{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:58:04Z","timestamp":1784764684470,"version":"3.55.0"},"reference-count":143,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Identifying historical trajectories is a useful exercise in research, as it helps clarify important, perhaps even \u201cparadigmatic\u201d, shifts in thinking and moving forward in science. In this review, the development of research regarding the role of the transcription factor \u201caryl hydrocarbon receptor\u201d (AHR) as a mediator of the toxicity of environmental pollution towards a link between the environment and a healthy adaptive response of the immune system and the skin is discussed. From this fascinating development, the opportunities for targeting the AHR in the therapy of many diseases become clear.<\/jats:p>","DOI":"10.3390\/ijms22041844","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T22:41:25Z","timestamp":1613169685000},"page":"1844","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor\u2014A Personal Perspective on Thymus and Skin"],"prefix":"10.3390","volume":"22","author":[{"given":"Charlotte","family":"Esser","sequence":"first","affiliation":[{"name":"IUF-Leibniz Research Institute for Environmental Medicine, Auf\u2019m Hennekamp 50, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF00364649","article-title":"Medical problems raised by the TCDD contamination in Seveso, Italy","volume":"40","author":"Reggiani","year":"1978","journal-title":"Arch. 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