{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:36:03Z","timestamp":1765888563766,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Air Liquide Sant\u00e9 International","award":["Argon project"],"award-info":[{"award-number":["Argon project"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Argon inhalation attenuates multiorgan failure (MOF) after experimental ischemic injury. We hypothesized that this protection could involve decreased High Mobility Group Box 1 (HMGB1) systemic release. We investigated this issue in an animal model of MOF induced by aortic cross-clamping. Anesthetized rabbits were submitted to supra-coeliac aortic cross-clamping for 30 min, followed by 300 min of reperfusion. They were randomly divided into three groups (n = 7\/group). The Control group inhaled nitrogen (70%) and oxygen (30%). The Argon group was exposed to a mixture of argon (70%) and oxygen (30%). The last group inhaled nitrogen\/oxygen (70\/30%) with an administration of the HMGB1 inhibitor glycyrrhizin (4 mg\/kg i.v.) 5 min before aortic unclamping. At the end of follow-up, cardiac output was significantly higher in Argon and Glycyrrhizin vs. Control (60 \u00b1 4 and 49 \u00b1 4 vs. 33 \u00b1 8 mL\/kg\/min, respectively). Metabolic acidosis was attenuated in Argon and Glycyrrhizin vs. Control, along with reduced amount of norepinephrine to reverse arterial hypotension. This was associated with reduced interleukin-6 and HMGB1 plasma concentration in Argon and Glycyrrhizin vs. Control. End-organ damages were also attenuated in the liver and kidney in Argon and Glycyrrhizin vs. Control, respectively. Argon inhalation reduced HMGB1 blood level after experimental aortic cross-clamping and provided similar benefits to direct HMGB1 inhibition.<\/jats:p>","DOI":"10.3390\/ijms22063257","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T14:08:16Z","timestamp":1616508496000},"page":"3257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Argon Attenuates Multiorgan Failure in Relation with HMGB1 Inhibition"],"prefix":"10.3390","volume":"22","author":[{"given":"Quentin","family":"de Roux","sequence":"first","affiliation":[{"name":"Service D\u2019anesth\u00e9sie\u2013R\u00e9animation Chirurgicale, DMU CARE, DHU A\u2013TVB, H\u00f4pitaux Universitaires Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP), F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, F-94700 Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Lidouren","sequence":"additional","affiliation":[{"name":"The Mondor Institute for Biomedical Research, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, F-94700 Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agathe","family":"Kudela","sequence":"additional","affiliation":[{"name":"Service D\u2019anesth\u00e9sie\u2013R\u00e9animation Chirurgicale, DMU CARE, DHU A\u2013TVB, H\u00f4pitaux Universitaires Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP), F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, F-94700 Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Slassi","sequence":"additional","affiliation":[{"name":"The Mondor Institute for Biomedical Research, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, F-94700 Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0069-3276","authenticated-orcid":false,"given":"Matthias","family":"Kohlhauer","sequence":"additional","affiliation":[{"name":"The Mondor Institute for Biomedical Research, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, F-94700 Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Boissady","sequence":"additional","affiliation":[{"name":"The Mondor Institute for Biomedical Research, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, F-94700 Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Chalopin","sequence":"additional","affiliation":[{"name":"Air Liquide Sant\u00e9 International, Centre Innovation Paris, F-78350 Les Loges en Josas, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0945-6365","authenticated-orcid":false,"given":"G\u00e9raldine","family":"Farjot","sequence":"additional","affiliation":[{"name":"Air Liquide Sant\u00e9 International, Centre Innovation Paris, F-78350 Les Loges en Josas, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Billoet","sequence":"additional","affiliation":[{"name":"Air Liquide Sant\u00e9 International, Centre Innovation Paris, F-78350 Les Loges en Josas, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-2914","authenticated-orcid":false,"given":"Patrick","family":"Bruneval","sequence":"additional","affiliation":[{"name":"UMR 970, Paris Cardiovascular Research Center, INSERM, H\u00f4pital Europ\u00e9en Georges Pompidou, F-75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijan","family":"Ghaleh","sequence":"additional","affiliation":[{"name":"The Mondor Institute for Biomedical Research, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, F-94700 Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-4052","authenticated-orcid":false,"given":"Nicolas","family":"Mongardon","sequence":"additional","affiliation":[{"name":"Service D\u2019anesth\u00e9sie\u2013R\u00e9animation Chirurgicale, DMU CARE, DHU A\u2013TVB, H\u00f4pitaux Universitaires Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP), F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, F-94700 Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6602-939X","authenticated-orcid":false,"given":"Renaud","family":"Tissier","sequence":"additional","affiliation":[{"name":"The Mondor Institute for Biomedical Research, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Paris Est Cr\u00e9teil, F-94010 Cr\u00e9teil, France"},{"name":"The Mondor Institute for Biomedical Research, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, F-94700 Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/MCC.0b013e3283307a3b","article-title":"Is MOF an Outcome Parameter or a Transient, Adaptive State in Critical Illness?","volume":"15","author":"Mongardon","year":"2009","journal-title":"Curr. 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