{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:39:22Z","timestamp":1792035562074,"version":"4.4.0"},"reference-count":79,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009409","name":"Russian Science Support Foundation","doi-asserted-by":"publisher","award":["18-15-00046"],"award-info":[{"award-number":["18-15-00046"]}],"id":[{"id":"10.13039\/100009409","id-type":"DOI","asserted-by":"publisher"}]},{"name":"government assignment for FRC Kazan Scientific Center of RAS","award":["\u0410\u0410\u0410\u0410-\u041018-118022790083-9"],"award-info":[{"award-number":["\u0410\u0410\u0410\u0410-\u041018-118022790083-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Adrenoceptor activators and blockers are widely used clinically for the treatment of cardiovascular and pulmonary disorders. More recently, adrenergic agents have also been used to treat neurodegenerative diseases. Recent studies indicate a location of sympathetic varicosities in close proximity to neuromuscular junctions. The pressing question is whether there could be any effects of endo- or exogenous catecholamines on cholinergic neuromuscular transmission. It was shown that the pharmacological stimulation of adrenoceptors, as well as sympathectomy, can affect both acetylcholine release from motor nerve terminals and the functioning of postsynaptic acetylcholine receptors. In this review, we discuss the recent data regarding the effects of adrenergic drugs on neurotransmission at the neuromuscular junction. The elucidation of the molecular mechanisms by which the clinically relevant adrenomimetics and adrenoblockers regulate quantal acetylcholine release from the presynaptic nerve terminals and postsynaptic sensitivity may help in the design of highly effective and well-tolerated sympathomimetics for treating a number of neurodegenerative diseases accompanied by synaptic defects.<\/jats:p>","DOI":"10.3390\/ijms22094611","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T10:41:58Z","timestamp":1619606518000},"page":"4611","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction"],"prefix":"10.3390","volume":"22","author":[{"given":"Ellya","family":"Bukharaeva","sequence":"first","affiliation":[{"name":"Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 420111 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venera","family":"Khuzakhmetova","sequence":"additional","affiliation":[{"name":"Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 420111 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Dmitrieva","sequence":"additional","affiliation":[{"name":"Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 420111 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Tsentsevitsky","sequence":"additional","affiliation":[{"name":"Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 420111 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rudolf, R., Khan, M., and Witzemann, V. (2019). Motor endplate\u2014Anatomical, functional, and molecular concepts in the historical perspective. Cells, 8.","DOI":"10.3390\/cells8050387"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lepore, E., Casola, I., Dobrowolny, G., and Musar\u00f2, A. (2019). Neuromuscular junction as an entity of nerve-muscle communication. Cells, 8.","DOI":"10.3390\/cells8080906"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"610964","DOI":"10.3389\/fnmol.2020.610964","article-title":"The Neuromuscular Junction in Health and Disease: Molecular Mechanisms Governing Synaptic Formation and Homeostasis","volume":"13","author":"Cruz","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1113\/jphysiol.1895.sp000564","article-title":"The physiological effects of extracts of the suprarenal capsules","volume":"18","author":"Oliver","year":"1895","journal-title":"J. Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1113\/jphysiol.1897.sp000680","article-title":"On the general physiological effects of extracts of the suprarenal capsules","volume":"22","author":"Vincent","year":"1897","journal-title":"J. Physiol."},{"key":"ref_6","first-page":"194","article-title":"Die sympatetische Innervation der Skelettmuskeln","volume":"6","author":"Orbeli","year":"1923","journal-title":"Bull. Inst. Sci. Leshaft."},{"key":"ref_7","first-page":"139","article-title":"The influence of the sympathetic nervous system on the function of the striated muscle","volume":"6","author":"Ginetsinsky","year":"1923","journal-title":"Russ. Fiziol. Zhurnal"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1093\/hmg\/ddz059","article-title":"Salbutamol modifies the neuromuscular junction in a mouse model of ColQ myasthenic syndrome","volume":"28","author":"McMacken","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13195","DOI":"10.1111\/apha.13195","article-title":"The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability","volume":"225","author":"Rodrigues","year":"2019","journal-title":"Acta Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1093\/brain\/awz322","article-title":"b2-Adrenergic receptor agonists ameliorate the adverse effect of long-term pyridostigmine on neuromuscular junction structure","volume":"142","author":"Vanhaesebrouck","year":"2019","journal-title":"BRAIN"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/gerona\/glaa022","article-title":"Aging Blunts Sympathetic Neuron Regulation of Motoneurons Synaptic Vesicle Release Mediated by \u03b21\u2013 and \u03b12B\u2013Adrenergic Receptors in Geriatric Mice","volume":"75","author":"Wang","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"103563","DOI":"10.1016\/j.mcn.2020.103563","article-title":"Postganglionic sympathetic neurons, but not locus coeruleus optostimulation, activates neuromuscular transmission in the adult mouse in vivo","volume":"109","author":"Wang","year":"2020","journal-title":"Cell. Mol. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"101305","DOI":"10.1016\/j.arr.2021.101305","article-title":"The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia","volume":"67","author":"Delbono","year":"2021","journal-title":"Age Res. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S1474-4422(14)70201-7","article-title":"Congenital myasthenic syndromes: Pathogenesis, diagnosis, and treatment","volume":"14","author":"Engel","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Cruz, P.M.R., Palace, J., and Beeson, D. (2018). The neuromuscular junction and wide heterogeneity of congenital myasthenic syndromes. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061677"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.nmd.2012.11.004","article-title":"Salbutamol benefits children with congenital myasthenic syndrome due to DOK7mutations","volume":"23","author":"Burke","year":"2013","journal-title":"Neuromuscul. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1093\/hmg\/ddaa116","article-title":"Effect of salbutamol on neuromuscular junction function and structure in a mouse model of DOK7 congenital myasthenia","volume":"29","author":"Webster","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ghazanfari, N., Morsch, M., Tse, N., Reddel, S.W., and Phillips, W.D. (2014). Effects of the \u00df2-adrenoceptor agonist, albuterol, in a mouse model of anti-MuSK myasthenia gravis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087840"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.nbd.2015.10.006","article-title":"\u03b22-Adrenoceptor agonists as novel, safe and potentially effective therapies for Amyotrophic lateral sclerosis (ALS)","volume":"85","author":"Bartus","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fnmol.2020.00086","article-title":"Myasthenia Gravis: From the viewpoint of pathogenicity focusing on acetylcholine receptor clustering, trans\u2013synaptic homeostasis and synaptic stability","volume":"13","author":"Takamori","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Limanaqi, F., Busceti, C.L., Biagioni, F., Cantini, F., Lenzi, P., and Fornai, F. (2020). Cell-clearing systems bridging repeat expansion proteotoxicity and neuromuscular junction alterations in ALS and SBMA. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114021"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1113\/jphysiol.1952.sp004735","article-title":"Spontaneous subthreshold activity at motor nerve endings","volume":"117","author":"Fatt","year":"1952","journal-title":"J. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1113\/jphysiol.1958.sp005974","article-title":"Some effects produced by adrenaline upon neuromuscular propagation in rats","volume":"141","author":"Krnjevic","year":"1958","journal-title":"J. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1113\/jphysiol.1970.sp009293","article-title":"Effects of catecholamines on the neuromuscular junction in the rat diaphragm","volume":"211","author":"Kuba","year":"1970","journal-title":"J. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1113\/jphysiol.1971.sp009557","article-title":"Noradrenaline action on nerve terminal in the rat diaphragm","volume":"217","author":"Kuba","year":"1971","journal-title":"J. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"E1479","DOI":"10.1152\/ajpendo.00664.2007","article-title":"Alpha- and beta-adrenergic receptors: Ahlquist\u2019s landmark hypothesis of a single mediator with two receptors","volume":"293","author":"Bylund","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/syn.890070202","article-title":"Transduction of the modulatory effect of catecholamines at the mammalian motor neuron terminal","volume":"7","author":"Chen","year":"1991","journal-title":"Synapse"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1476-5381.1983.tb11047.x","article-title":"Microelectrode recording of the effects of agonists and antagonists on alpha-adrenoceptors on rat somatic nerve terminals","volume":"80","author":"Lim","year":"1983","journal-title":"Br. J. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mcn.2019.01.007","article-title":"Sympathomimetics regulate neuromuscular junction transmission through TRPV1, P\/Q\u2013 and N\u2013type Ca2+ channels","volume":"95","author":"Rodrigues","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"103550","DOI":"10.1016\/j.mcn.2020.103550","article-title":"Sympathomimetics regulate quantal acetylcholine release at neuromuscular junctions through various types of adrenoreceptors","volume":"108","author":"Tsentsevitsky","year":"2020","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neuroscience.2019.10.049","article-title":"Diverse effects of noradrenaline and adrenaline on the quantal secretion of acetylcholine at the mouse neuromuscular junction","volume":"423","author":"Tsentsevitsky","year":"2019","journal-title":"Neurosci"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0006-8993(81)90455-8","article-title":"Noradrenaline augments tetanic potentiation of transmitter release by a calcium dependent process","volume":"214","author":"Bergman","year":"1981","journal-title":"Brain Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1476-5381.1966.tb01665.x","article-title":"Effects of sympathomimetic amines on neuromuscular transmission","volume":"27","author":"Bowman","year":"1966","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00174860","article-title":"Effects of the facilitatory compounds catechol, guanidine, noradrenaline and phencyclidine on presynaptic currents of mouse motor nerve terminals","volume":"338","author":"Anderson","year":"1988","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0074-7742(08)60100-2","article-title":"Acetylcholine at motor nerves: Storage, release, and presynaptic modulation by autoreceptors and adrenoceptors","volume":"4","author":"Wessler","year":"1992","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1152\/physrev.1989.69.3.864","article-title":"Modulation of neurotransmitter release by presynaptic autoreceptors","volume":"69","author":"Starke","year":"1989","journal-title":"Physiol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1476-5381.1988.tb11574.x","article-title":"\u03b2\u2013Adrenoceptor stimulation enhances transmitter output from the rat phrenic nerve","volume":"94","author":"Wessler","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0014-2999(89)90876-5","article-title":"Stimulation of alpha 1-adrenoceptors increases electrically evoked [3H]-acetylcholine release from the rat phrenic nerve","volume":"174","author":"Wessler","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1440-1681.1990.tb01261.x","article-title":"Stimulation of beta 1-adrenoceptors enhances electrically evoked [3H]-acetylcholine release from rat phrenic nerve","volume":"17","author":"Wessler","year":"1990","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/BF00169543","article-title":"Evidence that catecholamines increase acetylcholine release from neuromuscular junction through stimulation of alpha\u20131 adrenoceptors","volume":"343","author":"Vizi","year":"1991","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/0024-3205(82)90540-9","article-title":"Noradrenergic-mediated potentiation of acetylcholine release from the phrenic nerve: Evidence for presynaptic alpha 1-adrenoceptor involvement","volume":"31","author":"Snider","year":"1982","journal-title":"Life Sci."},{"key":"ref_42","first-page":"148","article-title":"Effect of clonidine on neuromuscular transmission and the nicotinic acetylcholine receptor","volume":"8","author":"Chiou","year":"1984","journal-title":"Proc. Natl. Sci. Counc. Repub. China. B"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10571-020-00840-3","article-title":"Adrenaline Facilitates Synaptic Transmission by Synchronizing Release of Acetylcholine Quanta from Motor Nerve Endings","volume":"41","author":"Khuzakhmetova","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"15795","DOI":"10.1016\/S0021-9258(19)49605-1","article-title":"Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs","volume":"267","author":"Eason","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_45","first-page":"274","article-title":"Effects of Gi and beta2AR overexpression on the survival of rat cardiac myocytes injured by isoprenaline","volume":"23","author":"Sun","year":"2007","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.ne.15.030192.000511","article-title":"Adrenergic receptors as models for G protein-coupled receptors","volume":"15","author":"Kobilka","year":"1992","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0006-8993(81)91090-8","article-title":"Neurophysiological consequences of presynaptic receptor activation: Changes in noradrenergic terminal excitability","volume":"226","author":"Nakamura","year":"1981","journal-title":"Brain Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0306-4522(85)90167-8","article-title":"Catecholamine inhibition of calcium action potentials in rat locus coeruleus neurones","volume":"14","author":"Williams","year":"1985","journal-title":"Neuroscience"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1113\/jphysiol.1980.sp013198","article-title":"Alpha-drenergic inhibition of calcium-dependent potentials in rat sympathetic neurones","volume":"301","author":"Horn","year":"1980","journal-title":"J. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1476-5381.1984.tb10794.x","article-title":"Pharmacological characterization of amine receptors on embryonic chick sensory neurones","volume":"82","author":"Canfield","year":"1984","journal-title":"Br. J. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1471-4159.1986.tb08488.x","article-title":"Role of adenylate cyclase in presynaptic alpha 2-adrenoceptor- and mu-opioid receptor-mediated inhibition of [3H]noradrenaline release from rat brain cortex slices","volume":"46","author":"Schoffelmeer","year":"1986","journal-title":"J. Neurochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1098\/rspb.1965.0016","article-title":"The measurement of synaptic delay, and the time course of acetylcholine release at the neuromuscular junction","volume":"161","author":"Katz","year":"1965","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1113\/jphysiol.1972.sp010054","article-title":"The kinetics of transmitter release at the frog neuromuscular junction","volume":"227","author":"Barrett","year":"1972","journal-title":"J. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev-physiol-021113-170338","article-title":"Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release","volume":"76","author":"Kaeser","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1471-4159.2006.04282.x","article-title":"Modulation of the kinetics of evoked quantal release at mouse neuromuscular junctions by calcium and strontium","volume":"100","author":"Bukharaeva","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1113\/jphysiol.1988.sp017225","article-title":"The kinetics of quantal releases during end-plate currents at the frog neuromuscular junction","volume":"402","year":"1988","journal-title":"J. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF00196832","article-title":"Modelling endplate currents: Dependence on quantum secretion probability and decay of miniature current","volume":"23","author":"Giniatullin","year":"1995","journal-title":"Eur. Biophys. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF02463151","article-title":"Synchronization of evoked secretion of quanta of mediator as a mechanism facilitating the action of sympathomimetics","volume":"30","author":"Bukharaeva","year":"2000","journal-title":"Neurosci. Behav. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/j.1469-7793.1999.0879s.x","article-title":"Noradrenaline synchronizes evoked quantal release at frog neuromuscular junctions","volume":"517","author":"Bukcharaeva","year":"1999","journal-title":"J. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1113\/jphysiol.2001.012752","article-title":"Protein kinase A cascade regulates quantal release dispersion at frog muscle endplate","volume":"538","author":"Bukharaeva","year":"2002","journal-title":"J. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.conb.2005.05.006","article-title":"Presynaptic calcium and control of vesicle fusion","volume":"15","author":"Schneggenburger","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/ALN.0000000000001213","article-title":"\u03b12-Adrenergic Receptor and Isoflurane Modulation of Presynaptic Ca2+ Influx and Exocytosis in Hippocampal Neurons","volume":"125","author":"Hara","year":"2016","journal-title":"Anesthesiology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0006-8993(96)00894-3","article-title":"Block of the endplate acetylcholine receptor channel by the sympathomimetic agents ephedrine, pseudoephedrine, and albuterol","volume":"740","author":"Milone","year":"1996","journal-title":"Brain Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0006-8993(93)90025-I","article-title":"Ephedrine: Effects on neuromuscular transmission","volume":"623","author":"Sieb","year":"1993","journal-title":"Brain Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.expneurol.2013.06.012","article-title":"A mouse model of the slow channel myasthenic syndrome: Neuromuscular physiology and effects of ephedrine treatment","volume":"248","author":"Webster","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3233\/JND-170293","article-title":"Beta-2 adrenergic receptor agonists enhance AChR clustering in C2C12 myotubes: Implications for therapy of myasthenic disorders","volume":"5","author":"Clausen","year":"2018","journal-title":"J. Neuromuscul. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1073\/pnas.1524272113","article-title":"Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease","volume":"113","author":"Khan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/0006-2952(91)90516-8","article-title":"Characterization of \u03b21- and \u03b22-adrenoreceptors in rat skeletal muscles","volume":"42","author":"Kim","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1152\/physrev.00028.2007","article-title":"Role of beta-adrenoceptor signaling in skeletal muscle: Implications for muscle wasting and disease","volume":"88","author":"Lynch","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1152\/japplphysiol.01055.2013","article-title":"Activating cAMP\/PKA signaling in skeletal muscle suppresses the ubiquitin\u2013proteasome\u2013dependent proteolysis: Implications for sympathetic regulation","volume":"117","author":"Silveira","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Straka, T., Vita, V., Prokshi, K., H\u00f6rner, S.J., Khan, M.M., Pirazzini, M., Williams, M.P.I., Hafner, M., Zaglia, T., and Rudolf, R. (2018). Postnatal development and distribution of sympathetic innervation in mouse skeletal muscle. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19071935"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4161\/auto.26841","article-title":"Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors","volume":"10","author":"Khan","year":"2014","journal-title":"Autophagy"},{"key":"ref_73","first-page":"343","article-title":"Die doppelte (motorische und sympathische) erente Innervation der quergestreiften Muskelfasern","volume":"44","author":"Boeke","year":"1913","journal-title":"Anat. Anz."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0022-510X(88)90228-6","article-title":"Peptidergic and adrenergic regulation of the intracellular 3\u2032,5\u2032-cyclic adenosine monophosphate content in cultured rat Schwann cells","volume":"88","author":"Yasuda","year":"1988","journal-title":"J. Neurol. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/jnc.14975","article-title":"Nicotinic \u03b17 receptor-induced adenosine release from perisynaptic Schwann cells controls acetylcholine spillover from motor endplates","volume":"154","author":"Oliveira","year":"2020","journal-title":"J. Neurochem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1471-4159.2009.06512.x","article-title":"GABA synthesis in Schwann cells is induced by the neuroactive steroid allopregnanolone","volume":"112","author":"Magnaghi","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fncir.2014.00141","article-title":"GABA as a rising gliotransmitter","volume":"8","author":"Yoon","year":"2014","journal-title":"Front. Neural Circuits"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"11870","DOI":"10.1523\/JNEUROSCI.0329-14.2014","article-title":"Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by \u03b17 nicotinic receptors and butyrylcholinesterase","volume":"34","author":"Petrov","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1139\/y99-008","article-title":"Glutaminergic and adrenergic receptors expressed on adult guinea pig Schwann cells in vitro","volume":"77","author":"Fink","year":"1999","journal-title":"Can. J. Physiol. Pharmacol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/9\/4611\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:53:37Z","timestamp":1760162017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/9\/4611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,28]]},"references-count":79,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["ijms22094611"],"URL":"https:\/\/doi.org\/10.3390\/ijms22094611","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,28]]}}}