{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:39:30Z","timestamp":1778035170361,"version":"3.51.4"},"reference-count":181,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neurotrophic factors (NTFs) are essential for cell growth, survival, synaptic plasticity, and maintenance of specific neuronal population in the central nervous system. Multiple studies have demonstrated that alterations in the levels and activities of NTFs are related to the pathology and symptoms of neurodegenerative disorders, such as Parkinson\u2019s disease (PD), Alzheimer\u2019s disease (AD), and Huntington\u2019s disease. Hence, the key molecule that can regulate the expression of NTFs is an important target for gene therapy coupling adeno-associated virus vector (AAV) gene. We have previously reported that the Ras homolog protein enriched in brain (Rheb)\u2013mammalian target of rapamycin complex 1 (mTORC1) axis plays a vital role in preventing neuronal death in the brain of AD and PD patients. AAV transduction using a constitutively active form of Rheb exerts a neuroprotective effect through the upregulation of NTFs, thereby promoting the neurotrophic interaction between astrocytes and neurons in AD conditions. These findings suggest the role of Rheb as an important regulator of the regulatory system of NTFs to treat neurodegenerative diseases. In this review, we present an overview of the role of Rheb in neurodegenerative diseases and summarize the therapeutic potential of AAV serotype 1 (AAV1)-Rheb(S16H) transduction in the treatment of neurodegenerative disorders, focusing on diseases, such as AD and PD.<\/jats:p>","DOI":"10.3390\/ijms22063064","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T11:48:22Z","timestamp":1615981702000},"page":"3064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic Potential of AAV1-Rheb(S16H) Transduction against Neurodegenerative Diseases"],"prefix":"10.3390","volume":"22","author":[{"given":"Youngpyo","family":"Nam","sequence":"first","affiliation":[{"name":"Brain Science and Engineering Institute, Kyungpook National University, Daegu 41944, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-9563","authenticated-orcid":false,"given":"Gyeong Joon","family":"Moon","sequence":"additional","affiliation":[{"name":"Center for Cell Therapy, Asan Institute for Life Science, Asan Medical Center, Seoul 05505, Korea"},{"name":"Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul 05505, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0299-1613","authenticated-orcid":false,"given":"Sang Ryong","family":"Kim","sequence":"additional","affiliation":[{"name":"Brain Science and Engineering Institute, Kyungpook National University, Daegu 41944, Korea"},{"name":"School of Life Sciences, Kyungpook National University, Daegu 41566, Korea"},{"name":"BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dugger, B.N., and Dickson, D.W. 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