{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:44:25Z","timestamp":1793321065693,"version":"4.5.0"},"reference-count":96,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agence Nationale de la Recherche (ANR)","award":["ANR-20-JPW2-0002-04"],"award-info":[{"award-number":["ANR-20-JPW2-0002-04"]}]},{"name":"France Alzheimer et Maladies apparent\u00e9es","award":["#22,2013"],"award-info":[{"award-number":["#22,2013"]}]},{"name":"Artois University","award":["BQR-ABCA7"],"award-info":[{"award-number":["BQR-ABCA7"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["DFG 263024513"],"award-info":[{"award-number":["DFG 263024513"]}]},{"name":"Ministerium f\u00fcr Wirtschaft und Wissenschaft Sachsen-Anhalt\/ Germany","award":["ZS\/2016\/05\/78617"],"award-info":[{"award-number":["ZS\/2016\/05\/78617"]}]},{"name":"Latvian Council of Science","award":["lzp-2018\/1-0275"],"award-info":[{"award-number":["lzp-2018\/1-0275"]}]},{"name":"Nasjonalforeningen","award":["16154"],"award-info":[{"award-number":["16154"]}]},{"name":"HelseS\u00d8","award":["2019054, 2019055"],"award-info":[{"award-number":["2019054, 2019055"]}]},{"name":"Barnekreftforeningen","award":["19008"],"award-info":[{"award-number":["19008"]}]},{"name":"EEA grant\/Norges grants","award":["TA\u010cR TARIMAD TO100078"],"award-info":[{"award-number":["TA\u010cR TARIMAD TO100078"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["#643417"],"award-info":[{"award-number":["#643417"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Several studies, including genome wide association studies (GWAS), have strongly suggested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer\u2019s disease (AD). This ABC transporter is now considered as an important genetic determinant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.<\/jats:p>","DOI":"10.3390\/ijms22094603","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T21:18:20Z","timestamp":1619558300000},"page":"4603","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Role of ABCA7 in Human Health and in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"22","author":[{"given":"Shiraz","family":"Dib","sequence":"first","affiliation":[{"name":"UR2465, LBHE-Blood\u2013Brain Barrier Laboratory, University Artois, 62300 Lens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7355-4213","authenticated-orcid":false,"given":"Jens","family":"Pahnke","sequence":"additional","affiliation":[{"name":"Department of Neuro-\/Pathology, University of Oslo and Oslo University Hospital, Sognsvannsveien 20, 0372 Oslo, Norway"},{"name":"LIED, University of L\u00fcbeck, Ratzenburger Allee 160, 23538 L\u00fcbeck, Germany"},{"name":"Department of Pharmacology, Faculty of Medicine, University of Latvia, Jelgavas iela 3, 1004 Riga, Latvia"},{"name":"Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-5026","authenticated-orcid":false,"given":"Fabien","family":"Gosselet","sequence":"additional","affiliation":[{"name":"UR2465, LBHE-Blood\u2013Brain Barrier Laboratory, University Artois, 62300 Lens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1002\/1873-3468.13935","article-title":"Structural and functional diversity calls for a new classification of ABC transporters","volume":"594","author":"Thomas","year":"2020","journal-title":"FEBS Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-981-13-7647-4_2","article-title":"ABC Family Transporters","volume":"1141","author":"Liu","year":"2019","journal-title":"Adv. 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