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It can also be seen during tumor growth and other fibroproliferative disorders. These processes result from a wide spectrum of cross-talks between mesenchymal, epithelial and inflammatory\/immune cells that have not yet been fully understood. In the present review, we aimed to describe the molecular features of fibroblasts and their interactions with immune and epithelial cells and extracellular matrix. We also compared different types of fibroblasts and their roles in skin repair and regeneration following burn injury. In summary, here we briefly review molecular changes underlying hypertrophic scarring following burns throughout all basic wound healing stages, i.e. during inflammation, proliferation and maturation.<\/jats:p>","DOI":"10.3390\/ijms22020897","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T05:17:34Z","timestamp":1610947054000},"page":"897","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation)"],"prefix":"10.3390","volume":"22","author":[{"given":"Mat\u00fa\u0161","family":"\u010coma","sequence":"first","affiliation":[{"name":"Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Ko\u0161ice, Slovakia"},{"name":"Department of Pharmacology, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Fr\u00f6hlichov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology, Louise Pasteur University Hospital, 041 90 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luk\u00e1\u0161","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Ko\u0161ice, Slovakia"},{"name":"Center of Clinical and Preclinical Research MediPark, Pavol Jozef \u0160af\u00e1rik University, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Zaj\u00ed\u010dek","sequence":"additional","affiliation":[{"name":"Prague Burn Centre, Third Faculty of Medicine, Charles University and University Hospital Kr\u00e1lovsk\u00e9 Vinohrady, 100 34 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Urban","sequence":"additional","affiliation":[{"name":"Prague Burn Centre, Third Faculty of Medicine, Charles University and University Hospital Kr\u00e1lovsk\u00e9 Vinohrady, 100 34 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-1493","authenticated-orcid":false,"given":"Pavol","family":"Szabo","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic"},{"name":"BIOCEV, 252 50 Vestec, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160t\u011bp\u00e1n","family":"Nov\u00e1k","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, 150 06 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Fetissov","sequence":"additional","affiliation":[{"name":"Prague Burn Centre, Third Faculty of Medicine, Charles University and University Hospital Kr\u00e1lovsk\u00e9 Vinohrady, 100 34 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"Dvo\u0159\u00e1nkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic"},{"name":"BIOCEV, 252 50 Vestec, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-8403","authenticated-orcid":false,"suffix":"Jr.","given":"Karel","family":"Smetana","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic"},{"name":"BIOCEV, 252 50 Vestec, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3398-3408","authenticated-orcid":false,"given":"Peter","family":"G\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Ko\u0161ice, Slovakia"},{"name":"Center of Clinical and Preclinical Research MediPark, Pavol Jozef \u0160af\u00e1rik University, 040 11 Ko\u0161ice, Slovakia"},{"name":"Prague Burn Centre, Third Faculty of Medicine, Charles University and University Hospital Kr\u00e1lovsk\u00e9 Vinohrady, 100 34 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/bmj.326.7380.88","article-title":"Skin 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