{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:35:07Z","timestamp":1791920107762,"version":"4.3.4"},"reference-count":251,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Anemia, characterized by a decrease of the hemoglobin level in the blood and a reduction in carrying capacity of oxygen, is a major public health problem which affects people of all ages. The methods used to treat anemia are blood transfusion and oral administration of iron-based supplements, but these treatments are associated with a number of side effects, such as nausea, vomiting, constipation, and stomach pain, which limit its long-term use. In addition, oral iron supplements are poorly absorbed in the intestinal tract, due to overexpression of hepcidin, a peptide hormone that plays a central role in iron homeostasis. In this review, we conducted an analysis of the literature on biologically active compounds and plant extracts used in the treatment of various types of anemia. The purpose of this review is to provide up-to-date information on the use of these compounds and plant extracts, in order to explore their therapeutic potential. The advantage of using them is that they are available from natural resources and can be used as main, alternative, or adjuvant therapies in many diseases, such as various types of anemia.<\/jats:p>","DOI":"10.3390\/ijms22041883","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T02:08:12Z","timestamp":1613268492000},"page":"1883","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Natural Antioxidants in Anemia Treatment"],"prefix":"10.3390","volume":"22","author":[{"given":"Coralia","family":"Cotoraci","sequence":"first","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, Vasile Goldis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Ciceu","sequence":"additional","affiliation":[{"name":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Godis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alciona","family":"Sasu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, Vasile Goldis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8510-6653","authenticated-orcid":false,"given":"Anca","family":"Hermenean","sequence":"additional","affiliation":[{"name":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Godis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"},{"name":"Department of Histology, Faculty of Medicine, Vasile Goldis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tifs.2020.02.021","article-title":"Iron deficiency anemia: A comprehensive review on iron absorption, bioavailability and emerging food fortification approaches","volume":"99","author":"Kumar","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_2","unstructured":"World Health Organization (2020, December 27). Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. Available online: https:\/\/www.who.int\/vmnis\/indicators\/haemoglobin.pdf."},{"key":"ref_3","unstructured":"Rhodes, C.E., and Varacallo, M. (2020, December 27). Physiology, oxygen transport, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538336\/."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0140-6736(10)62304-5","article-title":"Anaemia in low-income and middle-income countries","volume":"378","author":"Balarajan","year":"2011","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1017\/S1368980008002401","article-title":"Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993\u20132005","volume":"12","author":"McLean","year":"2009","journal-title":"Publ. Health Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Figueiredo, A.C.M.G., Gomes-Filho, I.S., Silva, R.B., Pereira, P.P.S., Mata, F.A.F.D., Lyrio, A.O., Souza, E.S., Cruz, S.S., and Pereira, M.G. (2018). Maternal anemia and low birth weight: A systematic review and meta-analysis. Nutrients, 10.","DOI":"10.3390\/nu10050601"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"f3443","DOI":"10.1136\/bmj.f3443","article-title":"Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: Systematic review and meta-analysis","volume":"346","author":"Haider","year":"2013","journal-title":"BMJ"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3945\/ajcn.115.107896","article-title":"Maternal anemia and risk of adverse birth and health outcomes in low- and middle-income countries: Systematic review and meta-analysis","volume":"103","author":"Rahman","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/ajcn\/85.4.931","article-title":"An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function","volume":"85","author":"McCann","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_10","unstructured":"Hillman, R.S., and Ault, K.A. (2001). Clinical approach to anemia. Hematology in Clinical Practice, McGraw-Hill."},{"key":"ref_11","unstructured":"GBD 2015 Disease and Injury Incidence and Prevalence Collaborators (2016). Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet, 388, 1545\u20131602."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.3748\/wjg.15.4627","article-title":"Classification of anemia for gastroenterologists","volume":"15","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_13","unstructured":"Rozman, C., Feliu, E., Gra\u00f1ena, A., Monserrat, E., and Vives Corrons, J.L. (1981). Hematologia. Atlas Practico Para El Medico General, Salvat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1172\/JCI107651","article-title":"Bone marrow erythropoiesis in the anemia of infection, inflammation, and malignancy","volume":"53","author":"Zucker","year":"1974","journal-title":"J. Clin. Invest."},{"key":"ref_15","unstructured":"Chaudhry, H.S., and Kasarla, M.R. (2020, December 22). Microcytic hypochromic anemia, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470252\/."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2147\/DHPS.S230935","article-title":"Anemia and related factors among highly active antiretroviral therapy experienced children in Hawassa Comprehensive Specialized Hospital, Southern Ethiopia: Emphasis on Patient Management","volume":"12","author":"Fenta","year":"2020","journal-title":"Drug Healthc. Patient Saf."},{"key":"ref_17","first-page":"437","article-title":"Anemia in older adults","volume":"98","author":"Lanier","year":"2018","journal-title":"Am. Fam. Physician"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.36290\/vnl.2018.067","article-title":"Differential diagnosis of anemia","volume":"64","year":"2018","journal-title":"Vnitri Lek."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/SHK.0000000000001009","article-title":"Hemoglobin-based oxygen carriers: Current state-of-the-art and novel molecules","volume":"52","year":"2019","journal-title":"Shock"},{"key":"ref_20","unstructured":"Patel, S., Jose, A., and Mohiuddin, S.S. (2020, December 17). Physiology, oxygen transport and carbon dioxide dissociation curve, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539815\/."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000496492","article-title":"Iron deficiency anemia in chronic kidney disease","volume":"142","author":"Schechter","year":"2019","journal-title":"Acta Haematol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000496965","article-title":"Management of perioperative iron deficiency anemia","volume":"142","author":"Bisbe","year":"2019","journal-title":"Acta Haematol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000496967","article-title":"The role of intravenous iron in the treatment of anemia associated with cancer and chemotherapy","volume":"142","author":"Rodgers","year":"2019","journal-title":"Acta Haematol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Chuncharunee, S., Teawtrakul, N., Siritanaratkul, N., and Chueamuangphan, N. (2019). Review of disease-related complications and management in adult patients with thalassemia: A multi-center study in Thailand. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0214148"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000496966","article-title":"Safety of oral and intravenous iron","volume":"142","author":"DeLoughery","year":"2019","journal-title":"Acta Haematol."},{"key":"ref_26","unstructured":"Ems, T., St Lucia, K., and Huecker, M.R. (2020, December 17). Biochemistry, iron absorption, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK448204\/."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJMra1401038","article-title":"Iron-deficiency anemia","volume":"372","author":"Camaschella","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/ajh.21682","article-title":"Anemia management in chronic kidney disease: Intravenous iron steps forward","volume":"85","author":"Coyne","year":"2010","journal-title":"Am. J. Hematol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1080\/10408398.2019.1630599","article-title":"Mechanism and intervention measures of iron side effects on the intestine","volume":"60","author":"Qi","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/jn\/130.3.621","article-title":"Both iron deficiency and daily iron supplements increase lipid peroxidation in rats","volume":"130","author":"Knutson","year":"2000","journal-title":"J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/00017285-199705000-00002","article-title":"Dietary iron supplements in the elderly: To use or not to use?","volume":"32","author":"Connor","year":"1997","journal-title":"Nutr. Today"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1753-4887.1996.tb03794.x","article-title":"Iron metabolism: A comprehensive review","volume":"54","author":"Beard","year":"1996","journal-title":"Nutr. Rev."},{"key":"ref_33","first-page":"7","article-title":"Are we at risk for heart disease because of normal iron status?","volume":"51","author":"Beard","year":"1993","journal-title":"Nutr. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1011023111048","article-title":"Oral repletion of iron induces free radical mediated alterations in the gastrointestinal tract of rat","volume":"219","author":"Srigiridhar","year":"2001","journal-title":"Mol. Cell Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1046\/j.1432-1327.2000.01595.x","article-title":"Glutathione, oxidative stress and neurodegeneration","volume":"267","author":"Schulz","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"20841","DOI":"10.3390\/molecules201119725","article-title":"Phytochelators intended for clinical use in iron overload, other diseases of iron imbalance and free radical pathology","volume":"20","author":"Kontoghiorghe","year":"2015","journal-title":"Molecules"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3109\/13880209.2014.923000","article-title":"Efficacy behind activity-phytotherapeutics are not different from pharmaceuticals","volume":"53","author":"Varoni","year":"2015","journal-title":"Pharm. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Trivedi, S., and Pandey, R. (2020). 5\u2032-Hydroxy-6, 7, 8, 3\u2032, 4\u2032-pentamethoxyflavone extends longevity mediated by DR-induced autophagy and oxidative stress resistance in C. elegans. Geroscience.","DOI":"10.1007\/s11357-020-00229-6"},{"key":"ref_39","first-page":"563251","article-title":"Management of anemia of inflammation in the elderly","volume":"2012","author":"Madeddu","year":"2012","journal-title":"Anemia"},{"key":"ref_40","unstructured":"Warner, M.J., and Kamran, M.T. (2020, December 17). Iron deficiency anemia, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK448065\/."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"H207","DOI":"10.1111\/j.1750-3841.2008.00930.x","article-title":"Effect of squid ink melanin-Fe on iron deficiency anemia remission","volume":"73","author":"Lei","year":"2008","journal-title":"J. Food Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.bmcl.2011.10.100","article-title":"Physicochemical properties and inhibition effect on iron deficiency anemia of a novel polysaccharide-iron complex (LPPC)","volume":"22","author":"Zhang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0149-2918(01)80135-1","article-title":"Considerations for optimal iron use for anemia due to chronic kidney disease","volume":"23","author":"Hudson","year":"2001","journal-title":"Clin. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.carbpol.2005.04.019","article-title":"Interactions between iron(III) and sucrose, dextran, or starch in complexes","volume":"61","author":"Somsook","year":"2005","journal-title":"Carbohydr. Polym."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.biortech.2016.04.090","article-title":"Optimization study on the hydrogen peroxide pretreatment and production of bioethanol from seaweed Ulva prolifera biomass","volume":"214","author":"Li","year":"2016","journal-title":"Bioresour. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.carbpol.2012.07.077","article-title":"Chemical characteristic of an anticoagulant-active sulfated polysaccharide from Enteromorpha clathrata","volume":"90","author":"Qi","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ijbiomac.2018.12.214","article-title":"Structure characterization of low molecular weight sulfate Ulva polysaccharide and the effect of its derivative on iron deficiency anemia","volume":"126","author":"Li","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2174\/0929867043365189","article-title":"Natural medicine: The genus Angelica","volume":"11","author":"Sarker","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11655-007-0297-0","article-title":"Effect of Angelica sinensis polysaccharide-iron complex on iron deficiency anemia in rats","volume":"13","author":"Wang","year":"2007","journal-title":"Chin. J. Integr. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1089\/jmf.2012.2231","article-title":"Polysaccharide isolated from Angelica sinensis inhibits hepcidin expression in rats with iron deficiency anemia","volume":"15","author":"Liu","year":"2012","journal-title":"J. Med. Food"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1039\/c4fo00006d","article-title":"The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia","volume":"5","author":"Zhang","year":"2014","journal-title":"Food Funct."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0378-8741(96)01458-4","article-title":"Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture","volume":"54","author":"Raman","year":"1996","journal-title":"J. Ethnopharmacol."},{"key":"ref_53","first-page":"363","article-title":"The effect of Angelica polysaccharide on proliferation and differentiation of hematopoietic progenitor cell","volume":"76","author":"Wang","year":"1996","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_54","first-page":"2977","article-title":"Studies on evaluation of physical and chemical composition of beetroot (Beta vulgaris L.)","volume":"6","author":"Kale","year":"2018","journal-title":"Int. J. Chem. Stud."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.3390\/nu7042801","article-title":"The potential benefits of red beetroot supplementation in health and disease","volume":"7","author":"Clifford","year":"2015","journal-title":"Nutrients"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9","DOI":"10.9790\/1959-0210913","article-title":"Beet root juice on haemoglobin among adolescent girls","volume":"2","author":"Priya","year":"2013","journal-title":"IOSR J. Nurs. Health Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5897\/ISABB-JFAS2017.0070","article-title":"Effect of red beetroot (Beta vulgaris L.) intake on the level of some hematological tests in a group of female volunteers","volume":"8","year":"2018","journal-title":"ISABB. J. Food Agric. Sci."},{"key":"ref_58","first-page":"e82300","article-title":"The effects of consuming 6 weeks of beetroot juice (Beta vulgaris L.) on hematological parameters in female soccer players","volume":"22","author":"Lotfi","year":"2018","journal-title":"J. Kermanshah Univ. Med. Sci."},{"key":"ref_59","first-page":"55","article-title":"An experimental study to determine the effectiveness of beetroot juice on hemoglobin among girls of selected hostel girls, Bidar, Karnataka","volume":"4","author":"Kavitha","year":"2020","journal-title":"World J. Adv. Healthc. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"893","DOI":"10.30994\/sjik.v9i2.354","article-title":"Effect of beet powder (Beta Vulgaris L.) with Fe supplementation on increasing hemoglobin, hematocrit, and erythrocyte levels in pregnant women with anemia","volume":"9","author":"Triana","year":"2020","journal-title":"STRADA J. Ilm. Kesehat."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.nutres.2014.07.003","article-title":"Dietary iron supplements and Moringa oleifera leaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats","volume":"34","author":"Saini","year":"2014","journal-title":"Nutr. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijbiomac.2019.03.196","article-title":"Antioxidant, immunomodulatory, oxidative stress inhibitory and iron supplementation effect of Astragalus membranaceus polysaccharide-iron (III) complex on iron-deficiency anemia mouse model","volume":"132","author":"Jia","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_63","first-page":"78","article-title":"Ginger supplementary therapy for iron absorption in iron deficiency anemia","volume":"11","author":"Kulkarni","year":"2012","journal-title":"Indian J. Tradit. Knowl."},{"key":"ref_64","first-page":"580","article-title":"Quercetin modulates iron homeostasis and iNOS expression of splenic macrophages in a rat model of iron deficiency anemia","volume":"16","author":"Mazhar","year":"2018","journal-title":"Chin. J. Nat. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ijbiomac.2017.12.033","article-title":"A novel low molecular weight Enteromorpha polysaccharide-iron (III) complex and its effect on rats with iron deficiency anemia (IDA)","volume":"108","author":"Cui","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jnim.2015.12.001","article-title":"Optimizing dose of aqueous extract of Mangifera indica L stem bark for treating anaemia and its effect on some disaccharidases activity in iron deficient weanling rats","volume":"3","author":"Modupe","year":"2016","journal-title":"J. Nutr. Intermed. Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnim.2018.02.001","article-title":"Dose-dependent effects of Theobroma cacao in iron deficient anemia treatment in rats","volume":"12","author":"Modupe","year":"2018","journal-title":"J. Nutr. Intermed. Metab."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3945\/jn.113.174201","article-title":"Screening identifies the Chinese medicinal plant Caulis spatholobi as an effective HAMP expression inhibitor","volume":"143","author":"Guan","year":"2013","journal-title":"J. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"120","DOI":"10.33546\/bnj.69","article-title":"Effect of consuming papaya (Carica papaya Linn.) on the level of hemoglobin and hematocrit in pregnant women with anemia","volume":"3","author":"Eliagita","year":"2017","journal-title":"Belitung Nurs. J."},{"key":"ref_70","first-page":"8","article-title":"Sweet potatoes consumption on increased hemoglobin levels in first trimester pregnant women","volume":"1","author":"Felina","year":"2019","journal-title":"Bloss. J. Midwifery"},{"key":"ref_71","first-page":"58","article-title":"The anti-anaemic properties of Baobab fruit (Adansonia digitata)","volume":"1","author":"Kheiri","year":"2006","journal-title":"FRC J. Food. Sci. Technol."},{"key":"ref_72","first-page":"278","article-title":"The effect of aqueous extract of Hibiscus sabdariffa seeds on hematological parameters of anemic rats","volume":"5","author":"Ahmed","year":"2013","journal-title":"Int. J. Phytomed."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2147\/tcrm.2007.3.2.291","article-title":"Exjade(R) (deferasirox, ICL670) in the treatment of chronic iron overload associated with blood transfusion","volume":"3","author":"Cappellini","year":"2007","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.bbagen.2008.09.010","article-title":"Iron overload following red blood cell transfusion and its impact on disease severity","volume":"1790","author":"Ozment","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_75","first-page":"262","article-title":"The management of patients with Cooley\u2019s anemia: Transfusions and splenectomy","volume":"32","author":"Piomelli","year":"1995","journal-title":"Semin. Hematol."},{"key":"ref_76","first-page":"142","article-title":"Hydrophilic phytochelators in iron overload condition","volume":"4","author":"Hezaveh","year":"2019","journal-title":"J. Nutr. Food Secur."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.tox.2011.10.017","article-title":"Maternal quercetin intake during pregnancy results in an adapted iron homeostasis at adulthood","volume":"290","author":"Vanhees","year":"2011","journal-title":"Toxicology"},{"key":"ref_78","unstructured":"Watson, R.R., Preedy, V.R., and Zibadi, S. (2014). Polyphenols and low iron bioavailability. Polyphenols in Human Health and Disease, Academic Press."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Lesjak, M., Hoque, R., Balesaria, S., Skinner, V., Debnam, E.S., Srai, S.K., and Sharp, P.A. (2014). Quercetin inhibits intestinal iron absorption and ferroportin transporter expression in vivo and in vitro. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102900"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jinorgbio.2011.02.003","article-title":"In vitro analysis of iron chelating activity of flavonoids","volume":"105","author":"Bovicelli","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"828","DOI":"10.3945\/jn.110.134031","article-title":"Ascorbic acid offsets the inhibitory effect of bioactive dietary polyphenolic compounds on transepithelial iron transport in Caco-2 intestinal cells","volume":"141","author":"Kim","year":"2011","journal-title":"J. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00394-018-1680-7","article-title":"Quercetin inhibits intestinal non-haem iron absorption by regulating iron metabolism genes in the tissues","volume":"58","author":"Lesjak","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3945\/jn.109.117499","article-title":"Bioactive dietary polyphenols decrease heme iron absorption by decreasing basolateral iron release in human intestinal Caco-2 cells","volume":"140","author":"Ma","year":"2010","journal-title":"J. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0005-2760(96)00122-1","article-title":"Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes","volume":"1304","author":"Guo","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"7970","DOI":"10.1021\/jf048741x","article-title":"Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method","volume":"52","author":"Apak","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/jn\/138.9.1647","article-title":"Bioactive dietary polyphenolic compounds reduce nonheme iron transport across human intestinal cell monolayers","volume":"138","author":"Kim","year":"2008","journal-title":"J. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"01021","DOI":"10.3389\/fphar.2020.01021","article-title":"Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications","volume":"11","author":"Rayess","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.freeradbiomed.2005.11.003","article-title":"Iron chelation in the biological activity of curcumin","volume":"40","author":"Jiao","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1182\/blood-2008-05-155952","article-title":"Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator","volume":"113","author":"Jiao","year":"2009","journal-title":"Blood"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0014-5793(00)01211-4","article-title":"Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase","volume":"468","author":"Day","year":"2000","journal-title":"FEBS Lett."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/ajcn\/80.1.15","article-title":"How should we assess the effects of exposure to dietary polyphenols in vitro?","volume":"80","author":"Kroon","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0753-3322(02)00205-6","article-title":"Absorption and metabolism of polyphenols in the gut and impact on health","volume":"56","author":"Scalbert","year":"2002","journal-title":"Biomed. Pharmacother."},{"key":"ref_93","first-page":"45673","article-title":"Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages","volume":"2007","author":"Nieminen","year":"2007","journal-title":"Mediat. Inflamm."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.freeradbiomed.2015.11.001","article-title":"Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption","volume":"89","author":"Bayele","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cbi.2011.12.005","article-title":"Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38","volume":"195","author":"Bravo","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Lesjak, M., and Srai, S.K.S. (2019). Role of Dietary Flavonoids in Iron Homeostasis. Pharmaceuticals, 12.","DOI":"10.3390\/ph12030119"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.foodchem.2010.08.012","article-title":"The molecular basis of working mechanism of natural polyphenolic antioxidants","volume":"125","author":"Leopoldini","year":"2011","journal-title":"Food Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0891-5849(02)00759-1","article-title":"Iron release, oxidative stress and erythrocyte ageing","volume":"32","author":"Comporti","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0014-5793(97)01182-4","article-title":"Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity","volume":"416","author":"Ferrali","year":"1997","journal-title":"FEBS Lett."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.freeradbiomed.2011.01.005","article-title":"Quercetin-iron chelates are transported via glucose transporters","volume":"50","author":"Vlachodimitropoulou","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12013-009-9043-x","article-title":"A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding","volume":"53","author":"Perron","year":"2009","journal-title":"Cell Biochem. Biophys."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1080\/1071576021000016463","article-title":"Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity","volume":"36","author":"Mira","year":"2002","journal-title":"Free Radic. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jnutbio.2015.10.015","article-title":"The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression","volume":"30","author":"Mu","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2008.03.059","article-title":"The effect of an iron (III) chelator, silybin, on the proliferation and cell cycle of Jurkat cells: A comparison with desferrioxamine","volume":"589","author":"Gharagozloo","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0162-0134(01)00198-2","article-title":"Silybin, a new iron-chelating agent","volume":"85","author":"Borsari","year":"2001","journal-title":"J. Inorg. Biochem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/ejcn.2010.136","article-title":"The iron-chelating potential of silybin in patients with hereditary haemochromatosis","volume":"64","author":"Hutchinson","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/MCG.0b013e31815cff36","article-title":"Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C","volume":"42","author":"Bares","year":"2008","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"H143","DOI":"10.1111\/j.1750-3841.2011.02184.x","article-title":"Bioactive dietary polyphenols inhibit heme iron absorption in a dose-dependent manner in human intestinal Caco-2 Cells","volume":"76","author":"Ma","year":"2011","journal-title":"J. Food Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jnutbio.2014.02.009","article-title":"Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6\/SMAD4 signaling pathway","volume":"25","author":"Tang","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1017\/S0007114513004005","article-title":"Black soyabean seed coat extract regulates iron metabolism by inhibiting the expression of hepcidin","volume":"111","author":"Mu","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.etap.2016.03.005","article-title":"Natural iron chelators: Protective role in A549 cells of flavonoids-rich extracts of Citrus juices in Fe3+-induced oxidative stress","volume":"43","author":"Ferlazzo","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jinorgbio.2008.11.003","article-title":"Iron-binding and anti-Fenton properties of baicalein and baicalin","volume":"103","author":"Perez","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1002\/hep.26490","article-title":"The small molecule, genistein, increases hepcidin expression in human hepatocytes","volume":"58","author":"Zhen","year":"2013","journal-title":"Hepatology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1053\/j.jrn.2011.09.007","article-title":"Vitamin C affects the expression of hepcidin and erythropoietin receptor in HepG2 cells","volume":"22","author":"Chiu","year":"2012","journal-title":"J. Ren. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Fustinoni-Reis, A.M., Arruda, S.F., Dourado, L.P., da Cunha, M.S., and Siqueira, E. (2016). Tucum-Do-Cerrado (Bactrissetosa Mart.) consumption modulates iron homeostasis and prevents iron-induced oxidative stress in the rat liver. Nutrients, 8.","DOI":"10.3390\/nu8020038"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1039\/C5FO00855G","article-title":"The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice","volume":"7","author":"Cheng","year":"2016","journal-title":"Food Funct."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5539\/gjhs.v7n7p137","article-title":"The effects of Medicago sativa and Allium porrum on iron overload in rats","volume":"7","author":"Mirzaei","year":"2015","journal-title":"Glob. J. Health Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1615\/IntJMedMushrooms.v17.i9.50","article-title":"In vivo iron-chelating activity and phenolic profiles of the angel\u2019s wings mushroom, Pleurotus porrigens (Higher Basidiomycetes)","volume":"17","author":"Khalili","year":"2015","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3109\/13880209.2014.959612","article-title":"Nerium indicum leaf alleviates iron-induced oxidative stress and hepatic injury in mice","volume":"53","author":"Ghate","year":"2015","journal-title":"Pharm. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1177\/0748233713483195","article-title":"Amelioration of iron overload-induced liver toxicity by a potent antioxidant and iron chelator, Emblica officinalis Gaertn","volume":"31","author":"Sarkar","year":"2015","journal-title":"Toxicol. Ind. Health"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Chaudhuri, D., Ghate, N.B., Panja, S., and Mandal, N. (2016). Role of phenolics from Spondias pinnata bark in amelioration of iron overload induced hepatic damage in Swiss albino mice. BMC Pharmacol. Toxicol., 17.","DOI":"10.1186\/s40360-016-0077-6"},{"key":"ref_122","first-page":"281","article-title":"Protective effect of Clerodendrum colebrookianum leaves against iron-induced oxidative stress and hepatotoxicity in Swiss albino mice","volume":"53","author":"Das","year":"2015","journal-title":"Indian J. Exp. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Sarkar, R., Hazra, B., and Mandal, N. (2012). Reducing power and iron chelating property of Terminalia chebula (Retz.) alleviates iron induced liver toxicity in mice. BMC Complement. Altern. Med., 12.","DOI":"10.1186\/1472-6882-12-144"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejphar.2006.01.067","article-title":"Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury","volume":"535","author":"Zhang","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.15171\/jhp.2019.04","article-title":"Mangiferin and mangiferin-containing leaf extract from Mangifera foetida L. for therapeutic attenuation of experimentally induced iron overload in a rat model","volume":"8","author":"Estuningtyas","year":"2019","journal-title":"J. Herbmed Pharmacol."},{"key":"ref_126","unstructured":"Baldwin, C., and Olarewaju, O. (2020, December 27). Hemolytic anemia, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK558904\/."},{"key":"ref_127","first-page":"354","article-title":"Hemolytic anemia: Evaluation and differential diagnosis","volume":"98","author":"Phillips","year":"2018","journal-title":"Am. Fam. Phys."},{"key":"ref_128","first-page":"81","article-title":"Effect of aqueous extract of Brassica oleraceae var italica (Broccoli) inflorescence in phenylhydrazine induced anemic rats","volume":"5","author":"Avula","year":"2015","journal-title":"Bull. Pharm. Res."},{"key":"ref_129","first-page":"3726","article-title":"Haematic and hepatroprotective potentials of Hypoestes triflora aqueous leaf extract in guinea-pigs","volume":"5","author":"Bavhure","year":"2014","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_130","first-page":"79","article-title":"Activity of aqueous extract of Phyllanthus niruri Linn in 2,4-dinitrophenylhydrazine induced anaemic rats","volume":"4","author":"Muhammad","year":"2020","journal-title":"J. Pharm. Pharmacol. Res."},{"key":"ref_131","first-page":"16","article-title":"Effect of Gossypium hirsutum L. ethanol leaf extract on phenylhydrazine-induced anaemic rats","volume":"7","author":"Midala","year":"2017","journal-title":"J. Nat. Sci. Res."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Goorani, S., Koohi, M., Zangeneh, A., Zangeneh, M., and Moradi, R. (2018). Pharmacological evaluation of anti-anemic property of aqueous extracts of Falcaria vulgaris leaf in rats. Comp. Clin. Path., 1\u20137.","DOI":"10.1007\/s00580-018-2839-6"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e7722","DOI":"10.1590\/1414-431x20187722","article-title":"Laboratory evidence for the hematopoietic potential of Beta vulgaris leaf and stalk extract in a phenylhydrazine model of anemia","volume":"51","author":"Gheith","year":"2018","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_134","first-page":"1","article-title":"Effects of Pterocarpus erinaceus stem bark aqueous extract on anemic rats","volume":"2","author":"Nadro","year":"2014","journal-title":"Sci. Res. J."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/ajrb\/2019\/v4i130057","article-title":"Haematinic effects of aqueous extract of Lophira lanceolata leaves in phenylhydrazine-induced anaemia in wistar rats","volume":"4","author":"Osafanme","year":"2019","journal-title":"Asian J. Res. Biochem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5530\/pj.2015.2.2","article-title":"Effects of standardized stem bark extract of Mangifera indica L. in wistar rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia","volume":"7","author":"Sani","year":"2015","journal-title":"Pharmacogn. J."},{"key":"ref_137","first-page":"85","article-title":"Haematinic properties of methanolic stem bark and fruit extracts of Ficus sur in rats pre-exposed to phenylhydrazine-induced haemolytic anaemia","volume":"20","author":"Adebayo","year":"2017","journal-title":"Afr. J. Biomed. Res."},{"key":"ref_138","first-page":"217","article-title":"Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats","volume":"16","author":"Onyeabo","year":"2017","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3329\/bjp.v4i2.1641","article-title":"Elemental compositions and anti-anemic property of Harungana madagascariensis stem bark","volume":"4","author":"Iwalewa","year":"2009","journal-title":"Bangladesh J. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"62","DOI":"10.12692\/ijb\/8.4.62-71","article-title":"Efficiency of Sorghum bicolor extract in the treatment of induced anemia on Wistar rats","volume":"8","author":"Tchogou","year":"2016","journal-title":"Int. J. Biosci."},{"key":"ref_141","first-page":"1","article-title":"Fluted Pumpkin (Telfairia occidentalis) protects against phenyl hydrazine-induced anaemia and associated toxicities in rats","volume":"20","author":"Oladele","year":"2020","journal-title":"Adv. Tradit. Med."},{"key":"ref_142","first-page":"14","article-title":"Anti-anaemic potential of aqueous extract of Spinacia oleracea leaf in phenylhydrazine-treated rats","volume":"7","author":"Luka","year":"2014","journal-title":"N. Y. Sci. J."},{"key":"ref_143","first-page":"2389","article-title":"The haematinic activity of the methanol leaf extract of Brillantasia nitens Lindau (Acanthaceae) in rats","volume":"8","author":"Akah","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"ref_144","first-page":"01","article-title":"Effect of ethanol leaf extract of Acacia nilotica on phenyl hydrazine induced anemia in rats","volume":"13","author":"Sarkiyayi","year":"2018","journal-title":"IOSR J. Pharm. Biol. Sci."},{"key":"ref_145","first-page":"65","article-title":"Effect of Solanum nigrum methanol leaf extract on phenylhydrazine induced anemia in rats","volume":"11","author":"Aduwamai","year":"2018","journal-title":"Jordan J. Biol. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3109\/19390211.2016.1155685","article-title":"Hematopoietic effect of Amaranthus cruentus extract on phenylhydrazine-induced toxicity in rats","volume":"13","author":"Pandey","year":"2016","journal-title":"J. Diet. Suppl."},{"key":"ref_147","first-page":"680","article-title":"Antianaemic potentials of some plant extracts on phenyl hydrazine-induced anaemia in rabbits","volume":"4","author":"Ogbe","year":"2010","journal-title":"J. Med. Plants Res."},{"key":"ref_148","first-page":"140","article-title":"Effect of Hibiscus sabdariffa anthocyanins on 2,4-dinitrophenylhydrazine-induced hematotoxicity in rabbits","volume":"3","author":"Ologundudu","year":"2009","journal-title":"Afr. J. Biochem. Res."},{"key":"ref_149","first-page":"48","article-title":"Evaluation of the haematinic activities of extracts of Justicia secunda Vahl leaves in red blood cells of laboratory rats","volume":"08","author":"Yamoah","year":"2020","journal-title":"J. Biosci. Med."},{"key":"ref_150","unstructured":"Khan, I., and Shaikh, H. (2020, December 27). Cooley anemia, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557522\/."},{"key":"ref_151","first-page":"e2009006","article-title":"Iron metabolism in thalassemia and sickle cell disease","volume":"1","author":"Mariani","year":"2009","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/ajh.20809","article-title":"Multi-Center Study of Iron Overload Research Group. Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload","volume":"82","author":"Fung","year":"2007","journal-title":"Am. J. Hematol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.burns.2006.04.004","article-title":"Influence of silymarin and its flavonolignans on H2O2-induced oxidative stress in human keratinocytes and mouse fibroblasts","volume":"32","year":"2006","journal-title":"Burns"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.intimp.2006.04.004","article-title":"Effects of silymarin on the proliferation and glutathione levels of peripheral blood mononuclear cells from beta-thalassemia major patients","volume":"6","author":"Alidoost","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1086\/315919","article-title":"Effect of transfusional iron overload on immune response","volume":"182","author":"Giardina","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/088800102753356194","article-title":"Immunological status of Thalassemia syndrome","volume":"19","author":"Ezer","year":"2002","journal-title":"Pediatr. Hematol. Oncol. J."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3109\/09637486.2010.482521","article-title":"Chelating, antioxidant and hypoglycaemic potential of Muscari comosum (L.) Mill. bulb extracts","volume":"61","author":"Loizzo","year":"2010","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1080\/14786410903075507","article-title":"Flavonoids and antioxidant activity of Rosa agrestis leaves","volume":"24","author":"Bitis","year":"2010","journal-title":"Nat. Prod. Res."},{"key":"ref_159","first-page":"93408","article-title":"Correlation between the in vitro iron chelating activity and poly phenol and flavonoid contents of some medicinal plants","volume":"12","author":"Ebrahimzadeh","year":"2009","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-3-211-33328-0_26","article-title":"Green tea catechins as brain-permeable, non toxic iron chelators to \u201ciron out iron\u201d from the brain","volume":"71","author":"Mandel","year":"2006","journal-title":"J. Neural. Transm. Suppl."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.2174\/138161211798072463","article-title":"Importance of iron chelation in free radical-induced oxidative stress and human disease","volume":"17","author":"Jomova","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.4155\/fmc.09.121","article-title":"Synthetic and natural iron chelators: Therapeutic potential and clinical use","volume":"1","author":"Hatcher","year":"2009","journal-title":"Future Med. Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/092986707779941159","article-title":"Silybin and silymarin\u2014New and emerging applications in medicine","volume":"14","author":"Gazak","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"ref_164","first-page":"3046373","article-title":"Potential Effects of Silymarin and Its Flavonolignan Components in Patients with \u03b2-Thalassemia Major: A Comprehensive Review in 2015","volume":"2016","author":"Salehifar","year":"2016","journal-title":"Adv. Pharmacol. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.intimp.2013.04.016","article-title":"Immunomodulatory effects of silymarin in patients with \u03b2-thalassemia major","volume":"16","author":"Gharagozloo","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/ejh.12061","article-title":"A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in \u03b2-thalassemia major patients receiving desferrioxamine","volume":"90","author":"Moayedi","year":"2013","journal-title":"Eur. J. Haematol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2174\/1871526515666150731113305","article-title":"Therapeutic value of combined therapy with Deferiprone and Silymarin as iron chelators in Egyptian Children with Beta Thalassemia major","volume":"15","author":"Hagag","year":"2015","journal-title":"Infect. Disord. Drug Targets"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4084\/mjhid.2013.065","article-title":"Therapeutic value of combined therapy with deferasirox and silymarin on iron overload in children with beta thalassemia","volume":"5","author":"Hagag","year":"2013","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3324\/haematol.2013.090076","article-title":"Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice","volume":"99","author":"Franco","year":"2014","journal-title":"Haematologica"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.clinbiochem.2009.10.057","article-title":"Improvement in oxidative stress and antioxidant parameters in beta-thalassemia\/Hb E patients treated with curcuminoids","volume":"43","author":"Kalpravidh","year":"2010","journal-title":"Clin. Biochem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2174\/157340607781745447","article-title":"Curcumin contributes to in vitro removal of non-transferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma","volume":"3","author":"Srichairatanakool","year":"2007","journal-title":"Med. Chem."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/ptr.2379","article-title":"Fermented papaya preparation as redox regulator in blood cells of beta-thalassemic mice and patients","volume":"22","author":"Amer","year":"2008","journal-title":"Phytother. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.biopha.2018.10.017","article-title":"Green tea extract modulates oxidative tissue injury in beta-thalassemic mice by chelation of redox iron and inhibition of lipid peroxidation","volume":"108","author":"Koonyosying","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2174\/157340611794072724","article-title":"Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids","volume":"7","author":"Thephinlap","year":"2011","journal-title":"Med. Chem."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/157340607780620608","article-title":"Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress","volume":"3","author":"Thephinlap","year":"2007","journal-title":"Med. Chem."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1039\/C9FO02424G","article-title":"Consumption of a green tea extract-curcumin drink decreases blood urea nitrogen and redox iron in \u03b2-thalassemia patients","volume":"11","author":"Koonyosying","year":"2020","journal-title":"Food Funct."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00247-007-0567-1","article-title":"MRI evaluation of tissue iron burden in patients with bea-thalassaemia major","volume":"37","author":"Argyropoulou","year":"2007","journal-title":"Pediatr. Radiol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/GIM.0b013e3181cd68ed","article-title":"Beta-thalassemia","volume":"12","author":"Cao","year":"2010","journal-title":"Genet. Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1749-6632.2010.05585.x","article-title":"Hepcidin in beta-thalassemia","volume":"1202","author":"Nemeth","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1472-8206.2009.00681.x","article-title":"Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: A randomized double-blind clinical trial","volume":"23","author":"Gharagozloo","year":"2009","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"100245","DOI":"10.1016\/j.hermed.2018.11.001","article-title":"Nigella sativa improves anemia, enhances immunity and relieves iron overload-induced oxidative stress as a novel promising treatment in children having beta-thalassemia major","volume":"16","author":"Hablas","year":"2019","journal-title":"J. Herb. Med."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1002\/ptr.3116","article-title":"Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation","volume":"24","author":"Fibach","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1002\/ptr.6118","article-title":"An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in \u03b2-thalassemia major patients: A double-blind randomized controlled clinical trial","volume":"32","author":"Mohammadi","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.apjtb.2015.09.007","article-title":"Combined treatment of 3-hydroxypyridine-4-one derivatives and green tea extract to induce hepcidin expression in iron-overloaded \u03b2-thalassemic mice","volume":"5","author":"Upanan","year":"2015","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Lazarus, H.M., and Schmaier, A.H. (2019). Anemia: Clinical approach. Concise Guide to Hematology, Springer.","DOI":"10.1007\/978-3-319-97873-4"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"a011684","DOI":"10.1101\/cshperspect.a011684","article-title":"Classification of the disorders of hemoglobin","volume":"3","author":"Forget","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"269659","DOI":"10.1155\/2013\/269659","article-title":"Phytomedicines and nutraceuticals: Alternative therapeutics for sickle cell anemia","volume":"2013","author":"Imaga","year":"2013","journal-title":"Sci. World J."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"607436","DOI":"10.1155\/2012\/607436","article-title":"Traditional Herbal Management of Sickle Cell Anemia: Lessons from Nigeria","volume":"2012","author":"Ameh","year":"2012","journal-title":"Anemia"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/0973-7847.112849","article-title":"Search for antisickling agents from plants","volume":"7","author":"Dash","year":"2013","journal-title":"Pharmacogn. Rev."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.phymed.2006.05.008","article-title":"In vitro antidrepanocytary actvity (anti-sickle cell anemia) of some congolese plants","volume":"14","author":"Mpiana","year":"2007","journal-title":"Phytomedicine"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Oniyangi, O., and Cohall, D.H. (2015). Phytomedicines (medicines derived from plants) for sickle cell disease. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD004448.pub5"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1182\/blood.V77.6.1334.1334","article-title":"Vanillin, a potential agent for the treatment of sickle cell anemia","volume":"77","author":"Abraham","year":"1991","journal-title":"Blood"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.freeradbiomed.2013.08.181","article-title":"Oxidative stress in sickle cell disease: An overview of erythrocyte redox metabolism and current antioxidant therapeutic strategies","volume":"65","author":"Silva","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3389\/fphys.2019.00976","article-title":"The effect of antioxidants on the properties of red blood cells from patients with sickle cell anemia","volume":"10","author":"Hannemann","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.etp.2010.03.005","article-title":"Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells","volume":"63","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.lwt.2007.06.010","article-title":"In vitro antioxidant properties of rutin","volume":"41","author":"Yang","year":"2008","journal-title":"LWT Food Sci. Technol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cbi.2015.02.021","article-title":"Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: Role of NF\u03baB\/MAPK pathway","volume":"231","author":"Nafees","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.jpba.2006.11.029","article-title":"Combined antioxidant effects of rutin and vitamin C in Triton X-100 micelles","volume":"43","author":"Guo","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"e01905","DOI":"10.1016\/j.heliyon.2019.e01905","article-title":"Sickling-preventive effects of rutin is associated with modulation of deoxygenated haemoglobin, 2,3-bisphosphoglycerate mutase, redox status and alteration of functional chemistry in sickle erythrocytes","volume":"5","author":"Muhammad","year":"2019","journal-title":"Heliyon"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1177\/0960327119895815","article-title":"Sickling-suppressive effects of chrysin may be associated with sequestration of deoxy-haemoglobin, 2,3-bisphosphoglycerate mutase, alteration of redox homeostasis and functional chemistry of sickle erythrocytes","volume":"39","author":"Muhammad","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3233\/CH-151972","article-title":"Pfaffia paniculata extract improves red blood cell deformability in sickle cell patients","volume":"62","author":"Mozar","year":"2015","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"772","DOI":"10.3923\/ajbs.2019.772.778","article-title":"Anti-sickling properties of aqueous extracts of Dennettia tripetala and Physalis angulata","volume":"12","author":"Essien","year":"2019","journal-title":"Asian J. Biol. Sci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1076\/phbi.37.2.152.6090","article-title":"Anti-sickling potential of Terminalia catappa leaf extract","volume":"37","author":"Mgbemene","year":"1999","journal-title":"Pharm. Biol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/ptr.1323","article-title":"Anti-sickling potential of a Nigerian herbal formula (ajawaron HF) and the major plant component (Cissus populnea L. CPK)","volume":"17","author":"Moody","year":"2003","journal-title":"Phytother. Res."},{"key":"ref_205","first-page":"102","article-title":"Antisickling property of Carica papaya leaf extract","volume":"3","author":"Imaga","year":"2009","journal-title":"Afr. J. Biochem. Res."},{"key":"ref_206","first-page":"639","article-title":"Antisickling and toxicological profiles of leaf and stem of Parquetina nigrescens L.","volume":"4","author":"Imaga","year":"2010","journal-title":"J. Med. Plants Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"484","DOI":"10.9734\/BJMMR\/2015\/14608","article-title":"Anti-sickling and membrane stabilizing effects of Carica papaya leaf extract","volume":"6","author":"Naiho","year":"2015","journal-title":"Br. J. Med. Med. Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.phymed.2008.10.013","article-title":"Antisickling properties of divanilloylquinic acids isolated from Fagara zanthoxyloides Lam. (Rutaceae)","volume":"16","author":"Ouattara","year":"2009","journal-title":"Phytomedicine"},{"key":"ref_209","first-page":"7","article-title":"Effects of aqueous extracts of Zanthoxylum macrophylla roots on membrane stability of human erythrocytes of different genotypes","volume":"17","author":"Elekwa","year":"2005","journal-title":"Biokemistri"},{"key":"ref_210","first-page":"7","article-title":"In vitro effects of aqueous extracts of Zanthoxylum macrophylla roots on adenosine triphosphatases from human erythrocytes of different genotypes","volume":"17","author":"Elekwa","year":"2005","journal-title":"Biokemistri"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1568061","DOI":"10.1155\/2016\/1568061","article-title":"Sickled erythrocytes reversal and membrane stabilizing compounds in Telfairia occidentalis","volume":"2016","author":"Atabo","year":"2016","journal-title":"Scientifica"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"20","DOI":"10.13189\/ijbb.2018.060102","article-title":"In vitro investigation of the anti-sickling and erythrocyte membrane stabilizing potentials of Elaesis guineensis Jacq Flower","volume":"6","author":"Ogwutum","year":"2018","journal-title":"Int. J. Biochem. Biophys."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jtcme.2017.08.002","article-title":"Antioxidant properties and membrane stabilization effects of methanol extract of Mucuna pruriens leaves on normal and sickle erythrocytes","volume":"9","author":"Anosike","year":"2018","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Pauline, N., Cabral, B.N., Anatole, P.C., Jocelyne, A.M., Bruno, M., and Jeanne, N.Y. (2013). The in vitro antisickling and antioxidant effects of aqueous extracts Zanthoxyllum heitzii on sickle cell disorder. BMC Complement. Altern. Med., 13.","DOI":"10.1186\/1472-6882-13-162"},{"key":"ref_215","first-page":"13191","article-title":"The antisickling potentials of four Curcubits (T. occidentalis, C. maxima; C. sativus and C. lonatus)","volume":"1","author":"Nwaoguikpe","year":"2013","journal-title":"Sch. J. App. Med. Sci."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Afolabi, I.S., Osikoya, I.O., Fajimi, O.D., Usoro, P.I., Ogunleye, D.O., Bisi-Adeniyi, T., Adeyemi, A.O., and Adekeye, B.T. (2012). Solenostemon monostachyus, Ipomoea involucrata and Carica papaya seed oil versus Glutathione, or Vernonia amygdalina: Methanolic extracts of novel plants for the management of sickle cell anemia disease. BMC Complement. Altern. Med., 12.","DOI":"10.1186\/1472-6882-12-262"},{"key":"ref_217","first-page":"7","article-title":"In vitro antisickling potentials of ethanol extract of Annona muricata, Delonix regia and Senna alata","volume":"2","author":"Essien","year":"2019","journal-title":"Recent Trends Pharm. Sci. Res."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s13659-015-0070-6","article-title":"Anti-sickling activity of ursolic acid isolated from the leaves of Ocimum gratissimum L. (Lamiaceae)","volume":"5","author":"Tshilanda","year":"2015","journal-title":"Nat. Prod. Bioprospect."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0975-7406.94812","article-title":"Moringa oleifera Lam. (Moringaceae) grown in Nigeria: In vitro antisickling activity on deoxygenated erythrocyte cells","volume":"4","author":"Adejumo","year":"2012","journal-title":"J. Pharm. Bioallied. Sci."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Abere, T.A., Okoye, C.J., Agoreyo, F.O., Eze, G.I., Jesuorobo, R.I., Egharevba, C.O., and Aimator, P.O. (2015). Antisickling and toxicological evaluation of the leaves of Scoparia dulcis Linn (Scrophulariaceae). BMC Complement. Altern. Med., 15.","DOI":"10.1186\/s12906-015-0928-5"},{"key":"ref_221","first-page":"1947","article-title":"Antisickling agent in an extract of unripe pawpaw (Carica papaya): Is it real?","volume":"5","author":"Oduola","year":"2006","journal-title":"Afr. J. Biotechnol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3923\/pjbs.2007.788.791","article-title":"Phytochemical and antisickling studies of the leaves of Hymenocardia acida Tul (Euphorbiaceae)","volume":"10","author":"Ibrahim","year":"2007","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_223","first-page":"58","article-title":"The effect of Aloe vera plant (Aloe barbadensis) extracts on sickle cell blood (HbSS)","volume":"1","author":"Nwaoguikpe","year":"2010","journal-title":"Afri. J. Food Sci. Tech."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"803S","DOI":"10.1093\/jn\/136.3.803S","article-title":"Aged garlic extract is a potential therapy for sickle-cell anemia","volume":"136","author":"Takasu","year":"2006","journal-title":"J. Nutr."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Omer, R.H., Yousif, N.A., Fadlalla, T.A., Elradi, W.E.O., Elbasheir, M.M., and allah, E.I.A. (2020). In vitro antisickling activity of Moringa oleifera extracts on sickle cells. Res. Sq.","DOI":"10.21203\/rs.3.rs-32121\/v1"},{"key":"ref_226","first-page":"117","article-title":"The anti-sickling mechanism of Amphimas pterocarpoides (Cesalpiniaceae) against sickle cell anemia","volume":"7","author":"Biapa","year":"2019","journal-title":"Acad. J. Med. Plants"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1080\/07391102.2019.1645735","article-title":"Potential of isoquercitrin as antisickling agent: A multi-spectroscopic, thermophoresis and molecular modeling approach","volume":"38","author":"Syed","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Fadlalla, T.A., Yousif, N.A., Omer, R.H., Elbasheir, M.M., Elradi, W.O., and Abdallah, E.I. (2020). In vitro anti sickling activity of Hyphaene thebaica fruits extract on sickle cell. Res. Sq., 1\u201312.","DOI":"10.21203\/rs.3.rs-32120\/v1"},{"key":"ref_229","first-page":"1","article-title":"Repurposing of genistein as anti-sickling agent: Elucidation by multi spectroscopic, thermophoresis, and molecular modeling techniques","volume":"11","author":"Syed","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s11626-020-00512-y","article-title":"In vitro assessment of the anti-sickling properties of Buchholzia coriacea and Mucuna pruriens seed extracts","volume":"56","author":"Ikechukwu","year":"2020","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"ref_231","unstructured":"Kaushansky, K., and Williams, W.J. (2010). Aplastic anemia: Acquired and inherited. Williams Hematology, McGraw-Hill Medical. [8th ed.]."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1053\/j.seminhematol.2013.03.028","article-title":"Aplastic anemia: What have we learned from animal models and from the clinic","volume":"50","author":"Scheinberg","year":"2013","journal-title":"Semin. Hematol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1182\/blood-2006-03-010777","article-title":"Current concepts in the pathophysiology and treatment of aplastic anemia","volume":"108","author":"Young","year":"2006","journal-title":"Blood"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000491816","article-title":"The risk of clonal evolution of granulocyte colony-stimulating factor for acquired aplastic anemia: A systematic review and meta-analysis","volume":"140","author":"Ding","year":"2018","journal-title":"Acta Haematol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1182\/bloodadvances.2018021162","article-title":"Severe aplastic anemia: Allogeneic bone marrow transplantation as first-line treatment","volume":"2","author":"Georges","year":"2018","journal-title":"Blood Adv."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.hoc.2018.03.001","article-title":"The pathophysiology of acquired aplastic anemia: Current concepts revisited","volume":"32","author":"Schoettler","year":"2018","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_237","first-page":"711","article-title":"[Acquired aplastic anemia: Recent advances in pathophysiology and treatment]","volume":"59","author":"Yamazaki","year":"2018","journal-title":"[Rinsho Ketsueki] Jpn. J. Clin. Hematol."},{"key":"ref_238","unstructured":"Moore, C.A., and Krishnan, K. (2020, December 22). Aplastic Anemia, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534212\/."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1182\/asheducation.V2012.1.292.3798310","article-title":"Aplastic anemia: Therapeutic updates in immunosuppression and transplantation","volume":"2012","author":"Scheinberg","year":"2012","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/MOH.0b013e328365af83","article-title":"Haematopoietic stem cell transplantation for acquired aplastic anaemia","volume":"20","author":"Young","year":"2013","journal-title":"Curr. Opin. Hematol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/bmt.2012.229","article-title":"Treatment and hematopoietic SCT in aplastic anemia","volume":"48","author":"Passweg","year":"2013","journal-title":"Bone Marrow Transplant."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s11655-012-1292-4","article-title":"Research and development of the effective components of Panaxdiol saponin as new Chinese patent medicine for treating hemocytopenia","volume":"18","author":"Gao","year":"2012","journal-title":"Chin. J. Integr. Med."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1745-7254.2007.00551.x","article-title":"Effects of notoginosides on proliferation and upregulation of GR nuclear transcription factor in hematopoietic cells","volume":"28","author":"Gao","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s11655-012-1210-z","article-title":"Effects of sodium copper chlorophyllin on mesenchymal stem cell function in aplastic anemia mice","volume":"19","author":"Yin","year":"2013","journal-title":"Chin. J. Integr. Med."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s11655-012-1306-4","article-title":"Panax notoginseng saponins induced up-regulation, phosphorylation and binding activity of MEK, ERK, AKT, PI-3K protein kinases and GATA transcription factors in hematopoietic cells","volume":"19","author":"Sun","year":"2013","journal-title":"Chin. J. Integr. Med."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s11655-012-1179-7","article-title":"Effects of Panax notoginseng saponins on proliferation and differentiation in NIH3T3 cells","volume":"18","author":"Yin","year":"2012","journal-title":"Chin. J. Integr. Med."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.biopha.2018.03.175","article-title":"Saponins from Panax notoginseng leaves improve the symptoms of aplastic anemia and aberrant immunity in mice","volume":"102","author":"Zhao","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_248","first-page":"660","article-title":"Iron chelation effect of curcumin and baicalein on aplastic anemia mouse model with iron overload","volume":"22","author":"Dijiong","year":"2019","journal-title":"Iran J. Basic Med. Sci."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/abbs\/gmx062","article-title":"Ginseng saponin Rb1 enhances hematopoietic function and dendritic cells differentiation","volume":"9","author":"Zhang","year":"2017","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1007\/s11655-019-3049-z","article-title":"Panaxdiol saponins component promotes hematopoiesis and modulates T lymphocyte dysregulation in aplastic anemia model mice","volume":"25","author":"Zheng","year":"2019","journal-title":"Chin. J. Integr. Med."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1142\/S0192415X15500196","article-title":"Effects of the total saponins from Dioscorea nipponica on immunoregulation in aplastic anemia mice","volume":"43","author":"Wang","year":"2015","journal-title":"Am. J. Chin. 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