{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:48:33Z","timestamp":1789872513620,"version":"4.0.1"},"reference-count":43,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003654","name":"Korea Environmental Industry and Technology Institute","doi-asserted-by":"publisher","award":["2019002490006"],"award-info":[{"award-number":["2019002490006"]}],"id":[{"id":"10.13039\/501100003654","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acrylamide is a commonly used industrial chemical that is known to be neurotoxic to mammals. However, its developmental toxicity is rarely assessed in mammalian models because of the cost and complexity involved. We used zebrafish to assess the neurotoxicity, developmental and behavioral toxicity of acrylamide. At 6 h post fertilization, zebrafish embryos were exposed to four concentrations of acrylamide (10, 30, 100, or 300 mg\/L) in a medium for 114 h. Acrylamide caused developmental toxicity characterized by yolk retention, scoliosis, swim bladder deficiency, and curvature of the body. Acrylamide also impaired locomotor activity, which was measured as swimming speed and distance traveled. In addition, treatment with 100 mg\/L acrylamide shortened the width of the brain and spinal cord, indicating neuronal toxicity. In summary, acrylamide induces developmental toxicity and neurotoxicity in zebrafish. This can be used to study acrylamide neurotoxicity in a rapid and cost-efficient manner.<\/jats:p>","DOI":"10.3390\/ijms22073518","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T16:01:57Z","timestamp":1617033717000},"page":"3518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Developmental and Neurotoxicity of Acrylamide to Zebrafish"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4703-5791","authenticated-orcid":false,"given":"Jong-Su","family":"Park","sequence":"first","affiliation":[{"name":"Biosystem Research Group, Korea Institute of Toxicology, Daejeon 34111, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-7502","authenticated-orcid":false,"given":"Palas","family":"Samanta","sequence":"additional","affiliation":[{"name":"Biosystem Research Group, Korea Institute of Toxicology, Daejeon 34111, Korea"},{"name":"Department of Environmental Science, Sukanta Mahavidyalaya, University of North Bengal, Dhupguri, West Bengal 735210, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5987-3389","authenticated-orcid":false,"given":"Sangwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Biosystem Research Group, Korea Institute of Toxicology, Daejeon 34111, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieon","family":"Lee","sequence":"additional","affiliation":[{"name":"Biosystem Research Group, Korea Institute of Toxicology, Daejeon 34111, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Woo","family":"Cho","sequence":"additional","affiliation":[{"name":"Toxic Pathology Research Group, Korea Institute of Toxicology, Daejeon 34111, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang-Suk","family":"Chun","sequence":"additional","affiliation":[{"name":"Biosystem Research Group, Korea Institute of Toxicology, Daejeon 34111, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokjoo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Molecular Toxicity Research Group, Korea Institute of Toxicology, Daejeon 34111, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Biosystem Research Group, Korea Institute of Toxicology, Daejeon 34111, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pbb.2011.12.006","article-title":"Neurobehavioral and transcriptional effects of acrylamide in juvenile rats","volume":"101","author":"Seale","year":"2012","journal-title":"Pharmacol. 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