{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:37:17Z","timestamp":1784939837641,"version":"3.55.0"},"reference-count":89,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work was financed by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers &quot;Digital biodesign and personalized healthcare&quot;","award":["075-15-2020-926"],"award-info":[{"award-number":["075-15-2020-926"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A viral infection that involves virus invasion, protein synthesis, and virion assembly is typically accompanied by sharp fluctuations in the intracellular levels of metabolites. Under certain conditions, dramatic metabolic shifts can result in various types of cell death. Here, we review different types of adenovirus-induced cell death associated with changes in metabolic profiles of the infected cells. As evidenced by experimental data, in most cases changes in the metabolome precede cell death rather than represent its consequence. In our previous study, the induction of autophagic cell death was observed following adenovirus-mediated lactate production, acetyl-CoA accumulation, and ATP release, while apoptosis was demonstrated to be modulated by alterations in acetate and asparagine metabolism. On the other hand, adenovirus-induced ROS production and ATP depletion were demonstrated to play a significant role in the process of necrotic cell death. Interestingly, the accumulation of ceramide compounds was found to contribute to the induction of all the three types of cell death mentioned above. Eventually, the characterization of metabolite analysis could help in uncovering the molecular mechanism of adenovirus-mediated cell death induction and contribute to the development of efficacious oncolytic adenoviral vectors.<\/jats:p>","DOI":"10.3390\/ijms22010464","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T21:18:57Z","timestamp":1609881537000},"page":"464","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Metabolome-Driven Regulation of Adenovirus-Induced Cell Death"],"prefix":"10.3390","volume":"22","author":[{"given":"Anastasia","family":"Laevskaya","sequence":"first","affiliation":[{"name":"Group of Experimental Biotherapy and Diagnostic, Institute for Regenerative Medicine, World-Class Research Center \u201cDigital Biodesign and Personalized Healthcare\u201d, Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Borovjagin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7773-2435","authenticated-orcid":false,"given":"Peter S.","family":"Timashev","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine, World-Class Research Center \u201cDigital Biodesign and Personalized Healthcare\u201d, Sechenov First Moscow State Medical University, 119991 Moscow, Russia"},{"name":"Department of Polymers and Composites, N.N.Semenov Institute of Chemical Physics, 4 Kosygin St., 119991 Moscow, Russia"},{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskiye Gory 1-3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0096-5107","authenticated-orcid":false,"given":"Maciej S.","family":"Lesniak","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Northwestern University, Chicago, IL 60601, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-0363","authenticated-orcid":false,"given":"Ilya","family":"Ulasov","sequence":"additional","affiliation":[{"name":"Group of Experimental Biotherapy and Diagnostic, Institute for Regenerative Medicine, World-Class Research Center \u201cDigital Biodesign and Personalized Healthcare\u201d, Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4939-7172-5_13","article-title":"NMR and MS Methods for Metabolomics","volume":"Volume 1641","author":"Gautier","year":"2017","journal-title":"Drug Safety Evaluation"},{"key":"ref_2","unstructured":"Bizzarri, M., D\u2019Anselmi, F., Valerio, M., Cucina, A., Proietti, S., Dinicola, S., Pasqualato, A., Manetti, C., Galli, L., and Giuliani, A. 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