{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:32:03Z","timestamp":1788571923339,"version":"build-2803163510"},"reference-count":192,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Duchenne Parent Project-Spain: 2016-2018 and 2019 Grants","award":["2016-2018 and 2019 Grants"],"award-info":[{"award-number":["2016-2018 and 2019 Grants"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>microRNAs (miRNAs) are small non-coding RNAs required for the post-transcriptional control of gene expression. MicroRNAs play a critical role in modulating muscle regeneration and stem cell behavior. Muscle regeneration is affected in muscular dystrophies, and a critical point for the development of effective strategies for treating muscle disorders is optimizing approaches to target muscle stem cells in order to increase the ability to regenerate lost tissue. Within this framework, miRNAs are emerging as implicated in muscle stem cell response in neuromuscular disorders and new methodologies to regulate the expression of key microRNAs are coming up. In this review, we summarize recent advances highlighting the potential of miRNAs to be used in conjunction with gene replacement therapies, in order to improve muscle regeneration in the context of Duchenne Muscular Dystrophy (DMD).<\/jats:p>","DOI":"10.3390\/ijms22084236","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T11:21:38Z","timestamp":1618831298000},"page":"4236","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy"],"prefix":"10.3390","volume":"22","author":[{"given":"Amelia Eva","family":"Ar\u00e1nega","sequence":"first","affiliation":[{"name":"Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje Las Lagunillas s\/n, 23009 Jaen, Spain"},{"name":"Medina Foundation, Technology Park of Health Sciences, Av. del Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-2754","authenticated-orcid":false,"given":"Estefan\u00eda","family":"Lozano-Velasco","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje Las Lagunillas s\/n, 23009 Jaen, Spain"},{"name":"Medina Foundation, Technology Park of Health Sciences, Av. del Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-4413","authenticated-orcid":false,"given":"Lara","family":"Rodriguez-Outeiri\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje Las Lagunillas s\/n, 23009 Jaen, Spain"},{"name":"Medina Foundation, Technology Park of Health Sciences, Av. del Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicitas","family":"Ram\u00edrez de Acu\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje Las Lagunillas s\/n, 23009 Jaen, Spain"},{"name":"Medina Foundation, Technology Park of Health Sciences, Av. del Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5669-7164","authenticated-orcid":false,"given":"Diego","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje Las Lagunillas s\/n, 23009 Jaen, Spain"},{"name":"Medina Foundation, Technology Park of Health Sciences, Av. del Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1343-8274","authenticated-orcid":false,"given":"Francisco","family":"Hern\u00e1ndez-Torres","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje Las Lagunillas s\/n, 23009 Jaen, Spain"},{"name":"Medina Foundation, Technology Park of Health Sciences, Av. del Conocimiento 34, 18016 Granada, Spain"},{"name":"Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Avda. de la Investigaci\u00f3n 11, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ydbio.2017.07.026","article-title":"Regulation and Phylogeny of Skeletal Muscle Regeneration","volume":"433","author":"Baghdadi","year":"2018","journal-title":"Dev. 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