{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:57:15Z","timestamp":1760234235533,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["606614"],"award-info":[{"award-number":["606614"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["739593"],"award-info":[{"award-number":["739593"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GINOP","award":["2.1-2016-0016","2.3.2-15-2016-00022"],"award-info":[{"award-number":["2.1-2016-0016","2.3.2-15-2016-00022"]}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["128322"],"award-info":[{"award-number":["128322"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FEKUTSTRAT","award":["20765-3\/2018"],"award-info":[{"award-number":["20765-3\/2018"]}]},{"name":"Ministry of Innovation and Technology","award":["TKP-BIOImaging"],"award-info":[{"award-number":["TKP-BIOImaging"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Bc-DLFL.1 is a novel spontaneous, high-grade transplantable mouse B-cell lymphoma model for selective serosal propagation. These cells attach to the omentum and mesentery and show dissemination in mesenteric lymph nodes. We aimed to investigate its early stage spread at one day post-intraperitoneal inoculation of lymphoma cells (n = 18 mice), and its advanced stage at seven days post-inoculation with in vivo [18F]FDG-PET and [18F]PET\/MRI, and ex vivo by autoradiography and Cherenkov luminescence imaging (CLI). Of the early stage group, nine animals received intraperitoneal injections, and nine received intravenous [18F]FDG injections. The advanced stage group (n = 3) received intravenous FDG injections. In the early stage, using autoradiography we observed a marked accumulation in the mesentery after intraperitoneal FDG injection. Using other imaging methods and autoradiography, following the intravenous injection of FDG no accumulations were detected. At the advanced stage, tracer accumulation was clearly detected in mesenteric lymph nodes and in the peritoneum after intravenous administration using PET. We confirmed the results with immunohistochemistry. Our results in this model highlight the importance of local FDG administration during diagnostic imaging to precisely assess early peritoneal manifestations of other malignancies (colon, stomach, ovary). These findings also support the importance of applying topical therapies, in addition to systemic treatments in peritoneal cancer spread.<\/jats:p>","DOI":"10.3390\/ijms22094431","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T12:08:30Z","timestamp":1619179710000},"page":"4431","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intraperitoneal Glucose Transport to Micrometastasis: A Multimodal In Vivo Imaging Investigation in a Mouse Lymphoma Model"],"prefix":"10.3390","volume":"22","author":[{"given":"Zsombor","family":"Ritter","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Z\u00e1mb\u00f3","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinkai","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3363-3862","authenticated-orcid":false,"given":"D\u00e1vid","family":"Sz\u00f6ll\u0151si","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1niel","family":"Dezs\u0151","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-487X","authenticated-orcid":false,"given":"Hussain","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildik\u00f3","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolett","family":"Heged\u0171s","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, 1094 Budapest, Hungary"},{"name":"CROmed Ltd., 1047 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Tuch","sequence":"additional","affiliation":[{"name":"Lightpoint Medical Ltd., Chesham HP51PE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunal","family":"Vyas","sequence":"additional","affiliation":[{"name":"Lightpoint Medical Ltd., Chesham HP51PE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Balogh","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-0413","authenticated-orcid":false,"given":"Domokos","family":"M\u00e1th\u00e9","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, 1094 Budapest, Hungary"},{"name":"CROmed Ltd., 1047 Budapest, Hungary"},{"name":"Hungarian Centre of Excellence for Molecular Medicine, In Vivo Imaging ACF, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00259-009-1297-4","article-title":"FDG PET and PET\/CT: EANM procedure guidelines for tumour PET imaging: Version 1.0","volume":"37","author":"Boellaard","year":"2010","journal-title":"Eur. 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