{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:37:27Z","timestamp":1790127447922,"version":"4.0.1"},"reference-count":69,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Medicine RWTH Aachen University","award":["Clinician Scientist Program"],"award-info":[{"award-number":["Clinician Scientist Program"]}]},{"name":"Interdisciplinary Centre for Clinical Research IZKF Aachen","award":["junior research group"],"award-info":[{"award-number":["junior research group"]}]},{"name":"Britisch Heart Foundation","award":["CS\/14\/3\/31002"],"award-info":[{"award-number":["CS\/14\/3\/31002"]}]},{"name":"Singapore Ministry of Health\u2019s National Medical Research Council","award":["NMRC\/CSA-SI\/0011\/2017"],"award-info":[{"award-number":["NMRC\/CSA-SI\/0011\/2017"]}]},{"name":"Singapore Ministry of Health\u2019s National Medical Research Council","award":["NMRC\/CGAug16C006"],"award-info":[{"award-number":["NMRC\/CGAug16C006"]}]},{"name":"COST (European Cooperation in Science and Technology)","award":["EU-CARDIOPROTECTION CA16225"],"award-info":[{"award-number":["EU-CARDIOPROTECTION CA16225"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Phosphatidylserines are known to sustain skeletal muscle activity during intense activity or hypoxic conditions, as well as preserve neurocognitive function in older patients. Our previous studies pointed out a potential cardioprotective role of phosphatidylserine in heart ischemia. Therefore, we investigated the effects of phosphatidylserine oral supplementation in a mouse model of acute myocardial infarction (AMI). We found out that phosphatidylserine increases, significantly, the cardiomyocyte survival by 50% in an acute model of myocardial ischemia-reperfusion. Similar, phosphatidylserine reduced significantly the infarcted size by 30% and improved heart function by 25% in a chronic model of AMI. The main responsible mechanism seems to be up-regulation of protein kinase C epsilon (PKC-\u03b5), the main player of cardio-protection during pre-conditioning. Interestingly, if the phosphatidylserine supplementation is started before induction of AMI, but not after, it selectively inhibits neutrophil\u2019s activation, such as Interleukin 1 beta (IL-1\u03b2) expression, without affecting the healing and fibrosis. Thus, phosphatidylserine supplementation may represent a simple way to activate a pre-conditioning mechanism and may be a promising novel strategy to reduce infarct size following AMI and to prevent myocardial injury during myocardial infarction or cardiac surgery. Due to the minimal adverse effects, further investigation in large animals or in human are soon possible to establish the exact role of phosphatidylserine in cardiac diseases.<\/jats:p>","DOI":"10.3390\/ijms22094401","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T13:59:14Z","timestamp":1619099954000},"page":"4401","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Phosphatidylserine Supplementation as a Novel Strategy for Reducing Myocardial Infarct Size and Preventing Adverse Left Ventricular Remodeling"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2308-6543","authenticated-orcid":false,"given":"David","family":"Schumacher","sequence":"first","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Department of Anesthesiology, University Hospital, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Curaj","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Department of Geriatric Medicine, University Hospital, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Staudt","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Cordes","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5593-3623","authenticated-orcid":false,"given":"Andreea R.","family":"Dumitra\u015fcu","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7393-861X","authenticated-orcid":false,"given":"Benjamin","family":"Rolles","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Institute of Immunology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Beckers","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Intermediate Care, University Hospital, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefin","family":"Soppert","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Department of Intensive Care and Intermediate Care, University Hospital, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1088-4933","authenticated-orcid":false,"given":"Mihaela","family":"Rusu","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakine","family":"Simsekyilmaz","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinan","family":"Kneizeh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Medicine, University Hospital Aachen, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrishan J. A.","family":"Ramachandra","sequence":"additional","affiliation":[{"name":"Cardiovascular &amp; Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore"},{"name":"National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0729-4956","authenticated-orcid":false,"given":"Derek J.","family":"Hausenloy","sequence":"additional","affiliation":[{"name":"Cardiovascular &amp; Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore"},{"name":"National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore"},{"name":"Yong Loo Lin School of Medicine, National University Singapore, Singapore 169857, Singapore"},{"name":"The Hatter Cardiovascular Institute, University College London, London WC1E 6HX, UK"},{"name":"Cardiovascular Research Center, College of Medical and Health Sciences, Asia University, Taichung 41354, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1253-3272","authenticated-orcid":false,"given":"Elisa A.","family":"Liehn","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Intermediate Care, University Hospital, RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Department of Cardiology, Angiology and Intensive Medicine, University Hospital Aachen, 52074 Aachen, Germany"},{"name":"Human Genetic Laboratory, University for Medicine and Pharmacy, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"ref_1","first-page":"774","article-title":"The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: A continual challenge","volume":"38","author":"Heusch","year":"2016","journal-title":"Eur. 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