{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:03:33Z","timestamp":1790485413585,"version":"4.1.0"},"reference-count":73,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The possible cardioprotective effects of translocator protein (TSPO) modulation with its ligand 4\u2032-Chlorodiazepam (4\u2032-ClDzp) in isoprenaline (ISO)-induced rat myocardial infarction (MI) were evaluated, alone or in the presence of L-NAME. Wistar albino male rats (b.w. 200\u2013250 g, age 6\u20138 weeks) were divided into 4 groups (10 per group, total number N = 40), and certain substances were applied: 1. ISO 85 mg\/kg b.w. (twice), 2. ISO 85 mg\/kg b.w. (twice) + L-NAME 50 mg\/kg b.w., 3. ISO 85 mg\/kg b.w. (twice) + 4\u2032-ClDzp 0.5 mg\/kg b.w., 4. ISO 85 mg\/kg b.w. (twice) + 4\u2032-ClDzp 0.5 mg\/kg b.w. + L-NAME 50 mg\/kg b.w. Blood and cardiac tissue were sampled for myocardial injury and other biochemical markers, cardiac oxidative stress, and for histopathological evaluation. The reduction of serum levels of high-sensitive cardiac troponin T hs cTnT and tumor necrosis factor alpha (TNF-\u03b1), then significantly decreased levels of serum homocysteine Hcy, urea, and creatinine, and decreased levels of myocardial injury enzymes activities superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as lower grades of cardiac ischemic changes were demonstrated in ISO-induced MI treated with 4\u2032-ClDzp. It has been detected that co-treatment with 4\u2032-ClDzp + L-NAME changed the number of registered parameters in comparison to 4\u2032-ClDzp group, indicating that NO (nitric oxide) should be important in the effects of 4\u2032-ClDzp.<\/jats:p>","DOI":"10.3390\/ijms22062867","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T20:17:40Z","timestamp":1615493860000},"page":"2867","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Translocator Protein Modulation by 4\u2032-Chlorodiazepam and NO Synthase Inhibition Affect Cardiac Oxidative Stress, Cardiometabolic and Inflammatory Markers in Isoprenaline-Induced Rat Myocardial Infarction"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-2519","authenticated-orcid":false,"given":"Ana","family":"Ilic","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Clinical Hospital Center \u201cDr. Dragisa Misovic\u2014Dedinje\u201d, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8270-3089","authenticated-orcid":false,"given":"Dusan","family":"Todorovic","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2886-7058","authenticated-orcid":false,"given":"Slavica","family":"Mutavdzin","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Novica","family":"Boricic","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Bozic Nedeljkovic","sequence":"additional","affiliation":[{"name":"Institute for Physiology and Biochemistry \u201cIvan Djaja\u201d, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Stankovic","sequence":"additional","affiliation":[{"name":"Center for Medical Biochemistry, Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-5129","authenticated-orcid":false,"given":"Tatjana","family":"Simic","sequence":"additional","affiliation":[{"name":"Institute of Medical and Clinical Biochemistry, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Predrag","family":"Stevanovic","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Reanimatology and Intensive Care Medicine, University Clinical Hospital Center \u201cDr. Dragisa Misovic\u2014Dedinje\u201d, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8486-6527","authenticated-orcid":false,"given":"Vera","family":"Celic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinical Hospital Center \u201cDr. Dragisa Misovic\u2014Dedinje\u201d, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-9438","authenticated-orcid":false,"given":"Dragan","family":"Djuric","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijcard.2005.11.003","article-title":"The management of acute myocardial infarction in developing countries","volume":"111","author":"Abdallah","year":"2006","journal-title":"Int. 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