{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:39:42Z","timestamp":1788748782327,"version":"build-2803163510"},"reference-count":128,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002147; 82073618"],"award-info":[{"award-number":["82002147; 82073618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2019M662543"],"award-info":[{"award-number":["2019M662543"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["20A330004; 21A310026"],"award-info":[{"award-number":["20A330004; 21A310026"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Enteroviruses (EVs) are common RNA viruses that can cause various types of human diseases and conditions such as hand, foot, and mouth disease (HFMD), myocarditis, meningitis, sepsis, and respiratory disorders. Although EV infections in most patients are generally mild and self-limiting, a small number of young children can develop serious complications such as encephalitis, acute flaccid paralysis, myocarditis, and cardiorespiratory failure, resulting in fatalities. Established evidence has suggested that certain non-coding RNAs (ncRNAs) such as microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) are involved in the occurrence and progression of many human diseases. Recently, the involvement of ncRNAs in the course of EV infection has been reported. Herein, the authors focus on recent advances in the understanding of ncRNAs in EV infection from basic viral pathogenesis to clinical prospects, providing a reference basis and new ideas for disease prevention and research directions.<\/jats:p>","DOI":"10.3390\/ijms22062904","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T11:56:55Z","timestamp":1615550215000},"page":"2904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Essential Role of Non-Coding RNAs in Enterovirus Infection: From Basic Mechanisms to Clinical Prospects"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-0827","authenticated-orcid":false,"given":"Peiyu","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6129-0310","authenticated-orcid":false,"given":"Shuaiyin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China"},{"name":"Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangcai","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-0808","authenticated-orcid":false,"given":"Yuefei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s41579-018-0005-4","article-title":"The life cycle of non-polio enteroviruses and how to target it","volume":"16","author":"Baggen","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/QCO.0000000000000187","article-title":"The epidemiology of non-polio enteroviruses: Recent advances and outstanding questions","volume":"28","author":"Parker","year":"2015","journal-title":"Curr. Opin. Infect Dis."},{"key":"ref_4","unstructured":"Centers for Disease Control and Prevention (2011). Clusters of acute respiratory illness associated with human enterovirus 68\u2014Asia, Europe, and United States, 2008\u20132010. MMWR Morb. Mortal. Wkly. Rep., 60, 1301\u20131304."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrcardio.2015.108","article-title":"Viral myocarditis\u2014Diagnosis, treatment options, and current controversies","volume":"12","author":"Pollack","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S1473-3099(19)30632-2","article-title":"Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: An observational cohort study","volume":"20","author":"Messacar","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1348-0421.2012.00411.x","article-title":"Acute respiratory infections due to enterovirus 68 in Yamagata, Japan between 2005 and 2010","volume":"56","author":"Ikeda","year":"2012","journal-title":"Microbiol. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.diagmicrobio.2012.02.019","article-title":"Human rhinovirus and human respiratory enterovirus (EV68 and EV104) infections in hospitalized patients in Italy, 2008-2009","volume":"73","author":"Piralla","year":"2012","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_9","first-page":"1430","article-title":"Enterovirus 68 among children with severe acute respiratory infection, the Philippines","volume":"17","author":"Imamura","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.virol.2011.11.021","article-title":"Emergence and epidemic occurrence of enterovirus 68 respiratory infections in The Netherlands in 2010","volume":"423","author":"Meijer","year":"2012","journal-title":"Virology"},{"key":"ref_11","first-page":"798","article-title":"Severe respiratory illness associated with enterovirus D68\u2014Missouri and Illinois, 2014","volume":"63","author":"Midgley","year":"2014","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1152\/physrev.00041.2015","article-title":"Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches","volume":"96","author":"Beermann","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.3389\/fmicb.2018.02422","article-title":"Innate Immunity Evasion by Enteroviruses Linked to Epidemic Hand-Foot-Mouth Disease","volume":"9","author":"Jin","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.devcel.2005.01.018","article-title":"Specific effects of microRNAs on the plant transcriptome","volume":"8","author":"Schwab","year":"2005","journal-title":"Dev. Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.molcel.2010.03.013","article-title":"Posttranscriptional regulation of microRNA biogenesis in animals","volume":"38","author":"Siomi","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature03049","article-title":"Processing of primary microRNAs by the Microprocessor complex","volume":"432","author":"Denli","year":"2004","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Salzman, J., Gawad, C., Wang, P.L., Lacayo, N., and Brown, P.O. (2012). Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030733"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhang, C., Qin, L., Li, D., Zhou, G., Dang, D., Chen, S., Sun, T., Zhang, R., and Wu, W. (2018). Characterization of Critical Functions of Long Non-Coding RNAs and mRNAs in Rhabdomyosarcoma Cells and Mouse Skeletal Muscle Infected by Enterovirus 71 Using RNA-Seq. Viruses, 10.","DOI":"10.3390\/v10100556"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.bbrc.2012.11.101","article-title":"lncRNA expression signatures in response to enterovirus 71 infection","volume":"430","author":"Yin","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fcimb.2017.00133","article-title":"Analysis of miRNAs Involved in Mouse Brain Damage upon Enterovirus 71 Infection","volume":"7","author":"Yang","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Cui, L., Qi, Y., Li, H., Ge, Y., Zhao, K., Qi, X., Guo, X., Shi, Z., Zhou, M., and Zhu, B. (2011). Serum microRNA expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027071"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.bbrc.2017.09.141","article-title":"Long non-coding RNA expression profiles in different severity EV71-infected hand foot and mouth disease patients","volume":"493","author":"Meng","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Jin, J., Li, R., Jiang, C., Zhang, R., Ge, X., Liang, F., Sheng, X., Dai, W., Chen, M., and Wu, J. (2017). Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells. BMC Genom., 18.","DOI":"10.1186\/s12864-016-3253-6"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Song, J., Hu, Y., Li, J., Zheng, H., Wang, J., Guo, L., Ning, R., Li, H., Yang, Z., and Fan, H. (2017). Different microRNA profiles reveal the diverse outcomes induced by EV71 and CA16 infection in human umbilical vein endothelial cells using high-throughput sequencing. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0177657"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biocel.2016.10.011","article-title":"Different microRNA alterations contribute to diverse outcomes following EV71 and CA16 infections: Insights from high-throughput sequencing in rhesus monkey peripheral blood mononuclear cells","volume":"81","author":"Hu","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s12250-019-00152-x","article-title":"Expression Profile and Function Analysis of Long Non-coding RNAs in the Infection of Coxsackievirus B3","volume":"34","author":"Tong","year":"2019","journal-title":"Virol Sin."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"17876","DOI":"10.1038\/s41598-019-54188-w","article-title":"Construction of miRNA-target networks using microRNA profiles of CVB3-infected HeLa cells","volume":"9","author":"Yao","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.3892\/etm.2016.3607","article-title":"Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3","volume":"12","author":"Sun","year":"2016","journal-title":"Exp. Ther Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000343750","article-title":"MicroRNAs regulate the pathogenesis of CVB3-induced viral myocarditis","volume":"56","author":"Zhang","year":"2013","journal-title":"Intervirology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s00705-013-1695-6","article-title":"MicroRNA-21 and -146b are involved in the pathogenesis of murine viral myocarditis by regulating TH-17 differentiation","volume":"158","author":"Liu","year":"2013","journal-title":"Arch. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/CIRCRESAHA.112.267443","article-title":"MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis","volume":"111","author":"Corsten","year":"2012","journal-title":"Circ. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2337\/db15-0956","article-title":"Coxsackievirus B5 Infection Induces Dysregulation of microRNAs Predicted to Target Known Type 1 Diabetes Risk Genes in Human Pancreatic Islets","volume":"65","author":"Kim","year":"2016","journal-title":"Diabetes"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.febslet.2014.12.006","article-title":"miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor","volume":"589","author":"Lam","year":"2015","journal-title":"FEBS Lett"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.molmed.2016.11.003","article-title":"MicroRNA Regulation of RNA Virus Replication and Pathogenesis","volume":"23","author":"Trobaugh","year":"2017","journal-title":"Trends Mol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3389\/fcimb.2020.00312","article-title":"The Role of Non-coding RNAs in Viral Myocarditis","volume":"10","author":"Zhang","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1093\/nar\/gkt058","article-title":"MiR-10a* up-regulates coxsackievirus B3 biosynthesis by targeting the 3D-coding sequence","volume":"41","author":"Tong","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.antiviral.2011.12.004","article-title":"MiR-342-5p suppresses coxsackievirus B3 biosynthesis by targeting the 2C-coding region","volume":"93","author":"Wang","year":"2012","journal-title":"Antiviral Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00018-012-1104-4","article-title":"MicroRNA-203 enhances coxsackievirus B3 replication through targeting zinc finger protein-148","volume":"70","author":"Hemida","year":"2013","journal-title":"Cell Mol. Life Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11010-017-2947-7","article-title":"MicroRNA-20b suppresses the expression of ZFP-148 in viral myocarditis","volume":"429","author":"Xu","year":"2017","journal-title":"Mol. Cell Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1007\/s00018-013-1411-4","article-title":"MiR-126 promotes coxsackievirus replication by mediating cross-talk of ERK1\/2 and Wnt\/beta-catenin signal pathways","volume":"70","author":"Ye","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1093\/eurheartj\/ehv321","article-title":"The microRNA-221\/-222 cluster balances the antiviral and inflammatory response in viral myocarditis","volume":"36","author":"Corsten","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1128\/JVI.02655-12","article-title":"Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome","volume":"87","author":"Zheng","year":"2013","journal-title":"J. Virol."},{"key":"ref_47","first-page":"943","article-title":"MiR373 and miR542-5p regulate the replication of enterovirus 71 in rhabdomyosarcoma cells","volume":"30","author":"Yang","year":"2014","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.antiviral.2018.02.015","article-title":"Honeysuckle-encoded microRNA2911 inhibits Enterovirus 71 replication via targeting VP1 gene","volume":"152","author":"Li","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/2211-5463.12197","article-title":"miR-127-5p negatively regulates enterovirus 71 replication by directly targeting SCARB2","volume":"7","author":"Feng","year":"2017","journal-title":"FEBS Open Bio"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11262-014-1114-4","article-title":"miR-27a suppresses EV71 replication by directly targeting EGFR","volume":"49","author":"Zhang","year":"2014","journal-title":"Virus Genes"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13578-017-0135-9","article-title":"Hsa-let-7c-5p augments enterovirus 71 replication through viral subversion of cell signaling in rhabdomyosarcoma cells","volume":"7","author":"Zhou","year":"2017","journal-title":"Cell Biosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.antiviral.2015.09.016","article-title":"Enterovirus 71 induces autophagy by regulating has-miR-30a expression to promote viral replication","volume":"124","author":"Fu","year":"2015","journal-title":"Antivir. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1128\/JVI.02143-15","article-title":"Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein","volume":"90","author":"Tang","year":"2016","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chom.2010.12.001","article-title":"Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E","volume":"9","author":"Ho","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Sun, Y., Feng, L., Li, J., Xu, H., Mei, X., Feng, L., Sun, H., Gao, J., and Zhang, X. (2019). miR-545 promoted enterovirus 71 replication via directly targeting phosphatase and tensin homolog and tumor necrosis factor receptor-associated factor 6. J. Cell. Physiol.","DOI":"10.1002\/jcp.28222"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"11356","DOI":"10.1128\/JVI.01400-14","article-title":"Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response","volume":"88","author":"Xu","year":"2014","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s13238-012-2081-y","article-title":"MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-lambda1","volume":"4","author":"Li","year":"2013","journal-title":"Protein Cell"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1038\/ncomms4344","article-title":"Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon","volume":"5","author":"Ho","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.virusres.2017.05.008","article-title":"Enterovirus 71-induced has-miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1","volume":"237","author":"Feng","year":"2017","journal-title":"Virus Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Kvansakul, M. (2017). Viral Infection and Apoptosis. Viruses, 9.","DOI":"10.3390\/v9120356"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1007\/s00705-020-04783-4","article-title":"GATA1\/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells","volume":"165","author":"Zhang","year":"2020","journal-title":"Arch. Virol."},{"key":"ref_62","first-page":"565","article-title":"Research progress on pathophysiological function of SOS1 protein","volume":"70","author":"Hao","year":"2018","journal-title":"Sheng Li Xue Bao"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/B978-0-12-407696-9.00005-1","article-title":"Chapter Five\u2014Roles of Poly(ADP-Ribose) Glycohydrolase in DNA Damage and Apoptosis","volume":"Volume 304","author":"Jeon","year":"2013","journal-title":"International Review of Cell and Molecular Biology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/cmi.12401","article-title":"miR-146a and miR-370 coordinate enterovirus 71-induced cell apoptosis through targeting SOS1 and GADD45\u03b2","volume":"17","author":"Chang","year":"2015","journal-title":"Cell. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e13043","DOI":"10.1111\/cmi.13043","article-title":"Host relieves lnc-IRAK3-3-sequestered miR-891b to attenuate apoptosis in Enterovirus 71 infection","volume":"21","author":"Liao","year":"2019","journal-title":"Cell. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"16422","DOI":"10.1038\/s41598-017-16616-7","article-title":"MiR-16-5p mediates a positive feedback loop in EV71-induced apoptosis and suppresses virus replication","volume":"7","author":"Zheng","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3892\/mmr.2015.3482","article-title":"Enterovirus 71 induces apoptosis of SHSY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression","volume":"12","author":"Du","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/jmv.25482","article-title":"microRNA-34a aggravates coxsackievirus B3-induced apoptosis of cardiomyocytes through the SIRT1-p53 pathway","volume":"91","author":"Jiang","year":"2019","journal-title":"J. Med. Virol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"E103","DOI":"10.25011\/cim.v36i2.19573","article-title":"MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis","volume":"36","author":"He","year":"2013","journal-title":"Clin. Invest. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.virol.2019.01.025","article-title":"Coxsackievirus B infection induces the extracellular release of miR-590-5p, a proviral microRNA","volume":"529","author":"Germano","year":"2019","journal-title":"Virology"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Zhang, B.Y., Zhao, Z., and Jin, Z. (2016). Expression of miR-98 in myocarditis and its influence on transcription of the FAS\/FASL gene pair. Genet. Mol. Res., 15.","DOI":"10.4238\/gmr.15027627"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fendo.2018.00338","article-title":"PTEN: Tumor Suppressor and Metabolic Regulator","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Zhang, X., Gao, X., Hu, J., Xie, Y., Zuo, Y., Xu, H., and Zhu, S. (2019). ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020407"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/1040841X.2018.1499608","article-title":"miRNAs in enterovirus infection","volume":"44","author":"Engelmann","year":"2018","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/cr.2011.13","article-title":"NF-kappaB in immunobiology","volume":"21","author":"Hayden","year":"2011","journal-title":"Cell Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1261\/rna.071985.119","article-title":"MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection","volume":"26","author":"Fei","year":"2020","journal-title":"Rna"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.3892\/mmr.2015.3539","article-title":"Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection","volume":"12","author":"Chen","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_80","first-page":"3500","article-title":"A role of pre-mir-10a coding region variant in host susceptibility to coxsackie virus-induced myocarditis","volume":"19","author":"Liao","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.21037\/cdt-20-545","article-title":"The pro-apoptosis and pro-inflammation role of LncRNA HIF1A-AS1 in Coxsackievirus B3-induced myocarditis via targeting miR-138","volume":"10","author":"Cao","year":"2020","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_82","first-page":"634","article-title":"miR-217 and miR-543 downregulation mitigates inflammatory response and myocardial injury in children with viral myocarditis by regulating the SIRT1\/AMPK\/NF-\u03baB signaling pathway","volume":"45","author":"Xia","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/2211-5463.12490","article-title":"MicroR-9-5p suppresses EV71 replication through targeting NF\u03baB of the RIG-I-mediated innate immune response","volume":"8","author":"Li","year":"2018","journal-title":"FEBS Open Bio"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1002\/jcb.26567","article-title":"Effects of microrna-93 on mouse cardiac microvascular endothelial cells injury and inflammatory response by mediating SPP1 through the NF-KappaB pathway","volume":"120","author":"Ma","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1002\/jcp.27262","article-title":"PI3k\/AKT signaling pathway: Erythropoiesis and beyond","volume":"234","author":"Jafari","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fcimb.2018.00278","article-title":"Host MicroRNA hsa-miR-494-3p Promotes EV71 Replication by Directly Targeting PTEN","volume":"8","author":"Zhao","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: A 10-year update","volume":"92","author":"Kyriakis","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cell.2009.06.044","article-title":"Phosphorylation of the human microRNA-generating complex mediates MAPK\/Erk signaling","volume":"139","author":"Paroo","year":"2009","journal-title":"Cell"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s12967-019-2077-y","article-title":"The protective role of microRNA-21 against coxsackievirus B3 infection through targeting the MAP2K3\/P38 MAPK signaling pathway","volume":"17","author":"He","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1099\/jgv.0.000967","article-title":"Enterovirus 71 antagonizes the antiviral activity of host STAT3 and IL-6R with partial dependence on virus-induced miR-124","volume":"98","author":"Chang","year":"2017","journal-title":"J. Gen. Virol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4049\/jimmunol.1701692","article-title":"MicroRNA-302 Cluster Downregulates Enterovirus 71-Induced Innate Immune Response by Targeting KPNA2","volume":"201","author":"Peng","year":"2018","journal-title":"J. Immunol."},{"key":"ref_92","first-page":"450","article-title":"The effect of microRNA-21 on myocardial fibrosis in mice with chronic viral myocarditis","volume":"46","author":"Xue","year":"2018","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"ref_93","unstructured":"Cohen, J., Powderly, W.G., and Opal, S.M. (2017). 3\u2014Host Responses to Infection. Infectious Diseases, Elsevier. [4th ed.]."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/B978-0-12-387664-5.00003-0","article-title":"The control of adaptive immune responses by the innate immune system","volume":"109","author":"Schenten","year":"2011","journal-title":"Adv. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.2217\/fmb.10.101","article-title":"Type B coxsackieviruses and their interactions with the innate and adaptive immune systems","volume":"5","author":"Kemball","year":"2010","journal-title":"Future Microbiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nri2998","article-title":"Expanding TRAF function: TRAF3 as a tri-faced immune regulator","volume":"11","author":"Tseng","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Li, D., Chen, S., Zhang, W., Zhang, C., Sun, T., Du, Y., Ding, R., Gao, Y., Jin, Y., and Duan, G. (2020). MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling. Cell. Mol. Immunol.","DOI":"10.2139\/ssrn.3546029"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"12341","DOI":"10.1111\/jcmm.15720","article-title":"Long non-coding RNA MEG3 inhibits M2 macrophage polarization by activating TRAF6 via microRNA-223 down-regulation in viral myocarditis","volume":"24","author":"Xue","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/odi.13283","article-title":"Exosomes from EV71-infected oral epithelial cells can transfer miR-30a to promote EV71 infection","volume":"26","author":"Wang","year":"2020","journal-title":"Oral Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/15384101.2019.1704512","article-title":"Downregulation of miR-155-5p facilitates enterovirus 71 replication through suppression of type I IFN response by targeting FOXO3\/IRF7 pathway","volume":"19","author":"Yang","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s11658-020-00203-2","article-title":"Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome","volume":"25","author":"Tong","year":"2020","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2017.05.023","article-title":"Coordinated circRNA Biogenesis and Function with NF90\/NF110 in Viral Infection","volume":"67","author":"Li","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.molcel.2017.05.022","article-title":"Sensing Self and Foreign Circular RNAs by Intron Identity","volume":"67","author":"Chen","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Hildreth, A.D., and O\u2019Sullivan, T.E. (2019). Tissue-Resident Innate and Innate-Like Lymphocyte Responses to Viral Infection. Viruses, 11.","DOI":"10.3390\/v11030272"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1203\/01.pdr.0000238247.86041.19","article-title":"Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71","volume":"60","author":"Chang","year":"2006","journal-title":"Pediatr. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fped.2019.00283","article-title":"Long Non-coding RNA Expression Profile and Functional Analysis in Children With Acute Fulminant Myocarditis","volume":"7","author":"Liu","year":"2019","journal-title":"Front. Pediatr."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3389\/fimmu.2020.00539","article-title":"Dysregulated CD4+ T Cells and microRNAs in Myocarditis","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"22613","DOI":"10.1038\/srep22613","article-title":"Silencing MicroRNA-155 Attenuates Cardiac Injury and Dysfunction in Viral Myocarditis via Promotion of M2 Phenotype Polarization of Macrophages","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, Mechanisms, and Significance of Macrophage Plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.omtn.2020.06.017","article-title":"lncRNA AK085865 Promotes Macrophage M2 Polarization in CVB3-Induced VM by Regulating ILF2-ILF3 Complex-Mediated miRNA-192 Biogenesis","volume":"21","author":"Zhang","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.yexcr.2018.03.004","article-title":"MiR-223\/Pknox1 axis protects mice from CVB3-induced viral myocarditis by modulating macrophage polarization","volume":"366","author":"Gou","year":"2018","journal-title":"Exp. Cell Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1038\/leu.2012.106","article-title":"Impact of serum storage conditions on microRNA stability","volume":"26","author":"Grasedieck","year":"2012","journal-title":"Leukemia"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"103214","DOI":"10.1016\/j.bioorg.2019.103214","article-title":"The role of long noncoding RNA in major human disease","volume":"92","author":"Zhang","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12943-020-01286-3","article-title":"Circular RNA: Metabolism, functions and interactions with proteins","volume":"19","author":"Zhou","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"24149","DOI":"10.1038\/srep24149","article-title":"Elevated expression of circulating miR876-5p is a specific response to severe EV71 infections","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Aleshcheva, G., Pietsch, H., Escher, F., and Schultheiss, H.P. (2020). MicroRNA profiling as a novel diagnostic tool for identification of patients with inflammatory and\/or virally induced cardiomyopathies. ESC Heart Fail.","DOI":"10.1002\/ehf2.13090"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/CIRCHEARTFAILURE.114.001475","article-title":"Differential Cardiac MicroRNA Expression Predicts the Clinical Course in Human Enterovirus Cardiomyopathy","volume":"8","author":"Kuehl","year":"2015","journal-title":"Circ. Heart Fail."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12265-018-9814-0","article-title":"Circulating MicroRNAs: A Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis","volume":"11","author":"Goldberg","year":"2018","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5603\/CJ.a2019.0036","article-title":"MiR-1\/133 attenuates cardiomyocyte apoptosis and electrical remodeling in mice with viral myocarditis","volume":"27","author":"Li","year":"2020","journal-title":"Cardiol. J."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nbt0713-577","article-title":"First microRNA mimic enters clinic","volume":"31","author":"Bouchie","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa1209026","article-title":"Treatment of HCV infection by targeting microRNA","volume":"368","author":"Janssen","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/nm.1776","article-title":"Engineering microRNA responsiveness to decrease virus pathogenicity","volume":"14","author":"Kelly","year":"2008","journal-title":"Nat. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.chom.2008.08.003","article-title":"Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines","volume":"4","author":"Barnes","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11010-011-1136-3","article-title":"MicroRNA- 1 represses Cx43 expression in viral myocarditis","volume":"362","author":"Xu","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.phymed.2018.06.031","article-title":"Astragalus Root dry extract restores connexin43 expression by targeting miR-1 in viral myocarditis","volume":"46","author":"Wang","year":"2018","journal-title":"Phytomedicine"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/6\/2904\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:35:02Z","timestamp":1760160902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/6\/2904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,12]]},"references-count":128,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["ijms22062904"],"URL":"https:\/\/doi.org\/10.3390\/ijms22062904","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,12]]}}}