{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:17Z","timestamp":1791895577064,"version":"4.3.4"},"reference-count":25,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT)","award":["2018R1A5A2025272"],"award-info":[{"award-number":["2018R1A5A2025272"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT)","award":["2019R1A2C1002555"],"award-info":[{"award-number":["2019R1A2C1002555"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT)","award":["202012D09"],"award-info":[{"award-number":["202012D09"]}]},{"name":"Korea Institute of Oriental Medicine (KIOM)","award":["KSN2013210"],"award-info":[{"award-number":["KSN2013210"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Visceral pain frequently produces referred pain at somatic sites due to the convergence of somatic and visceral afferents. In skin overlying the referred pain, neurogenic spots characterized by hyperalgesia, tenderness and neurogenic inflammation are found. We investigated whether neurogenic inflammatory spots function as acupoints in the rat model of bile duct ligation-induced liver injury. The majority of neurogenic spots were found in the dorsal trunk overlying the referred pain and matched with locations of acupoints. The spots, as well as acupoints, showed high electrical conductance and enhanced expression of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP). Electroacupuncture at neurogenic spots reduced serum hepatocellular enzyme activities and histological patterns of acute liver injury in bile duct ligation (BDL) rats. The results suggest that the neurogenic spots have therapeutic effects as acupoints on hepatic injury in bile-duct ligated rats.<\/jats:p>","DOI":"10.3390\/ijms22041974","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T21:35:42Z","timestamp":1613597742000},"page":"1974","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Electroacupuncture at Neurogenic Spots in Referred Pain Areas Attenuates Hepatic Damages in Bile Duct-Ligated Rats"],"prefix":"10.3390","volume":"22","author":[{"given":"Yoo Jung","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7953-7094","authenticated-orcid":false,"given":"Yeonhee","family":"Ryu","sequence":"additional","affiliation":[{"name":"Korean Medicine Fundamental Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Chan","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Research Center, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2495-9115","authenticated-orcid":false,"given":"Hee Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"ref_1","unstructured":"Pomeranz, G.S.B. 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Toxicol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/4\/1974\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:25:10Z","timestamp":1760160310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/4\/1974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["ijms22041974"],"URL":"https:\/\/doi.org\/10.3390\/ijms22041974","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]}}}