{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:08:33Z","timestamp":1791925713763,"version":"4.3.4"},"reference-count":318,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cholesterol homeostasis is essential in normal physiology of all cells. One of several proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 (ABCA1), a transmembrane protein widely expressed in many tissues. One of its main functions is the efflux of intracellular free cholesterol and phospholipids across the plasma membrane to combine with apolipoproteins, mainly apolipoprotein A-I (Apo A-I), forming nascent high-density lipoprotein-cholesterol (HDL-C) particles, the first step of reverse cholesterol transport (RCT). In addition, ABCA1 regulates cholesterol and phospholipid content in the plasma membrane affecting lipid rafts, microparticle (MP) formation and cell signaling. Thus, it is not surprising that impaired ABCA1 function and altered cholesterol homeostasis may affect many different organs and is involved in the pathophysiology of a broad array of diseases. This review describes evidence obtained from animal models, human studies and genetic variation explaining how ABCA1 is involved in dyslipidemia, coronary heart disease (CHD), type 2 diabetes (T2D), thrombosis, neurological disorders, age-related macular degeneration (AMD), glaucoma, viral infections and in cancer progression.<\/jats:p>","DOI":"10.3390\/ijms22041593","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:54:35Z","timestamp":1612486475000},"page":"1593","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-8108","authenticated-orcid":false,"given":"Leonor","family":"Jacobo-Albavera","sequence":"first","affiliation":[{"name":"Laboratorio de Gen\u00f3mica de Enfermedades Cardiovasculares, Direcci\u00f3n de Investigaci\u00f3n, Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN), Mexico City CP14610, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6049-0430","authenticated-orcid":false,"given":"Mayra","family":"Dom\u00ednguez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00f3mica de Enfermedades Cardiovasculares, Direcci\u00f3n de Investigaci\u00f3n, Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN), Mexico City CP14610, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1620-9928","authenticated-orcid":false,"given":"Diana Jhoseline","family":"Medina-Leyte","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00f3mica de Enfermedades Cardiovasculares, Direcci\u00f3n de Investigaci\u00f3n, Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN), Mexico City CP14610, Mexico"},{"name":"Posgrado en Ciencias Biol\u00f3gicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Coyoac\u00e1n, Mexico City CP04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Gonz\u00e1lez-Garrido","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00f3mica de Enfermedades Cardiovasculares, Direcci\u00f3n de Investigaci\u00f3n, Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN), Mexico City CP14610, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-7690","authenticated-orcid":false,"given":"Teresa","family":"Villarreal-Molina","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00f3mica de Enfermedades Cardiovasculares, Direcci\u00f3n de Investigaci\u00f3n, Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN), Mexico City CP14610, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat. 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