{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:16:39Z","timestamp":1790381799628,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19-015-00329"],"award-info":[{"award-number":["19-015-00329"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Parameters of 24-h rhythm in intraocular pressure (IOP) were assessed in patients with stable or advanced primary open-angle glaucoma (S-POAG\/A-POAG) and referenced to the phase of \u201cmarker\u201d circadian temperature rhythm of each patient. Body temperature and IOP were measured over a 72-h span in 115 participants (65 S-POAG and 50 A-POAG). Retinal Ganglion Cell (RGC) damage was assessed by high-definition optical coherence tomography. The 24-h IOP rhythm in A-POAG patients peaked during the night, opposite to the daytime phase position in S-POAG patients (p &lt; 0.0001). The 24-h IOP phase correlated with RGC loss (p &lt; 0.0001). The internal phase shift between IOP and body temperature gradually increased with POAG progression (p &lt; 0.001). Angiotensin converting enzyme Alu-repeat deletion\/insertion (ACE I\/D) emerged as a candidate gene polymorphism, which may play a role in the alteration of the circadian IOP variability in advanced glaucoma. To conclude, a reliable estimation of the 24-h rhythm in IOP requires the degree of RGC damage to be assessed. In advanced POAG, the 24-h phase of IOP tended to occur during the night and correlated with RGC loss, being progressively delayed relative to the phase of temperature.<\/jats:p>","DOI":"10.3390\/ijms22010359","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T10:10:37Z","timestamp":1609409437000},"page":"359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Disruption of 24-Hour Rhythm in Intraocular Pressure Correlates with Retinal Ganglion Cell Loss in Glaucoma"],"prefix":"10.3390","volume":"22","author":[{"given":"Vladimir","family":"Neroev","sequence":"first","affiliation":[{"name":"Helmholtz Research Institute of Eye Diseases, 105062 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-8619","authenticated-orcid":false,"given":"Tatyana","family":"Malishevskaya","sequence":"additional","affiliation":[{"name":"Helmholtz Research Institute of Eye Diseases, 105062 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Weinert","sequence":"additional","affiliation":[{"name":"Institute of Biology\/Zoology, Martin Luther University, 06108 Halle-Wittenberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei","family":"Astakhov","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, 197022 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-3639","authenticated-orcid":false,"given":"Sergey","family":"Kolomeichuk","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Institute of Biology of the Karelian Science Center of the Russian Academy of Sciences, 185910 Petrozavodsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1698-1590","authenticated-orcid":false,"given":"Germaine","family":"Cornelissen","sequence":"additional","affiliation":[{"name":"Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-2535","authenticated-orcid":false,"given":"Yana","family":"Kabitskaya","sequence":"additional","affiliation":[{"name":"\u0421enter for Genomic Technologies, Northern Trans-Ural State Agricultural University, 625003 Tyumen, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Boiko","sequence":"additional","affiliation":[{"name":"\u0421enter for Genomic Technologies, Northern Trans-Ural State Agricultural University, 625003 Tyumen, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Nemtsova","sequence":"additional","affiliation":[{"name":"State Autonomous Health Care Institution Tyumen Regional Ophthalmological Dispensary, 625048 Tyumen, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-1033","authenticated-orcid":false,"given":"Denis","family":"Gubin","sequence":"additional","affiliation":[{"name":"Department of Biology, Medical University, 625023 Tyumen, Russia"},{"name":"Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science, 634009 Tomsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.preteyeres.2016.07.002","article-title":"24-h monitoring devices and nyctohemeral rhythms of intraocular pressure","volume":"55","author":"Aptel","year":"2016","journal-title":"Prog. 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