{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:06:57Z","timestamp":1790384817875,"version":"4.1.0"},"reference-count":173,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Obstructive sleep apnoea (OSA) is a common disease which is characterised by repetitive collapse of the upper airways during sleep resulting in chronic intermittent hypoxaemia and frequent microarousals, consequently leading to sympathetic overflow, enhanced oxidative stress, systemic inflammation, and metabolic disturbances. OSA is associated with increased risk for cardiovascular morbidity and mortality, and accelerated coagulation, platelet activation, and impaired fibrinolysis serve the link between OSA and cardiovascular disease. In this article we briefly describe physiological coagulation and fibrinolysis focusing on processes which could be altered in OSA. Then, we discuss how OSA-associated disturbances, such as hypoxaemia, sympathetic system activation, and systemic inflammation, affect these processes. Finally, we critically review the literature on OSA-related changes in markers of coagulation and fibrinolysis, discuss potential reasons for discrepancies, and comment on the clinical implications and future research needs.<\/jats:p>","DOI":"10.3390\/ijms22062834","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T04:46:53Z","timestamp":1615438013000},"page":"2834","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Coagulation and Fibrinolysis in Obstructive Sleep Apnoea"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8983-740X","authenticated-orcid":false,"given":"Andras","family":"Bikov","sequence":"first","affiliation":[{"name":"North West Lung Centre, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"},{"name":"Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester M13 9MT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Meszaros","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary"},{"name":"Department of Pulmonology and Sleep Disorders Centre, University Hospital Zurich, 8006 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-981X","authenticated-orcid":false,"given":"Esther Irene","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Sleep Disorders Centre, University Hospital Zurich, 8006 Zurich, Switzerland"},{"name":"Centre of Competence Sleep &amp; Health Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1164\/rccm.201106-0964OC","article-title":"Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: A randomized controlled trial","volume":"184","author":"Kohler","year":"2011","journal-title":"Am. 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