{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:03:10Z","timestamp":1790758990322,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Periodontitis is the inflammatory destruction of the tooth-surrounding and -supporting tissue, resulting at worst in tooth loss. Another locally aggressive disease of the oral cavity is tooth resorption (TR). This is associated with the destruction of the dental mineralized tissue. However, the underlying pathomechanisms remain unknown. The complement system, as well as mast cells (MCs), are known to be involved in osteoclastogenesis and bone loss. The complement factors C3 and C5 were previously identified as key players in periodontal disease. Therefore, we hypothesize that complement factors and MCs might play a role in alveolar bone and tooth resorption. To investigate this, we used the cat as a model because of the naturally occurring high prevalence of both these disorders in this species. Teeth, gingiva samples and serum were collected from domestic cats, which had an appointment for dental treatment under anesthesia, as well as from healthy cats. Histological analyses, immunohistochemical staining and the CH-50 and AH-50 assays revealed increased numbers of osteoclasts and MCs, as well as complement activity in cats with TR. Calcifications score in the gingiva was highest in animals that suffer from TR. This indicates that MCs and the complement system are involved in the destruction of the mineralized tissue in this condition.<\/jats:p>","DOI":"10.3390\/ijms22052759","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T12:08:01Z","timestamp":1615291681000},"page":"2759","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased Presence of Complement Factors and Mast Cells in Alveolar Bone and Tooth Resorption"],"prefix":"10.3390","volume":"22","author":[{"given":"Kathrin","family":"Luntzer","sequence":"first","affiliation":[{"name":"Center for Trauma Research Ulm (ZTF), University of Ulm, 89081 Ulm, Germany"},{"name":"Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, University Medical Center, 89081 Ulm, Germany"},{"name":"Small Animal Clinic Ravensburg Evidensia GmbH, Eywiesenstra\u00dfe 4, 88212 Ravensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Lackner","sequence":"additional","affiliation":[{"name":"Center for Trauma Research Ulm (ZTF), University of Ulm, 89081 Ulm, Germany"},{"name":"Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, University Medical Center, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Weber","sequence":"additional","affiliation":[{"name":"Center for Trauma Research Ulm (ZTF), University of Ulm, 89081 Ulm, Germany"},{"name":"Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, University Medical Center, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9789-6189","authenticated-orcid":false,"given":"Yvonne","family":"M\u00f6dinger","sequence":"additional","affiliation":[{"name":"Center for Trauma Research Ulm (ZTF), University of Ulm, 89081 Ulm, Germany"},{"name":"Institute of Orthopedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-1979","authenticated-orcid":false,"given":"Anita","family":"Ignatius","sequence":"additional","affiliation":[{"name":"Center for Trauma Research Ulm (ZTF), University of Ulm, 89081 Ulm, Germany"},{"name":"Institute of Orthopedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Gebhard","sequence":"additional","affiliation":[{"name":"Center for Trauma Research Ulm (ZTF), University of Ulm, 89081 Ulm, Germany"},{"name":"Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, University Medical Center, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann-Yvonne","family":"Mihaljevic","sequence":"additional","affiliation":[{"name":"Im Andermannsberg 45, 88212 Ravensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-2613","authenticated-orcid":false,"given":"Melanie","family":"Haffner-Luntzer","sequence":"additional","affiliation":[{"name":"Center for Trauma Research Ulm (ZTF), University of Ulm, 89081 Ulm, Germany"},{"name":"Institute of Orthopedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1474-0785","authenticated-orcid":false,"given":"Miriam","family":"Kalbitz","sequence":"additional","affiliation":[{"name":"Center for Trauma Research Ulm (ZTF), University of Ulm, 89081 Ulm, Germany"},{"name":"Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, University Medical Center, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1902\/jop.2007.060264","article-title":"Case Definitions for Use in Population-Based Surveillance of Periodontitis","volume":"78","author":"Page","year":"2007","journal-title":"J. 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