{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:04:24Z","timestamp":1790438664611,"version":"4.1.0"},"reference-count":69,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"INSERM","award":["UMR-1245"],"award-info":[{"award-number":["UMR-1245"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>MgSO4 is widely used in the prevention of preterm neurological disabilities but its modes of action remain poorly established. We used a co-hybridization approach using the transcriptome in 5-day old mice treated with a single dose of MgSO4 (600 mg\/kg), and\/or exposed to hypoxia-ischemia (HI). The transcription of hundreds of genes was altered in all the groups. MgSO4 mainly produced repressions culminating 6 h after injection. Bio-statistical analysis revealed the repression of synaptogenesis and axonal development. The putative targets of MgSO4 were Mnk1 and Frm1. A behavioral study of adults did not detect lasting effects of neonatal MgSO4 and precluded NMDA-receptor-mediated side effects. The effects of MgSO4 plus HI exceeded the sum of the effects of separate treatments. MgSO4 prior to HI reduced inflammation and the innate immune response probably as a result of cytokine inhibition (Ccl2, Ifng, interleukins). Conversely, MgSO4 had little effect on HI-induced transcription by RNA-polymerase II. De novo MgSO4-HI affected mitochondrial function through the repression of genes of oxidative phosphorylation and many NAD-dehydrogenases. It also likely reduced protein translation by the repression of many ribosomal proteins, essentially located in synapses. All these effects appeared under the putative regulatory MgSO4 induction of the mTORC2 Rictor coding gene. Lasting effects through Sirt1 and Frm1 could account for this epigenetic footprint.<\/jats:p>","DOI":"10.3390\/ijms22084253","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T05:35:25Z","timestamp":1618896925000},"page":"4253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Neuroprotective Magnesium Sulfate Treatment on Brain Transcription Response to Hypoxia Ischemia in Neonate Mice"],"prefix":"10.3390","volume":"22","author":[{"given":"B\u00e9r\u00e9nice","family":"Le Dieu-Lugon","sequence":"first","affiliation":[{"name":"INSERM-UMR1245, Team 4, Epigenetics and Physiopathology of Neurodevelopmental Brain Lesions, Facult\u00e9 de M\u00e9decine et de Pharmacie, Normandie Universit\u00e9 Rouen, 22 Boulevard Gambetta, 76183 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dupr\u00e9","sequence":"additional","affiliation":[{"name":"INSERM-UMR1245, Team 4, Epigenetics and Physiopathology of Neurodevelopmental Brain Lesions, Facult\u00e9 de M\u00e9decine et de Pharmacie, Normandie Universit\u00e9 Rouen, 22 Boulevard Gambetta, 76183 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Derambure","sequence":"additional","affiliation":[{"name":"INSERM-UMR1245, Team 1, Genetic Predisposition to Cancer, Facult\u00e9 de M\u00e9decine et de Pharmacie, Normandie Universit\u00e9, 22 Boulevard Gambetta, 76183 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Janin","sequence":"additional","affiliation":[{"name":"INSERM-UMR1245, Team 4, Epigenetics and Physiopathology of Neurodevelopmental Brain Lesions, Facult\u00e9 de M\u00e9decine et de Pharmacie, Normandie Universit\u00e9 Rouen, 22 Boulevard Gambetta, 76183 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno J.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"INSERM-UMR1245, Team 4, Epigenetics and Physiopathology of Neurodevelopmental Brain Lesions, Facult\u00e9 de M\u00e9decine et de Pharmacie, Normandie Universit\u00e9 Rouen, 22 Boulevard Gambetta, 76183 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-148X","authenticated-orcid":false,"given":"St\u00e9phane","family":"Marret","sequence":"additional","affiliation":[{"name":"INSERM-UMR1245, Team 4, Epigenetics and Physiopathology of Neurodevelopmental Brain Lesions, Facult\u00e9 de M\u00e9decine et de Pharmacie, Normandie Universit\u00e9 Rouen, 22 Boulevard Gambetta, 76183 Rouen, France"},{"name":"Neonatal Pediatrics, Intensive Care Unit and Neuropediatrics, Rouen University Hospital, 1 Rue de Germont, 76031 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Arabo","sequence":"additional","affiliation":[{"name":"CURIB, CURIB, Facult\u00e9 des Sciences et Techniques, Normandie Universit\u00e9, Place Emile Blondel, 76130 Mont-Saint Aignan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-5427","authenticated-orcid":false,"given":"Philippe","family":"Leroux","sequence":"additional","affiliation":[{"name":"INSERM-UMR1245, Team 4, Epigenetics and Physiopathology of Neurodevelopmental Brain Lesions, Facult\u00e9 de M\u00e9decine et de Pharmacie, Normandie Universit\u00e9 Rouen, 22 Boulevard Gambetta, 76183 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jpeds.2016.06.053","article-title":"Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns","volume":"178","author":"Gano","year":"2016","journal-title":"J. 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