{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:32:55Z","timestamp":1790195575194,"version":"4.1.0"},"reference-count":180,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UK Research and Innovation","award":["UKRI Future Leaders Fellowship MR\/S033947\/1"],"award-info":[{"award-number":["UKRI Future Leaders Fellowship MR\/S033947\/1"]}]},{"name":"Alzheimer's Society","award":["511"],"award-info":[{"award-number":["511"]}]},{"name":"Alzheimer's Research UK","award":["ARUK-PG2019B-020"],"award-info":[{"award-number":["ARUK-PG2019B-020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neurodegenerative disorders are a highly prevalent class of diseases, whose pathological mechanisms start before the appearance of any clear symptoms. This fact has prompted scientists to search for biomarkers that could aid early treatment. These currently incurable pathologies share the presence of aberrant aggregates called amyloids in the nervous system, which are composed of specific proteins. In this review, we discuss how these proteins, their conformations and modifications could be exploited as biomarkers for diagnostic purposes. We focus on proteins that are associated with the most prevalent neurodegenerative disorders, including Alzheimer\u2019s and Parkinson\u2019s diseases, amyotrophic lateral sclerosis, and frontotemporal dementia. We also describe current challenges in detection, the most recent techniques with diagnostic potentials and possible future developments in diagnosis.<\/jats:p>","DOI":"10.3390\/ijms22084128","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T10:20:11Z","timestamp":1618568411000},"page":"4128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Diagnostic Potential of Amyloidogenic Proteins"],"prefix":"10.3390","volume":"22","author":[{"given":"Yiyun","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devkee Mahesh","family":"Vadukul","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Gialama","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Thrush","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe Thomas","family":"White","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-4420","authenticated-orcid":false,"given":"Francesco Antonio","family":"Aprile","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1017\/S0144686X19001247","article-title":"The securitisation of dementia: Socialities of securitisation on secure dementia care units","volume":"41","author":"Graham","year":"2021","journal-title":"Ageing Soc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fmolb.2015.00054","article-title":"Molecular diagnostics of neurodegenerative disorders","volume":"2","author":"Agrawal","year":"2015","journal-title":"Front. 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