{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:33:52Z","timestamp":1792204432586,"version":"4.4.0"},"reference-count":118,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T00:00:00Z","timestamp":1610236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Medicinal mushrooms have important health benefits and exhibit a broad spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, antihyperlipidemic, antidiabetic, digestive, hepatoprotective, neuroprotective, nephroprotective, osteoprotective, and hypotensive activities. The growing interest in mycotherapy requires a strong commitment from the scientific community to expand clinical trials and to propose supplements of safe origin and genetic purity. Bioactive compounds of selected medicinal mushrooms and their effects and mechanisms in in vitro and in vivo clinical studies are reported in this review. Besides, we analyzed the therapeutic use and pharmacological activities of mushrooms.<\/jats:p>","DOI":"10.3390\/ijms22020634","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T19:55:56Z","timestamp":1610308556000},"page":"634","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":418,"title":["Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8646-5594","authenticated-orcid":false,"given":"Giuseppe","family":"Venturella","sequence":"first","affiliation":[{"name":"Department of Agricultural, Food and Forest Sciences, University of Palermo, Viale delle Scienze, Bldg. 5, I-90128 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Forest Sciences, University of Palermo, Viale delle Scienze, Bldg. 5, I-90128 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortunato","family":"Cirlincione","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Forest Sciences, University of Palermo, Viale delle Scienze, Bldg. 5, I-90128 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Gargano","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Science, University of Bari Aldo Moro, Via Amendola 165\/A, I-70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4103\/2319-4170.138318","article-title":"Medicinal mushroom science: Current perspectives, advances, evidences, and challenges","volume":"37","author":"Wasser","year":"2014","journal-title":"Biomed. J."},{"key":"ref_2","first-page":"106","article-title":"What medicinal mushroom can do?","volume":"5","author":"Elkhateeb","year":"2020","journal-title":"Chem. Res. J."},{"key":"ref_3","first-page":"32","article-title":"Immune modulation from five major mushrooms: Application to integrative oncology","volume":"13","author":"Guggenheim","year":"2014","journal-title":"Integr. Med. (Encinitas)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.14200\/jrm.2017.6.0108","article-title":"Neurological activity of Lion\u2019s mane (Hericium erinaceus)","volume":"6","author":"Spelman","year":"2017","journal-title":"J. Restor. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"580656","DOI":"10.3389\/fphar.2020.580656","article-title":"Significance of medicinal mushrooms in integrative oncology: A narrative review","volume":"11","author":"Jeitler","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_6","unstructured":"Frost, M. Three popular medicinal mushroom supplements: A review of human clinical trials. 2016, All Faculty Publications. 1609. Available online: https:\/\/scholarsarchive.byu.edu\/facpub\/1609."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tibtech.2013.09.003","article-title":"Mushroom immunomodulators: Unique molecules with unlimited applications","volume":"31","year":"2013","journal-title":"Trends Biotechnol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.2174\/15680266113136660198","article-title":"Mycotherapy of Ccancer: An update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action","volume":"13","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zhao, S., Gao, Q., Rong, C., Wang, S., Zhao, Z., Liu, Y., and Xu, J. (2020). Immunomodulatory effects of edible and medicinalmushrooms and their bioactive immunoregulatory products. J. Fungi, 6.","DOI":"10.3390\/jof6040269"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12865-015-0100-5","article-title":"A study on immunomodulatory mechanism of Polysaccharopeptide mediated by TLR4 signaling pathway","volume":"16","author":"Wang","year":"2015","journal-title":"BMC Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3389\/fimmu.2017.01087","article-title":"Immunonodulatory properties of Coriuolus versicolor: The role of Polysaccharopeptide","volume":"8","author":"Saleh","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_12","first-page":"207","article-title":"Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China","volume":"23","author":"Chang","year":"2017","journal-title":"Discov. Med."},{"key":"ref_13","first-page":"1201","article-title":"The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells","volume":"13","author":"Yang","year":"2005","journal-title":"Oncol. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Valent\u00edn, M., L\u00f3pez, S., Rivera, M., R\u00edos-Olivares, E., Cubano, L., and Boukli, N.M. (2018). Naturally derived anti-HIV polysaccharides peptide (PSP) triggers a toll-like receptor 4-dependent antiviral immune response. J. Immunol. Res., 2018.","DOI":"10.1155\/2018\/8741698"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1158\/1078-0432.CCR-10-1763","article-title":"Polysaccharide Krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells","volume":"17","author":"Lu","year":"2011","journal-title":"Clin. Cancer. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2174\/0929867003374705","article-title":"Immunomodulation as anti-cancer activity of polysaccharide-protein complexes","volume":"7","author":"Ooi","year":"2000","journal-title":"Curr. Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/1534735415572883","article-title":"Polysaccharide K and Coriolus versicolor extracts for lung cancer: A systematic review","volume":"14","author":"Fritz","year":"2015","journal-title":"Integr. Cancer Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3892\/etm.2012.537","article-title":"Correlation between efficacy of PSK postoperative adjuvant immunochemotherapy for gastric cancer and expression of MHC class I","volume":"3","author":"Ito","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"ref_19","first-page":"81","article-title":"Coriolus versicolor polysaccharide regulates inflammatory cytokines expression and ameliorates hyperlipidemia in mice","volume":"49","author":"Xu","year":"2016","journal-title":"Acta Sci. Natur. Univ. Nankaiensis"},{"key":"ref_20","first-page":"84","article-title":"Health benefits of Ganoderma lucidum as a medicinal mushroom","volume":"7(sp 1)","author":"Bulam","year":"2019","journal-title":"TURJAF"},{"key":"ref_21","first-page":"63","article-title":"Biologically active metabolites of the genus Ganoderma: Three decades of myco-chemistry research","volume":"34","author":"Trigos","year":"2011","journal-title":"Rev. Mex. Mic."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1016\/j.bmcl.2010.06.093","article-title":"Lanostane triterpenes from Ganoderma lucidum suppress the adipogenesis in 3T3-L1 cells through down-regulation of SREBP-1c","volume":"20","author":"Lee","year":"2010","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2008.11.005","article-title":"Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum","volume":"602","author":"Miyamoto","year":"2009","journal-title":"Eur, J. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.18632\/oncoscience.316","article-title":"The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression","volume":"3(7\u20138)","author":"Xie","year":"2016","journal-title":"Oncoscience"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kim, J., Kim, H., Kim, J.H., Kwon, O., Son, E., Lee, C., and Park, Y. (2016). Effects of Ganodermanondiol, a new melanogenesis inhibitor from the medicinal mushroom Ganoderma lucidum. Int. Mol. Sci., 17.","DOI":"10.3390\/ijms17111798"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Xu, Y., Yuan, H., Luo, Y., Zhao, Y., and Xiao, J. (2020). Ganoderic acid D protects human amniotic mesenchymal stem cells against oxidative stress-induced senescence through the PERK\/NRF2 signaling pathway. Oxid. Med. Cell. Longev., 2020.","DOI":"10.1155\/2020\/8291413"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2174\/1871520611313050002","article-title":"The use of lentinan for treating gastric cancer","volume":"13","author":"Ina","year":"2013","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s00432-018-2718-1","article-title":"Lentinan as an immunotherapeutic for treating lung cancer: A review of 12 years clinical studies in China","volume":"144","author":"Zhang","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/s41598-017-01462-4","article-title":"Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production","volume":"7","author":"Ahn","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_30","first-page":"39","article-title":"In vitro inhibitory effects of lentinan on rat glioma cells","volume":"25","author":"Li","year":"2014","journal-title":"Biomed. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s13046-018-0932-y","article-title":"Lentinan inhibits tumor angiogenesis via interferon \u03b3 and in a T cell independent manner","volume":"37","author":"Deng","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nutres.2012.11.005","article-title":"Aqueous extracts of Lentinula edodes and Pleurotus sajor-caju exhibit high antioxidant capability and promising in vitro antitumor activity","volume":"33","author":"Finimundy","year":"2013","journal-title":"Nutr. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.intimp.2006.04.002","article-title":"Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans","volume":"6","author":"Sarangi","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"ref_34","first-page":"1307","article-title":"Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway","volume":"33","author":"Jedinak","year":"2008","journal-title":"Int. J. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1475-2891-10-52","article-title":"Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-\u03baB and AP-1 signaling","volume":"10","author":"Jedinak","year":"2011","journal-title":"Nutr. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ijbiomac.2017.01.043","article-title":"Antioxidant, antitumor and immunostimulatory activities of the polypeptide from Pleurotus eryngii mycelium","volume":"97","author":"Sun","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1615\/IntJMedMushr.v16.i1.50","article-title":"In vitro antitumor effects of the cold-water extracts of Mediterranean species of genus Pleurotus (higher Basidiomycetes) on human colon cancer cells","volume":"16","author":"Fontana","year":"2014","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1089\/jmf.2012.0222","article-title":"Genes related to suppression of malignant phenotype induced by Maytake D-fraction in breast cancer cells","volume":"16","author":"Alonso","year":"2013","journal-title":"J. Med. Food"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/01635581.2017.1247891","article-title":"Antitumoral effects of D-fraction from Grifola frondosa (Maitake) mushroom in breast cancer","volume":"69","author":"Alonso","year":"2017","journal-title":"Nutr. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"23396","DOI":"10.18632\/oncotarget.25174","article-title":"Antitumoral and antimetastatic activity of Maitake D-fraction in triple-negative breast cancer cells","volume":"9","author":"Alonso","year":"2018","journal-title":"Oncotarget"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1039\/C5FO00497G","article-title":"Hypoglicemic effects of Grifola frondosa (M) polysaccharides F2 and F3 through improvement of insulin in diabetic rats","volume":"6","author":"Xiao","year":"2015","journal-title":"Food Funct."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/01635581.2016.1134599","article-title":"Grifola frondosa glycoprotein GFG-3a arrests S phase, alters proteome, and induces apoptosis in human gastric cancer cells","volume":"68","author":"Cui","year":"2016","journal-title":"Nutr. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1358\/dof.2008.033.02.1173290","article-title":"Compounds for dementia from Hericium erinaceum","volume":"33","author":"Kawagishi","year":"2008","journal-title":"Drugs Future"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Chong, P.S., Fung, M., Wong, K.H., and Lim, L.W. (2020). Therapeutic potential of Hericium erinaceus for depressive disorders. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010163"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12967-016-0831-y","article-title":"Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade","volume":"14","author":"Kuo","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Li, I., Lee, L., Tzeng, T., Chen, W., Chen, Y., Shiao, Y., and Chen, C. (2018). Neurohealth properties of Hericium erinaceus mycelia enriched with erinacines. Behav. Neurol., 2018.","DOI":"10.1155\/2018\/5802634"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000480338","article-title":"A comparative proteomic analysis of Erinacine A\u2019s inhibition of gastric cancer cell viability and invasiveness","volume":"43","author":"Kuo","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.3389\/fphar.2019.01174","article-title":"Induction apoptosis of erinacine A in human colorectal cancer cells involving the expression of TNFR, Fas, and Fas ligand via the JNK\/p300\/p50 signaling pathway with histone acetylation","volume":"10","author":"Lee","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wang, L., Huang, C., Chen, Y., Chen, C., Chen, C., and Chuang, C. (2019). Anti-inflammatory effect of erinacine C on NO production through down-regulation of NF-\u03baB and activation of Nrf2-mediated HO-1 in BV2 microglial cells treated with LPS. Molecules, 24.","DOI":"10.3390\/molecules24183317"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1055\/a-0942-2087","article-title":"Antcin-A modulates epithelial-to-mesenchymal transition and inhibits migratory and invasive potentials of human breast cancer cells via p53-mediated miR-200c activation","volume":"85","author":"Kumar","year":"2019","journal-title":"Planta Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Chen, Y., Liu, Y., El-Shazly, M., Wu, T., Chang, J., and Wu, Y. (2019). Antrodia cinnamomea, a treasured medicinal mushroom, induces growth arrest in breast cancer cells, T47D cells: New mechanisms emerge. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040833"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"108453","DOI":"10.1016\/j.jnutbio.2020.108453","article-title":"Examining the health effects and bioactive components in Agaricus bisporus mushrooms: A scoping review","volume":"84","author":"Blumfield","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"281","DOI":"10.15414\/jmbfs.2017\/18.7.3.281-286","article-title":"The nutritional and medical benefits of Agaricus bisporus: A review","volume":"7","author":"Atila","year":"2017","journal-title":"J. Microbiol. Biotechnol. Food Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1080\/01635580802192866","article-title":"White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice","volume":"60","author":"Adams","year":"2008","journal-title":"Nutr Cancer."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ahmed, O.M., Ebaid, H., El-Nahass, S., Ragab, M., and Alhazza, I.M. (2020). Nephroprotective Effect of Pleurotus ostreatus and Agaricus bisporus Extracts and Carvedilol on Ethylene Glycol-Induced Urolithiasis: Roles of NF-\u03baB, p53, Bcl-2, Bax and Bak. Biomolecules, 10.","DOI":"10.3390\/biom10091317"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1615\/IntJMedMushrooms.2018025408","article-title":"Anti-Inflammatory Potential of In Vitro Cultures of the White Button Mushroom, Agaricus bisporus (Agaricomycetes), in Caco-2 Cells","volume":"20","author":"Muszynska","year":"2018","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1080\/11263504.2017.1301590","article-title":"Medicinal mushrooms: Valuable biological resources of high exploitation potential","volume":"151","author":"Gargano","year":"2017","journal-title":"Plant Biosyst."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1615\/IntJMedMushr.v4.i4.30","article-title":"Medicinal Properties and Clinical Effects of Culinary-Medicinal Mushroom Agaricus blazei Murrill (Agaricomycetideae) (Review)","volume":"4","author":"Mizuno","year":"2002","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"179","DOI":"10.5650\/jos.56.179","article-title":"Therapy of myeloma in vivo using marine phospholip in combination with Agaricus blazei Murill as an immune respond activator","volume":"56","author":"Murakawa","year":"2007","journal-title":"J. Oleo Sci."},{"key":"ref_60","first-page":"145","article-title":"A low molecular weight polysaccharide isolated from Agaricus blazei supresses tumor growth and angiogenesis in vivo","volume":"21","author":"Niu","year":"2009","journal-title":"Oncol Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.bjp.2016.05.013","article-title":"Antimicrobial properties of the mushroom Agaricus blazei\u2013integrative review","volume":"26","author":"Lima","year":"2016","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1615\/IntJMedMushr.v11.i2.20","article-title":"Effect of Oral Administration of Dried Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae), Fruit Bodies on Anti-\u03b2-Glucan Antibody Titers in Humans","volume":"11","author":"Ishibashi","year":"2009","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-7961-7-6","article-title":"An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy","volume":"7","author":"Ellertsen","year":"2009","journal-title":"Clin Mol Allergy"},{"key":"ref_64","unstructured":"(2020, December 01). MSD Manual. Professional Edition. Available online: https:\/\/www.msdmanuals.com\/professional."},{"key":"ref_65","first-page":"23","article-title":"Nutraceuticals: Definitions, European regulations and clinical applications (Nutraceutica: Definizione, regolamentazione e applicazioni)","volume":"6","author":"Pirillo","year":"2014","journal-title":"Giorn. Ital. Farmacoecon. Farmacoutiliz."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"809614","DOI":"10.1155\/2012\/809614","article-title":"Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: A pilot clinical trial","volume":"2012","author":"Zhao","year":"2012","journal-title":"Evid. Based Complementary Altern. Med."},{"key":"ref_67","first-page":"589","article-title":"Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy","volume":"14","author":"Ahn","year":"2004","journal-title":"Int. J. Gynecol. Cancer."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1442-2042.2010.02528.x","article-title":"Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: An open-label study","volume":"17","author":"Yoshimura","year":"2010","journal-title":"Int. J. Urol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Ohno, S., Sumiyoshi, Y., Hashine, K., Shirato, A., Kyo, S., and Inoue, M. (2011). Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid. Based Complementary Altern. Med., 2011.","DOI":"10.1155\/2011\/192381"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Hetland, G., Tangen, J., Mahmood, F., Mirlashari, M.R., Nissen-Meyer, L.S.H., Nentwich, I., Therkelsen, S.P., Tj\u00f8nnfjord, G.E., and Johnson, E. (2020). Antitumor, anti-inflammatory and antiallergic effects of Agaricus blazei mushroom extract and the related medicinal Basidiomycetes mushrooms, Hericium erinaceus and Grifola frondosa: A review of preclinical and clinical studies. Nutrients, 12.","DOI":"10.3390\/nu12051339"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"718539","DOI":"10.1155\/2015\/718539","article-title":"Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: A randomized, double blinded clinical study","volume":"2015","author":"Tangen","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_72","first-page":"236","article-title":"Can maitake MD-fraction aid cancer patients?","volume":"7","author":"Kodama","year":"2002","journal-title":"Altern. Med. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s00432-009-0562-z","article-title":"A phase I\/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: Immunological effects","volume":"135","author":"Deng","year":"2009","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00262-014-1628-6","article-title":"Maitake mushroom extract in myelodysplastic syndromes (MDS): A phase II study","volume":"64","author":"Wesa","year":"2015","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1053\/rmed.2003.1490","article-title":"Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer","volume":"97","author":"Tsang","year":"2003","journal-title":"Respir. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10147-010-0033-1","article-title":"PSK may suppress CD57(+) T cells to improve survival of advanced gastric cancer patients","volume":"15","author":"Akagi","year":"2010","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s00595-017-1555-1","article-title":"Phase III trial comparing UFT + PSK to UFT + LV in stage IIB, III colorectal cancer (MCSGO-CCTG)","volume":"48","author":"Miyake","year":"2018","journal-title":"Surg. Today"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00280-017-3466-7","article-title":"Randomized phase III trial comparing surgery alone to UFT+PSK for stage II rectal cancer (JFMC38 trial)","volume":"81","author":"Okuno","year":"2018","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1089\/acm.2016.0136","article-title":"Coriolus versicolor (Yunzhi) use as therapy in advanced hepatocellular carcinoma patients with poor liver function or who are unfit for standard therapy","volume":"23","author":"Chay","year":"2017","journal-title":"J. Altern. Complement. Med."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Torkelson, C., Sweet, E., Martzen, M.R., Sasagawa, M., Wenner, C.A., Gay, J., Putiri, A., and Standish, L.G. (2012). Phase 1 clinical trial of Trametes versicolor in women with breast cancer. ISRN Oncol., 2012.","DOI":"10.5402\/2012\/251632"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"40","DOI":"10.22159\/ijap.2020.v12s4.40103","article-title":"Medicinal mushroom bioactives: Potential sources for anti-cancer drug development","volume":"12","author":"Janardhanan","year":"2020","journal-title":"Int. J. App. Pharm."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1615\/InterJMedicMush.v5.i4.40","article-title":"A randomized, placebo-controlled, multicenter study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) polysaccharides (Ganopoly\u00ae) in patients with advanced lung cancer","volume":"5","author":"Gao","year":"2003","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1081\/IMM-120022979","article-title":"Effects of Ganopoly\u00ae (A Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients","volume":"32","author":"Gao","year":"2003","journal-title":"Immunol. Invest."},{"key":"ref_84","first-page":"1","article-title":"A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas","volume":"59","author":"Oka","year":"2010","journal-title":"Hiroshima J. Med. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jtcme.2015.11.004","article-title":"Enhancement of the Th1-phenotype immune system by the intake of Oyster mushroom (Tamogitake) extract in a double-blind, placebocontrolled study","volume":"6","author":"Tanaka","year":"2015","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1002\/cncr.29421","article-title":"A phase I trial of mushroom powder in patients with biochemically recurrent prostate cancer: Roles of cytokines and myeloid-derived suppressor cells (MDSCs) for Agaricus bisporus induced PSA responses","volume":"121","author":"Twardowski","year":"2015","journal-title":"Cancer"},{"key":"ref_87","first-page":"586","article-title":"Life quality of postsurgical patients with colorectal cancer after supplemented diet with agaricus sylvaticus fungus","volume":"25","year":"2010","journal-title":"Nutr. Hosp."},{"key":"ref_88","first-page":"176","article-title":"The effects of Agaricus sylvaticus fungi dietary supplementation on the metabolism and blood pressure of patients with colorectal cancer during post surgical phase","volume":"26","year":"2011","journal-title":"Nutr. Hosp."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4103\/0253-7613.111894","article-title":"Effect of Agaricus sylvaticus supplementation on nutritional status and adverse events of chemotherapy of breast cancer: A randomized, placebo-controlled, double-blind clinical trial","volume":"45","author":"Valadares","year":"2013","journal-title":"Indian J. Pharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s12906-016-1312-9","article-title":"A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for patients with advanced cancer","volume":"16","author":"Tsai","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5306\/wjco.v2.i10.339","article-title":"Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy","volume":"2","author":"Ina","year":"2011","journal-title":"World J. Clin. Oncol."},{"key":"ref_92","unstructured":"Ma, J. (2014). Efficacy of lentinan combined with NP regimen in treatment of patients with advanced nonsmall-cell lung cancer and its effect on immunologic function. Zhongguo Fei Ai Za Zhi (Chinese Journal of Lung cancer), Corpus ID: 75303359."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s12253-018-0545-y","article-title":"Immunomodulatory effect of Lentinan on aberrant T subsets and cytokines profile in non-small cell lung cancer patients","volume":"26","author":"Wang","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"ref_94","first-page":"633","article-title":"The effects of active Hexose correlated compound (AHCC) on levels of CD4+ and CD8+ in patients with epithelial ovarian cancer or peritoneal cancer receiving platinum based chemotherapy","volume":"18","author":"Sukhnikhom","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/01635581.2014.884232","article-title":"Reduction of adverse effects by a mushroom product, active hexose correlated compound (AHCC) in patients with advanced cancer during chemotherapy--the significance of the levels of HHV-6 DNA in saliva as a surrogate biomarker during chemotherapy","volume":"66","author":"Ito","year":"2014","journal-title":"Nutr. Cancer."},{"key":"ref_96","first-page":"e652","article-title":"Polysaccharide from lentinus edodes for integrative cancer treatment: Immunomodulatory effects on lymphocyte population","volume":"3","author":"Bonucci","year":"2016","journal-title":"WCRJ"},{"key":"ref_97","first-page":"e1089","article-title":"Management and treatment of sarcopenia in fifty patients receiving chemotherapy with AHCC (active hexose correlated compound)","volume":"5","author":"Zhiqiang","year":"2018","journal-title":"WCRJ"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1089\/acm.2006.6054","article-title":"The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: A randomized, double-blinded, and placebo-controlled clinical trial","volume":"13","author":"Hsu","year":"2007","journal-title":"J. Altern. Complement. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.29219\/fnr.v64.4451","article-title":"A mushroom diet reduced the risk of pregnancy-induced hypertension and macrosomia: A randomized clinical trial","volume":"64","author":"Sun","year":"2020","journal-title":"Food Nutr. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"29540","DOI":"10.1038\/srep29540","article-title":"A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome","volume":"6","author":"Klupp","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3329\/mmj.v16i1.261","article-title":"Oyster mushroom reduced blood glucose and cholesterol in diabetic subjects","volume":"16","author":"Khatun","year":"2007","journal-title":"Mymensingh Med. J."},{"key":"ref_102","first-page":"267","article-title":"Clinical studies on the hypolipidemic and antioxidant effects of selected natural substances","volume":"109","author":"Kajaba","year":"2008","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jff.2010.11.004","article-title":"Lipid lowering effects of oyster mushroom (Pleurotus ostreatus) in humans","volume":"3","author":"Schneider","year":"2011","journal-title":"J. Funct. Foods"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3329\/bjmb.v6i1.13280","article-title":"Effects of Pleurotus ostreatus on blood pressure and glycemic status of hypertensive diabetic male volunteers","volume":"6","author":"Choudhury","year":"2013","journal-title":"Bangladesh J. Med. Biochem."},{"key":"ref_105","first-page":"37","article-title":"Pleurotus ostreatus improves lipid profile of obese hypertensive non-diabetic males","volume":"7","author":"Choudhury","year":"2013","journal-title":"Bangladesh J. Mushroom."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3329\/imcj.v8i1.22982","article-title":"Effect of edible mushroom (Pleurotus ostreatus) on type-2 diabetics","volume":"8","author":"Sayeed","year":"2014","journal-title":"Ibrahim Med. Coll. J."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ptr.5255","article-title":"Hypoglycaemic activity of culinary Pleurotus ostreatus and P. cystidiosus mushrooms in healthy volunteers and type 2 diabetic patients on diet control and the possible mechanisms of action","volume":"29","author":"Jayasuriya","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/jmf.2005.8.53","article-title":"A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia","volume":"8","author":"Tang","year":"2005","journal-title":"J. Med. Food."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/ptr.2634","article-title":"Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial","volume":"23","author":"Mori","year":"2009","journal-title":"Phytother. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fnagi.2020.00155","article-title":"Prevention of early Alzheimer\u2019s disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study","volume":"12","author":"Li","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2220\/biomedres.31.231","article-title":"Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake","volume":"31","author":"Nagano","year":"2010","journal-title":"Biomed. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pmu.2014.02.004","article-title":"Marked improvement of neurocognitive impairement after treatment with compounds from Hericium erinaceum: A case study of recurrent depressive disorder","volume":"3","author":"Inanaga","year":"2014","journal-title":"Pers. Med. Universe"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Vigna, L., Morelli, F., Agnelli, G.M., Napolitano, F., Ratto, D., Occhinegro, A., Di Iorio, C., Savino, E., Girometta, C., and Brandalise, F. (2019). Hericium erinaceus improves mood and sleep disorders inpatients affected by overweight or obesity: Could circulating pro-BDNF and BDNF be potential biomarkers?. Evid. Based Complementary Altern. Med., 2019.","DOI":"10.1155\/2019\/7861297"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Palomares, M.R., Rodriguez, J., Phung, S., Stanczyc, F.Z., Lacey, S.F., Synolds, S.D., Denison, T.W., Frankel, P.H., and Chen, S. (2011). A dose-finding clinical trial of mushroom powder in postmenopausal breast cancer survivors for secondary breast cancer prevention. J. Clin. Oncol., 29.","DOI":"10.1200\/jco.2011.29.15_suppl.1582"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Hess, J., Wang, Q., Gould, T., and Slavin, J. (2018). Impact of Agaricus bisporus mushroom consumption on gut health markers in healthy adults. Nutrients, 10.","DOI":"10.3390\/nu10101402"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.intimp.2012.11.020","article-title":"Immunomodulatory effect of pleuran (\u03b2-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections","volume":"15","author":"Jesenak","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"8562309","DOI":"10.1155\/2020\/8562309","article-title":"Efficacy of Pleuran (\u03b2-Glucan from Pleurotus ostreatus) in the management of Herpes Simplex Virus Type 1 infection. Evid","volume":"2020","author":"Urbancikova","year":"2020","journal-title":"Based Complement. Alternat. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.pmu.2015.03.006","article-title":"The effects of Hericium erinaceum (Amyloban\u00ae 3399)on sleep quality and subjective well-being among female undergraduate students: A pilot study","volume":"4","author":"Okamura","year":"2015","journal-title":"Pers. Med. Universe"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/2\/634\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:09:28Z","timestamp":1760159368000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/2\/634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,10]]},"references-count":118,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["ijms22020634"],"URL":"https:\/\/doi.org\/10.3390\/ijms22020634","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,10]]}}}