{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:05:42Z","timestamp":1783191942328,"version":"3.54.6"},"reference-count":121,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>It is the focus of increasing interest to investigate the effects of long-chain n-3 and long-chain n-6 polyunsaturated fatty acids (LC n-3 PUFAs; LC n-6 PUFAs) on psychiatric symptoms in a transdiagnostic perspective. There is some evidence that low levels of LC n-3 PUFAs and a higher ratio of LC n-6 to LC n-3 PUFAs in plasma and blood cells are associated with aggressive and impulsive behaviours. Therefore, implementation of LC n-3 PUFAs may produce positive effects on hostility, aggression, and impulsivity in both psychiatric and non-psychiatric samples across different stages of life. A possible mechanism of action of LC n-3 PUFAs in conditions characterized by a high level of impulsivity and aggression is due to the effect of these compounds on the serotonin system and membrane stability. Studies that evaluated the effects of LC n-3 PUFAs on impulsivity and aggressiveness indicated that addition of rather low doses of these agents to antipsychotic treatment might reduce agitation and violent behaviours in psychosis, attention deficit hyperactivity disorder, personality disorders, and impulsive control and conduct disorders. The present review is aimed at examining and discussing available data from recent trials on this topic.<\/jats:p>","DOI":"10.3390\/ijms22020620","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T19:55:56Z","timestamp":1610308556000},"page":"620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of Polyunsaturated Fatty Acids (PUFAs) on Impulsive Behaviours and Aggressiveness in Psychiatric Disorders"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6555-8000","authenticated-orcid":false,"given":"Silvio","family":"Bellino","sequence":"first","affiliation":[{"name":"Center for Personality Disorders, Psychiatric Clinic, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bozzatello","sequence":"additional","affiliation":[{"name":"Center for Personality Disorders, Psychiatric Clinic, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Badino","sequence":"additional","affiliation":[{"name":"Center for Personality Disorders, Psychiatric Clinic, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Mantelli","sequence":"additional","affiliation":[{"name":"Center for Personality Disorders, Psychiatric Clinic, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Rocca","sequence":"additional","affiliation":[{"name":"Center for Personality Disorders, Psychiatric Clinic, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-food-111317-095850","article-title":"Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits","volume":"9","author":"Shahidi","year":"2018","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000228997","article-title":"Fat and fatty acid requirements and recommendations for infants of 0\u20132 years and children of 2\u201318 years","volume":"55","author":"Uauy","year":"2009","journal-title":"Ann. Nutr. Metabol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3389\/fimmu.2019.00837","article-title":"Clinical advances in immunonutrition and atherosclerosis: A review","volume":"10","author":"Lapuente","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/MOL.0000000000000493","article-title":"Regression of atherosclerosis: Lessons learned from genetically modified mouse models","volume":"29","author":"Burke","year":"2018","journal-title":"Curr Opin Lipidol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/jn\/137.4.855","article-title":"Dietary (n-3) fatty acids and brain development","volume":"137","author":"Innis","year":"2007","journal-title":"J. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"99R","DOI":"10.1203\/01.PDR.0000160542.69840.0F","article-title":"Controversial nutrients that potentially affect preterm neurodevelopment: Essential fatty acids and iron","volume":"57","author":"Georgieff","year":"2005","journal-title":"Pediatr. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12603-011-0009-5","article-title":"High dietary and plasma levels of the omega-3 fatty acid docosahexanoic acid are associated with decreased dementia risk: The Rancho Bernado study","volume":"15","author":"Lopez","year":"2011","journal-title":"J. Nutr. Health Aging."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.freeradbiomed.2008.05.021","article-title":"Microglia and myeloperoxidase: A deadly partnership in neurodegenerative disease","volume":"45","author":"Lefkowitz","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbr.2014.11.010","article-title":"Omega-3 fatty acids improve behavioral coping to stress in multiparous rats","volume":"15","author":"Gonzales","year":"2015","journal-title":"Behav. Brain Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ebiom.2017.02.020","article-title":"Nutritional Psychiatry: Where to Next?","volume":"17","author":"Jacka","year":"2017","journal-title":"EBioMedicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1172\/JCI118507","article-title":"The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study","volume":"97","author":"Hamazaki","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/sj.ejcn.1601739","article-title":"Dietary intake of n-3, n-6 fatty acids and fish: Relationship with hostility in young adults-the CARDIA study","volume":"58","author":"Iribarren","year":"2004","journal-title":"Eur. J. Clin. Nut."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.plefa.2004.03.006","article-title":"Essential fatty acids and their role in the treatment of impulsivity disorders","volume":"7","author":"Hallahan","year":"2004","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jnutbio.2004.10.009","article-title":"Theeffect of fish oil on physical aggression in schoolchildren\u2014A randomized, double-blind, placebo-controlled trial","volume":"16","author":"Itomura","year":"2005","journal-title":"J. Nutr. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neubiorev.2016.07.017","article-title":"The effect of omega-3 fatty acids on aggression: A meta-analysis","volume":"69","author":"Gajos","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Meyer, B.J., Byrne, M.K., Collier, C., Parletta, N., Crawford, D., Winberg, P.C., Webster, D., Chapman, K., Thomas, G., and Dally, J. (2015). Baseline omega-3 index correlates with aggressive and attention deficit disorder behaviours in adult prisoners. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120220"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1176\/appi.ajp.161.11.2005","article-title":"Malnutrition at age 3 years and externalizing behavior problems at ages 8, 11, and 17 years","volume":"161","author":"Liu","year":"2004","journal-title":"Am. J. Psychiat."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/jama.282.5.455","article-title":"Prenatal exposure to wartime famine and development of antisocial personality disorder in early adulthood","volume":"282","author":"Neugebauer","year":"1999","journal-title":"JAMA"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sanchez-Paez, P., Perez-Templado, J., Saiz-Ruiz, J., Pastor, O., and Ibanez, A. (2020). Essential fatty acids and Barratt impulsivity in gambling disorder. BMC Psychiatry, 20.","DOI":"10.1186\/s12888-020-02496-1"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0376-8716(03)00168-6","article-title":"Polyunsaturated fatty acid status and aggression in cocaine addicts","volume":"71","author":"Branchey","year":"2003","journal-title":"Drug Alcohol. Depend."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.avb.2008.06.003","article-title":"Role of Serotonin and Dopamine System Interactions in the Neurobiology of Impulsive Aggression and its Comorbidity with other Clinical Disorders","volume":"13","author":"Seo","year":"2008","journal-title":"Aggress. Violent. Behav."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.biopsych.2011.07.033","article-title":"Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression","volume":"71","author":"Passamonti","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"ref_23","first-page":"207","article-title":"Omega-3 DHA and EPA for cognition, behavior, and mood: Clinical findings and structural-functional synergies with cell membrane phospholipids","volume":"12","author":"Kidd","year":"2007","journal-title":"Altern. Med. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pscychresns.2009.03.012","article-title":"Prefrontal structural and functional brain imaging findings in antisocial, violent, and psychopathic individuals: A meta-analysis","volume":"174","author":"Yang","year":"2009","journal-title":"Psychiatry Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1096\/fj.14-268342","article-title":"Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: Relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior","volume":"29","author":"Patrick","year":"2015","journal-title":"FASEB J."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Bozzatello, P., Rocca, P., Mantelli, E., and Bellino, S. (2019). Polyunsaturated Fatty Acids: What is Their Role in Treatment of Psychiatric Disorders?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215257"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Bozzatello, P., De Rosa, M.L., Rocca, P., and Bellino, S. (2020). Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176042"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.eurpsy.2007.09.005","article-title":"Psychiatric diagnosis and aggression before acute hospitalisation","volume":"23","author":"Colasanti","year":"2008","journal-title":"Eur. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Witt, K., van Dorn, R., and Fazel, S. (2013). Risk factors for violence in psychosis: Systematic review and meta-regression analysis of 110 studies. PLoS ONE, 8.","DOI":"10.1371\/annotation\/f4abfc20-5a38-4dec-aa46-7d28018bbe38"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/oxfordjournals.schbul.a007140","article-title":"Reduced red blood cell membrane essential polyunsaturated fatty acids in first episode schizophrenia at neuroleptic-naive baseline","volume":"30","author":"Reddy","year":"2004","journal-title":"Schizophr. Bull."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.schres.2012.08.014","article-title":"A meta-analysis of the polyunsaturated fatty acid composition of erythrocyte membranes in schizophrenia","volume":"141","author":"Klomp","year":"2012","journal-title":"Schizophr. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.psychres.2010.02.016","article-title":"Hostility of drug-free patients with schizophrenia and n\u22123 polyunsaturated fatty acid levels in red blood cells","volume":"177","author":"Watari","year":"2010","journal-title":"Psychiatry Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1742-1241.2008.01797.x","article-title":"Heterogeneity of violence in schizophrenia and implications for long-term treatment","volume":"62","author":"Volavka","year":"2008","journal-title":"Int. J. Clin. Pract."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1001\/archpsyc.63.6.622","article-title":"Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder","volume":"63","author":"Krakowski","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/070674371305800705","article-title":"Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria for psychosis: A post hoc subgroup analysis of a double-blind, randomized controlled trial","volume":"58","author":"Amminger","year":"2013","journal-title":"Can. J. Psychiatry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7934","DOI":"10.1038\/ncomms8934","article-title":"Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study","volume":"6","author":"Amminger","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_37","first-page":"103","article-title":"Randomized, placebo-controlled clinical trial of omega-3 as supplemental treatment in schizophrenia","volume":"18","author":"Jamilian","year":"2014","journal-title":"Glob. J. Health Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1176\/appi.ajp.159.9.1596","article-title":"Randomized, placebo-controlled study of ethyl-eicosapentaenoic acid as supplemental treatment in schizophrenia","volume":"159","author":"Emsley","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0022-3956(01)00048-6","article-title":"A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms","volume":"36","author":"Peet","year":"2002","journal-title":"J. Psychiat. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.schres.2007.05.023","article-title":"Omega-3 and violence in schizophrenia","volume":"96","author":"Brosseau","year":"2007","journal-title":"Schizophr. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.schres.2017.08.026","article-title":"Effects of Omega-3 in the treatment of violent schizophrenia patients","volume":"195","author":"Qiao","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3389\/fpsyt.2020.00312","article-title":"No Impact of Omega-3 Fatty Acid Supplementation on Symptoms or Hostility among Patients with Schizophrenia","volume":"11","author":"Qiao","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1177\/1039856219878644","article-title":"Borderline personality disorder and violence","volume":"27","author":"Sarkar","year":"2019","journal-title":"Australas. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S1121189X00001561","article-title":"Orbitofrontal cortex abnormalities in schizophrenia","volume":"19","author":"Bellani","year":"2010","journal-title":"Epidemiol. Psichiatr. Soc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pscychresns.2007.08.007","article-title":"Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder","volume":"163","author":"Chanen","year":"2008","journal-title":"Psychiatry Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/hbm.20588","article-title":"A voxel-based morphometry study of frontal gray matter correlates of impulsivity","volume":"30","author":"Matsuo","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0925-4927(03)00064-7","article-title":"Impulsivity and prefrontal hypometabolism in borderline person- ality disorder","volume":"123","author":"Soloff","year":"2003","journal-title":"Psychiatry Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1176\/appi.ajp.2008.07111774","article-title":"Neurobiology of aggression and violence","volume":"165","author":"Siever","year":"2008","journal-title":"Am. J. Psychiatry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archneur.1967.00470260003001","article-title":"Psychiatric disorder with intracranial tumors of limbic system","volume":"17","author":"Malamud","year":"1967","journal-title":"Arch. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pscychresns.2006.05.010","article-title":"Hippocampal volume reduction and history of aggressive behaviour in patients with borderline personality disorder","volume":"154","author":"Zetzsche","year":"2007","journal-title":"Psychiatry Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1176\/appi.ajp.160.1.167","article-title":"Omega-3 fatty acid treatment of women with borderline personality disorder: A double blind, placebo-controlled pilot study","volume":"160","author":"Zanarini","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1192\/bjp.bp.106.022707","article-title":"Omega-3 fatty acids supplementation in patients with recurrent self-harm: Single center double bind randomized controlled trial","volume":"190","author":"Hallahan","year":"2007","journal-title":"Br. J. Psychiatry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1017\/ipm.2016.34","article-title":"Lipids and polyunsaturated fatty acid levels in deliberate self-harm: A 10-year follow-up study","volume":"34","author":"Gallagher","year":"2017","journal-title":"Ir. J. Psychol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1192\/bjp.bp.105.019562","article-title":"Lipids and essential fatty acids in patients presenting with self-harm","volume":"190","author":"Garland","year":"2007","journal-title":"Br. J. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/0269881113510072","article-title":"Efficacy of omega-3fatty acids in the treatment of borderline personality disorder: A study of the association with valproic acid","volume":"28","author":"Bellino","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s40261-017-0617-x","article-title":"Combination of omega-3 fatty acids and valproic acid in treatment of borderline personality disorder: A follow-up study","volume":"38","author":"Bozzatello","year":"2018","journal-title":"Clin. Drug Investig."},{"key":"ref_57","first-page":"CD005653","article-title":"Pharmacological interventions for borderline personality disorder","volume":"16","author":"Stoffers","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1192\/bjp.bp.108.062984","article-title":"Pharmacotherapy for border line personality disorder: \u2028Cochrane systematic review of randomised trials","volume":"196","author":"Lieb","year":"2010","journal-title":"Br. J. Psychiatry."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11920-018-0894-y","article-title":"Omega-3 Supplementation as a Dietary Intervention to Reduce Aggressive and Antisocial Behavior","volume":"20","author":"Choy","year":"2018","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Toro, R., Garc\u00eda, J., and Basurto, F.Z. (2020). Antisocial Disorders in Adolescence and Youth, According to Structural, Emotional, and Cognitive Transdiagnostic Variables: A Systematic Review. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17093036"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/archpsyc.58.8.737","article-title":"Emotion in criminal offenders with psychopathy and borderline personality disorder","volume":"58","author":"Herpertz","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1037\/a0025308","article-title":"Inhibitory control and negative emotional processing in psycho- pathy and antisocial personality disorder","volume":"121","author":"Verona","year":"2012","journal-title":"J. Abnorm. Psychol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.biopsych.2016.02.030","article-title":"Serotonin 1B Receptor Binding Is Associated with Trait Anger and Level of Psychopathy in Violent Offenders","volume":"82","author":"Perfalk","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/0006-3223(87)90051-5","article-title":"Plasma phospholipid essential fatty acids and prostaglandins in alcoholic, habitually violent, and impulsive offenders","volume":"22","author":"Virkkunen","year":"1987","journal-title":"Biol. Psychiatry"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/09540260600582967","article-title":"Omega-3 fatty acid defi- ciencies in neurodevelopment, aggression and autonomic dysregulation: Opportunities for intervention","volume":"18","author":"Hibbeln","year":"2006","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1017\/S0007114515004390","article-title":"A randomised double-blind placebo-controlled trial investigating the behavioural effects of vitamin, mineral and n-3 fatty acid supplementation in typically developing adolescent schoolchildren","volume":"115","author":"Tammam","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/jcpp.12314","article-title":"Reduction in behavior problems with omega-3 supplementation in children aged 8\u201316 years: A randomized, double-blind, placebo-controlled, stratified, parallel-group trial","volume":"56","author":"Raine","year":"2015","journal-title":"J. Child. Psychol. Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Raine, A., Chu Fung, A.L., Gao, Y., and Lee, T.M.C. (2020). Omega-3 supplementation, child antisocial behavior,\u2028and psychopathic personality: A randomized, double-blind, placebo-controlled, strati ed, parallel group trial. Eur. Child. Adolesc. Psychiatry.","DOI":"10.1007\/s00787-020-01513-8"},{"key":"ref_70","first-page":"1","article-title":"Impact of Omega-3 Fatty Acids Among Other Nonpharmacological Interventions on Behavior and Quality of Life in Children with Compromised Conduct in Spain","volume":"17","year":"2018","journal-title":"J. Diet. Suppl."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1192\/bjp.181.1.22","article-title":"Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners","volume":"181","author":"Gesh","year":"2002","journal-title":"Br. J. Psychiatry"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/jcpp.12565","article-title":"Nutritional supplementation to reduce child aggression: A randomized, stratified, single-blind, factorial trial","volume":"57","author":"Raine","year":"2016","journal-title":"J. Child. Psychol. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Raine, A., Ang, R.P., Choy, O., Hibbeln, J.R., Ho, R.M.-H., Lim, C.G., Lim-Ashworth, N.S.J., Ling, S., Liu, J.C.J., and Ooi, Y.P. (2017). An omega-3 and social skills intervention for childhood externalizing behavior problems: A randomized, stratified, double-blind, pla- cebo-controlled, factorial trial. Psychol. Med.","DOI":"10.1017\/S0033291718000983"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13989","article-title":"The neurobiology of addiction","volume":"1451","author":"Uhl","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/HRP.0000000000000051","article-title":"Gambling Disorder and Other Behavioral Addictions: Recognition and Treatment","volume":"23","author":"Yau","year":"2015","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/j.1360-0443.2009.02533.x","article-title":"Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals","volume":"104","author":"Lawrence","year":"2009","journal-title":"Addiction"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nn1579","article-title":"Neural systems of reinforcement for drug addiction: From actions to habits to compulsion","volume":"8","author":"Everitt","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000343970","article-title":"Essential fatty acids as potential anti-inflammatory agents in the treatment of aective disorders","volume":"28","author":"Song","year":"2013","journal-title":"Mod. Trends Pharmacopsychiatr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.pnpbp.2007.10.020","article-title":"Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers","volume":"32","author":"Branchey","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.psychres.2007.01.004","article-title":"Long-chain n-3 polyunsaturated fatty acids decrease feelings of anger in substance abusers","volume":"15","author":"Branchey","year":"2008","journal-title":"Psychiatry Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"133.e140","DOI":"10.1016\/j.jpsychires.2014.06.012","article-title":"Low plasma eicosapentaenoic acid levels are associated with elevated trait aggression and impulsivity in major depressive disorder with\u2028a history of comorbid substance use disorder","volume":"57","author":"Beier","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1469-7610.2006.01618.x","article-title":"Common emotional and behavioural disorders in preschool children: Presentation, nosology, and epidemiology","volume":"47","author":"Egger","year":"2006","journal-title":"J. Child. Psychol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jad.2017.11.087","article-title":"Light up ADHD: I. Cortical hemodynamic responses measured by functional Near Infrared Spectroscopy (fNIRS): Special Section on \"Translational and Neuroscience Studies in Affective Disorders\" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summarise relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders","volume":"234","author":"Mauri","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neubiorev.2018.04.016","article-title":"Impulsive aggression and response inhibition in attention-deficit\/hyperactivity disorder and disruptive behavioral disorders: Findings from a systematic review","volume":"90","author":"Puiu","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e796","DOI":"10.1542\/peds.2010-0086","article-title":"Stimulant-responsive and stimulant-refractory aggressive behavior among children with ADHD","volume":"126","author":"Blader","year":"2010","journal-title":"Pediatrics"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0031-9384(95)02207-4","article-title":"Omega-3fatty acids in boys with behavior, learning, and health problems","volume":"59","author":"Stevens","year":"1996","journal-title":"Physiol. Behav."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.plefa.2013.03.009","article-title":"Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder","volume":"88","author":"Gow","year":"2013","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0306-9877(81)90014-1","article-title":"A lack of essential fatty acids as a possible cause of hyperactivity in children","volume":"7","author":"Colquhoun","year":"1981","journal-title":"Med. Hypotheses"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.3945\/ajcn.111.015800","article-title":"Effect of fatty acid status in cord blood serum on children\u2019s behavioral difficulties at 10 y of age: Results from the LISAplus study","volume":"94","author":"Kohlboeck","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1067\/mpd.2001.116050","article-title":"A randomized, double-blind, placebo controlled trial of docosahexaenoic acid supplementation in children with attention-deficit\/hyperactivity disorder","volume":"139","author":"Voigt","year":"2001","journal-title":"J. Pediatr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.plefa.2014.04.004","article-title":"Effect of supplementation with long-chain \u03c9-3 polyunsaturated fatty acids on behavior and cognition in children with attention deficit\/hyperactivity disorder (ADHD): A randomized placebo-controlled intervention trial","volume":"91","author":"Schwanda","year":"2014","journal-title":"Prostaglandins Leukort. Essent. Fat. Acids"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1111\/j.1651-2227.2010.01871.x","article-title":"EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD","volume":"99","author":"Gustafsson","year":"2010","journal-title":"Acta Paediatr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.eurpsy.2011.05.004","article-title":"The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: A double-blind placebo-controlled trial, followed by an open-label extension","volume":"27","author":"Manor","year":"2012","journal-title":"Eur. Psychiatry"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s11745-006-1155-0","article-title":"EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors","volume":"38","author":"Stevens","year":"2003","journal-title":"Lipids"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.ejcn.1601830","article-title":"Eect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit\/hyperactivity disorder\u2014A placebo-controlled double-blind study","volume":"58","author":"Hirayama","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_96","first-page":"OC01","article-title":"Effect of Poly Unsaturated Fatty Acids Administration on Children with Attention Deficit Hyperactivity Disorder: A Randomized Controlled Trial","volume":"10","author":"Anand","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1038\/npp.2015.73","article-title":"Reduced symptoms of inattention after dietary omega-3 fatty acid supplementation in boys with and without attention deficit\/hyperactivity disorder","volume":"40","author":"Bos","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41398-019-0633-0","article-title":"High-dose eicosapentaenoic acid (EPA) improves attention and vigilance in children and adolescents with attention deficit hyperactivity disorder (ADHD) and low endogenous EPA levels","volume":"20","author":"Chang","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/pch\/14.2.89","article-title":"Omega-3 fatty acid treatment of children with attention-deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled study","volume":"14","author":"Vanasse","year":"2009","journal-title":"Paediatr. Child. Health"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/1087054708316261","article-title":"Omega-3\/omega-6 fatty acids for attention deficit hyperactivity disorder: A randomized placebo-controlled trial in children and adolescents","volume":"12","author":"Johnson","year":"2009","journal-title":"J. Atten. Disord."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1089\/cap.2015.0052","article-title":"Biochemical and Psychological Effects of Omega-3\/6 Supplements in Male Adolescents with Attention-Deficit\/Hyperactivity Disorder: A Randomized, Placebo-Controlled, Clinical Trial","volume":"25","author":"Matsudaira","year":"2015","journal-title":"J. Child. Adolesc. Psychopharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/1087054712463962","article-title":"Efficacy of Polyunsaturated Fatty Acids (PUFA) in the Treatment of Attention Deficit Hyperactivity Disorder","volume":"21","author":"Assareh","year":"2017","journal-title":"J. Atten. Disord."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0278-5846(01)00254-8","article-title":"A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties","volume":"26","author":"Richardson","year":"2002","journal-title":"Prog. Neupopsychopharmacol. Biol. Psychiatry"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/01.DBP.0000267558.88457.a5","article-title":"Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHD","volume":"28","author":"Sinn","year":"2007","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1177\/0883073811435243","article-title":"Combined \u03c9-3 and \u03c9-6 supplementation in children with attention-deficit hyperactivity disorder (ADHD) refractory to methylphenidate treatment","volume":"27","author":"Perera","year":"2012","journal-title":"J. Child. Neurol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/1087054713518239","article-title":"Efficacy and Safety of Omega-3\/6 Fatty Acids, Methylphenidate, and a Combined Treatment in Children with ADHD","volume":"21","author":"Breuer","year":"2017","journal-title":"J. Atten Disord."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/09540260600582009","article-title":"Essential fatty acids and their role in conditions characterised by impulsivity","volume":"18","author":"Garland","year":"2006","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Bozzatello, P., Brignolo, E., De Grandi, E., and Bellino, S. (2016). Supplementation with Omega-3 Fatty Acids in Psychiatric Disorders: A Review of Literature Data. J. Clin. Med., 27.","DOI":"10.3390\/jcm5080067"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.plipres.2008.02.001","article-title":"Fish oils and aggression or hostility","volume":"47","author":"Hamazaki","year":"2008","journal-title":"Prog. Lipid Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1017\/S0954422408998620","article-title":"Is there a role for n-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials","volume":"21","author":"Appleton","year":"2008","journal-title":"Nutr. Res. Rev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"669","DOI":"10.4088\/JCP.10cs05959blu","article-title":"Complementary and alternative medicine in major depressive disorder: The American Psychiatric Association Task Force report","volume":"71","author":"Freeman","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority (EFSA)Panel on Dietetic Products, Nutrition and Allergies (NDA) (2012). Scientific \u2028Opinion on the Tolerable Upper Intake Level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) \u2028and docosapentaenoic acid (DPA). EFSA J., 10, 2815.","DOI":"10.2903\/j.efsa.2012.2815"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S0140-6736(07)60527-3","article-title":"Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis","volume":"369","author":"Yokoyama","year":"2007","journal-title":"Lancet"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1161\/STROKEAHA.107.509455","article-title":"Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: Subanalysis of the JELIS trial","volume":"39","author":"Tanaka","year":"2008","journal-title":"Stroke"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1194\/jlr.M300217-JLR200","article-title":"Effectsofdietaryn-3orn-6fattyacidsoninterleukin-1beta-induced anxiety, stress, and inflammatory responses in rats","volume":"44","author":"Song","year":"2003","journal-title":"J. Lipid Res."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Hartweg, J., Perera, R., Montori, V., Dinneen, S., Neil, H.A., and Farmer, A. (2008). Omega-3polyunsaturatedfatty acids (HUFA) for type 2 diabetes mellitus. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD003205.pub2"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/MOL.0b013e328321b3be","article-title":"Potentialimpactofomega-3treatmentoncardiovascular disease in type 2 diabetes","volume":"20","author":"Hartweg","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_118","first-page":"1","article-title":"Effectsofomega-3fattyacids on lipids and glycemic control in type II diabetes and the metabolic syndrome and on inflammatory bowel disease, rheumatoid arthritis, renal disease, systemic lupus erythematosus, and osteoporosis","volume":"89","author":"MacLean","year":"2004","journal-title":"Evid. Rep. Technol. Assess. (Summ.)"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1476-511X-8-36","article-title":"Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: A randomized, placebo controlled, cross-over study","volume":"8","author":"Bloomer","year":"2009","journal-title":"Lipids Health Dis."},{"key":"ref_120","unstructured":"VKM (Norwegian Scientific Committee for Food Safety) (2016, June 20). Opinion of the Steering Committee of the Norwegian Scientific Committee for Food Safety: Evaluation of Negative and Positive Health Effects of n-3 Fatty Acids as Constituents of Food Supplements and Fortified Foods. Available online: http:\/\/english.vkm.no\/dav\/031c000d1a.pdf."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Farmer, A., Montori, V., Dinneen, S., and Clar, C. (2001). Fish oil in people with type 2 diabetes mellitus. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD003205"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/2\/620\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:09:17Z","timestamp":1760159357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/2\/620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,9]]},"references-count":121,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["ijms22020620"],"URL":"https:\/\/doi.org\/10.3390\/ijms22020620","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,9]]}}}