{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:20:13Z","timestamp":1790781613687,"version":"4.1.0"},"reference-count":18,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Ministry of Health and Welfare, Korea","award":["HI17C1257"],"award-info":[{"award-number":["HI17C1257"]}]},{"name":"the National Research Foundation of Korea","award":["NRF-2019R1A2C1086949"],"award-info":[{"award-number":["NRF-2019R1A2C1086949"]}]},{"name":"Seoul St. Mary\u2019s Hospital, The Catholic University of Korea","award":["Research Fund"],"award-info":[{"award-number":["Research Fund"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>BCL-2 interacting cell death suppressor (BIS) is a multifunctional protein that has been implicated in cancer and myopathy. Various mutations of the BIS gene have been identified as causative of cardiac dysfunction in some dilated cardiomyopathy (DCM) patients. This was recently verified in cardiac-specific knock-out (KO) mice. In this study, we developed tamoxifen-inducible cardiomyocyte-specific BIS-KO (Bis-iCKO) mice to assess the role of BIS in the adult heart using the Cre-loxP strategy. The disruption of the Bis gene led to impaired ventricular function and subsequent heart failure due to DCM, characterized by reduced left ventricular contractility and dilatation that were observed using serial echocardiography and histology. The development of DCM was confirmed by alterations in Z-disk integrity and increased expression of several mRNAs associated with heart failure and remodeling. Furthermore, aggregation of desmin was correlated with loss of small heat shock protein in the Bis-iCKO mice, indicating that BIS plays an essential role in the quality control of cardiac proteins, as has been suggested in constitutive cardiac-specific KO mice. Our cardiac-specific BIS-KO mice may be a useful model for developing therapeutic interventions for DCM, especially late-onset DCM, based on the distinct phenotypes and rapid progressions.<\/jats:p>","DOI":"10.3390\/ijms22031343","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T09:25:22Z","timestamp":1611912322000},"page":"1343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["An Adult Mouse Model of Dilated Cardiomyopathy Caused by Inducible Cardiac-Specific Bis Deletion"],"prefix":"10.3390","volume":"22","author":[{"given":"Hye Hyeon","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"},{"name":"Institute of Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Young","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"},{"name":"Institute of Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Seung","family":"Ko","sequence":"additional","affiliation":[{"name":"Laboratory Animal Research Center, Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunghyun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"},{"name":"Institute of Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"},{"name":"Department of Biomedicine &amp; Health Sciences, Graduate School, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoung","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"},{"name":"Institute of Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Lim","family":"Kim","sequence":"additional","affiliation":[{"name":"Integrative Research Support Center, Laboratory of Electron Microscope, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-9546","authenticated-orcid":false,"given":"Hun Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Joong","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5970-194X","authenticated-orcid":false,"given":"Jeong Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"},{"name":"Institute of Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul 16591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1038\/sj.onc.1203043","article-title":"Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death","volume":"18","author":"Lee","year":"1999","journal-title":"Oncogene"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.semcdb.2017.08.049","article-title":"Role of BAG3 in cancer progression: A therapeutic opportunity","volume":"78","author":"Basile","year":"2018","journal-title":"Semin. 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