{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:12:22Z","timestamp":1790784742928,"version":"4.1.0"},"reference-count":139,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","award":["PRID 2018 (MONT_SID18_01)"],"award-info":[{"award-number":["PRID 2018 (MONT_SID18_01)"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Resistance to chemotherapy still remains a major challenge in the clinic, impairing the quality of life and survival rate of patients. The identification of unconventional chemosensitizing agents is therefore an interesting aspect of cancer research. Resveratrol has emerged in the last decades as a fascinating molecule, able to modulate several cancer-related molecular mechanisms, suggesting a possible application as an adjuvant in cancer management. This review goes deep into the existing literature concerning the possible chemosensitizing effect of resveratrol associated with the most conventional chemotherapeutic drugs. Despite the promising effects observed in different cancer types in in vitro studies, the clinical translation still presents strong limitations due to the low bioavailability of resveratrol. Recently, efforts have been moved in the field of drug delivery to identifying possible strategies\/formulations useful for a more effective administration. Despite the necessity of a huge implementation in this research area, resveratrol appears as a promising molecule able to sensitize resistant tumors to drugs, suggesting its potential use in therapy-refractory cancer patients.<\/jats:p>","DOI":"10.3390\/ijms22042049","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T09:06:10Z","timestamp":1613725570000},"page":"2049","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0350-8403","authenticated-orcid":false,"given":"Veronica","family":"Cocetta","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-5401","authenticated-orcid":false,"given":"Vincenzo","family":"Quagliariello","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-3655","authenticated-orcid":false,"given":"Francesco","family":"Fiorica","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Az. 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Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1177\/1535370219839163","article-title":"Cancer drug development: The missing links","volume":"244","author":"Kunnumakkara","year":"2019","journal-title":"Exp. Biol. Med."},{"key":"ref_3","first-page":"399","article-title":"Why Chemotherapy Can Fail?","volume":"13","author":"Majchrzak","year":"2010","journal-title":"Polish J. Vet. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"59950","DOI":"10.18632\/oncotarget.19048","article-title":"The molecular mechanisms of chemoresistance in cancers","volume":"8","author":"Zheng","year":"2017","journal-title":"Oncotarget"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.18632\/oncotarget.14021","article-title":"Chemoresistance and targeted therapies in ovarian and endometrial cancers","volume":"8","author":"Brasseur","year":"2016","journal-title":"Oncotarget"},{"key":"ref_6","first-page":"1","article-title":"Linking metabolic reprogramming to therapy resistance in cancer","volume":"1868","author":"Morandi","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) Bioenerg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrc2981","article-title":"Regulation of cancer cell metabolism","volume":"11","author":"Cairns","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1749-6632.2010.05852.x","article-title":"Chemosensitization of tumors by resveratrol","volume":"1215","author":"Gupta","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000443404","article-title":"Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents","volume":"25","author":"Cragg","year":"2015","journal-title":"Med. Princ. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.fitote.2017.10.007","article-title":"Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression","volume":"124","author":"Catanzaro","year":"2018","journal-title":"Fitoterapia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2184.2009.00585.x","article-title":"Cell-cycle inhibition and apoptosis induced by curcumin and cisplatin or oxaliplatin in human ovarian carcinoma cells","volume":"42","author":"Montopoli","year":"2009","journal-title":"Cell Prolif."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Berretta, M., Quagliariello, V., Maurea, N., Di Francia, R., Sharifi, S., Facchini, G., Rinaldi, L., Piezzo, M., Manuela, C., and Nunnari, G. (2020). Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies. Antioxidants, 9.","DOI":"10.3390\/antiox9121182"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ko, J.-H., Sethi, G., Um, J.-Y., Shanmugam, M.K., Arfuso, F., Kumar, A.P., Bishayee, A., and Ahn, K.S. (2017). The Role of Resveratrol in Cancer Therapy. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122589"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1021\/jf0112973","article-title":"Plant Foods and Herbal Sources of Resveratrol","volume":"50","author":"Burns","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0885-5765(89)90043-X","article-title":"The significance of stilbene phytoalexins in the Plasmopara viticola-grapevine interaction","volume":"34","author":"Dercks","year":"1989","journal-title":"Physiol. Mol. Plant Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.bbadis.2015.01.014","article-title":"The pharmacology of resveratrol in animals and humans","volume":"1852","author":"Park","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/mnfr.200700290","article-title":"Quantification of free and protein-boundtrans-resveratrol metabolites and identification oftrans-resveratrol-C\/O-conjugated diglucuronides\u2014Two novel resveratrol metabolites in human plasma","volume":"52","author":"Burkon","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1124\/dmd.106.013664","article-title":"Resveratrol in Human Hepatoma HepG2 Cells: Metabolism and Inducibility of Detoxifying Enzymes","volume":"35","author":"Hanet","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.5344\/ajev.1991.42.1.41","article-title":"The Production of Resveratrol (3,5,4\u2032-Trihydroxystilbene) by Grape Berries in Different Developmental Stages","volume":"42","author":"Jeandet","year":"1991","journal-title":"Am. J. Enol Vitic."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5344\/ajev.1995.46.2.159","article-title":"A Global Survey of Trans-Resveratrol Concentrations in Commercial Wines","volume":"46","author":"Goldberg","year":"1995","journal-title":"Am. J. Enol Vitic."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/0140-6736(92)91277-F","article-title":"Wine, alcohol, platelets, and the French paradox for coronary heart disease","volume":"339","author":"Renaud","year":"1992","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.275.5297.218","article-title":"Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes","volume":"275","author":"Jang","year":"1997","journal-title":"Science"},{"key":"ref_23","first-page":"148","article-title":"Multiplicity of effects and health benefits of resveratrol","volume":"52","year":"2016","journal-title":"Rev. Esp. Med. Nucl. Imagen Mol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bbadis.2014.11.004","article-title":"Resveratrol and cancer: Challenges for clinical translation","volume":"1852","author":"Singh","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1749-6632.2010.05851.x","article-title":"Resveratrol in cancer management: where are we and where we go from here?","volume":"1215","author":"Ndiaye","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"R209","DOI":"10.1530\/ERC-13-0171","article-title":"Resveratrol and cancer: focus on in vivo evidence","volume":"21","author":"Carter","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"52517","DOI":"10.18632\/oncotarget.9593","article-title":"Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence","volume":"7","author":"Kotecha","year":"2016","journal-title":"Oncotarget"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Nawaz, W., Zhou, Z., Deng, S., Ma, X., Ma, X., Li, C., and Shu, X. (2017). Therapeutic Versatility of Resveratrol Derivatives. Nutrients, 9.","DOI":"10.3390\/nu9111188"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1089\/jmf.2016.3856","article-title":"Cardiovascular Protective Effects and Clinical Applications of Resveratrol","volume":"20","author":"Cho","year":"2017","journal-title":"J. Med. Food"},{"key":"ref_30","first-page":"4131","article-title":"Resveratrol attenuates neurological deficit and neuroinflammation following intracerebral hemorrhage","volume":"15","author":"Cai","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Berretta, M., Bignucolo, A., Di Francia, R., Comello, F., Facchini, G., Ceccarelli, M., Iaffaioli, R.V., Quagliariello, V., and Maurea, N. (2020). Resveratrol in Cancer Patients: From Bench to Bedside. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082945"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.278.5340.1073","article-title":"Recent Advances in Chemoprevention of Cancer","volume":"278","author":"Hong","year":"1997","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20100136","article-title":"Multifaceted link between cancer and inflammation","volume":"32","author":"Sethi","year":"2011","journal-title":"Biosci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Brockmueller, A., Sameri, S., Liskova, A., Zhai, K., Varghese, E., Samuel, S.M., B\u00fcsselberg, D., Kubatka, P., and Shakibaei, M. (2021). Resveratrol\u2019s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism. Cancers, 13.","DOI":"10.3390\/cancers13020188"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/mnfr.200800148","article-title":"Resveratrol addiction: To die or not to die","volume":"53","author":"Shakibaei","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Han, Y., Jo, H., Cho, J.H., Dhanasekaran, D.N., and Song, Y.S. (2019). Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040925"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"35448","DOI":"10.18632\/oncotarget.26234","article-title":"Naturally occurring compounds as pancreatic cancer therapeutics","volume":"9","author":"Lohse","year":"2018","journal-title":"Oncotarget"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Buhrmann, C., Shayan, P., Popper, B., Goel, A., and Shakibaei, M. (2016). Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells. Nutrients, 8.","DOI":"10.3390\/nu8030145"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Buhrmann, C., Shayan, P., Goel, A., and Shakibaei, M. (2017). Resveratrol Regulates Colorectal Cancer Cell Invasion by Modulation of Focal Adhesion Molecules. Nutrients, 9.","DOI":"10.3390\/nu9101073"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"38050","DOI":"10.1074\/jbc.M112.377028","article-title":"Resveratrol Modulates Interleukin-1\u03b2-induced Phosphatidylinositol 3-Kinase and Nuclear Factor \u03baB Signaling Pathways in Human Tenocytes","volume":"287","author":"Busch","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1074\/jbc.M806708200","article-title":"Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates \u03b2-Catenin Signaling and NF\u03baB-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells","volume":"284","author":"Bourguignon","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1021\/acs.jafc.9b01667","article-title":"Noncoding RNAs as Molecular Targets of Resveratrol Underlying Its Anticancer Effects","volume":"67","author":"Wang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11060-015-1718-0","article-title":"Altered expression of long non-coding RNAs during genotoxic stress-induced cell death in human glioma cells","volume":"122","author":"Liu","year":"2015","journal-title":"J. Neuro-Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/jcmm.12397","article-title":"Targeting lung cancer stem-like cells with TRAIL gene armed oncolytic adenovirus","volume":"19","author":"Yang","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ji, Q., Liu, X., Fu, X., Zhang, L., Sui, H., Zhou, L., Sun, J., Cai, J., Qin, J., and Ren, J. (2013). Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt\/\u03b2-Catenin Signal Pathway. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078700"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/sj.bjc.6603755","article-title":"Non-genomic action of resveratrol on androgen and oestrogen receptors in prostate cancer: modulation of the phosphoinositide 3-kinase pathway","volume":"96","author":"Clementi","year":"2007","journal-title":"Br. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1158\/1078-0432.CCR-07-1719","article-title":"Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma","volume":"14","author":"Sarkaria","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kiskova, T., Kubatka, P., B\u00fcsselberg, D., and Kassayova, M. (2020). The Plant-Derived Compound Resveratrol in Brain Cancer: A Review. Biomolecules, 10.","DOI":"10.3390\/biom10010161"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2176\/nmc.ra.2018-0141","article-title":"Potential Strategies Overcoming the Temozolomide Resistance for Glioblastoma","volume":"58","author":"Jiapaer","year":"2018","journal-title":"Neurol. Medico-Chir."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1093\/brain\/awz202","article-title":"Acquired temozolomide resistance in MGMT-deficient glioblastoma cells is associated with regulation of DNA repair by DHC2","volume":"142","author":"Yi","year":"2019","journal-title":"Brain"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/0971-5851.171543","article-title":"Therapeutic approach beyond conventional temozolomide for newly diagnosed glioblastoma: Review of the present evidence and future direction","volume":"36","author":"Rath","year":"2015","journal-title":"Indian J. Med Paediatr. Oncol."},{"key":"ref_52","unstructured":"Decleves, X., Amiel, A., Scherrmann, J.-Y.D., and Scherrmann, J.M. (2020, December 15). Role of ABC Transporters in the Chemoresistance of Human Gliomas. Available online: https:\/\/www.eurekaselect.com\/56392\/article."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1755-5949.2012.00319.x","article-title":"Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS-dependent AMPK-TSC-mTOR Signaling Pathway","volume":"18","author":"Yuan","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3892\/or.2015.4346","article-title":"Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation","volume":"35","author":"Li","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s10616-018-0197-5","article-title":"Apoptotic effects of \u03b5-viniferin in combination with cis-platin in C6 cells","volume":"70","author":"Incesu","year":"2018","journal-title":"Cytotechnology"},{"key":"ref_56","first-page":"2050","article-title":"Resveratrol reverses temozolomide resistance by downregulation of MGMT in T98G glioblastoma cells by the NF-\u03baB-dependent pathway","volume":"27","author":"Zhang","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1002\/jcp.27409","article-title":"Resveratrol restores sensitivity of glioma cells to temozolamide through inhibiting the activation of Wnt signaling pathway","volume":"234","author":"Yang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Filippi-Chiela, E.C., Thom\u00e9, M.P., E Silva, M.M.B., Pelegrini, A.L., Ledur, P.F., Garicochea, B., Zamin, L.L., and Lenz, G. (2013). Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells. BMC Cancer, 13.","DOI":"10.1186\/1471-2407-13-147"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2478\/raon-2019-0018","article-title":"Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy","volume":"53","author":"Makovec","year":"2019","journal-title":"Radiol. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e1257","DOI":"10.1038\/cddis.2013.428","article-title":"Systems biology of cisplatin resistance: past, present and future","volume":"5","author":"Galluzzi","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/onc.2011.384","article-title":"Molecular mechanisms of cisplatin resistance","volume":"31","author":"Galluzzi","year":"2011","journal-title":"Oncogene"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/bs.ircmb.2020.01.005","article-title":"Links between cancer metabolism and cisplatin resistance","volume":"354","author":"Cocetta","year":"2020","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Cocetta, V., Ragazzi, E., and Montopoli, M. (2019). Mitochondrial Involvement in Cisplatin Resistance. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143384"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Giacomini, I., Cocetta, V., Carrara, M., Ragazzi, E., and Montopoli, M. (2020). Plumbagin Induces Cell Cycle Arrest and Apoptosis in A431 Cisplatin-Resistant Cancer Cells. Nat. Prod. Commun., 15.","DOI":"10.1177\/1934578X20921627"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.3892\/ijo.2015.3124","article-title":"Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis","volume":"47","author":"Ma","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1745-7270.2008.00393.x","article-title":"Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901","volume":"40","author":"Xing","year":"2008","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/abbs\/gmw026","article-title":"The synergistic effect of resveratrol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells","volume":"48","author":"Hui","year":"2016","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tibs.2010.05.003","article-title":"Glutamine addiction: A new therapeutic target in cancer","volume":"35","author":"Wise","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"474","DOI":"10.5483\/BMBRep.2018.51.9.114","article-title":"Resveratrol enhances cisplatin-induced apoptosis in human hepatoma cells via glutamine metabolism inhibition","volume":"51","author":"Liu","year":"2018","journal-title":"BMB Rep."},{"key":"ref_70","first-page":"53","article-title":"Combinations of resveratrol, cisplatin and oxaliplatin applied to human ovarian cancer cells","volume":"32","author":"Nessa","year":"2012","journal-title":"Anticancer Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"353","DOI":"10.7150\/jca.13754","article-title":"Ellagic Acid and Resveratrol Prevent the Development of Cisplatin Resistance in the Epithelial Ovarian Cancer Cell Line A2780","volume":"7","author":"Engelke","year":"2016","journal-title":"J. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.ajog.2005.11.030","article-title":"Use of Resveratrol to improve the effectiveness of cisplatin and doxorubicin: Study in human gynecologic cancer cell lines and in rodent heart","volume":"194","author":"Rezk","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s00280-011-1640-x","article-title":"Resveratrol induces SIRT1- and energy\u2013stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment","volume":"68","author":"Roos","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1090.11","DOI":"10.1096\/fasebj.30.1_supplement.1090.11","article-title":"Antiproliferative Effect of Resveratrol and Oxaliplatin on Colon Cancer Cells","volume":"30","author":"Daniel","year":"2016","journal-title":"FASEB J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4174\/astr.2014.86.2.68","article-title":"Antichemosensitizing effect of resveratrol in cotreatment with oxaliplatin in HCT116 colon cancer cell","volume":"86","author":"Park","year":"2014","journal-title":"Ann. Surg. Treat. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1007\/s10495-014-0988-x","article-title":"Resveratrol-induced potentiation of the antitumor effects of oxaliplatin is accompanied by an altered cytokine profile of human monocyte-derived macrophages","volume":"19","author":"Kaminski","year":"2014","journal-title":"Apoptosis"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12935-014-0152-2","article-title":"Chemosensitizing and nephroprotective effect of resveratrol in cisplatin\u2014Treated animals","volume":"15","author":"Osman","year":"2015","journal-title":"Cancer Cell Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/tox.21952","article-title":"Resveratrol Enhances Chemosensitivity in Mouse Melanoma Model Through Connexin 43 Upregulation","volume":"30","author":"Cheng","year":"2015","journal-title":"Environ. Toxicol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fcvm.2020.00035","article-title":"Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?","volume":"7","author":"Murabito","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.drup.2009.07.001","article-title":"Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib","volume":"12","author":"Broxterman","year":"2009","journal-title":"Drug Resist. Updat."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bbagen.2013.10.023","article-title":"Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin","volume":"1840","author":"Kim","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) Gen. Subj."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.phymed.2015.12.020","article-title":"Resveratrol improves the anticancer effects of doxorubicin in vitro and in vivo models: A mechanistic insight","volume":"23","author":"Rai","year":"2016","journal-title":"Phytomedicine"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature15748","article-title":"Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance","volume":"527","author":"Fischer","year":"2015","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13046-016-0487-8","article-title":"Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN\/Akt signaling pathway in gastric cancer","volume":"36","author":"Xu","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/cam4.1993","article-title":"Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1\/\u03b2-catenin signaling pathway in breast cancer","volume":"8","author":"Jin","year":"2019","journal-title":"Cancer Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"16283","DOI":"10.1002\/jcb.28910","article-title":"Resveratrol chemosensitizes adriamycin-resistant breast cancer cells by modulating miR-122-5p","volume":"120","author":"Zhang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijpharm.2018.09.016","article-title":"Comparative study of the therapeutic effect of Doxorubicin and Resveratrol combination on 2D and 3D (spheroids) cell culture models","volume":"551","author":"Barros","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"36855","DOI":"10.1038\/srep36855","article-title":"Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity","volume":"6","author":"Khaleel","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.phymed.2018.06.046","article-title":"Resveratrol mediated cancer cell apoptosis, and modulation of multidrug resistance proteins and metabolic enzymes","volume":"55","author":"Eid","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0306-3623(97)00383-2","article-title":"Tumor Resistance To Antimetabolites","volume":"30","author":"Kinsella","year":"1998","journal-title":"Gen. Pharmacol. Vasc. Syst."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000086183","article-title":"Mechanisms of Drug Resistance in Cancer Chemotherapy","volume":"14","author":"Luqmani","year":"2005","journal-title":"Med. Princ. Pract."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.3390\/cancers2031717","article-title":"5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs","volume":"2","author":"Miura","year":"2010","journal-title":"Cancers"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3390\/molecules13081551","article-title":"5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies","volume":"13","author":"Zhang","year":"2008","journal-title":"Molecules"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"32943","DOI":"10.18632\/oncotarget.25993","article-title":"Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells","volume":"9","author":"Chung","year":"2018","journal-title":"Oncotarget"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000331733","article-title":"Resveratrol Potentiates the Cytotoxic Oxidative Stress Induced by Chemotherapy in Human Colon Cancer Cells","volume":"28","author":"Santandreu","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.3892\/mmr.2015.3675","article-title":"Anti-angiogenic effects of resveratrol in combination with 5-fluorouracil on B16 murine melanoma cells","volume":"12","author":"Lee","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.3748\/wjg.v10.i20.3048","article-title":"Effect of resveratrol and in combination with 5-FU on murine liver cancer","volume":"10","author":"Wu","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Buhrmann, C., Yazdi, M., Popper, B., Shayan, P., Goel, A., Aggarwal, B.B., and Shakibaei, M. (2018). Resveratrol Chemosensitizes TNF-\u03b2-Induced Survival of 5-FU-Treated Colorectal Cancer Cells. Nutrients, 10.","DOI":"10.3390\/nu10070888"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bcp.2015.08.105","article-title":"Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer","volume":"98","author":"Buhrmann","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Amrutkar, M., and Gladhaug, I.P. (2017). Pancreatic Cancer Chemoresistance to Gemcitabine. Cancers, 9.","DOI":"10.3390\/cancers9110157"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e12514","DOI":"10.1111\/cpr.12514","article-title":"Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1","volume":"52","author":"Zhou","year":"2019","journal-title":"Cell Prolif."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ijc.25041","article-title":"Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabinein vitroand in orthotopic mouse model of human pancreatic cancer","volume":"127","author":"Harikumar","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Cheng, L., Yan, B., Chen, K., Jiang, Z., Zhou, C., Cao, J., Qian, W., Li, J., Sun, L., and Ma, J. (2020, December 17). Resveratrol-Induced Downreg-ulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS\/Nrf2 Signaling Pathways. Available online: https:\/\/www.hindawi.com\/journals\/omcl\/2018\/9482018\/.","DOI":"10.1155\/2018\/9482018"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Jiang, Z., Chen, X., Chen, K., Sun, L., Gao, L., Zhou, C., Lei, M., Duan, W., Wang, Z., and Ma, Q. (2016). YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine. Nutrients, 8.","DOI":"10.3390\/nu8100546"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00432-020-03384-7","article-title":"Gemcitabine potentiates anti-tumor effect of resveratrol on pancreatic cancer via down-regulation of VEGF-B","volume":"147","author":"Yang","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_106","first-page":"6869","article-title":"The modulation study of multiple drug resistance in bladder cancer by curcumin and resveratrol","volume":"18","author":"Cho","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"R2","DOI":"10.1186\/bcr3083","article-title":"Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells","volume":"14","author":"Reed","year":"2012","journal-title":"Breast Cancer Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"15061","DOI":"10.1038\/cddiscovery.2015.61","article-title":"Resveratrol chemosensitizes HER-2-overexpressing breast cancer cells to docetaxel chemoresistance by inhibiting docetaxel-mediated activation of HER-2\u2013Akt axis","volume":"1","author":"Vinod","year":"2015","journal-title":"Cell Death Discov."},{"key":"ref_109","first-page":"5363","article-title":"Resveratrol augments paclitaxel treatment in MDA-MB-231 and paclitaxel-resistant MDA-MB-231 breast cancer cells","volume":"34","author":"Herbert","year":"2014","journal-title":"Anticancer Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1158\/1535-7163.71.3.1","article-title":"Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin\u2019s lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis","volume":"3","author":"Jazirehi","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1002\/jcp.27309","article-title":"Potentiation of paclitaxel effect by resveratrol in human breast cancer cells by counteracting the 17\u03b2-estradiol\/estrogen receptor \u03b1\/neuroglobin pathway","volume":"234","author":"Cipolletti","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_112","first-page":"1","article-title":"Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells","volume":"2019","author":"Braidy","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fonc.2018.00227","article-title":"Recent Advances in the Treatment of Breast Cancer","volume":"8","author":"Tong","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Nevedomskaya, E., Baumgart, S.J., and Haendler, B. (2018). Recent Advances in Prostate Cancer Treatment and Drug Discovery. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051359"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"De Amicis, F., Chimento, A., Montalto, F.I., Casaburi, I., Sirianni, R., and Pezzi, V. (2019). Steroid Receptor Signallings as Targets for Resveratrol Actions in Breast and Prostate Cancer. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051087"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/sj.bjc.6600477","article-title":"Molecular classification of selective oestrogen receptor modulators on the basis of gene expression profiles of breast cancer cells expressing oestrogen receptor \u03b1","volume":"87","author":"Levenson","year":"2002","journal-title":"Br. J. Cancer"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"14138","DOI":"10.1073\/pnas.94.25.14138","article-title":"Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor","volume":"94","author":"Gehm","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/(SICI)1097-4652(199906)179:3<297::AID-JCP7>3.0.CO;2-P","article-title":"Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells","volume":"179","author":"Lu","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1096\/fj.10-178871","article-title":"Resveratrol, through NF-Y\/p53\/Sin3\/HDAC1 complex phosphorylation, inhibits estrogen receptor \u03b1 gene expression via p38 MAPK \/CK2 signaling in human breast cancer cells","volume":"25","author":"Giordano","year":"2011","journal-title":"FASEB J."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Fernandes, G.F.S., Silva, G.D.B., Pavan, A.R., Chiba, D.E., Chin, C.M., and Dos Santos, J.L. (2017). Epigenetic Regulatory Mechanisms Induced by Resveratrol. Nutrients, 9.","DOI":"10.3390\/nu9111201"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.lfs.2018.04.035","article-title":"Apoptosis induction in human breast cancer cell lines by synergic effect of raloxifene and resveratrol through increasing proapoptotic genes","volume":"205","author":"Mirzapur","year":"2018","journal-title":"Life Sci."},{"key":"ref_122","first-page":"2488","article-title":"Resveratrol induces prostate cancer cell entry into s phase and inhibits DNA synthesis","volume":"62","author":"Kuwajerwala","year":"2002","journal-title":"Cancer Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"105406","DOI":"10.1016\/j.jsbmb.2019.105406","article-title":"Resveratrol inhibits DHT-induced progression of prostate cancer cell line through interfering with the AR and CXCR4 pathway","volume":"192","author":"Jang","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1593\/tlo.09328","article-title":"Androgens Induce Functional CXCR4 through ERG Factor Expression in TMPRSS2-ERG Fusion-Positive Prostate Cancer Cells","volume":"3","author":"Cai","year":"2010","journal-title":"Transl. Oncol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Havens, A.M., Jung, Y., Sun, Y.X., Wang, J., Shah, R.B., B\u00fchring, H.J., Pienta, K., and Taichman, R.S. (2006). The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis. BMC Cancer, 6.","DOI":"10.1186\/1471-2407-6-195"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ol.2020.12032","article-title":"Resveratrol inhibits proliferation and promotes apoptosis via the androgen receptor splicing variant 7 and PI3K\/AKT signaling pathway in LNCaP prostate cancer cells","volume":"20","author":"Ye","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1615\/CritRevEukaryotGeneExpr.2019027836","article-title":"Current Update on Preclinical and Clinical Studies of Resveratrol, a Naturally Occurring Phenolic Compound","volume":"29","author":"Samuel","year":"2019","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/15734064113096660053","article-title":"Chemistry, Stability and Bioavailability of Resveratrol","volume":"10","author":"Franciosoa","year":"2014","journal-title":"Med. Chem."},{"key":"ref_129","unstructured":"Kashyap, D., Tuli, H.S., Yerer, M.B., Sharma, A., Sak, K., Srivastava, S., Pandey, A., Garg, V.K., Sethi, G., and Bishayee, A. (2019). Natural product-based nanoformulations for cancer therapy: Opportunities and challenges. Semin. Cancer Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"35267","DOI":"10.1038\/srep35267","article-title":"Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"22390","DOI":"10.1038\/srep22390","article-title":"Combination Therapy using Co-encapsulated Resveratrol and Paclitaxel in Liposomes for Drug Resistance Reversal in Breast Cancer Cells in vivo","volume":"6","author":"Meng","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Berretta, M., Rinaldi, L., Taibi, R., Tralongo, P., Fulvi, A., Montesarchio, V., Madeddu, G., Magistri, P., Bimonte, S., and Trov\u00f2, M. (2020). Physician Attitudes and Perceptions of Complementary and Alternative Medicine (CAM): A Multicentre Italian Study. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00594"},{"key":"ref_133","unstructured":"Berretta, M., Di Francia, R., Cazzavillan, S., Rossi, P., Scorba, A., Sciacca, P.G., and Santag\u00e0, D. (2019). Integrative Medicine in Oncology, Milan 19th October 2019. World Cancer Res. J., 6."},{"key":"ref_134","unstructured":"\u0130nci, H., and \u0130nci, F. (2020). Complementary and Alternative Medicine Awareness in Cancer Patients Receiving Chemotherapy. World Cancer Res. J., 7."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"24401","DOI":"10.18632\/oncotarget.14224","article-title":"Use of Complementary and Alternative Medicine (CAM) in cancer patients: An Italian multicenter survey","volume":"8","author":"Berretta","year":"2017","journal-title":"Oncotarget"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Dehghan, M., Ghaedi Heidari, F., Malakoutikhah, A., and Mokhtarabadi, S. (2019). Complementary and Alternative Medicine Usage and Its Determinant Factors among Iranian Patients with Cancer. World Cancer Res. J., 6.","DOI":"10.18502\/jfrh.v14i3.4671"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/283634","article-title":"Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum Levels in Patients with Psoriasis Vulgaris","volume":"2015","author":"Antiga","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Stohs, S.J., Chen, O., Ray, S.D., Ji, J., Bucci, L.R., and Preuss, H.G. (2020). Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review. Antioxidants, 25.","DOI":"10.3390\/molecules25061397"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Quagliariello, V., Vecchione, R., Coppola, C., Di Cicco, C., De Capua, A., Piscopo, G., Paciello, R., Narciso, V., Formisano, C., and Taglialatela-Scafati, O. (2018). Cardioprotective Effects of Nanoemulsions Loaded with Anti-Inflammatory Nutraceuticals against Doxorubicin-Induced Cardiotoxicity. Nutrients, 10.","DOI":"10.3390\/nu10091304"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/4\/2049\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:26:04Z","timestamp":1760160364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/4\/2049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,19]]},"references-count":139,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["ijms22042049"],"URL":"https:\/\/doi.org\/10.3390\/ijms22042049","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,19]]}}}