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Since ECS function overlaps or integrates with many other cell signaling systems, this review aims at updating the knowledge about the possible crosstalk between ECS and estrogen system (ES) at both central and peripheral level, with focuses on the central nervous system, reproduction, and cancer.<\/jats:p>","DOI":"10.3390\/ijms22020972","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T11:39:55Z","timestamp":1611056395000},"page":"972","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-5447","authenticated-orcid":false,"given":"Antonietta","family":"Santoro","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mele","sequence":"additional","affiliation":[{"name":"Department of Movement Sciences and Wellbeing, Parthenope University of Naples, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-7284","authenticated-orcid":false,"given":"Marianna","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Viggiano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania Lucia","family":"Nori","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2174-1118","authenticated-orcid":false,"given":"Rosaria","family":"Meccariello","sequence":"additional","affiliation":[{"name":"Department of Movement Sciences and Wellbeing, Parthenope University of Naples, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.gene.2005.11.004","article-title":"Evolutionary origins of the endocannabinoid system","volume":"370","author":"McPartland","year":"2006","journal-title":"Gene"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1749-6632.2009.04437.x","article-title":"The endocannabinoid system: An ancient signaling involved in the control of male fertility","volume":"1163","author":"Fasano","year":"2009","journal-title":"Ann. 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