{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:00:29Z","timestamp":1790319629988,"version":"4.1.0"},"reference-count":213,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007642","name":"Universit\u00e0 degli Studi di Roma Tor Vergata","doi-asserted-by":"publisher","award":["Mission Sustainability: Tissue engineering to study myelination processes\u201d"],"award-info":[{"award-number":["Mission Sustainability: Tissue engineering to study myelination processes\u201d"]}],"id":[{"id":"10.13039\/501100007642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The myelin sheath wraps around axons, allowing saltatory currents to be transmitted along neurons. Several genetic, viral, or environmental factors can damage the central nervous system (CNS) myelin sheath during life. Unless the myelin sheath is repaired, these insults will lead to neurodegeneration. Remyelination occurs spontaneously upon myelin injury in healthy individuals but can fail in several demyelination pathologies or as a consequence of aging. Thus, pharmacological intervention that promotes CNS remyelination could have a major impact on patient\u2019s lives by delaying or even preventing neurodegeneration. Drugs promoting CNS remyelination in animal models have been identified recently, mostly as a result of repurposing phenotypical screening campaigns that used novel oligodendrocyte cellular models. Although none of these have as yet arrived in the clinic, promising candidates are on the way. Many questions remain. Among the most relevant is the question if there is a time window when remyelination drugs should be administrated and why adult remyelination fails in many neurodegenerative pathologies. Moreover, a significant challenge in the field is how to reconstitute the oligodendrocyte\/axon interaction environment representative of healthy as well as disease microenvironments in drug screening campaigns, so that drugs can be screened in the most appropriate disease-relevant conditions. Here we will provide an overview of how the field of in vitro models developed over recent years and recent biological findings about how oligodendrocytes mature after reactivation of their staminal niche. These data have posed novel questions and opened new views about how the adult brain is repaired after myelin injury and we will discuss how these new findings might change future drug screening campaigns for CNS regenerative drugs.<\/jats:p>","DOI":"10.3390\/ijms22062891","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T11:56:55Z","timestamp":1615550215000},"page":"2891","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Current Challenges for Drug Discovery in CNS Remyelination"],"prefix":"10.3390","volume":"22","author":[{"given":"Sonia","family":"Balestri","sequence":"first","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Viale della Ricerca Scientifica, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Del Giovane","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Viale della Ricerca Scientifica, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Sposato","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Viale della Ricerca Scientifica, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ferrarelli","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Viale della Ricerca Scientifica, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7963-7554","authenticated-orcid":false,"given":"Antonella","family":"Ragnini-Wilson","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome \u201cTor Vergata\u201d, Viale della Ricerca Scientifica, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/j.cub.2015.07.056","article-title":"CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes","volume":"25","author":"Bechler","year":"2015","journal-title":"Curr. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/s41598-018-37745-7","article-title":"Acute and Chronic Demyelinated CNS Lesions Exhibit Opposite Elastic Properties","volume":"9","author":"Urbanski","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Bribi\u00e1n, A., Medina-Rodr\u00edguez, E.M., Josa-Prado, F., Garc\u00eda-\u00c1lvarez, I., Mach\u00edn-D\u00edaz, I., Esteban, P.F., Murcia-Belmonte, V., Vega-Zelaya, L., Pastor, J., and Garrido, L. (2020). Functional Heterogeneity of Mouse and Human Brain OPCs: Relevance for Preclinical Studies in Multiple Sclerosis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061681"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00401-020-02217-8","article-title":"Extrinsic Immune Cell-Derived, but Not Intrinsic Oligodendroglial Factors Contribute to Oligodendroglial Differentiation Block in Multiple Sclerosis","volume":"140","author":"Starost","year":"2020","journal-title":"Acta Neuropathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fncel.2020.00079","article-title":"Astrocytes and Microglia as Major Players of Myelin Production in Normal and Pathological Conditions","volume":"14","author":"Traiffort","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12647","article-title":"A Regenerative Approach to the Treatment of Multiple Sclerosis","volume":"502","author":"Deshmukh","year":"2013","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature14335","article-title":"Drug-Based Modulation of Endogenous Stem Cells Promotes Functional Remyelination in Vivo","volume":"522","author":"Najm","year":"2015","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrd.2017.111","article-title":"Opportunities and Challenges in Phenotypic Drug Discovery: An Industry Perspective","volume":"16","author":"Moffatt","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrd.2017.115","article-title":"Remyelination Therapies: A New Direction and Challenge in Multiple Sclerosis","volume":"16","author":"Plemel","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S1474-4422(20)30140-X","article-title":"Remyelination in Multiple Sclerosis: From Basic Science to Clinical Translation","volume":"19","author":"Lubetzki","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1021\/acsptsci.9b00068","article-title":"Remyelination Pharmacotherapy Investigations Highlight Diverse Mechanisms Underlying Multiple Sclerosis Progression","volume":"2","author":"Melchor","year":"2019","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.3892\/mmr.2017.7186","article-title":"Implications of White Matter Damage in Amyotrophic Lateral Sclerosis (Review)","volume":"16","author":"Zhou","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1001\/archpsyc.60.5.443","article-title":"White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction","volume":"60","author":"Davis","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/S0140-6736(03)14289-4","article-title":"Oligodendrocyte Dysfunction in Schizophrenia and Bipolar Disorder","volume":"362","author":"Tkachev","year":"2003","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neulet.2005.06.051","article-title":"Polymorphisms of Myelin-Associated Glycoprotein Gene Are Associated with Schizophrenia in the Chinese Han Population","volume":"388","author":"Wan","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.pnpbp.2013.04.019","article-title":"White Matter Deficits in First Episode Schizophrenia: An Activation Likelihood Estimation Meta-Analysis","volume":"45","author":"Yao","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Rahi, S., and Mehan, S. (2020). Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals. Cell. Mol. Neurobiol.","DOI":"10.1007\/s10571-020-01010-1"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.stem.2019.08.015","article-title":"Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells","volume":"25","author":"Neumann","year":"2019","journal-title":"Cell Stem Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.tins.2016.02.004","article-title":"Pushing Forward: Remyelination as the New Frontier in CNS Diseases","volume":"39","author":"Kremer","year":"2016","journal-title":"Trends Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/ana.24620","article-title":"Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis","volume":"79","author":"Bodini","year":"2016","journal-title":"Ann. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.inffus.2017.10.007","article-title":"Deep Learning for Pixel-Level Image Fusion: Recent Advances and Future Prospects","volume":"42","author":"Liu","year":"2018","journal-title":"Inf. Fusion"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","article-title":"Brain Development in Rodents and Humans: Identifying Benchmarks of Maturation and Vulnerability to Injury across Species","volume":"106\u2013107","author":"Semple","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41591-019-0388-4","article-title":"Time to Revisit Oligodendrocytes in Multiple Sclerosis","volume":"25","author":"Nave","year":"2019","journal-title":"Nat. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00415-019-09421-x","article-title":"Promoting Remyelination in Multiple Sclerosis","volume":"268","author":"Cunniffe","year":"2021","journal-title":"J. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nrneurol.2012.200","article-title":"Neuroprotection and Repair in Multiple Sclerosis","volume":"8","author":"Franklin","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nmeth.2105","article-title":"A Culture System to Study Oligodendrocyte Myelination Processes Using Engineered Nanofibers","volume":"9","author":"Lee","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/s41598-017-18744-6","article-title":"Engineered 3D-Printed Artificial Axons","volume":"8","author":"Jagielska","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-019-0356-z","article-title":"Deep Learning for High-Throughput Quantification of Oligodendrocyte Ensheathment at Single-Cell Resolution","volume":"2","author":"Xu","year":"2019","journal-title":"Commun. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/nm.3618","article-title":"Micropillar Arrays as a High-Throughput Screening Platform for Therapeutics in Multiple Sclerosis","volume":"20","author":"Mei","year":"2014","journal-title":"Nat. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e18246","DOI":"10.7554\/eLife.18246","article-title":"Accelerated Remyelination during Inflammatory Demyelination Prevents Axonal Loss and Improves Functional Recovery","volume":"5","author":"Mei","year":"2016","journal-title":"Elife"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"134673","DOI":"10.1016\/j.neulet.2019.134673","article-title":"Mechanical Regulation of Oligodendrocyte Biology","volume":"717","author":"Makhija","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fbioe.2020.00057","article-title":"3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres","volume":"8","author":"Sharma","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Porcu, G., Serone, E., De Nardis, V., Di Giandomenico, D., Lucisano, G., Scardapane, M., Poma, A., and Ragnini-Wilson, A. (2015). Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxR\u03b3 Receptor Activation. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144550"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lariosa-Willingham, K.D., Rosler, E.S., Tung, J.S., Dugas, J.C., Collins, T.L., and Leonoudakis, D. (2016). A High Throughput Drug Screening Assay to Identify Compounds That Promote Oligodendrocyte Differentiation Using Acutely Dissociated and Purified Oligodendrocyte Precursor Cells. BMC Res. Notes, 9.","DOI":"10.1186\/s13104-016-2220-2"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s42466-019-0026-0","article-title":"An Unmet Clinical Need: Roads to Remyelination in MS","volume":"1","author":"Weyers","year":"2019","journal-title":"Neurol. Res. Pract."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41598-018-35734-4","article-title":"Remyelination Promoting Therapies in Multiple Sclerosis Animal Models: A Systematic Review and Meta-Analysis","volume":"9","author":"Hooijmans","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Nocita, E., Del Giovane, A., Tiberi, M., Boccuni, L., Fiorelli, D., Sposato, C., Romano, E., Basoli, F., Trombetta, M., and Rainer, A. (2019). EGFR\/ErbB Inhibition Promotes OPC Maturation up to Axon Engagement by Co-Regulating PIP2 and MBP. Cells, 8.","DOI":"10.3390\/cells8080844"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nn.2702","article-title":"Retinoid X Receptor Gamma Signaling Accelerates CNS Remyelination","volume":"14","author":"Huang","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_39","first-page":"1016","article-title":"Treatment with Retinoid X Receptor Agonist IRX4204 Ameliorates Experimental Autoimmune Encephalomyelitis","volume":"8","author":"Chandraratna","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"23226","DOI":"10.1016\/S0021-9258(18)54486-0","article-title":"Molecular Basis of Thyroid Hormone Regulation of Myelin Basic Protein Gene Expression in Rodent Brain","volume":"266","author":"Farsetti","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"15784","DOI":"10.1016\/S0021-9258(19)49603-8","article-title":"Characterization of Myelin Basic Protein Thyroid Hormone Response Element and Its Function in the Context of Native and Heterologous Promoter","volume":"267","author":"Farsetti","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"102015","DOI":"10.1016\/j.msard.2020.102015","article-title":"Phase I Randomized Trial of Liothyronine for Remyelination in Multiple Sclerosis: A Dose-Ranging Study with Assessment of Reliability of Visual Outcomes","volume":"41","author":"Wooliscroft","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/brain\/awq386","article-title":"Fumaric Acid Esters Exert Neuroprotective Effects in Neuroinflammation via Activation of the Nrf2 Antioxidant Pathway","volume":"134 Pt 3","author":"Linker","year":"2011","journal-title":"Brain"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1471-4159.2012.07883.x","article-title":"Quetiapine Prevents Oligodendrocyte and Myelin Loss and Promotes Maturation of Oligodendrocyte Progenitors in the Hippocampus of Global Cerebral Ischemia Mice","volume":"123","author":"Bi","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.schres.2012.04.006","article-title":"Quetiapine Enhances Oligodendrocyte Regeneration and Myelin Repair after Cuprizone-Induced Demyelination","volume":"138","author":"Zhang","year":"2012","journal-title":"Schizophr. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/cns.12154","article-title":"Quetiapine Fumarate for the Treatment of Multiple Sclerosis: Focus on Myelin Repair","volume":"19","author":"Zhornitsky","year":"2013","journal-title":"CNS Neurosci. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/jamaneurol.2015.4807","article-title":"Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis","volume":"73","author":"Negrotto","year":"2016","journal-title":"JAMA Neurol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00415-016-8341-7","article-title":"Lesion Remyelinating Activity of GSK239512 versus Placebo in Patients with Relapsing-Remitting Multiple Sclerosis: A Randomised, Single-Blind, Phase II Study","volume":"264","author":"Schwartzbach","year":"2017","journal-title":"J. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S1474-4422(19)30137-1","article-title":"Safety and Efficacy of Opicinumab in Patients with Relapsing Multiple Sclerosis (SYNERGY): A Randomised, Placebo-Controlled, Phase 2 Trial","volume":"18","author":"Cadavid","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1713648","DOI":"10.1080\/19420862.2020.1713648","article-title":"Functional Activity of Anti-LINGO-1 Antibody Opicinumab Requires Target Engagement at a Secondary Binding Site","volume":"12","author":"Hanf","year":"2020","journal-title":"MAbs"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/S0140-6736(17)32346-2","article-title":"Clemastine Fumarate as a Remyelinating Therapy for Multiple Sclerosis (ReBUILD): A Randomised, Controlled, Double-Blind, Crossover Trial","volume":"390","author":"Green","year":"2017","journal-title":"Lancet"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1217697","article-title":"ApoE-Directed Therapeutics Rapidly Clear \u03b2-Amyloid and Reverse Deficits in AD Mouse Models","volume":"335","author":"Cramer","year":"2012","journal-title":"Science"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cummings, J.L., Zhong, K., Kinney, J.W., Heaney, C., Moll-Tudla, J., Joshi, A., Pontecorvo, M., Devous, M., Tang, A., and Bena, J. (2016). Double-Blind, Placebo-Controlled, Proof-of-Concept Trial of Bexarotene Xin Moderate Alzheimer\u2019s Disease. Alzheimers Res. Ther., 8.","DOI":"10.1186\/s13195-016-0173-2"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1507\/endocrj1954.27.521","article-title":"Effects of Domperidone on Serum Prolactin Levels in Human Beings","volume":"27","author":"Fujino","year":"1980","journal-title":"Endocrinol. Jpn."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"576974","DOI":"10.1016\/j.jneuroim.2019.576974","article-title":"Domperidone-Induced Elevation of Serum Prolactin Levels and Immune Response in Multiple Sclerosis","volume":"334","author":"Koch","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1742-2094-1-3","article-title":"Effect of Pioglitazone Treatment in a Patient with Secondary Multiple Sclerosis","volume":"1","author":"Pershadsingh","year":"2004","journal-title":"J. Neuroinflamm."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1189\/jlb.0803402","article-title":"Anti-Inflammatory and Antiproliferative Actions of PPAR-Gamma Agonists on T Lymphocytes Derived from MS Patients","volume":"75","author":"Schmidt","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/S0140-6736(98)00057-9","article-title":"Interferon Beta Therapy for Multiple Sclerosis","volume":"352","author":"Goodkin","year":"1998","journal-title":"Lancet"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2165\/11591110-000000000-00000","article-title":"The Mechanism of Action of Interferon-\u03b2 in Relapsing Multiple Sclerosis","volume":"25","author":"Kieseier","year":"2011","journal-title":"CNS Drugs"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/S0140-6736(13)62242-4","article-title":"Effect of High-Dose Simvastatin on Brain Atrophy and Disability in Secondary Progressive Multiple Sclerosis (MS-STAT): A Randomised, Placebo-Controlled, Phase 2 Trial","volume":"383","author":"Chataway","year":"2014","journal-title":"Lancet"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1474-4422(17)30113-8","article-title":"Effect of High-Dose Simvastatin on Cognitive, Neuropsychiatric, and Health-Related Quality-of-Life Measures in Secondary Progressive Multiple Sclerosis: Secondary Analyses from the MS-STAT Randomised, Placebo-Controlled Trial","volume":"16","author":"Chan","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1126\/science.1254960","article-title":"Motor Skill Learning Requires Active Central Myelination","volume":"346","author":"McKenzie","year":"2014","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00401-017-1741-7","article-title":"Myelin Regulatory Factor Drives Remyelination in Multiple Sclerosis","volume":"134","author":"Duncan","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.conb.2017.09.014","article-title":"Myelin Plasticity and Behaviour\u2014Connecting the Dots","volume":"47","author":"Kaller","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/hbm.23482","article-title":"Distinct White Matter Injury Associated with Medial Temporal Lobe Atrophy in Alzheimer\u2019s versus Semantic Dementia","volume":"38","author":"Bejanin","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5114\/aoms.2018.76863","article-title":"The Role of Myelin Damage in Alzheimer\u2019s Disease Pathology","volume":"16","author":"Rejdak","year":"2020","journal-title":"Arch. Med. Sci."},{"key":"ref_67","first-page":"1089","article-title":"Meningeal B-Cell Follicles in Secondary Progressive Multiple Sclerosis Associate with Early Onset of Disease and Severe Cortical Pathology","volume":"130 Pt 4","author":"Magliozzi","year":"2007","journal-title":"Brain"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1093\/brain\/awr182","article-title":"Meningeal Inflammation Is Widespread and Linked to Cortical Pathology in Multiple Sclerosis","volume":"134 Pt 9","author":"Howell","year":"2011","journal-title":"Brain"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive Astrocytes: Production, Function, and Therapeutic Potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic Reactive Astrocytes Are Induced by Activated Microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"McMurran, C.E., Jones, C.A., Fitzgerald, D.C., and Franklin, R.J.M. (2016). CNS Remyelination and the Innate Immune System. Front. Cell Dev. Biol., 4.","DOI":"10.3389\/fcell.2016.00038"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 Microglia and Macrophages Drive Oligodendrocyte Differentiation during CNS Remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.stem.2011.11.019","article-title":"Rejuvenation of Regeneration in the Aging Central Nervous System","volume":"10","author":"Ruckh","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00415-009-0075-3","article-title":"Teriflunomide Reduces Behavioral, Electrophysiological, and Histopathological Deficits in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis","volume":"256","author":"Merrill","year":"2009","journal-title":"J. Neurol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e56621","DOI":"10.7554\/eLife.56621","article-title":"Remyelination Alters the Pattern of Myelin in the Cerebral Cortex","volume":"9","author":"Call","year":"2020","journal-title":"Elife"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41593-018-0121-5","article-title":"Myelin Remodeling through Experience-Dependent Oligodendrogenesis in the Adult Somatosensory Cortex","volume":"21","author":"Hughes","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/ncb2750","article-title":"The Quest for Myelin in the Adult Brain","volume":"15","author":"Zuccaro","year":"2013","journal-title":"Nat Cell Biol"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Del Giovane, A., and Ragnini-Wilson, A. (2018). Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113677"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tips.2014.03.002","article-title":"Targeting of Smoothened for Therapeutic Gain","volume":"35","author":"Ruat","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_80","first-page":"209","article-title":"Oligodendrocyte Progenitor Programming and Reprogramming: Toward Myelin Regeneration","volume":"1638 Pt B","author":"He","year":"2016","journal-title":"Brain Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/j.1471-4159.2006.04159.x","article-title":"Down-Regulation of WNK1 Protein Kinase in Neural Progenitor Cells Suppresses Cell Proliferation and Migration","volume":"99","author":"Sun","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1083\/jcb.201702150","article-title":"Regulation and Dysregulation of Axon Infrastructure by Myelinating Glia","volume":"216","author":"Pan","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/glia.20011","article-title":"Differential Generation of Oligodendrocytes from Human and Rodent Embryonic Spinal Cord Neural Precursors","volume":"47","author":"Chandran","year":"2004","journal-title":"Glia"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1523\/JNEUROSCI.3334-12.2013","article-title":"Sonic Hedgehog Signaling Is a Positive Oligodendrocyte Regulator during Demyelination","volume":"33","author":"Ferent","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1177\/1073858414531457","article-title":"Hedgehog: Multiple Paths for Multiple Roles in Shaping the Brain and Spinal Cord","volume":"21","author":"Ferent","year":"2015","journal-title":"Neuroscientist"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1096\/fj.14-267849","article-title":"MRT-92 Inhibits Hedgehog Signaling by Blocking Overlapping Binding Sites in the Transmembrane Domain of the Smoothened Receptor","volume":"29","author":"Hoch","year":"2015","journal-title":"FASEB J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.stemcr.2016.08.016","article-title":"Hedgehog Controls Quiescence and Activation of Neural Stem Cells in the Adult Ventricular-Subventricular Zone","volume":"7","author":"Daynac","year":"2016","journal-title":"Stem Cell Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1471-4159.2006.03896.x","article-title":"Increase of Proliferating Oligodendroglial Progenitors in the Adult Mouse Brain upon Sonic Hedgehog Delivery in the Lateral Ventricle","volume":"98","author":"Loulier","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1242\/dev.083691","article-title":"Roles for Hedgehog Signaling in Adult Organ Homeostasis and Repair","volume":"141","author":"Petrova","year":"2014","journal-title":"Development"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature14957","article-title":"Inhibition of Gli1 Mobilizes Endogenous Neural Stem Cells for Remyelination","volume":"526","author":"Samanta","year":"2015","journal-title":"Nature"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Niewiadomski, P., Niedzi\u00f3\u0142ka, S.M., Markiewicz, \u0141., U\u015bpie\u0144ski, T., Baran, B., and Chojnowska, K. (2019). Gli Proteins: Regulation in Development and Cancer. Cells, 8.","DOI":"10.3390\/cells8020147"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Rimkus, T.K., Carpenter, R.L., Qasem, S., Chan, M., and Lo, H.-W. (2016). Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors. Cancers, 8.","DOI":"10.3390\/cancers8020022"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/1873-3468.12999","article-title":"Epigenetic Modifications-Insight into Oligodendrocyte Lineage Progression, Regeneration, and Disease","volume":"592","author":"Gregath","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"E8246","DOI":"10.1073\/pnas.1802620115","article-title":"Oligodendrocyte Precursor Survival and Differentiation Requires Chromatin Remodeling by Chd7 and Chd8","volume":"115","author":"Marie","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"101592","DOI":"10.1016\/j.isci.2020.101592","article-title":"Sox17 Promotes Oligodendrocyte Regeneration by Dual Modulation of Hedgehog and Wnt Signaling","volume":"23","author":"Ming","year":"2020","journal-title":"iScience"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cell.2009.04.031","article-title":"Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination","volume":"138","author":"Emery","year":"2009","journal-title":"Cell"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"10130","DOI":"10.1073\/pnas.1821306116","article-title":"Gene Expression in Oligodendrocytes during Remyelination Reveals Cholesterol Homeostasis as a Therapeutic Target in Multiple Sclerosis","volume":"116","author":"Voskuhl","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41586-018-0360-3","article-title":"Accumulation of 8,9-Unsaturated Sterols Drives Oligodendrocyte Formation and Remyelination","volume":"560","author":"Hubler","year":"2018","journal-title":"Nature"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.devcel.2015.05.013","article-title":"Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system","volume":"34","author":"Nawaz","year":"2015","journal-title":"Dev. Cell"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.devcel.2015.06.011","article-title":"CNS Myelin Wrapping Is Driven by Actin Disassembly","volume":"34","author":"Zuchero","year":"2015","journal-title":"Dev. Cell"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mcn.2014.02.006","article-title":"LINGO-1 Regulates Oligodendrocyte Differentiation by Inhibiting ErbB2 Translocation and Activation in Lipid Rafts","volume":"60","author":"Lee","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1212\/NXI.0000000000000026","article-title":"Remyelination Therapy Goes to Trial for Multiple Sclerosis","volume":"1","author":"Brugarolas","year":"2014","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1128\/MCB.01375-08","article-title":"Convergent Functional Genomics of Oligodendrocyte Differentiation Identifies Multiple Autoinhibitory Signaling Circuits","volume":"29","author":"Gobert","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s13311-012-0152-7","article-title":"Remyelination Therapy for Multiple Sclerosis","volume":"10","author":"Keough","year":"2013","journal-title":"Neurotherapeutics"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e321","DOI":"10.1212\/NXI.0000000000000321","article-title":"Metabolomic Signatures Associated with Disease Severity in Multiple Sclerosis","volume":"4","author":"Villoslada","year":"2017","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuropharm.2015.10.010","article-title":"Oligodendrocyte Regeneration: Its Significance in Myelin Replacement and Neuroprotection in Multiple Sclerosis","volume":"110 Pt B","author":"Chamberlain","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41586-019-0903-2","article-title":"Altered Human Oligodendrocyte Heterogeneity in Multiple Sclerosis","volume":"566","author":"Agirre","year":"2019","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/glia.23607","article-title":"Diversity in the oligodendrocyte lineage: Plasticity or heterogeneity?","volume":"67","author":"Foerster","year":"2019","journal-title":"Glia"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.aaf6463","article-title":"Oligodendrocyte Heterogeneity in the Mouse Juvenile and Adult Central Nervous System","volume":"352","author":"Marques","year":"2016","journal-title":"Science"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nrn.2017.136","article-title":"Regenerating CNS Myelin\u2014From Mechanisms to Experimental Medicines","volume":"18","author":"Franklin","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/jnen\/nlz026","article-title":"Distinct Function-Related Molecular Profile of Adult Human A2B5-Positive Pre-Oligodendrocytes Versus Mature Oligodendrocytes","volume":"78","author":"Yaqubi","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41586-018-0842-3","article-title":"Dynamics of Oligodendrocyte Generation in Multiple Sclerosis","volume":"566","author":"Yeung","year":"2019","journal-title":"Nature"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2217\/nmt-2019-0024","article-title":"Diagnosis and Management of Secondary-Progressive Multiple Sclerosis: Time for Change","volume":"9","author":"Oh","year":"2019","journal-title":"Neurodegener. Dis. Manag."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41593-020-0637-3","article-title":"Motor learning promotes remyelination via new and surviving oligodendrocytes","volume":"23","author":"Bacmeister","year":"2020","journal-title":"Nat Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1021\/nl0620132","article-title":"Successful Differentiation of Mouse Neural Stem Cells on Layer-by-Layer Assembled Single-Walled Carbon Nanotube Composite","volume":"7","author":"Jan","year":"2007","journal-title":"Nano Lett."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.snb.2016.11.105","article-title":"Graphene as a New Material in Anticancer Therapy-in Vitro Studies","volume":"243","author":"Zuchowska","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1083\/jcb.10.1.67","article-title":"Ultrastructural Study of Remyelination in an Experimental Lesion in Adult Cat Spinal Cord","volume":"10","author":"Bunge","year":"1961","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1083\/jcb.109.1.273","article-title":"Movements of the Schwann Cell Nucleus Implicate Progression of the Inner (Axon-Related) Schwann Cell Process during Myelination","volume":"109","author":"Bunge","year":"1989","journal-title":"J. Cell Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0022-5320(76)80097-4","article-title":"Nonuniformity of the Oligodendroglial Ensheathment of Axons during Myelination in the Developing Rat Central Nervous System. A Serial Section Electron Microscopical Study","volume":"55","author":"Knobler","year":"1976","journal-title":"J. Ultrastruct. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/glia.21228","article-title":"CNS Live Imaging Reveals a New Mechanism of Myelination: The Liquid Croissant Model","volume":"59","author":"Sobottka","year":"2011","journal-title":"Glia"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cell.2013.11.044","article-title":"Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue","volume":"156","author":"Snaidero","year":"2014","journal-title":"Cell"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1073\/pnas.40.9.863","article-title":"The structure of the schwann cell and its relation to the axon in certain invertebrate nerve fibers","volume":"40","author":"Geren","year":"1954","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nchembio.2517","article-title":"Metabolomics-Based Discovery of a Metabolite That Enhances Oligodendrocyte Maturation","volume":"14","author":"Beyer","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00429-013-0691-7","article-title":"Localisation of N-Acetylaspartate in Oligodendrocytes\/Myelin","volume":"220","author":"Nordengen","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s11064-016-1985-y","article-title":"Oligodendrocytes Do Not Export NAA-Derived Aspartate In Vitro","volume":"42","author":"Amaral","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fnmol.2017.00161","article-title":"Increasing N-Acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease","volume":"10","author":"Appu","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/mrdd.20108","article-title":"Canavan Disease: A White Matter Disorder","volume":"12","author":"Kumar","year":"2006","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00221-016-4789-z","article-title":"The Neuronal Metabolite NAA Regulates Histone H3 Methylation in Oligodendrocytes and Myelin Lipid Composition","volume":"235","author":"Singhal","year":"2017","journal-title":"Exp. Brain Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/367572a0","article-title":"Initial Events of Myelination Involve Fyn Tyrosine Kinase Signalling","volume":"367","author":"Umemori","year":"1994","journal-title":"Nature"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1083\/jcb.200706164","article-title":"Activation of Oligodendroglial Fyn Kinase Enhances Translation of MRNAs Transported in HnRNP A2-Dependent RNA Granules","volume":"181","author":"White","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1083\/jcb.200304154","article-title":"Integrin-Linked Kinase Is Required for Laminin-2-Induced Oligodendrocyte Cell Spreading and CNS Myelination","volume":"163","author":"Chun","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"11794","DOI":"10.1523\/JNEUROSCI.0888-09.2009","article-title":"Laminin Alters Fyn Regulatory Mechanisms and Promotes Oligodendrocyte Development","volume":"29","author":"Relucio","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/35012083","article-title":"Glutamatergic Synapses on Oligodendrocyte Precursor Cells in the Hippocampus","volume":"405","author":"Bergles","year":"2000","journal-title":"Nature"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nn1162","article-title":"Synaptic Signaling between GABAergic Interneurons and Oligodendrocyte Precursor Cells in the Hippocampus","volume":"7","author":"Lin","year":"2004","journal-title":"Nat. Neurosci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1038\/s41467-019-12059-y","article-title":"Oligodendrocytes Express Synaptic Proteins That Modulate Myelin Sheath Formation","volume":"10","author":"Hughes","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"7844","DOI":"10.1038\/ncomms8844","article-title":"Nonsynaptic Junctions on Myelinating Glia Promote Preferential Myelination of Electrically Active Axons","volume":"6","author":"Wake","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/cne.901440207","article-title":"Control of Myelin Formation by Axon Caliber (with a Model of the Control Mechanism)","volume":"144","author":"Friede","year":"1972","journal-title":"J. Comp. Neurol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF00396614","article-title":"Isolation and Cultivation of Mature Oligodendroglial Cells","volume":"71","author":"Althaus","year":"1984","journal-title":"Naturwissenschaften"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/342430a0","article-title":"Target Size Regulates Calibre and Myelination of Sympathetic Axons","volume":"342","author":"Voyvodic","year":"1989","journal-title":"Nature"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/jnr.490210218","article-title":"Stimulation of Oligodendrocyte Differentiation in Culture by Growth in the Presence of a Monoclonal Antibody to Sulfated Glycolipid","volume":"21","author":"Bansal","year":"1988","journal-title":"J. Neurosci. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/jnr.490270317","article-title":"Glass Micro-Fibers: A Model System for Study of Early Events in Myelination","volume":"27","author":"Bullock","year":"1990","journal-title":"J. Neurosci. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000096509","article-title":"Coated Glass and Vicryl Microfibers as Artificial Axons","volume":"183","author":"Howe","year":"2006","journal-title":"Cells Tissues Organs"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF01540642","article-title":"Method of Production and Control of a Commercial Tissue Culture Surface","volume":"16","author":"Barker","year":"1994","journal-title":"J. Tissue Cult. Methods"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1021\/ac102897h","article-title":"Rapid Prototyping of Arrayed Microfluidic Systems in Polystyrene for Cell-Based Assays","volume":"83","author":"Young","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1089\/ten.teb.2018.0056","article-title":"The Evolution of Polystyrene as a Cell Culture Material","volume":"24","author":"Lerman","year":"2018","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1073\/pnas.1113540109","article-title":"Neurite Outgrowth Inhibitor Nogo-A Establishes Spatial Segregation and Extent of Oligodendrocyte Myelination","volume":"109","author":"Chong","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/B978-0-444-52137-8.00036-X","article-title":"Scaffolds to Promote Spinal Cord Regeneration","volume":"109","author":"Johnson","year":"2012","journal-title":"Handb. Clin. Neurol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/B978-0-444-63486-3.00016-5","article-title":"Neural ECM Mimetics","volume":"214","author":"Estrada","year":"2014","journal-title":"Prog. Brain Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuroscience.2013.11.007","article-title":"Role of Myelin Plasticity in Oscillations and Synchrony of Neuronal Activity","volume":"276","author":"Pajevic","year":"2014","journal-title":"Neuroscience"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1089\/scd.2012.0189","article-title":"Mechanical Environment Modulates Biological Properties of Oligodendrocyte Progenitor Cells","volume":"21","author":"Jagielska","year":"2012","journal-title":"Stem Cells Dev."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1039\/B610522J","article-title":"Soft Biological Materials and Their Impact on Cell Function","volume":"3","author":"Levental","year":"2007","journal-title":"Soft Matter"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"17759","DOI":"10.1073\/pnas.0606150103","article-title":"Viscoelastic Properties of Individual Glial Cells and Neurons in the CNS","volume":"103","author":"Lu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/nm1279","article-title":"Hyaluronan Accumulates in Demyelinated Lesions and Inhibits Oligodendrocyte Progenitor Maturation","volume":"11","author":"Back","year":"2005","journal-title":"Nat. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1021\/acsbiomaterials.7b00374","article-title":"Oligodendrocyte Precursor Cell Viability, Proliferation, and Morphology Is Dependent on Mesh Size and Storage Modulus in 3D Poly(Ethylene Glycol)-Based Hydrogels","volume":"3","author":"Russell","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/brain\/aws313","article-title":"Fibronectin Aggregation in Multiple Sclerosis Lesions Impairs Remyelination","volume":"136 Pt 1","author":"Stoffels","year":"2013","journal-title":"Brain"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.cellbio.19.111301.153011","article-title":"Adhesion-Dependent Cell Mechanosensitivity","volume":"19","author":"Bershadsky","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue Cells Feel and Respond to the Stiffness of Their Substrate","volume":"310","author":"Discher","year":"2005","journal-title":"Science"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1038\/ncomms7121","article-title":"The Adhesion G Protein-Coupled Receptor GPR56 Is a Cell-Autonomous Regulator of Oligodendrocyte Development","volume":"6","author":"Giera","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/ncb865","article-title":"CNS Integrins Switch Growth Factor Signalling to Promote Target-Dependent Survival","volume":"4","author":"Colognato","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1002\/jnr.21985","article-title":"A Novel Method for Isolating Schwann Cells Using the Extracellular Domain of Necl1","volume":"87","author":"Spiegel","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1021\/bm401558c","article-title":"Nanofibers Support Oligodendrocyte Precursor Cell Growth and Function as a Neuron-Free Model for Myelination Study","volume":"15","author":"Li","year":"2014","journal-title":"Biomacromolecules"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.semcancer.2005.05.004","article-title":"Matrigel: Basement Membrane Matrix with Biological Activity","volume":"15","author":"Kleinman","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2014.06.005","article-title":"Matrigel: From Discovery and ECM Mimicry to Assays and Models for Cancer Research","volume":"79\u201380","author":"Benton","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/pmic.200900758","article-title":"Matrigel: A Complex Protein Mixture Required for Optimal Growth of Cell Culture","volume":"10","author":"Hughes","year":"2010","journal-title":"Proteomics"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1073\/pnas.87.10.4002","article-title":"Epidermal Growth Factor or Transforming Growth Factor Alpha Is Required for Kidney Tubulogenesis in Matrigel Cultures in Serum-Free Medium","volume":"87","author":"Taub","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/jbmr.5650110312","article-title":"TGF-Beta and Basement Membrane Matrigel Stimulate the Chondrogenic Phenotype in Osteoblastic Cells Derived from Fetal Rat Calvaria","volume":"11","author":"Basic","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.nbd.2004.12.016","article-title":"Transplantation of Embryonic Stem Cells Overexpressing Bcl-2 Promotes Functional Recovery after Transient Cerebral Ischemia","volume":"19","author":"Wei","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/jcbfm.2009.219","article-title":"Transplantation of Human Neural Precursor Cells in Matrigel Scaffolding Improves Outcome from Focal Cerebral Ischemia after Delayed Postischemic Treatment in Rats","volume":"30","author":"Jin","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neures.2011.12.005","article-title":"Defining and Designing Polymers and Hydrogels for Neural Tissue Engineering","volume":"72","author":"Aurand","year":"2012","journal-title":"Neurosci. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1021\/acs.biomac.9b00891","article-title":"Synthetic 3D PEG-Anisogel Tailored with Fibronectin Fragments Induce Aligned Nerve Extension","volume":"20","author":"Licht","year":"2019","journal-title":"Biomacromolecules"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1021\/acs.biomac.0c01164","article-title":"3D Hyaluronic Acid Hydrogels for Modeling Oligodendrocyte Progenitor Cell Behavior as a Function of Matrix Stiffness","volume":"21","author":"Unal","year":"2020","journal-title":"Biomacromolecules"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1016\/j.biomaterials.2010.01.125","article-title":"The Effects of Hyaluronic Acid Hydrogels with Tunable Mechanical Properties on Neural Progenitor Cell Differentiation","volume":"31","author":"Seidlits","year":"2010","journal-title":"Biomaterials"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1021\/acs.chemrev.6b00520","article-title":"Functional Graphene Nanomaterials Based Architectures: Biointeractions, Fabrications, and Emerging Biological Applications","volume":"117","author":"Cheng","year":"2017","journal-title":"Chem. Rev."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.msec.2016.11.114","article-title":"Graphene Oxide as a Nanocarrier for Controlled Release and Targeted Delivery of an Anticancer Active Agent, Chlorogenic Acid","volume":"74","author":"Barahuie","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.7314\/APJCP.2013.14.11.6925","article-title":"PAMAM Dendrimers Augment Inhibitory Effects of Curcumin on Cancer Cell Proliferation: Possible Inhibition of Telomerase","volume":"14","author":"Mollazade","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/21691401.2014.927880","article-title":"Graphene: Synthesis, Bio-Applications, and Properties","volume":"44","author":"Abbasi","year":"2016","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/adhm.201500056","article-title":"Directed Neural Stem Cell Differentiation with a Functionalized Graphene Oxide Nanocomposite","volume":"4","author":"Weaver","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1002\/adma.201400523","article-title":"Guiding Stem Cell Differentiation into Oligodendrocytes Using Graphene-Nanofiber Hybrid Scaffolds","volume":"26","author":"Shah","year":"2014","journal-title":"Adv. Mater."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/glia.10282","article-title":"Transplantation of Glial-Restricted Precursor Cells into the Adult Spinal Cord: Survival, Glial-Specific Differentiation, and Preferential Migration in White Matter","volume":"45","author":"Han","year":"2004","journal-title":"Glia"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.1523\/JNEUROSCI.1065-05.2005","article-title":"Functional Recovery in Traumatic Spinal Cord Injury after Transplantation of Multineurotrophin-Expressing Glial-Restricted Precursor Cells","volume":"25","author":"Cao","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuropharm.2010.04.014","article-title":"Drug Reprofiling Using Zebrafish Identifies Novel Compounds with Potential Pro-Myelination Effects","volume":"59","author":"Buckley","year":"2010","journal-title":"Neuropharmacology"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1242\/dmm.001248","article-title":"Zebrafish Myelination: A Transparent Model for Remyelination?","volume":"1","author":"Buckley","year":"2008","journal-title":"Dis. Model. Mech."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<781::AID-JNR14>3.0.CO;2-4","article-title":"Partial Characterization of the 5\u2032-Flanking Region of Trout IP: A Po-like Gene Containing a PLP-like Promoter","volume":"50","author":"Jeserich","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12031-008-9035-0","article-title":"Features and Functions of Oligodendrocytes and Myelin Proteins of Lower Vertebrate Species","volume":"35","author":"Jeserich","year":"2008","journal-title":"J. Mol. Neurosci."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"14128","DOI":"10.1523\/JNEUROSCI.3491-13.2014","article-title":"Adult neural precursor cells from the subventricular zone contribute significantly to oligodendrocyte regeneration and remyelination","volume":"34","author":"Xing","year":"2014","journal-title":"J Neurosci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1460-9568.1995.tb01115.x","article-title":"Lines of Murine Oligodendroglial Precursor Cells Immortalized by an Activated Neu Tyrosine Kinase Show Distinct Degrees of Interaction with Axons in Vitro and in Vivo","volume":"7","author":"Jung","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fncel.2013.00284","article-title":"Axon-Glia Interaction and Membrane Traffic in Myelin Formation","volume":"7","author":"White","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1007\/s11064-010-0318-9","article-title":"Glial Cell Lines: An Overview","volume":"35","author":"Boullerne","year":"2010","journal-title":"Neurochem. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-60761-691-7_2","article-title":"Isolation and Maintenance of Mouse Epiblast Stem Cells","volume":"636","author":"Chenoweth","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1242\/dev.116061","article-title":"The Pluripotent State in Mouse and Human","volume":"142","author":"Davidson","year":"2015","journal-title":"Development"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nature05972","article-title":"New Cell Lines from Mouse Epiblast Share Defining Features with Human Embryonic Stem Cells","volume":"448","author":"Tesar","year":"2007","journal-title":"Nature"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1002\/jnr.22434","article-title":"Chemical Inducers and Transcriptional Markers of Oligodendrocyte Differentiation","volume":"88","author":"Joubert","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fphar.2016.00206","article-title":"Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish","volume":"7","author":"Ashikawa","year":"2016","journal-title":"Front. Pharmacol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddy186","article-title":"Drug Screening for Human Genetic Diseases Using IPSC Models","volume":"27","author":"Elitt","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41576-019-0100-z","article-title":"Induced Pluripotent Stem Cells in Disease Modelling and Drug Discovery","volume":"20","author":"Rowe","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/glia.23733","article-title":"Stem Cell Derived Oligodendrocytes to Study Myelin Diseases","volume":"68","author":"Chanoumidou","year":"2020","journal-title":"Glia"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12929-017-0362-8","article-title":"3D Brain Organoids Derived from Pluripotent Stem Cells: Promising Experimental Models for Brain Development and Neurodegenerative Disorders","volume":"24","author":"Lee","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/nprot.2014.158","article-title":"Generation of Cerebral Organoids from Human Pluripotent Stem Cells","volume":"9","author":"Lancaster","year":"2014","journal-title":"Nat. Protoc."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/0022-3859.81870","article-title":"Drug Repositioning: Re-Investigating Existing Drugs for New Therapeutic Indications","volume":"57","author":"Padhy","year":"2011","journal-title":"J. Postgrad. Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.drudis.2019.06.014","article-title":"Drug Repurposing: A Promising Tool to Accelerate the Drug Discovery Process","volume":"24","author":"Parvathaneni","year":"2019","journal-title":"Drug Discov. Today"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"14621","DOI":"10.1073\/pnas.1000138107","article-title":"Discovery of Drug Mode of Action and Drug Repositioning from Transcriptional Responses","volume":"107","author":"Iorio","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ddstr.2011.10.002","article-title":"Drug Repurposing from an Academic Perspective","volume":"8","author":"Oprea","year":"2011","journal-title":"Drug Discov. Today Ther. Strateg."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug Repurposing: Progress, Challenges and Recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.stem.2012.12.002","article-title":"Human IPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination","volume":"12","author":"Wang","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.stem.2017.06.012","article-title":"Human IPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia","volume":"21","author":"Windrem","year":"2017","journal-title":"Cell Stem Cell"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1801850","DOI":"10.1002\/adfm.201801850","article-title":"3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds","volume":"28","author":"Joung","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1242\/dev.150201","article-title":"The Hope and the Hype of Organoid Research","volume":"144","author":"Huch","year":"2017","journal-title":"Development"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nbt1001-971","article-title":"Feeder-Free Growth of Undifferentiated Human Embryonic Stem Cells","volume":"19","author":"Xu","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cell.2016.05.082","article-title":"Modeling Development and Disease with Organoids","volume":"165","author":"Clevers","year":"2016","journal-title":"Cell"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.stem.2013.11.002","article-title":"Functional Repair of CFTR by CRISPR\/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients","volume":"13","author":"Schwank","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.drudis.2019.11.010","article-title":"CNS Organoids: An Innovative Tool for Neurological Disease Modeling and Drug Neurotoxicity Screening","volume":"25","author":"Chhibber","year":"2020","journal-title":"Drug Discov. Today"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.stemcr.2019.04.011","article-title":"Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins","volume":"12","author":"Kim","year":"2019","journal-title":"Stem Cell Rep."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1089\/ten.tea.2017.0423","article-title":"Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells","volume":"24","author":"Yan","year":"2018","journal-title":"Tissue Eng. 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