-title":"Prognostic implications of monosomy 3 in uveal melanoma","volume":"347","author":"Prescher","year":"1996","journal-title":"Lancet"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1167\/iovs.17-21838","article-title":"Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma","volume":"58","author":"Scholz","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.ophtha.2017.12.022","article-title":"Genetic Background of Iris Melanomas and Iris Melanocytic Tumors of Uncertain Malignant Potential","volume":"125","author":"Vaarwater","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/bjc.2013.299","article-title":"Rotterdam Ocular Melanoma Study, g. Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11","volume":"109","author":"Koopmans","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1167\/iovs.14-14550","article-title":"Chromosome 3 status combined with BAP1 and EIF1AX mutation profiles are associated with metastasis in uveal melanoma","volume":"55","author":"Ewens","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/PAS.0000000000000645","article-title":"Comparing the Prognostic Value of BAP1 Mutation Pattern, Chromosome 3 Status, and BAP1 Immunohistochemistry in Uveal Melanoma","volume":"40","author":"Nelles","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1167\/iovs.11-8697","article-title":"Higher percentage of FISH-determined monosomy 3 and 8q amplification in uveal melanoma cells relate to poor patient prognosis","volume":"53","author":"Vaarwater","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1146\/annurev-biochem-060713-035802","article-title":"The scanning mechanism of eukaryotic translation initiation","volume":"83","author":"Hinnebusch","year":"2014","journal-title":"Annu. Rev. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tibs.2017.03.004","article-title":"Structural insights into the mechanism of scanning and start codon recognition in eukaryotic translation initiation","volume":"42","author":"Hinnebusch","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.cell.2014.09.050","article-title":"Integrated genomic characterization of papillary thyroid carcinoma","volume":"159","author":"Agrawal","year":"2014","journal-title":"Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1074\/jbc.272.12.7883","article-title":"Function of eukaryotic translation initiation factor 1A (eIF1A)(formerly called eIF-4C) in initiation of protein synthesis","volume":"272","author":"Chaudhuri","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/ng.2674","article-title":"Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3","volume":"45","author":"Martin","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ccell.2017.07.003","article-title":"Integrative analysis identifies four molecular and clinical subsets in uveal melanoma","volume":"32","author":"Robertson","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"E2424","DOI":"10.1073\/pnas.1207846109","article-title":"Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution","volume":"109","author":"Lee","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Violanti, S.S., Bononi, I., Gallenga, C.E., Martini, F., Tognon, M., and Perri, P. (2019). New insights into molecular oncogenesis and therapy of uveal melanoma. Cancers, 11.","DOI":"10.3390\/cancers11050694"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.celrep.2018.01.088","article-title":"Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types","volume":"23","author":"Seiler","year":"2018","journal-title":"Cell Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.molcel.2016.08.036","article-title":"Molecular architecture of SF3b and structural consequences of its cancer-related mutations","volume":"64","author":"Cretu","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1128\/MCB.18.8.4752","article-title":"A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site","volume":"18","author":"Gozani","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1093\/emboj\/cdf480","article-title":"Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein","volume":"21","author":"Will","year":"2002","journal-title":"EMBO J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.celrep.2015.09.053","article-title":"Cancer-associated SF3B1 hotspot mutations induce cryptic 3\u2032 splice site selection through use of a different branch point","volume":"13","author":"Darman","year":"2015","journal-title":"Cell Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"10615","DOI":"10.1038\/ncomms10615","article-title":"Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage","volume":"7","author":"Alsafadi","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1158\/2159-8290.CD-13-0330","article-title":"SF3B1 mutations are associated with alternative splicing in uveal melanoma","volume":"3","author":"Furney","year":"2013","journal-title":"Cancer Discov."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ng.2523","article-title":"Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma","volume":"45","author":"Harbour","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/bjo.2010.181289","article-title":"Chromosomal aberrations in iris melanomas","volume":"95","author":"Mensink","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ajo.2017.06.025","article-title":"Late Solitary Extraocular Recurrence From Previously Resected Iris Melanoma","volume":"181","author":"Fabian","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ophtha.2016.10.039","article-title":"Correlation of Gene Mutation Status with Copy Number Profile in Uveal Melanoma","volume":"124","author":"Yavuzyigitoglu","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.18632\/oncotarget.6614","article-title":"Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4","volume":"7","author":"Johansson","year":"2016","journal-title":"Oncotarget"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41467-017-02428-w","article-title":"Punctuated evolution of canonical genomic aberrations in uveal melanoma","volume":"9","author":"Field","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Van Poppelen, N.M., Drabarek, W., Smit, K.N., Vaarwater, J., Brands, T., Paridaens, D., Kilic, E., and de Klein, A. (2019). SRSF2 Mutations in Uveal Melanoma: A Preference for In-Frame Deletions?. Cancers, 11.","DOI":"10.3390\/cancers11081200"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature00766","article-title":"Mutations of the BRAF gene in human cancer","volume":"417","author":"Davies","year":"2002","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1001\/jamaophthalmol.2017.4837","article-title":"Molecular Characteristics of Conjunctival Melanoma Using Whole-Exome Sequencing","volume":"135","author":"Swaminathan","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1167\/iovs.14-14901","article-title":"Prevalence and implications of TERT promoter mutation in uveal and conjunctival melanoma and in benign and premalignant conjunctival melanocytic lesions","volume":"55","author":"Koopmans","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Van Ipenburg, J.N.N., Dubbink, H.J., van Ginderdeuren, R., Missotten, G.S., Paridaens, D., and Verdijk, R.M. (2020). Prognostic value of TERT promoter mutations in conjunctival melanomas in addition to clinicopathological features. Br. J. Ophthalmol.","DOI":"10.1136\/bjophthalmol-2020-317405"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1001\/jamaophthalmol.2015.1119","article-title":"Clinical Characteristics of Uveal Melanoma in Patients With Germline BAP1 Mutations","volume":"133","author":"Gupta","year":"2015","journal-title":"JAMA Ophthalmol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/pcmr.12046","article-title":"Prevalence of germline BAP1 mutation in a population-based sample of uveal melanoma cases","volume":"26","author":"Aoude","year":"2013","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.ophtha.2016.01.008","article-title":"BAP1 Germline Mutations in Finnish Patients with Uveal Melanoma","volume":"123","author":"Turunen","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.ajhg.2013.04.012","article-title":"Germline BAP1 mutations predispose to renal cell carcinomas","volume":"92","author":"Popova","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/gcc.22424","article-title":"Germline BAP1 alterations in familial uveal melanoma","volume":"56","author":"Rai","year":"2017","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Chau, C., van Doorn, R., van Poppelen, N.M., van der Stoep, N., Mensenkamp, A.R., Sijmons, R.H., van Paassen, B.W., van den Ouweland, A.M.W., Naus, N.C., and van der Hout, A.H. (2019). Families with BAP1-Tumor Predisposition Syndrome in The Netherlands: Path to Identification and a Proposal for Genetic Screening Guidelines. Cancers, 11.","DOI":"10.3390\/cancers11081114"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Ewens, K.G., Lalonde, E., Richards-Yutz, J., Shields, C.L., and Ganguly, A. (2018). Comparison of Germline versus Somatic BAP1 Mutations for Risk of Metastasis in Uveal Melanoma. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-5079-x"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Njauw, C.N., Kim, I., Piris, A., Gabree, M., Taylor, M., Lane, A.M., DeAngelis, M.M., Gragoudas, E., Duncan, L.M., and Tsao, H. (2012). Germline BAP1 inactivation is preferentially associated with metastatic ocular melanoma and cutaneous-ocular melanoma families. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035295"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/jnci\/djy171","article-title":"Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide","volume":"110","author":"Walpole","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/gcc.7","article-title":"Analysis of the exome aggregation consortium (ExAC) database suggests that the BAP1-tumor predisposition syndrome is underreported in cancer patients","volume":"57","author":"Massengill","year":"2018","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1038\/s41598-018-26040-0","article-title":"Germline mutation in the TP53 gene in uveal melanoma","volume":"8","author":"Hajkova","year":"2018","journal-title":"Sci Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0039-6257(93)90142-T","article-title":"Familial malignant melanoma of the uvea and p53: A Victorian detective story","volume":"37","author":"Jay","year":"1993","journal-title":"Surv. Ophthalmol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1001\/archopht.1983.01040020896012","article-title":"A prognostic factor study of disease-free interval and survival following enucleation for uveal melanoma","volume":"101","author":"Seddon","year":"1983","journal-title":"Arch. Ophthalmol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0161-6420(93)31470-3","article-title":"The prognostic value of tumor blood vessel morphology in primary uveal melanoma","volume":"100","author":"Folberg","year":"1993","journal-title":"Ophthalmology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1600-0420.1995.tb00039.x","article-title":"Prognostic indicators following enucleation for posterior uveal melanoma. A multivariate analysis of long-term survival with minimized loss to follow-up","volume":"73","author":"Seregard","year":"1995","journal-title":"Acta Ophthalmol. Scand."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1167\/iovs.12-10365","article-title":"Gender differences in clinical presentation and prognosis of uveal melanoma","volume":"54","author":"Zloto","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1167\/iovs.13-12195","article-title":"Genomic profile of 320 uveal melanoma cases: Chromosome 8p-loss and metastatic outcome","volume":"54","author":"Ewens","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/S0161-6420(91)32060-8","article-title":"Uveal melanoma and pregnancy. A report of 16 cases","volume":"98","author":"Shields","year":"1991","journal-title":"Ophthalmology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1167\/iovs.04-1460","article-title":"Concurrent loss of chromosome arm 1p and chromosome 3 predicts a decreased disease-free survival in uveal melanoma patients","volume":"46","author":"Kilic","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0140-6736(92)90861-V","article-title":"Chromosomal aberrations defining uveal melanoma of poor prognosis","volume":"339","author":"Prescher","year":"1992","journal-title":"Lancet"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/(SICI)1098-2264(199705)19:1<22::AID-GCC4>3.0.CO;2-2","article-title":"Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis","volume":"19","author":"Sisley","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1136\/bjo.85.12.1440","article-title":"Prediction of prognosis in patients with uveal melanoma using fluorescence in situ hybridisation","volume":"85","author":"Patel","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ophtha.2010.05.023","article-title":"Prognosis of uveal melanoma in 500 cases using genetic testing of fine-needle aspiration biopsy specimens","volume":"118","author":"Shields","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1158\/1078-0432.CCR-06-2383","article-title":"Loss of heterozygosity of chromosome 3 detected with single nucleotide polymorphisms is superior to monosomy 3 for predicting metastasis in uveal melanoma","volume":"13","author":"Onken","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1126\/science.1194472","article-title":"Frequent mutation of BAP1 in metastasizing uveal melanomas","volume":"330","author":"Harbour","year":"2010","journal-title":"Science"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/PAT.0000000000000002","article-title":"BAP1 protein loss by immunohistochemistry: A potentially useful tool for prognostic prediction in patients with uveal melanoma","volume":"45","author":"Shah","year":"2013","journal-title":"Pathology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/bjc.2014.417","article-title":"Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing","volume":"111","author":"Kalirai","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/modpathol.2014.43","article-title":"Clinical significance of immunohistochemistry for detection of BAP1 mutations in uveal melanoma","volume":"27","author":"Koopmans","year":"2014","journal-title":"Mod. Pathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1158\/1078-0432.CCR-06-2401","article-title":"Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma","volume":"13","author":"Worley","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/sj.eye.6702779","article-title":"Significance of gene expression analysis in uveal melanoma in comparison to standard risk factors for risk assessment of subsequent metastases","volume":"22","author":"Petrausch","year":"2008","journal-title":"Eye (London)"},{"key":"ref_105","first-page":"2578","article-title":"Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities","volume":"63","author":"Tschentscher","year":"2003","journal-title":"Cancer Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/CMR.0b013e3282feeac6","article-title":"Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling","volume":"18","author":"Worley","year":"2008","journal-title":"Melanoma Res."},{"key":"ref_107","first-page":"2599","article-title":"Prognostic significance of deregulated microRNAs in uveal melanomas","volume":"19","author":"Falzone","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0002-9394(14)76028-3","article-title":"Iris melanomas","volume":"99","author":"Geisse","year":"1985","journal-title":"Am. J. Ophthalmol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/bjo.78.4.252","article-title":"Prognostic factors in primary malignant melanoma of the conjunctiva: A clinicopathological study of 256 cases","volume":"78","author":"Paridaens","year":"1994","journal-title":"Br. J. Ophthalmol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jaapos.2011.10.012","article-title":"Iris melanoma: Features and prognosis in 317 children and adults","volume":"16","author":"Shields","year":"2012","journal-title":"J. AAPOS"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archophthalmol.2011.286","article-title":"Clinical and pathologic characteristics of biopsy-proven iris melanoma: A multicenter international study","volume":"130","author":"Khan","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ophtha.2012.06.053","article-title":"Iris melanoma management with iodine-125 plaque radiotherapy in 144 patients: Impact of melanoma-related glaucoma on outcomes","volume":"120","author":"Shields","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00417-019-04296-0","article-title":"Conservative management of suspicious melanocytic lesions of the iris","volume":"257","author":"Oxenreiter","year":"2019","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10549-018-4666-5","article-title":"Circulating free DNA integrity and concentration as independent prognostic markers in metastatic breast cancer","volume":"169","author":"Cheng","year":"2018","journal-title":"Breast. Cancer Res. Treat."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1007\/s00216-018-1316-z","article-title":"Highly sensitive and specific real-time PCR by employing serial invasive reaction as a sequence identifier for quantifying EGFR mutation abundance in cfDNA","volume":"410","author":"Xiang","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1167\/iovs.04-0344","article-title":"Conjunctival melanoma in the Netherlands: A nationwide study","volume":"46","author":"Missotten","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_117","first-page":"64","article-title":"Histologic features of conjunctival melanoma predictive of metastasis and death (an American Ophthalmological thesis)","volume":"110","author":"Esmaeli","year":"2012","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/j.ophtha.2011.05.025","article-title":"Prognostic significance of tumor-associated lymphangiogenesis in malignant melanomas of the conjunctiva","volume":"118","author":"Heindl","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1136\/bjophthalmol-2014-305730","article-title":"Prognostic factors for conjunctival melanoma: A study in ethnic Chinese patients","volume":"99","author":"Sheng","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000452473","article-title":"Systemic BRAF\/MEK Inhibitors as a Potential Treatment Option in Metastatic Conjunctival Melanoma","volume":"3","author":"Mor","year":"2017","journal-title":"Ocul. Oncol. Pathol."},{"key":"ref_121","first-page":"4353","article-title":"A quantitative analysis of the potential biomarkers of non-small cell lung cancer by circulating cell-free DNA","volume":"16","author":"Wei","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12943-018-0808-y","article-title":"Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer","volume":"17","author":"Takeshita","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1158\/1078-0432.CCR-04-0378","article-title":"Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases","volume":"10","author":"Allard","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Anand, K., Roszik, J., Gombos, D., Upshaw, J., Sarli, V., Meas, S., Lucci, A., Hall, C., and Patel, S. (2019). Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma. Cancers, 11.","DOI":"10.3390\/cancers11060856"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/ijc.28436","article-title":"Detection rate and prognostic value of circulating tumor cells and circulating tumor DNA in metastatic uveal melanoma","volume":"134","author":"Bidard","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_126","first-page":"1","article-title":"Clinical Application of Circulating Tumor Cells and Circulating Tumor DNA in Uveal Melanoma","volume":"2","author":"Aaron","year":"2018","journal-title":"JCO Precis. Oncol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1158\/1078-0432.CCR-06-2329","article-title":"Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma","volume":"13","author":"Schuster","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/CMR.0b013e32833906e3","article-title":"Tyrosinase mRNA levels in the blood of uveal melanoma patients: Correlation with the number of circulating tumor cells and tumor progression","volume":"20","author":"Pinzani","year":"2010","journal-title":"Melanoma Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2018.02.013","article-title":"Biogenesis and function of extracellular vesicles in cancer","volume":"188","author":"Bebelman","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Eldh, M., Olofsson Bagge, R., Lasser, C., Svanvik, J., Sjostrand, M., Mattsson, J., Lindner, P., Choi, D.S., Gho, Y.S., and Lotvall, J. (2014). MicroRNA in exosomes isolated directly from the liver circulation in patients with metastatic uveal melanoma. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-962"},{"key":"ref_131","first-page":"2085","article-title":"Exudative retinal detachment from malignant uveal melanoma: Predictors and prognostic significance","volume":"42","author":"Kivela","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/1\/336\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:48:12Z","timestamp":1760179692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/1\/336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,30]]},"references-count":131,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["ijms22010336"],"URL":"https:\/\/doi.org\/10.3390\/ijms22010336","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,30]]}}}