{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:20:41Z","timestamp":1791951641686,"version":"4.3.4"},"reference-count":238,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["413501650"],"award-info":[{"award-number":["413501650"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Aging represents the multifactorial decline in physiological function of every living organism. Over the past decades, several hallmarks of aging have been defined, including epigenetic deregulation. Indeed, multiple epigenetic events were found altered across different species during aging. Epigenetic changes directly contributing to aging and aging-related diseases include the accumulation of histone variants, changes in chromatin accessibility, loss of histones and heterochromatin, aberrant histone modifications, and deregulated expression\/activity of miRNAs. As a consequence, cellular processes are affected, which results in the development or progression of several human pathologies, including cancer, diabetes, osteoporosis, and neurodegenerative disorders. In this review, we focus on epigenetic mechanisms underlying aging-related processes in various species and describe how these deregulations contribute to human diseases.<\/jats:p>","DOI":"10.3390\/ijms22010401","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T19:54:46Z","timestamp":1609703686000},"page":"401","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":229,"title":["Epigenetics of Aging and Aging-Associated Diseases"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0673-3710","authenticated-orcid":false,"given":"Dominik","family":"Saul","sequence":"first","affiliation":[{"name":"Kogod Center on Aging and Division of Endocrinology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA"},{"name":"Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, 37075 Goettingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-7762","authenticated-orcid":false,"given":"Robyn Laura","family":"Kosinsky","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: Linking aging to chronic disease","volume":"159","author":"Kennedy","year":"2014","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/38444","article-title":"Crystal structure of the nucleosome core particle at 2.8 A resolution","volume":"389","author":"Luger","year":"1997","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nature01595","article-title":"The structure of DNA in the nucleosome core","volume":"423","author":"Richmond","year":"2003","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.sbi.2015.09.007","article-title":"Functional coupling between writers, erasers and readers of histone and DNA methylation","volume":"35","author":"Torres","year":"2015","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-019-0204-5","article-title":"The ageing epigenome and its rejuvenation","volume":"21","author":"Zhang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1101\/gad.233221.113","article-title":"Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging","volume":"28","author":"Hu","year":"2014","journal-title":"Genes Dev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.celrep.2013.05.043","article-title":"Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging","volume":"4","author":"Liu","year":"2013","journal-title":"Cell Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/nsmb.1897","article-title":"Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres","volume":"17","author":"Kubicek","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/s12276-020-00497-4","article-title":"Heterochromatin: An epigenetic point of view in aging","volume":"52","author":"Lee","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1006\/geno.2002.6850","article-title":"The human and mouse replication-dependent histone genes","volume":"80","author":"Marzluff","year":"2002","journal-title":"Genomics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"a019364","DOI":"10.1101\/cshperspect.a019364","article-title":"Histone variants and epigenetics","volume":"7","author":"Henikoff","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/nsmb.1665","article-title":"The histone variant macroH2A is an epigenetic regulator of key developmental genes","volume":"16","author":"Buschbeck","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1126\/science.1529340","article-title":"MacroH2A, a core histone containing a large nonhistone region","volume":"257","author":"Pehrson","year":"1992","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/ncomms2582","article-title":"MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency","volume":"4","author":"Qadeer","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1474-9726.2010.00666.x","article-title":"Age-associated increase in heterochromatic marks in murine and primate tissues","volume":"10","author":"Kreiling","year":"2011","journal-title":"Aging Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.1093\/nar\/gkx696","article-title":"Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape","volume":"45","author":"Tvardovskiy","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.celrep.2016.09.074","article-title":"Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs","volume":"17","author":"Piazzesi","year":"2016","journal-title":"Cell Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2015.06.014","article-title":"Critical Role of Histone Turnover in Neuronal Transcription and Plasticity","volume":"87","author":"Maze","year":"2015","journal-title":"Neuron"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.celrep.2018.01.020","article-title":"Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse Hippocampus","volume":"22","author":"Stefanelli","year":"2018","journal-title":"Cell Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/acel.12592","article-title":"Quantitative identification of senescent cells in aging and disease","volume":"16","author":"Biran","year":"2017","journal-title":"Aging Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1139\/o03-042","article-title":"Characteristics of gamma-H2AX foci at DNA double-strand breaks sites","volume":"81","author":"Pilch","year":"2003","journal-title":"Biochem. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cell.2005.06.013","article-title":"Complicated tails: Histone modifications and the DNA damage response","volume":"121","author":"Vidanes","year":"2005","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.yexcr.2004.07.022","article-title":"Replication protein A and gamma-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks","volume":"300","author":"Balajee","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/978-1-61779-998-3_40","article-title":"Histone H2AX phosphorylation: A marker for DNA damage","volume":"920","author":"Sharma","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/1947601910393957","article-title":"DNA methylation: Superior or subordinate in the epigenetic hierarchy?","volume":"2","author":"Jin","year":"2011","journal-title":"Genes Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.biochi.2012.05.016","article-title":"Mechanisms of DNA methylation and demethylation in mammals","volume":"94","author":"Auclair","year":"2012","journal-title":"Biochimie"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hyun, J., and Jung, Y. (2020). DNA Methylation in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218138"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature08514","article-title":"Human DNA methylomes at base resolution show widespread epigenomic differences","volume":"462","author":"Lister","year":"2009","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature14192","article-title":"Function and information content of DNA methylation","volume":"517","year":"2015","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.1210944","article-title":"Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA","volume":"333","author":"He","year":"2011","journal-title":"Science"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.1210597","article-title":"Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2013.12.019","article-title":"Reversing DNA methylation: Mechanisms, genomics, and biological functions","volume":"156","author":"Wu","year":"2014","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1101\/gad.276568.115","article-title":"Role of TET enzymes in DNA methylation, development, and cancer","volume":"30","author":"Rasmussen","year":"2016","journal-title":"Genes Dev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1093\/nar\/gks155","article-title":"Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation","volume":"40","author":"Hashimoto","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/em.22203","article-title":"Caenorhabditis elegans as an emerging model system in environmental epigenetics","volume":"59","author":"Weinhouse","year":"2018","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.cell.2015.04.005","article-title":"DNA Methylation on N6-Adenine in C. elegans","volume":"161","author":"Greer","year":"2015","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e5119","DOI":"10.7717\/peerj.5119","article-title":"Levels of DNA cytosine methylation in the Drosophila genome","volume":"6","author":"Deshmukh","year":"2018","journal-title":"PeerJ"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"R102","DOI":"10.1186\/gb-2013-14-9-r102","article-title":"Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape","volume":"14","author":"Day","year":"2013","journal-title":"Genome Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13059-015-0649-6","article-title":"Erratum to: DNA methylation age of human tissues and cell types","volume":"16","author":"Horvath","year":"2015","journal-title":"Genome Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ebiom.2017.03.046","article-title":"Biological Age Predictors","volume":"21","author":"Pedersen","year":"2017","journal-title":"EBioMedicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/138920212803251373","article-title":"Chromatin remodeling, DNA damage repair and aging","volume":"13","author":"Liu","year":"2012","journal-title":"Curr. Genomics"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.biochem.77.062706.153223","article-title":"The biology of chromatin remodeling complexes","volume":"78","author":"Clapier","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.4161\/15384101.2014.946834","article-title":"BRG1, the ATPase subunit of SWI\/SNF chromatin remodeling complex, interacts with HDAC2 to modulate telomerase expression in human cancer cells","volume":"13","author":"Wu","year":"2014","journal-title":"Cell Cycle"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wu, S., Ge, Y., Li, X., Yang, Y., Zhou, H., Lin, K., Zhang, Z., and Zhao, Y. (2020). BRM-SWI\/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1. PLoS Genet., 16.","DOI":"10.1371\/journal.pgen.1008799"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ncb2720","article-title":"DAF-16 employs the chromatin remodeller SWI\/SNF to promote stress resistance and longevity","volume":"15","author":"Riedel","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/acel.12129","article-title":"The Caenorhabditis elegans LET-418\/Mi2 plays a conserved role in lifespan regulation","volume":"12","author":"Pfefferli","year":"2013","journal-title":"Aging Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/cr.2013.113","article-title":"The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability","volume":"23","author":"Min","year":"2013","journal-title":"Cell Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.cmet.2014.04.004","article-title":"Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response","volume":"19","author":"Dang","year":"2014","journal-title":"Cell Metab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1038\/s41467-017-01903-8","article-title":"The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress","volume":"8","author":"Matilainen","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.fob.2013.08.007","article-title":"Contribution of histone N-terminal tails to the structure and stability of nucleosomes","volume":"3","author":"Iwasaki","year":"2013","journal-title":"FEBS Open Bio"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrg3173","article-title":"Histone methylation: A dynamic mark in health, disease and inheritance","volume":"13","author":"Greer","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nature09195","article-title":"Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans","volume":"466","author":"Greer","year":"2010","journal-title":"Nature"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Li, L., Greer, C., Eisenman, R.N., and Secombe, J. (2010). Essential functions of the histone demethylase lid. PLoS Genet., 6.","DOI":"10.1371\/journal.pgen.1001221"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Pu, M., Wang, M., Wang, W., Velayudhan, S.S., and Lee, S.S. (2018). Unique patterns of trimethylation of histone H3 lysine 4 are prone to changes during aging in Caenorhabditis elegans somatic cells. PLoS Genet., 14.","DOI":"10.1371\/journal.pgen.1007466"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Cruz, C., Della Rosa, M., Krueger, C., Gao, Q., Horkai, D., King, M., Field, L., and Houseley, J. (2018). Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells. Elife, 7.","DOI":"10.7554\/eLife.34081"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1101\/gad.263707.115","article-title":"H3K36 methylation promotes longevity by enhancing transcriptional fidelity","volume":"29","author":"Sen","year":"2015","journal-title":"Genes Dev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1101\/gad.254144.114","article-title":"Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span","volume":"29","author":"Pu","year":"2015","journal-title":"Genes Dev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1016\/j.celrep.2018.02.029","article-title":"Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression","volume":"22","author":"Su","year":"2018","journal-title":"Cell Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cmet.2011.07.001","article-title":"Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin\/IGF-1 signaling pathway","volume":"14","author":"Jin","year":"2011","journal-title":"Cell Metab."},{"key":"ref_62","first-page":"107","article-title":"Quality review in the Peer Review Organization Program","volume":"2","author":"Kelly","year":"1987","journal-title":"Qual. Assur. Util. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1073\/pnas.0907739107","article-title":"Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance","volume":"107","author":"Siebold","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/acel.12257","article-title":"RNA-seq of the aging brain in the short-lived fish N. furzeri\u2014conserved pathways and novel genes associated with neurogenesis","volume":"13","author":"Baumgart","year":"2014","journal-title":"Aging Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gene.2009.09.007","article-title":"The histone demethylase Dmel\\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila","volume":"450","author":"Lorbeck","year":"2010","journal-title":"Gene"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.stemcr.2016.05.007","article-title":"Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation","volume":"6","author":"Djeghloul","year":"2016","journal-title":"Stem Cell Reports"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"39195","DOI":"10.1074\/jbc.M205166200","article-title":"Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging","volume":"277","author":"Sarg","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s13059-016-1017-x","article-title":"Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability","volume":"17","author":"Nelson","year":"2016","journal-title":"Genome Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10522-008-9176-0","article-title":"Age-related difference of site-specific histone modifications in rat liver","volume":"10","author":"Kawakami","year":"2009","journal-title":"Biogerontology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature06736","article-title":"SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin","volume":"452","author":"Michishita","year":"2008","journal-title":"Nature"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2005.11.044","article-title":"Genomic instability and aging-like phenotype in the absence of mammalian SIRT6","volume":"124","author":"Mostoslavsky","year":"2006","journal-title":"Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2008.10.052","article-title":"SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span","volume":"136","author":"Kawahara","year":"2009","journal-title":"Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature10815","article-title":"The sirtuin SIRT6 regulates lifespan in male mice","volume":"483","author":"Kanfi","year":"2012","journal-title":"Nature"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41419-017-0085-5","article-title":"Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"25949","DOI":"10.1074\/jbc.C500181200","article-title":"Characterization of lysine 56 of histone H3 as an acetylation site in Saccharomyces cerevisiae","volume":"280","author":"Ozdemir","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.4161\/cc.8.11.8620","article-title":"Histone H3-K56 acetylation is important for genomic stability in mammals","volume":"8","author":"Yuan","year":"2009","journal-title":"Cell Cycle"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejps.2014.06.015","article-title":"Studying SIRT6 regulation using H3K56 based substrate and small molecules","volume":"63","author":"Kokkonen","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"101461","DOI":"10.1016\/j.isci.2020.101461","article-title":"SIRT7 Facilitates CENP-A Nucleosome Assembly and Suppresses Intestinal Tumorigenesis","volume":"23","author":"Liu","year":"2020","journal-title":"iScience"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"943","DOI":"10.18632\/aging.100399","article-title":"\u2018Relax and Repair\u2019 to restrain aging","volume":"3","author":"Krishnan","year":"2011","journal-title":"Aging (Albany NY)"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"21900","DOI":"10.1038\/srep21900","article-title":"Histone H3 N-terminal acetylation sites especially K14 are important for rDNA silencing and aging","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"12325","DOI":"10.1073\/pnas.1102789108","article-title":"Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice","volume":"108","author":"Krishnan","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3390\/ijms15011554","article-title":"Phosphorylation of Histone H2AX in the Mouse Brain from Development to Senescence","volume":"15","author":"Barral","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Oh, S., Suganuma, T., Gogol, M.M., and Workman, J.L. (2018). Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response. Elife, 7.","DOI":"10.7554\/eLife.36157"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s40610-016-0031-9","article-title":"Histone Modifications in Ageing and Lifespan Regulation","volume":"2","author":"Maleszewska","year":"2016","journal-title":"Curr. Mol. Biol. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.cell.2007.09.046","article-title":"Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS","volume":"131","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fonc.2012.00026","article-title":"Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer","volume":"2","author":"Cao","year":"2012","journal-title":"Front. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1038\/s41467-019-10136-w","article-title":"Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker","volume":"10","author":"Yang","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbrc.2011.02.008","article-title":"Resveratrol induces cellular senescence with attenuated mono-ubiquitination of histone H2B in glioma cells","volume":"407","author":"Gao","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.cellbio.23.090506.123406","article-title":"microRNA functions","volume":"23","author":"Bushati","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00439-019-02046-0","article-title":"MicroRNAs as modulators of longevity and the aging process","volume":"139","author":"Kinser","year":"2020","journal-title":"Hum. Genet."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.molmed.2019.04.007","article-title":"Tackling Aging by Using miRNA as a Target and a Tool","volume":"25","author":"Lai","year":"2019","journal-title":"Trends Mol. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","article-title":"miRBase: Annotating high confidence microRNAs using deep sequencing data","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1126\/science.1115596","article-title":"A developmental timing microRNA and its target regulate life span in C. elegans","volume":"310","author":"Boehm","year":"2005","journal-title":"Science"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Chawla, G., Deosthale, P., Childress, S., Wu, Y.-C., and Sokol, N.S. (2016). A let-7-to-miR-125 MicroRNA Switch Regulates Neuronal Integrity and Lifespan in Drosophila. PLoS Genet., 12.","DOI":"10.1371\/journal.pgen.1006247"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Huan, T., Chen, G., Liu, C., Bhattacharya, A., Rong, J., Chen, B.H., Seshadri, S., Tanriverdi, K., Freedman, J.E., and Larson, M.G. (2018). Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits. Aging Cell, 17.","DOI":"10.1111\/acel.12687"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"eaal2380","DOI":"10.1126\/science.aal2380","article-title":"Epigenetic plasticity and the hallmarks of cancer","volume":"357","author":"Flavahan","year":"2017","journal-title":"Science"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Nebbioso, A., Tambaro, F.P., Dell\u2019Aversana, C., and Altucci, L. (2018). Cancer epigenetics: Moving forward. PLoS Genet., 14.","DOI":"10.1371\/journal.pgen.1007362"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome\u2014Biological and translational implications","volume":"11","author":"Baylin","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Network (2012). Comprehensive molecular portraits of human breast tumours. Nature, 490, 61\u201370.","DOI":"10.1038\/nature11412"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2217\/epi.14.59","article-title":"Epigenetic mechanisms of breast cancer: An update of the current knowledge","volume":"6","author":"Dagdemir","year":"2014","journal-title":"Epigenomics"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1158\/0008-5472.CAN-03-3972","article-title":"Hypermethylation of CpG islands in primary and metastatic human prostate cancer","volume":"64","author":"Yegnasubramanian","year":"2004","journal-title":"Cancer Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/978-1-4939-1804-1_23","article-title":"Epigenetics in Breast and Prostate Cancer","volume":"1238","author":"Wu","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ccr.2010.12.014","article-title":"Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of \u03b1-ketoglutarate-dependent dioxygenases","volume":"19","author":"Xu","year":"2011","journal-title":"Cancer Cell"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cell.2017.11.031","article-title":"R-2HG Exhibits Anti-tumor Activity by Targeting FTO\/m6A\/MYC\/CEBPA Signaling","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fped.2017.00004","article-title":"MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches","volume":"5","author":"Winters","year":"2017","journal-title":"Front. Pediatr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.molcel.2019.01.021","article-title":"Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence","volume":"73","author":"Sen","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/leu.2016.347","article-title":"Loss of p300 Accelerates MDS-associated Leukemogenesis","volume":"31","author":"Cheng","year":"2016","journal-title":"Leukemia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5106","DOI":"10.1158\/0008-5472.CAN-15-0236","article-title":"Generation of a Selective Small Molecule Inhibitor of the CBP\/p300 Bromodomain for Leukemia Therapy","volume":"75","author":"Picaud","year":"2015","journal-title":"Cancer Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrc.2016.83","article-title":"Maintaining cell identity: PRC2-mediated regulation of transcription and cancer","volume":"16","author":"Comet","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature11606","article-title":"EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations","volume":"492","author":"McCabe","year":"2012","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12185-016-2124-x","article-title":"Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies","volume":"105","author":"Sashida","year":"2017","journal-title":"Int. J. Hematol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mad.2017.02.006","article-title":"Conserved effect of aging on DNA methylation and association with EZH2 polycomb protein in mice and humans","volume":"162","author":"Mozhui","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"12855","DOI":"10.18632\/oncotarget.14150","article-title":"AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX\/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis","volume":"8","author":"Singh","year":"2017","journal-title":"Oncotarget"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1084\/jem.20190250","article-title":"Dual roles of EZH2 in acute myeloid leukemia","volume":"216","author":"Skoda","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1053\/j.gastro.2015.07.011","article-title":"Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers","volume":"149","author":"Okugawa","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrgastro.2011.173","article-title":"Epigenetics and colorectal cancer","volume":"8","author":"Lao","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_120","first-page":"1165","article-title":"Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer","volume":"40","author":"Guo","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1158\/1541-7786.MCR-13-0644","article-title":"A Protein Interaction between \u03b2-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells","volume":"13","author":"Song","year":"2015","journal-title":"Mol. Cancer Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.3748\/wjg.v25.i23.2863","article-title":"Role of epigenetics in transformation of inflammation into colorectal cancer","volume":"25","author":"Yang","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1158\/1541-7786.MCR-09-0496","article-title":"Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6","volume":"8","author":"Foran","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/acel.12485","article-title":"Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study","volume":"15","author":"Ciccarone","year":"2016","journal-title":"Aging Cell"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"B268","DOI":"10.1093\/gerona\/56.6.B268","article-title":"Unexpected effects of a heterozygous dnmt1 null mutation on age-dependent DNA hypomethylation and autoimmunity","volume":"56","author":"Yung","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0092-8674(95)90329-1","article-title":"Suppression of intestinal neoplasia by DNA hypomethylation","volume":"81","author":"Laird","year":"1995","journal-title":"Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s00432-015-1972-8","article-title":"Hypermethylation of ITGA4, TFPI2 and VIMENTIN promoters is increased in inflamed colon tissue: Putative risk markers for colitis-associated cancer","volume":"141","author":"Gerecke","year":"2015","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.arcmed.2020.09.014","article-title":"Molecular Insights Into Colorectal Carcinoma","volume":"51","author":"Requena","year":"2020","journal-title":"Arch. Med. Res."},{"key":"ref_130","first-page":"4864","article-title":"Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1","volume":"60","author":"Fleisher","year":"2000","journal-title":"Cancer Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/ijc.11176","article-title":"Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines","volume":"106","author":"Arnold","year":"2003","journal-title":"Int. J. Cancer"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrc.2016.126","article-title":"Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer","volume":"17","author":"Dienstmann","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.3389\/fimmu.2017.01960","article-title":"Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?","volume":"8","author":"Fulop","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1128\/MCB.02429-06","article-title":"Epigenetic regulation of tumor necrosis factor alpha","volume":"27","author":"Sullivan","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.clim.2018.04.002","article-title":"Immune Senescence, Epigenetics and Autoimmunity","volume":"196","author":"Ray","year":"2018","journal-title":"Clin. Immunol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1266\/ggs.18-00016","article-title":"Age-associated changes in DNA methylation and expression of the TNF\u03b1 gene in pigs","volume":"93","author":"Wang","year":"2018","journal-title":"Genes Genet. Syst."},{"key":"ref_138","first-page":"449","article-title":"NF-\u03baB in Aging and Disease","volume":"2","author":"Tilstra","year":"2011","journal-title":"Aging Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"26771","DOI":"10.1074\/jbc.M802800200","article-title":"Role of the histone H3 lysine 4 methyltransferase, SET7\/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation","volume":"283","author":"Li","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"111160","DOI":"10.1016\/j.mad.2019.111160","article-title":"NF-\u03baB signaling in skin aging","volume":"184","author":"Wang","year":"2019","journal-title":"Mech. Ageing Dev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"52685","DOI":"10.18632\/oncotarget.10943","article-title":"The underlying mechanism of proinflammatory NF-\u03baB activation by the mTORC2\/Akt\/IKK\u03b1 pathway during skin aging","volume":"7","author":"Choi","year":"2016","journal-title":"Oncotarget"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.febslet.2012.04.002","article-title":"The enigmatic role of H2Bub1 in cancer","volume":"586","author":"Johnsen","year":"2012","journal-title":"FEBS Lett."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.celrep.2016.01.020","article-title":"RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer","volume":"14","author":"Tarcic","year":"2016","journal-title":"Cell Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ecco-jcc\/jjy165","article-title":"Loss of RNF40 Decreases NF-\u03baB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice","volume":"13","author":"Kosinsky","year":"2019","journal-title":"J. Crohns. Colitis"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"17663","DOI":"10.1038\/srep17663","article-title":"Multiple regulation pathways and pivotal biological functions of STAT3 in cancer","volume":"5","author":"Yuan","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.semcdb.2016.02.009","article-title":"STAT3 in the Systemic Inflammation of Cancer Cachexia","volume":"54","author":"Zimmers","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1172\/JCI124070","article-title":"TET repression and increased DNMT activity synergistically induce aberrant DNA methylation","volume":"130","author":"Takeshima","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"12416","DOI":"10.1073\/pnas.1811040116","article-title":"Dual mechanisms of posttranscriptional regulation of Tet2 by Let-7 microRNA in macrophages","volume":"116","author":"Jiang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"15538","DOI":"10.1073\/pnas.1412759111","article-title":"Obesity accelerates epigenetic aging of human liver","volume":"111","author":"Horvath","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1093\/humrep\/deaa206","article-title":"Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model","volume":"35","author":"Hanson","year":"2020","journal-title":"Hum. Reprod."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.18632\/aging.101670","article-title":"DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation","volume":"10","author":"Morin","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13059-015-0584-6","article-title":"DNA methylation age of blood predicts all-cause mortality in later life","volume":"16","author":"Marioni","year":"2015","journal-title":"Genome Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/imm.12244","article-title":"A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging","volume":"142","author":"Johnson","year":"2014","journal-title":"Immunology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13148-018-0585-x","article-title":"Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing","volume":"10","author":"Stevenson","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1016\/j.celrep.2018.05.057","article-title":"Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells","volume":"23","author":"Quinn","year":"2018","journal-title":"Cell Rep."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/cei.13344","article-title":"Type 2 diabetes is associated with the accumulation of senescent T cells","volume":"197","author":"Lau","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1189\/jlb.3RI0716-335R","article-title":"Human T cell immunosenescence and inflammation in aging","volume":"102","author":"Bektas","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.3389\/fimmu.2019.01525","article-title":"The Role of Epigenetics in Autoimmune\/Inflammatory Disease","volume":"10","author":"Surace","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.coi.2020.07.004","article-title":"New Treg cell-based therapies of autoimmune diseases: Towards antigen-specific immune suppression","volume":"67","author":"Mikami","year":"2020","journal-title":"Curr. Opin. Immunol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2217\/epi-2016-0143","article-title":"Age-associated DNA methylation changes in naive CD4+ T cells suggest an evolving autoimmune epigenotype in aging T cells","volume":"9","author":"Dozmorov","year":"2017","journal-title":"Epigenomics"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.clim.2015.09.013","article-title":"Altered expression of IL-10 family cytokines in monocytes from CRMO patients result in enhanced IL-1\u03b2 expression and release","volume":"161","author":"Hofmann","year":"2015","journal-title":"Clin. Immunol."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Wu, Z.-X., Cao, L., Li, X.-W., Jiang, W., Li, X.-Y., Xu, J., Wang, F., and Chen, G.-H. (2019). Accelerated Deficits of Spatial Learning and Memory Resulting From Prenatal Inflammatory Insult Are Correlated With Abnormal Phosphorylation and Methylation of Histone 3 in CD-1 Mice. Front. Aging Neurosci., 11.","DOI":"10.3389\/fnagi.2019.00114"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11914-020-00616-0","article-title":"Epigenetic Regulators of Mesenchymal Stem\/Stromal Cell Lineage Determination","volume":"18","author":"Cakouros","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e00177-17","DOI":"10.1128\/MCB.00177-17","article-title":"Tet-Mediated DNA Demethylation Is Required for SWI\/SNF-Dependent Chromatin Remodeling and Histone-Modifying Activities That Trigger Expression of the Sp7 Osteoblast Master Gene during Mesenchymal Lineage Commitment","volume":"37","author":"Sepulveda","year":"2017","journal-title":"Mol. Cell. Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8874742","article-title":"Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis","volume":"2020","author":"Wang","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1474-9726.2009.00535.x","article-title":"DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells","volume":"9","author":"Bork","year":"2010","journal-title":"Aging Cell"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13072-018-0247-4","article-title":"Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination","volume":"12","author":"Cakouros","year":"2019","journal-title":"Epigenetics Chromatin"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1038\/s41467-018-04464-6","article-title":"Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter","volume":"9","author":"Yang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Ko, N.-Y., Chen, L.-R., and Chen, K.-H. (2020). The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144886"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.celrep.2018.02.001","article-title":"Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain","volume":"22","author":"Gontier","year":"2018","journal-title":"Cell Rep."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-020-0378-8","article-title":"Control of mesenchymal stem cell biology by histone modifications","volume":"10","author":"Ren","year":"2020","journal-title":"Cell Biosci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/mt.2015.152","article-title":"Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis","volume":"24","author":"Jing","year":"2016","journal-title":"Mol. Ther."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1210\/clinem\/dgz300","article-title":"Circulating miR-181c-5p and miR-497-5p Are Potential Biomarkers for Prognosis and Diagnosis of Osteoporosis","volume":"105","author":"Ma","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S2213-8587(17)30138-9","article-title":"10 years of denosumab treatment in postmenopausal women with osteoporosis: Results from the phase 3 randomised FREEDOM trial and open-label extension","volume":"5","author":"Bone","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_175","first-page":"115680","article-title":"Epigenetic therapies of osteoporosis","volume":"142","author":"Ruosi","year":"2020","journal-title":"Bone"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mad.2018.03.005","article-title":"Epigenetic mechanisms in amyotrophic lateral sclerosis: A short review","volume":"174","author":"Dolinar","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00401-017-1760-4","article-title":"Conserved DNA methylation combined with differential frontal cortex and cerebellar expression distinguishes C9orf72-associated and sporadic ALS, and implicates SERPINA1 in disease","volume":"134","author":"Ebbert","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4331\/wjbc.v11.i2.62","article-title":"Epigenetic basis of Alzheimer disease","volume":"11","year":"2020","journal-title":"World J. Biol. Chem."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41583-020-0325-z","article-title":"Cellular senescence and Alzheimer disease: The egg and the chicken scenario","volume":"21","author":"Masliah","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1038\/sj.emboj.7601147","article-title":"HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies","volume":"25","author":"Valenta","year":"2006","journal-title":"EMBO J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41593-018-0101-9","article-title":"Dysregulation of the epigenetic landscape of normal aging in Alzheimer\u2019s disease","volume":"21","author":"Nativio","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cell.2005.08.011","article-title":"Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses","volume":"123","author":"Chen","year":"2005","journal-title":"Cell"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature20579","article-title":"Addendum: REST and stress resistance in ageing and Alzheimer\u2019s disease","volume":"540","author":"Lu","year":"2016","journal-title":"Nature"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature13163","article-title":"REST and Stress Resistance in Aging and Alzheimer\u2019s Disease","volume":"507","author":"Lu","year":"2014","journal-title":"Nature"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.conb.2017.12.008","article-title":"REST, a master transcriptional regulator in neurodegenerative disease","volume":"48","author":"Hwang","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/jnc.14961","article-title":"Correcting abnormalities in miR-124\/PTPN1 signaling rescues tau pathology in Alzheimer\u2019s disease","volume":"154","author":"Hou","year":"2020","journal-title":"J. Neurochem."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.arr.2016.11.008","article-title":"Are microRNAs true sensors of ageing and cellular senescence?","volume":"35","author":"Williams","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Kumar, P., Dezso, Z., MacKenzie, C., Oestreicher, J., Agoulnik, S., Byrne, M., Bernier, F., Yanagimachi, M., Aoshima, K., and Oda, Y. (2013). Circulating miRNA biomarkers for Alzheimer\u2019s disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069807"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00401-016-1590-9","article-title":"Epigenetic regulation in Parkinson\u2019s disease","volume":"132","author":"Ross","year":"2016","journal-title":"Acta Neuropathol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"15685","DOI":"10.1002\/chem.201803933","article-title":"Alpha-Synuclein Modulates the Physical Properties of DNA","volume":"24","author":"Jiang","year":"2018","journal-title":"Chemistry"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-54865-w","article-title":"Common genetic variants associated with Parkinson\u2019s disease display widespread signature of epigenetic plasticity","volume":"9","author":"Sharma","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.celrep.2014.09.023","article-title":"Large-scale identification of coregulated enhancer networks in the adult human brain","volume":"9","author":"Vermunt","year":"2014","journal-title":"Cell Rep."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/mds.27278","article-title":"Identification of new \u03b1-synuclein regulator by nontraditional drug development pipeline","volume":"33","author":"Chen","year":"2018","journal-title":"Mov. Disord."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1126\/science.aaf3934","article-title":"\u03b22-Adrenoreceptor is a Regulator of the \u03b1-Synuclein Gene Driving Risk of Parkinson\u2019s Disease","volume":"357","author":"Mittal","year":"2017","journal-title":"Science"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/j.bbadis.2018.11.014","article-title":"Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer\u2019s and Parkinson disease pathology","volume":"1865","author":"Esteves","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2016.05.060","article-title":"Histone H3 Acetylation in the Postmortem Parkinson\u2019s Disease Primary Motor Cortex","volume":"627","author":"Gebremedhin","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1093\/hmg\/ddl243","article-title":"Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity","volume":"15","author":"Kontopoulos","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"e13210","DOI":"10.1111\/acel.13210","article-title":"Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration","volume":"19","author":"Sun","year":"2020","journal-title":"Aging Cell"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"Kahn","year":"2006","journal-title":"Nature"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s40618-016-0473-1","article-title":"Epigenetics: Spotlight on type 2 diabetes and obesity","volume":"39","author":"Desiderio","year":"2016","journal-title":"J. Endocrinol. Investig."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1089\/ars.2017.7299","article-title":"Epigenetics and Immunometabolism in Diabetes and Aging","volume":"29","author":"Guzik","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cmet.2019.03.009","article-title":"Epigenetics in Human Obesity and Type 2 Diabetes","volume":"29","author":"Ling","year":"2019","journal-title":"Cell Metab."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1073\/pnas.0806560105","article-title":"Persistent epigenetic differences associated with prenatal exposure to famine in humans","volume":"105","author":"Heijmans","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/ije\/dym126","article-title":"Cohort profile: The Dutch Hunger Winter families study","volume":"36","author":"Lumey","year":"2007","journal-title":"Int. J. Epidemiol."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Li, Y., and Tollefsbol, T.O. (2011). p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017421"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1242\/jeb.107110","article-title":"Epigenetic linkage of aging, cancer and nutrition","volume":"218","author":"Daniel","year":"2015","journal-title":"J. Exp. Biol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.arr.2016.12.005","article-title":"Dietary restriction and lifespan: Lessons from invertebrate models","volume":"39","author":"Kapahi","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/10408398.2013.767221","article-title":"Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans","volume":"56","author":"Joseph","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"38186","DOI":"10.1038\/srep38186","article-title":"Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation","volume":"6","author":"Hou","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/biof.1400","article-title":"Effect of resveratrol and pterostilbene on aging and longevity","volume":"44","author":"Li","year":"2018","journal-title":"Biofactors"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Yessenkyzy, A., Saliev, T., Zhanaliyeva, M., Masoud, A.-R., Umbayev, B., Sergazy, S., Krivykh, E., Gulyayev, A., and Nurgozhin, T. (2020). Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research. Nutrients, 12.","DOI":"10.3390\/nu12051344"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.gene.2014.07.009","article-title":"Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity","volume":"548","author":"Nilsson","year":"2014","journal-title":"Gene"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Hannon, E., Knox, O., Sugden, K., Burrage, J., Wong, C.C.Y., Belsky, D.W., Corcoran, D.L., Arseneault, L., Moffitt, T.E., and Caspi, A. (2018). Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. PLoS Genet., 14.","DOI":"10.1371\/journal.pgen.1007544"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fgene.2019.00192","article-title":"Histone Modifications as an Intersection Between Diet and Longevity","volume":"10","author":"Kyriakou","year":"2019","journal-title":"Front. Genet."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4161\/epi.24506","article-title":"A genome-wide methylation study on obesity: Differential variability and differential methylation","volume":"8","author":"Xu","year":"2013","journal-title":"Epigenetics"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/molehr\/gaz049","article-title":"The effect of maternal high-fat\/high-sugar diet on offspring oocytes and early embryo development","volume":"25","author":"Andreas","year":"2019","journal-title":"Mol. Hum. Reprod."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4161\/epi.7.2.18972","article-title":"Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16 (INK4a) gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet","volume":"7","author":"Zheng","year":"2012","journal-title":"Epigenetics"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12263-018-0595-5","article-title":"High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats","volume":"13","author":"Zhang","year":"2018","journal-title":"Genes Nutr."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1007\/s00125-012-2717-8","article-title":"Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men","volume":"55","author":"Jacobsen","year":"2012","journal-title":"Diabetologia"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mce.2017.11.019","article-title":"The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets","volume":"472","author":"Hall","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jdiacomp.2018.08.012","article-title":"Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes","volume":"32","author":"Sommese","year":"2018","journal-title":"J. Diabetes Complicat."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/s00125-015-3837-8","article-title":"Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets","volume":"59","author":"Sandovici","year":"2016","journal-title":"Diabetologia"},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Dayeh, T., Volkov, P., Sal\u00f6, S., Hall, E., Nilsson, E., Olsson, A.H., Kirkpatrick, C.L., Wollheim, C.B., Eliasson, L., and R\u00f6nn, T. (2014). Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004160"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.4161\/cc.7.18.6687","article-title":"The yin and yang of the Cdkn2a locus in senescence and aging","volume":"7","author":"Baker","year":"2008","journal-title":"Cell Cycle"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00125-016-3967-7","article-title":"Islet biology, the CDKN2A\/B locus and type 2 diabetes risk","volume":"59","author":"Kong","year":"2016","journal-title":"Diabetologia"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1101\/gad.1742509","article-title":"Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a\/Arf expression and regeneration in diabetes mellitus","volume":"23","author":"Chen","year":"2009","journal-title":"Genes Dev."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.cmet.2015.07.025","article-title":"Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved \u03b2 Cell Function","volume":"22","author":"Avrahami","year":"2015","journal-title":"Cell Metab."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11892-018-1091-4","article-title":"Epigenetics Variation and Pathogenesis in Diabetes","volume":"18","author":"Zhang","year":"2018","journal-title":"Curr. Diab. Rep."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"16335","DOI":"10.1074\/jbc.M111.330373","article-title":"Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes","volume":"287","author":"Miao","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Rakyan, V.K., Beyan, H., Down, T.A., Hawa, M.I., Maslau, S., Aden, D., Daunay, A., Busato, F., Mein, C.A., and Manfras, B. (2011). Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet., 7.","DOI":"10.1371\/journal.pgen.1002300"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Vasu, S., Kumano, K., Darden, C.M., Rahman, I., Lawrence, M.C., and Naziruddin, B. (2019). MicroRNA Signatures as Future Biomarkers for Diagnosis of Diabetes States. Cells, 8.","DOI":"10.3390\/cells8121533"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Taheri, M., Eghtedarian, R., Ghafouri-Fard, S., and Omrani, M.D. (2020). Non-coding RNAs and type 2 diabetes mellitus. Arch. Physiol. Biochem., 1\u201310.","DOI":"10.3389\/fonc.2020.01370"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1089\/ars.2016.6844","article-title":"Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress","volume":"27","author":"Kamalden","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s13059-019-1824-y","article-title":"DNA methylation aging clocks: Challenges and recommendations","volume":"20","author":"Bell","year":"2019","journal-title":"Genome Biol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"e1600584","DOI":"10.1126\/sciadv.1600584","article-title":"Epigenetics and aging","volume":"2","author":"Pal","year":"2016","journal-title":"Sci. Adv."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mam.2017.08.006","article-title":"Single cell analysis of normal and leukemic hematopoiesis","volume":"59","author":"Povinelli","year":"2018","journal-title":"Mol. Aspects Med."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40364-019-0174-y","article-title":"Epigenetic heterogeneity in cancer","volume":"7","author":"Guo","year":"2019","journal-title":"Biomark. Res."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.biotechadv.2013.09.001","article-title":"Deconstructing stem cell population heterogeneity: Single-cell analysis and modeling approaches","volume":"31","author":"Wu","year":"2013","journal-title":"Biotechnol. Adv."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/1\/401\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:06:18Z","timestamp":1760159178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/1\/401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,2]]},"references-count":238,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["ijms22010401"],"URL":"https:\/\/doi.org\/10.3390\/ijms22010401","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,2]]}}}