{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:19:11Z","timestamp":1791656351657,"version":"4.3.4"},"reference-count":41,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The pathogenesis of endometriosis is still controversial, although it is known that the inflammatory immune response plays a critical role in this process. The resolution of inflammation is an active process where the activation of endogenous factors allows the host tissue to maintain homeostasis. The mechanisms by which pro-resolving mediators (PRM) act in endometriosis are still little explored. Thus, this integrative review aims to synthesize the available content regarding the role of PRM in endometriosis. Experimental and in vitro studies with Lipoxin A4 demonstrate a potential inhibitory effect on endometrial lesions\u2019 progression, attenuating pro-inflammatory and angiogenic signals, inhibiting proliferative and invasive action suppressing intracellular signaling induced by cytokines and estradiol, mainly through the FPR2\/ALX. Investigations with Resolvin D1 demonstrated the inhibition of endometrial lesions and decreased pro-inflammatory factors. Annexin A1 is expressed in the endometrium and is specifically present in women with endometriosis, although the available studies are still inconsistent. Thus, we believe there is a gap in knowledge regarding the PRM pathways in patients with endometriosis. It is important to note that these substances\u2019 therapeutic potential is evident since the immune and abnormal inflammatory responses play an essential role in endometriosis development and progression.<\/jats:p>","DOI":"10.3390\/ijms22094370","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T13:59:14Z","timestamp":1619099954000},"page":"4370","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Inflammatory Role of Pro-Resolving Mediators in Endometriosis: An Integrative Review"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6024-3800","authenticated-orcid":false,"given":"C\u00e1ssia","family":"de F\u00e1veri","sequence":"first","affiliation":[{"name":"Medical Residency Program in Ginecology and Obstetric, Hospital Regional Dr. Homero Miranda Gomes, S\u00e3o Jos\u00e9 88103-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9087-0469","authenticated-orcid":false,"given":"Paula M. Poeta","family":"Fermino","sequence":"additional","affiliation":[{"name":"Department Curso de Medicina, Campus Pedra Branca, Undergraduate Medical School, Universidade Sul de Santa Catarina\u2014UNISUL, Palho\u00e7a 88137-272, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-3552","authenticated-orcid":false,"given":"Anna P.","family":"Piovezan","sequence":"additional","affiliation":[{"name":"Postgraduate Studies in Health Science Program, Universidade do Sul de Santa Catarina\u2014UNISUL, Palho\u00e7a 88137-272, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-8214","authenticated-orcid":false,"given":"Lia K.","family":"Volpato","sequence":"additional","affiliation":[{"name":"Postgraduate Studies in Health Science Program, Universidade do Sul de Santa Catarina\u2014UNISUL, Palho\u00e7a 88137-272, Brazil"},{"name":"Ginecology and Obstetric Department, Hospital Regional Dr. Homero Miranda Gomes, S\u00e3o Jos\u00e9 88103-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Giudice, L.C., and Kao, L.C. 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