{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:49:18Z","timestamp":1787791758135,"version":"build-2784847793"},"reference-count":132,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG050049"],"award-info":[{"award-number":["AG050049"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG057842"],"award-info":[{"award-number":["AG057842"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL138685"],"award-info":[{"award-number":["HL138685"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK104184"],"award-info":[{"award-number":["DK104184"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM104357"],"award-info":[{"award-number":["P20GM104357"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL51971"],"award-info":[{"award-number":["P01 HL51971"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00DK113280"],"award-info":[{"award-number":["R00DK113280"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20PRE35210043"],"award-info":[{"award-number":["20PRE35210043"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ischemic stroke is one of the most disabling diseases and a leading cause of death globally. Despite advances in medical care, the global burden of stroke continues to grow, as no effective treatments to limit or reverse ischemic injury to the brain are available. However, recent preclinical findings have revealed the potential role of transient receptor potential cation 6 (TRPC6) channels as endogenous protectors of neuronal tissue. Activating TRPC6 in various cerebral ischemia models has been found to prevent neuronal death, whereas blocking TRPC6 enhances sensitivity to ischemia. Evidence has shown that Ca2+ influx through TRPC6 activates the cAMP (adenosine 3\u2019,5\u2019-cyclic monophosphate) response element-binding protein (CREB), an important transcription factor linked to neuronal survival. Additionally, TRPC6 activation may counter excitotoxic damage resulting from glutamate release by attenuating the activity of N-methyl-d-aspartate (NMDA) receptors of neurons by posttranslational means. Unresolved though, are the roles of TRPC6 channels in non-neuronal cells, such as astrocytes and endothelial cells. Moreover, TRPC6 channels may have detrimental effects on the blood\u2013brain barrier, although their exact role in neurovascular coupling requires further investigation. This review discusses evidence-based cell-specific aspects of TRPC6 in the brain to assess the potential targets for ischemic stroke management.<\/jats:p>","DOI":"10.3390\/ijms22042074","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T20:54:08Z","timestamp":1613768048000},"page":"2074","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-7981","authenticated-orcid":false,"given":"Shashank","family":"Shekhar","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yedan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2566-7501","authenticated-orcid":false,"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, I.M. Sechenov First Moscow State Medical University, Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5328-8050","authenticated-orcid":false,"given":"Letao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-0217","authenticated-orcid":false,"given":"Richard J.","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-3610","authenticated-orcid":false,"given":"Fan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Booz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0140-6736(06)68770-9","article-title":"Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data","volume":"367","author":"Lopez","year":"2006","journal-title":"Lancet"},{"key":"ref_3","unstructured":"Hall, M.J., Levant, S., and DeFrances, C.J. (2012). Hospitalization for Stroke in U.S. Hospitals, 1989\u20132009, US Department of Health and Human Services. NCHS Data Brief."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1474-4422(19)30030-4","article-title":"The global burden of stroke: Persistent and disabling","volume":"18","author":"Gorelick","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1474-4422(20)30272-6","article-title":"COVID-19 related stroke in young individuals","volume":"19","author":"Fifi","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fspor.2020.00057","article-title":"Physical Activity during the Coronavirus (COVID-19) Pandemic: Prevention of a Decline in Metabolic and Immunological Functions","volume":"2","author":"Jakobsson","year":"2020","journal-title":"Front. Sports Act. Living"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ncl.2008.07.003","article-title":"Epidemiology of ischemic and hemorrhagic stroke: Incidence, prevalence, mortality, and risk factors","volume":"26","author":"Grysiewicz","year":"2008","journal-title":"Neurol. Clin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1161\/STROKEAHA.119.026655","article-title":"Cilostazol Mono and Combination Treatments in Ischemic Stroke: An Updated Systematic Review and Meta-Analysis","volume":"50","author":"Kim","year":"2019","journal-title":"Stroke"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1161\/STROKEAHA.108.540112","article-title":"Hemorrhagic and ischemic strokes compared: Stroke severity, mortality, and risk factors","volume":"40","author":"Andersen","year":"2009","journal-title":"Stroke"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.2174\/1570159X16666180302115544","article-title":"Cell Death Mechanisms in Stroke and Novel Molecular and Cellular Treatment Options","volume":"16","author":"Sekerdag","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/01.STR.0000256294.46009.29","article-title":"Ca2+ signals and neuronal death in brain ischemia","volume":"38","author":"Bano","year":"2007","journal-title":"Stroke"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/01.RVI.0000108687.75691.0C","article-title":"Pathophysiology of focal cerebral ischemia: A therapeutic perspective","volume":"15","author":"Smith","year":"2004","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_13","first-page":"21","article-title":"Cerebral Autoregulation in Hypertension and Ischemic Stroke: A Mini Review","volume":"2017","author":"Shekhar","year":"2017","journal-title":"J. Pharm. Sci. Exp. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.pbb.2007.04.015","article-title":"Acute ischemic stroke: Overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia","volume":"87","author":"Durukan","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.freeradbiomed.2005.08.044","article-title":"Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia","volume":"40","author":"Hatcher","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"C135","DOI":"10.1152\/ajpcell.00136.2018","article-title":"Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke","volume":"316","author":"Yang","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuroscience.2004.06.046","article-title":"Edema and brain trauma","volume":"129","author":"Unterberg","year":"2004","journal-title":"Neuroscience"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/0166-2236(93)90156-G","article-title":"Regulation of the cerebral microcirculation during neural activity: Is nitric oxide the missing link?","volume":"16","author":"Iadecola","year":"1993","journal-title":"Trends Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110647","DOI":"10.1016\/j.biopha.2020.110647","article-title":"The Role of Transient Receptor Potential Channels in Blood-Brain Barrier Dysfunction after Ischemic Stroke","volume":"131","author":"Huang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/jnc.12045","article-title":"TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity","volume":"123","author":"Li","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-94-024-1088-4_6","article-title":"TRPC Channels and Stroke","volume":"976","author":"Huang","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1172\/JCI43165","article-title":"Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats","volume":"120","author":"Du","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Liang, J., and Zhang, Z. (2020). Higher Peripheral Blood MiR-488 Level Predicts Poor Prognosis of Acute Ischemic Stroke. Clin. Lab., 66.","DOI":"10.7754\/Clin.Lab.2020.191230"},{"key":"ref_24","first-page":"3551","article-title":"miR-135b levels in the peripheral blood serve as a marker associated with acute ischemic stroke","volume":"19","author":"Yang","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1097-2765(02)00448-3","article-title":"A unified nomenclature for the superfamily of TRP cation channels","volume":"9","author":"Montell","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.pharmthera.2006.05.013","article-title":"Cation channels of the transient receptor potential superfamily: Their role in physiological and pathophysiological processes of smooth muscle cells","volume":"112","author":"Dietrich","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"a003962","DOI":"10.1101\/cshperspect.a003962","article-title":"The role of transient receptor potential cation channels in Ca2+ signaling","volume":"2","author":"Gees","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gualdani, R., and Gailly, P. (2020). How TRPC Channels Modulate Hippocampal Function. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113915"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1074\/jbc.M804734200","article-title":"TRPC3 activation by erythropoietin is modulated by TRPC6","volume":"284","author":"Tong","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.biochem.75.103004.142819","article-title":"TRP channels","volume":"76","author":"Venkatachalam","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1469-7793.1999.0345p.x","article-title":"Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells","volume":"518","author":"Kamouchi","year":"1999","journal-title":"J. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1083\/jcb.138.6.1333","article-title":"Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion","volume":"138","author":"Zitt","year":"1997","journal-title":"J. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/16711","article-title":"Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol","volume":"397","author":"Hofmann","year":"1999","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.yfrne.2018.05.004","article-title":"TRPCing around the hypothalamus","volume":"51","author":"Kelly","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.conb.2004.05.003","article-title":"TRP ion channels in the nervous system","volume":"14","author":"Moran","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.00021.2006","article-title":"Transient receptor potential cation channels in disease","volume":"87","author":"Nilius","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/cphy.c180034","article-title":"Transient Receptor Potential Channels and Endothelial Cell Calcium Signaling","volume":"9","author":"Thakore","year":"2019","journal-title":"Compr. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.advenzreg.2011.09.005","article-title":"Phospholipase C signaling and calcium influx","volume":"52","author":"Putney","year":"2012","journal-title":"Adv. Biol. Regul."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Chen, X., Sooch, G., Demaree, I.S., White, F.A., and Obukhov, A.G. (2020). Transient Receptor Potential Canonical (TRPC) Channels: Then and Now. Cells, 9.","DOI":"10.3390\/cells9091983"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/19336950.2017.1324003","article-title":"beta-arrestin-1: Bridging GPCRs to active TRP channels","volume":"11","author":"Chai","year":"2017","journal-title":"Channels (Austin)"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"14335","DOI":"10.1038\/ncomms14335","article-title":"Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00424-010-0847-8","article-title":"Canonical TRP channels and mechanotransduction: From physiology to disease states","volume":"460","author":"Patel","year":"2010","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ceca.2008.06.003","article-title":"Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channels","volume":"45","author":"Dyachenko","year":"2009","journal-title":"Cell Calcium"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1016\/j.biomaterials.2013.12.030","article-title":"The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation","volume":"35","author":"Lei","year":"2014","journal-title":"Biomaterials"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Nikolaev, Y.A., Cox, C.D., Ridone, P., Rohde, P.R., Cordero-Morales, J.F., Vasquez, V., Laver, D.R., and Martinac, B. (2019). Mammalian TRP ion channels are insensitive to membrane stretch. J. Cell Sci., 132.","DOI":"10.1242\/jcs.238360"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1038\/emboj.2008.233","article-title":"Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction","volume":"27","author":"Storch","year":"2008","journal-title":"EMBO J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/glia.23141","article-title":"Sphingosine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes","volume":"65","author":"Shirakawa","year":"2017","journal-title":"Glia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/jnc.14215","article-title":"TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors","volume":"143","author":"Qu","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nn835","article-title":"Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways","volume":"5","author":"Hardingham","year":"2002","journal-title":"Nat. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1161\/STROKEAHA.108.521898","article-title":"Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance","volume":"39","author":"Chen","year":"2008","journal-title":"Stroke"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1523\/JNEUROSCI.0116-07.2007","article-title":"NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo","volume":"27","author":"Liu","year":"2007","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"C1103","DOI":"10.1152\/ajpcell.00249.2007","article-title":"Mechanisms of interleukin-1beta-induced Ca2+ signals in mouse cortical astrocytes: Roles of store- and receptor-operated Ca2+ entry","volume":"293","author":"Beskina","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"119539","DOI":"10.1016\/j.biomaterials.2019.119539","article-title":"Nongenetic optical modulation of neural stem cell proliferation and neuronal\/glial differentiation","volume":"225","author":"Wang","year":"2019","journal-title":"Biomaterials"},{"key":"ref_54","first-page":"749","article-title":"Astrocytes in the optic nerve head express putative mechanosensitive channels","volume":"21","author":"Choi","year":"2015","journal-title":"Mol. Vis."},{"key":"ref_55","first-page":"523","article-title":"TRPC6: An underlying target for human glaucoma","volume":"5","author":"Fan","year":"2012","journal-title":"Int. J. Ophthalmol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/glia.23180","article-title":"TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo","volume":"65","author":"Belkacemi","year":"2017","journal-title":"Glia"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s12035-014-9004-2","article-title":"TRPC Channels: Prominent Candidates of Underlying Mechanism in Neuropsychiatric Diseases","volume":"53","author":"Zeng","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zeitler, S., Schumacher, F., Monti, J., Anni, D., Guhathakurta, D., Kleuser, B., Friedland, K., Fejtova, A., Kornhuber, J., and Rhein, C. (2020). Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems. Cells, 9.","DOI":"10.3390\/cells9112502"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1038\/s41598-017-03404-6","article-title":"The Role of TRPC6 in the Neuroprotection of Calycosin against Cerebral Ischemic Injury","volume":"7","author":"Guo","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.12659\/MSM.904554","article-title":"Tetramethylpyrazine Protects Neurons from Oxygen-Glucose Deprivation-Induced Death","volume":"23","author":"Shao","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fnins.2017.00138","article-title":"Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca2+ Entry and Ca2+-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation","volume":"11","author":"Chen","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e205","DOI":"10.1002\/ctm2.205","article-title":"Low-glucose-sensitive TRPC6 dysfunction drives hypoglycemia-induced cognitive impairment in diabetes","volume":"10","author":"He","year":"2020","journal-title":"Clin. Transl. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00424-008-0618-y","article-title":"Functional roles of TRPC channels in the developing brain","volume":"458","author":"Tai","year":"2009","journal-title":"Pflug. Arch. Eur. J. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1523\/JNEUROSCI.3590-06.2007","article-title":"Endogenous brain-derived neurotrophic factor triggers fast calcium transients at synapses in developing dendrites","volume":"27","author":"Lang","year":"2007","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3390\/cells3020455","article-title":"Physiological Function and Characterization of TRPCs in Neurons","volume":"3","author":"Sun","year":"2014","journal-title":"Cells"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Dong, Y., Pu, K., Duan, W., Chen, H., Chen, L., and Wang, Y. (2018). Involvement of Akt\/CREB signaling pathways in the protective effect of EPA against interleukin-1beta-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons. BMC Neurosci., 19.","DOI":"10.1186\/s12868-018-0455-7"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nn1870","article-title":"TRPC channels promote cerebellar granule neuron survival","volume":"10","author":"Jia","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/10739680701762656","article-title":"Regulation of blood-brain barrier permeability by transient receptor potential type C and type v calcium-permeable channels","volume":"15","author":"Brown","year":"2008","journal-title":"Microcirculation"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00418-004-0720-y","article-title":"Expression of TRPC homologs in endothelial cells and smooth muscle layers of human arteries","volume":"122","author":"Yip","year":"2004","journal-title":"Histochem. Cell Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1002\/jcp.27234","article-title":"Muscarinic M5 receptors trigger acetylcholine-induced Ca2+ signals and nitric oxide release in human brain microvascular endothelial cells","volume":"234","author":"Zuccolo","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.1074\/jbc.M608288200","article-title":"Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin","volume":"282","author":"Singh","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1164\/rccm.201104-0717OC","article-title":"Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6","volume":"185","author":"Samapati","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/ncomms1660","article-title":"Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice","volume":"3","author":"Weissmann","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1161\/01.ATV.0000231518.86795.0f","article-title":"VEGF activates receptor-operated cation channels in human microvascular endothelial cells","volume":"26","author":"Cheng","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/10739680802220323","article-title":"VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6","volume":"15","author":"Glass","year":"2008","journal-title":"Microcirculation"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"H42","DOI":"10.1152\/ajpheart.00126.2020","article-title":"Pressure-induced constriction of the middle cerebral artery is abolished in TrpC6 knockout mice","volume":"319","author":"Nemeth","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"C1001","DOI":"10.1152\/ajpcell.00092.2016","article-title":"Local coupling of TRPC6 to ANO1\/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries","volume":"310","author":"Wang","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1161\/CIRCRESAHA.108.193227","article-title":"Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C\/diacylglycerol and phospholipase A2\/omega-hydroxylase\/20-HETE pathways","volume":"104","author":"Inoue","year":"2009","journal-title":"Circ. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1177\/0271678X18794835","article-title":"Impaired cerebral autoregulation and neurovascular coupling in middle cerebral artery stroke: Influence of severity?","volume":"39","author":"Salinet","year":"2019","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1468-1331.2010.03262.x","article-title":"Impaired neurovascular coupling in ischaemic stroke patients with large or small vessel disease","volume":"18","author":"Lin","year":"2011","journal-title":"Eur. J. Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1152\/japplphysiol.00966.2005","article-title":"Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease","volume":"100","author":"Girouard","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/hs0102.101816","article-title":"Changes of Neural Activity Correlate with the Severity of Cortical Ischemia in Patients with Unilateral Major Cerebral Artery Occlusion","volume":"33","author":"Bundo","year":"2002","journal-title":"Stroke"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuint.2019.04.005","article-title":"Astrocyte dysfunction and neurovascular impairment in neurological disorders: Correlation or causation?","volume":"128","author":"McConnell","year":"2019","journal-title":"Neurochem. Int."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"948","DOI":"10.3389\/fphys.2020.00948","article-title":"Structural and Functional Remodeling of the Brain Vasculature Following Stroke","volume":"11","author":"Lacoste","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature09613","article-title":"Glial and neuronal control of brain blood flow","volume":"468","author":"Attwell","year":"2010","journal-title":"Nature"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1161\/CIRCRESAHA.116.308427","article-title":"Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke","volume":"120","author":"Hu","year":"2017","journal-title":"Circ. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"124","DOI":"10.12997\/jla.2020.9.1.124","article-title":"Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity","volume":"9","author":"Nishida","year":"2020","journal-title":"J. Lipid Atheroscler"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"9785","DOI":"10.1096\/fj.201802811R","article-title":"TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN","volume":"33","author":"Shimauchi","year":"2019","journal-title":"FASEB J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"601324","DOI":"10.3389\/fncel.2020.601324","article-title":"The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes","volume":"14","author":"Hariharan","year":"2020","journal-title":"Front. Cell Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature13165","article-title":"Capillary pericytes regulate cerebral blood flow in health and disease","volume":"508","author":"Hall","year":"2014","journal-title":"Nature"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1523\/JNEUROSCI.2891-16.2016","article-title":"Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia","volume":"37","author":"Underly","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.neuron.2017.03.043","article-title":"Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis","volume":"94","author":"Andreone","year":"2017","journal-title":"Neuron"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41586-020-2026-1","article-title":"Caveolae in CNS arterioles mediate neurovascular coupling","volume":"579","author":"Chow","year":"2020","journal-title":"Nature"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nn.4542","article-title":"Upstream current for a downstream flow","volume":"20","author":"Filosa","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Xu, P., Xu, J., Li, Z., and Yang, Z. (2012). Expression of TRPC6 in renal cortex and hippocampus of mouse during postnatal development. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038503"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/jcbfm.2012.164","article-title":"Hyperforin attenuates brain damage induced by transient middle cerebral artery occlusion (MCAO) in rats via inhibition of TRPC6 channels degradation","volume":"33","author":"Lin","year":"2013","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.2353\/ajpath.2009.090400","article-title":"Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis","volume":"175","author":"Shukla","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/abbs\/gmz059","article-title":"Combined bone marrow stromal cells and oxiracetam treatments ameliorates acute cerebral ischemia\/reperfusion injury through TRPC6","volume":"51","author":"Wang","year":"2019","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neuroscience.2014.06.001","article-title":"IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice","volume":"274","author":"Zhang","year":"2014","journal-title":"Neuroscience"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/jnr.23529","article-title":"Brain transient receptor potential channels and stroke","volume":"93","author":"Zhang","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"7555","DOI":"10.1007\/s12035-016-0227-2","article-title":"TRPC3\/6\/7 Knockdown Protects the Brain from Cerebral Ischemia Injury via Astrocyte Apoptosis Inhibition and Effects on NF-\u043aB Translocation","volume":"54","author":"Chen","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s12975-016-0491-5","article-title":"Anesthesia in Experimental Stroke Research","volume":"7","author":"Hoffmann","year":"2016","journal-title":"Transl. Stroke Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1254\/fpj.154.138","article-title":"[Brain zinc dyshomeostasis and glial cells in ischemic stroke]","volume":"154","author":"Higashi","year":"2019","journal-title":"Nihon Yakurigaku Zasshi Folia Pharmacol. Jpn."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11906-020-1016-x","article-title":"Mechanisms of Synergistic Interactions of Diabetes and Hypertension in Chronic Kidney Disease: Role of Mitochondrial Dysfunction and ER Stress","volume":"22","author":"Wang","year":"2020","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.346.6206.237","article-title":"A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse","volume":"346","author":"Magnusson","year":"2014","journal-title":"Science"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Prikhodko, V., Chernyuk, D., Sysoev, Y., Zernov, N., Okovityi, S., and Popugaeva, E. (2020). Potential Drug Candidates to Treat TRPC6 Channel Deficiencies in the Pathophysiology of Alzheimer\u2019s Disease and Brain Ischemia. Cells, 9.","DOI":"10.3390\/cells9112351"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1096\/fj.07-8110com","article-title":"Hyperforin--a key constituent of St. John\u2019s wort specifically activates TRPC6 channels","volume":"21","author":"Leuner","year":"2007","journal-title":"FASEB J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"7500","DOI":"10.1038\/srep07500","article-title":"Protonophore properties of hyperforin are essential for its pharmacological activity","volume":"4","author":"Sell","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s12031-013-9977-8","article-title":"Neuroprotective effect of resveratrol on ischemia\/reperfusion injury in rats through TRPC6\/CREB pathways","volume":"50","author":"Lin","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3892\/mmr.2013.1543","article-title":"Neuroprotectin D1 attenuates brain damage induced by transient middle cerebral artery occlusion in rats through TRPC6\/CREB pathways","volume":"8","author":"Yao","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3892\/mmr.2013.1778","article-title":"Neuroprotection by (-)-epigallocatechin-3-gallate in a rat model of stroke is mediated through inhibition of endoplasmic reticulum stress","volume":"9","author":"Yao","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nn0507-537","article-title":"Something old, something new: BDNF-induced neuron survival requires TRPC channel function","volume":"10","author":"Sossin","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fnagi.2020.00070","article-title":"Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6","volume":"12","author":"Liu","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"146362","DOI":"10.1016\/j.brainres.2019.146362","article-title":"Efficacy of stem cell-based therapies for stroke","volume":"1722","author":"Chrostek","year":"2019","journal-title":"Brain Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuroscience.2019.06.041","article-title":"Over-Expression of TRPC6 via CRISPR Based Synergistic Activation Mediator in BMSCs Ameliorates Brain Injury in a Rat Model of Cerebral Ischemia\/Reperfusion","volume":"415","author":"Li","year":"2019","journal-title":"Neuroscience"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.2174\/0929867321666140716091229","article-title":"Effects of tetrahydrohyperforin in mouse hippocampal slices: Neuroprotection, long-term potentiation and TRPC channels","volume":"21","author":"Schuller","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ceca.2018.12.009","article-title":"Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels","volume":"78","author":"Hafner","year":"2019","journal-title":"Cell Calcium"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Vemana, H.P., Karim, Z.A., Conlon, C., and Khasawneh, F.T. (2015). A critical role for the transient receptor potential channel type 6 in human platelet activation. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125764"},{"key":"ref_120","first-page":"100685","article-title":"Mouse transient receptor potential channel type 6 selectively regulates agonist-induced platelet function","volume":"20","author":"Lin","year":"2019","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1182\/blood-2002-03-0723","article-title":"Expression and role of TRPC proteins in human platelets: Evidence that TRPC6 forms the store-independent calcium entry channel","volume":"100","author":"Hassock","year":"2002","journal-title":"Blood"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1538-7836.2011.04596.x","article-title":"Defective diacylglycerol-induced Ca2+ entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets","volume":"10","author":"Ramanathan","year":"2012","journal-title":"J. Thromb. Haemost."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1528-1167.2009.02279.x","article-title":"Flufenamic acid suppresses epileptiform activity in hippocampus by reducing excitatory synaptic transmission and neuronal excitability","volume":"51","author":"Fernandez","year":"2010","journal-title":"Epilepsia"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"454a","DOI":"10.1016\/j.bpj.2012.11.2513","article-title":"Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists","volume":"104","author":"Xu","year":"2013","journal-title":"Biophys. J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1039\/C8SC05536J","article-title":"Lipid-independent control of endothelial and neuronal TRPC3 channels by light","volume":"10","author":"Tiapko","year":"2019","journal-title":"Chem. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/mol.115.102863","article-title":"Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds","volume":"89","author":"Sawamura","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/mol.115.100792","article-title":"Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor","volume":"89","author":"Urban","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.nmd.2018.07.005","article-title":"GsMTx4-D provides protection to the D2.mdx mouse","volume":"28","author":"Ward","year":"2018","journal-title":"Neuromuscul. Disord."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1038\/jcbfm.2015.117","article-title":"20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats","volume":"35","author":"Shaik","year":"2015","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/sj.jcbfm.9600309","article-title":"Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia","volume":"26","author":"Poloyac","year":"2006","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ceca.2012.01.001","article-title":"Novel pharmacological TRPC inhibitors block hypoxia-induced vasoconstriction","volume":"51","author":"Urban","year":"2012","journal-title":"Cell Calcium"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"10156","DOI":"10.1073\/pnas.1815354116","article-title":"In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease","volume":"116","author":"Lin","year":"2019","journal-title":"Proc. Natl. Acad. Sci. 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