{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:47:34Z","timestamp":1772812054391,"version":"3.50.1"},"reference-count":119,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Human cytomegalovirus (HCMV) belongs to the \u03b2-herpesvirus family, which is transmitted in almost every part of the world and is carried by more than 90% of the general population. Increasing evidence indicates that HCMV infection triggers numerous diseases by disrupting the normal physiological activity of host cells, particularly apoptosis. Apoptosis disorder plays a key role in the initiation and development of multiple diseases. However, the relationship and molecular mechanism of HCMV-related diseases and apoptosis have not yet been systematically summarized. This review aims to summarize the role of apoptosis in HCMV-related diseases and provide an insight into the molecular mechanism of apoptosis induced by HCMV infection. We summarize the literature on HCMV-related diseases and suggest novel strategies for HCMV treatment by regulating apoptosis.<\/jats:p>","DOI":"10.3390\/ijms22084106","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T12:11:00Z","timestamp":1618488660000},"page":"4106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Apoptosis Disorder, a Key Pathogenesis of HCMV-Related Diseases"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6793-4524","authenticated-orcid":false,"given":"Zhongjie","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Special Medicine, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yashuo","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Qingdao University, Qingdao 266000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianjuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Special Medicine, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fimmu.2019.00078","article-title":"Cytokine-Mediated Induction and Regulation of Tissue Damage During Cytomegalovirus Infection","volume":"10","author":"Clement","year":"2019","journal-title":"Front Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Geisler, J., Touma, J., Rahbar, A., S\u00f6derberg-Naucl\u00e9r, C., and Vetvik, K. 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