{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:42:09Z","timestamp":1790185329071,"version":"4.1.0"},"reference-count":75,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The most known effects of endogenous Cushing\u2019s syndrome are the phenotypic changes and metabolic consequences. However, hypercortisolism can exert important effects on other endocrine axes. The hypothalamus\u2013pituitary\u2013thyroid axis activity can be impaired by the inappropriate cortisol secretion, which determinates the clinical and biochemical features of the \u201ccentral hypothyroidism\u201d. These findings have been confirmed by several clinical studies, which also showed that the cure of hypercortisolism can determine the recovery of normal hypothalamus\u2013pituitary\u2013thyroid axis activity. During active Cushing\u2019s syndrome, the \u201cimmunological tolerance\u201d guaranteed by the hypercortisolism can mask, in predisposed patients, the development of autoimmune thyroid diseases, which increases in prevalence after the resolution of hypercortisolism. However, the immunological mechanism is not the only factor that contributes to this phenomenon, which probably includes also deiodinase-impaired activity. Cushing\u2019s syndrome can also have an indirect impact on thyroid function, considering that some drugs used for the medical control of hypercortisolism are associated with alterations in the thyroid function test. These considerations suggest the utility to check the thyroid function in Cushing\u2019s syndrome patients, both during the active disease and after its remission.<\/jats:p>","DOI":"10.3390\/ijms22063131","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T03:41:21Z","timestamp":1616125281000},"page":"3131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Cushing\u2019s Syndrome Effects on the Thyroid"],"prefix":"10.3390","volume":"22","author":[{"given":"Rosa Maria","family":"Paragliola","sequence":"first","affiliation":[{"name":"Department of Translational Medicine and Surgery, Unit of Endocrinology, Universit\u00e0 Cattolica del Sacro Cuore-Fondazione Policlinico \u201cGemelli\u201d IRCCS, Largo Gemelli 8, I-00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Corsello","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Surgery, Unit of Endocrinology, Universit\u00e0 Cattolica del Sacro Cuore-Fondazione Policlinico \u201cGemelli\u201d IRCCS, Largo Gemelli 8, I-00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-0502","authenticated-orcid":false,"given":"Giampaolo","family":"Papi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Surgery, Unit of Endocrinology, Universit\u00e0 Cattolica del Sacro Cuore-Fondazione Policlinico \u201cGemelli\u201d IRCCS, Largo Gemelli 8, I-00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Pontecorvi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Surgery, Unit of Endocrinology, Universit\u00e0 Cattolica del Sacro Cuore-Fondazione Policlinico \u201cGemelli\u201d IRCCS, Largo Gemelli 8, I-00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore Maria","family":"Corsello","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Surgery, Unit of Endocrinology, Universit\u00e0 Cattolica del Sacro Cuore-Fondazione Policlinico \u201cGemelli\u201d IRCCS, Largo Gemelli 8, I-00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ecl.2007.10.010","article-title":"Cushing\u2019s syndrome","volume":"37","author":"Pivonello","year":"2008","journal-title":"Endocrinol. 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