{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:14:33Z","timestamp":1790007273609,"version":"4.0.1"},"reference-count":85,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondecyt","award":["1130213"],"award-info":[{"award-number":["1130213"]}]},{"name":"Fondecyt","award":["1181019"],"award-info":[{"award-number":["1181019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The gastrointestinal lumen is a rich source of eukaryotic and prokaryotic viruses which, together with bacteria, fungi and other microorganisms comprise the gut microbiota. Pathogenic viruses inhabiting this niche have the potential to induce local as well as systemic complications; among them, the viral ability to disrupt the mucosal barrier is one mechanism associated with the promotion of diarrhea and tissue invasion. This review gathers recent evidence showing the contributing effects of diet, gut microbiota and the enteric nervous system to either support or impair the mucosal barrier in the context of viral attack.<\/jats:p>","DOI":"10.3390\/ijms22094734","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T10:30:41Z","timestamp":1619692241000},"page":"4734","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Gut Susceptibility to Viral Invasion: Contributing Roles of Diet, Microbiota and Enteric Nervous System to Mucosal Barrier Preservation"],"prefix":"10.3390","volume":"22","author":[{"given":"Marcela","family":"Julio-Pieper","sequence":"first","affiliation":[{"name":"Grupo de NeuroGastroBioqu\u00edmica, Instituto de Qu\u00edmica, Facultad de Ciencias, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"L\u00f3pez-Aguilera","sequence":"additional","affiliation":[{"name":"Grupo de NeuroGastroBioqu\u00edmica, Instituto de Qu\u00edmica, Facultad de Ciencias, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johana","family":"Eyzaguirre-Vel\u00e1squez","sequence":"additional","affiliation":[{"name":"Grupo de NeuroGastroBioqu\u00edmica, Instituto de Qu\u00edmica, Facultad de Ciencias, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreto","family":"Olavarr\u00eda-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"APC Microbiome Ireland, University College Cork, T12 K8AF Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1978-6109","authenticated-orcid":false,"given":"Claudia","family":"Ibacache-Quiroga","sequence":"additional","affiliation":[{"name":"Centro de Micro-Bioinnovaci\u00f3n (CMBi), Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Farmacia, Universidad de Valpara\u00edso, Valpara\u00edso 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A.","family":"Bravo","sequence":"additional","affiliation":[{"name":"Grupo de NeuroGastroBioqu\u00edmica, Instituto de Qu\u00edmica, Facultad de Ciencias, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1458-3599","authenticated-orcid":false,"given":"Gonzalo","family":"Cruz","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Instituto de Fisiolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.chom.2019.09.009","article-title":"The human gut virome is highly diverse, stable, and individual specific","volume":"26","author":"Shkoporov","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/apt.14280","article-title":"Review article: The human intestinal virome in health and disease","volume":"46","author":"Carding","year":"2017","journal-title":"Aliment. 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