{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:36:36Z","timestamp":1773351396822,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Growth and maturation of hematopoietic stem cells (HSCs) are largely controlled at both transcriptional and post-transcriptional levels. In particular, hematopoietic development requires a tight control of protein synthesis. Furthermore, translational deregulation strongly contributes to hematopoietic malignancies. Researchers have recently identified a new layer of gene expression regulation that consists of chemical modification of RNA species, which led to the birth of the epitranscriptomics field. RNA modifications provide an additional level of control in hematopoietic development by acting as post-transcriptional regulators of lineage-specific genetic programs. Other reviews have already described the important role of the N6-methylation of adenosine (m6A) within mRNA species in regulating hematopoietic differentiation and diseases. The aim of this review is to summarize the current status of the role of RNA modifications in the regulation of ribosome function, beyond m6A. In particular, we discuss the importance of RNA modifications in tRNA and rRNA molecules. By balancing translational rate and fidelity, they play an important role in regulating normal and malignant hematopoietic development.<\/jats:p>","DOI":"10.3390\/ijms22094755","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T05:10:55Z","timestamp":1619759455000},"page":"4755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regulation of Ribosome Function by RNA Modifications in Hematopoietic Development and Leukemia: It Is Not Only a Matter of m6A"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-7912","authenticated-orcid":false,"given":"Francesco","family":"Fazi","sequence":"first","affiliation":[{"name":"Department of Anatomical, Histological, Forensic &amp; Orthopedic Sciences, Section of Histology &amp; Medical Embryology, Sapienza University of Rome, 00165 Rome, Italy"},{"name":"Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0743-7905","authenticated-orcid":false,"given":"Alessandro","family":"Fatica","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u2018Charles Darwin\u2019, Sapienza University of Rome, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0021-9258(18)70770-9","article-title":"Ribonucleic acids from yeast which contain a fifth nucleotide","volume":"227","author":"Davis","year":"1957","journal-title":"J. Biol. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"D303","DOI":"10.1093\/nar\/gkx1030","article-title":"MODOMICS: A database of RNA modification pathways. 2017 update","volume":"46","author":"Boccaletto","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrg.2016.169","article-title":"Detecting RNA modifications in the epitranscriptome: Predict and validate","volume":"18","author":"Helm","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41576-020-00295-8","article-title":"The epitranscriptome beyond m6A","volume":"22","author":"Wiener","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ianniello, Z., and Fatica, A. (2018). N6-Methyladenosine Role in Acute Myeloid Leukaemia. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082345"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-981-13-7342-8_4","article-title":"RNA N6-Methyladenosine Modification in Normal and Malignant Hematopoiesis","volume":"1143","author":"Weng","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s40778-020-00178-y","article-title":"The role of RNA epigenetic modification in normal and malignant hematopoiesis","volume":"6","author":"Vasic","year":"2020","journal-title":"Curr. Stem. Cell Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41556-019-0319-0","article-title":"RNA modifications regulating cell fate in cancer","volume":"21","author":"Delaunay","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Minervini, C.F., Parciante, E., Impera, L., Anelli, L., Zagaria, A., Specchia, G., Musto, P., and Albano, F. (2020). Epitranscriptomics in Normal and Malignant Hematopoiesis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186578"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.7150\/thno.41687","article-title":"Dysregulations of Functional RNA Modifications in Cancer, Cancer Stemness and Cancer Therapeutics","volume":"10","author":"Uddin","year":"2020","journal-title":"Theranostics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/MOH.0000000000000636","article-title":"The N6-methyladenosine RNA modification in acute myeloid leukemia","volume":"28","author":"Yankova","year":"2021","journal-title":"Curr. Opin. Hematol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature13035","article-title":"Haematopoietic stem cells require a highly regulated protein synthesis rate","volume":"509","author":"Signer","year":"2014","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.stem.2019.12.006","article-title":"Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms","volume":"26","author":"Spevak","year":"2020","journal-title":"Cell Stem. Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ccr.2010.01.021","article-title":"Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E","volume":"17","author":"Hsieh","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nature07449","article-title":"Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency","volume":"456","author":"Barna","year":"2008","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.15252\/embj.201591382","article-title":"The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis","volume":"34","author":"Tuorto","year":"2015","journal-title":"EMBO J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature25434","article-title":"Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation","volume":"554","author":"Shen","year":"2018","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2011.06.001","article-title":"Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation","volume":"20","author":"Reavie","year":"2011","journal-title":"Cancer Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11807","DOI":"10.1093\/nar\/gkz1043","article-title":"Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth","volume":"47","author":"Heissenberger","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00401-019-02062-4","article-title":"Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program","volume":"138","author":"Janin","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2018.03.008","article-title":"Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells","volume":"173","author":"Guzzi","year":"2018","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.celrep.2013.04.030","article-title":"H\/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation","volume":"3","author":"Bellodi","year":"2013","journal-title":"Cell Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ncb3563","article-title":"AML1-ETO requires enhanced C\/D box snoRNA\/RNP formation to induce self-renewal and leukaemia","volume":"9","author":"Zhou","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1182\/blood.2019004121","article-title":"Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acute myeloid leukemia cell proliferation","volume":"135","author":"Pauli","year":"2020","journal-title":"Blood"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1242\/jcs.183723","article-title":"NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner","volume":"129","author":"Waku","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/jb\/mvx086","article-title":"Nucleomethylin deficiency impairs embryonic erythropoiesis","volume":"163","author":"Murakami","year":"2018","journal-title":"J. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1101\/gad.333369.119","article-title":"Cho. Y.L.; Amarie, O.V.; Aguilar-Pimentel, A.; Klein-Rodewald, T.; Calzada-Wack, J.; et al. The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs","volume":"34","author":"Ignatova","year":"2020","journal-title":"Genes Dev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e49863","DOI":"10.15252\/embr.201949863","article-title":"The 18S rRNA m6A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation","volume":"21","author":"Xing","year":"2020","journal-title":"EMBO Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/nar\/gkz1147","article-title":"The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA","volume":"48","author":"Pinto","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: An evolving paradigm for stem cell biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s12185-016-1944-z","article-title":"mTORC signaling in hematopoiesis","volume":"103","author":"Wang","year":"2016","journal-title":"Int. J. Hematol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1101\/gad.282756.116","article-title":"The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs","volume":"30","author":"Signer","year":"2016","journal-title":"Genes Dev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.stem.2015.06.002","article-title":"Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells","volume":"17","author":"Cai","year":"2015","journal-title":"Cell Stem. Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molmed.2014.01.008","article-title":"Role of tRNA modifications in human diseases","volume":"20","author":"Torres","year":"2014","journal-title":"Trends Mol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrm.2017.77","article-title":"The emerging complexity of the tRNA world: Mammalian tRNAs beyond protein synthesis","volume":"19","author":"Schimmel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.cell.2016.06.042","article-title":"Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells","volume":"166","author":"Goncalves","year":"2016","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11131","DOI":"10.1128\/MCB.25.24.11131-11144.2005","article-title":"Periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype","volume":"25","author":"Rios","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nsmb.2357","article-title":"RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis","volume":"19","author":"Tuorto","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.cub.2006.04.027","article-title":"The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors","volume":"16","author":"Frye","year":"2006","journal-title":"Curr. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12094-012-0926-8","article-title":"MYC oncogene in myeloid neoplasias","volume":"15","author":"Delgado","year":"2013","journal-title":"Clin. Transl. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41594-020-00526-w","article-title":"TET2 chemically modifies tRNAs and regulates tRNA fragment levels","volume":"28","author":"He","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-genet-112618-043830","article-title":"Regulation and Function of RNA Pseudouridylation in Human Cells","volume":"54","author":"Borchardt","year":"2020","journal-title":"Annu Rev. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/s41467-018-04092-0","article-title":"The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level","volume":"9","author":"Kwon","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1038\/s41467-019-10432-5","article-title":"DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions","volume":"10","author":"Sauer","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41580-018-0078-y","article-title":"Ribosome assembly coming into focus","volume":"20","author":"Klinge","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0968-0004(02)02109-6","article-title":"rRNA modifications and ribosome function","volume":"27","author":"Decatur","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0955-0674(97)80005-1","article-title":"Function and synthesis of small nucleolar RNAs","volume":"9","author":"Tollervey","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1128\/MCB.05804-11","article-title":"Requirement of rRNA methylation for 80S ribosome assembly on a cohort of cellular internal ribosome entry sites","volume":"31","author":"Basu","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ccr.2013.08.013","article-title":"P53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer","volume":"24","author":"Marcel","year":"2013","journal-title":"Cancer Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.tibs.2015.07.008","article-title":"\u2018View from a bridge\u2019: A new perspective on eukaryotic rRNA base modification","volume":"40","author":"Sharma","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1182\/bloodadvances.2017006668","article-title":"Expression profiling of snoRNAs in normal hematopoiesis and AML","volume":"2","author":"Warner","year":"2018","journal-title":"Blood Adv."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1038\/leu.2012.111","article-title":"Specific small nucleolar RNA expression profiles in acute leukemia","volume":"26","author":"Valleron","year":"2012","journal-title":"Leukemia"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature13923","article-title":"RNA helicase DDX21 coordinates transcription and ribosomal RNA processing","volume":"518","author":"Calo","year":"2015","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/leu.2016.350","article-title":"p53 pathway dysfunction is highly prevalent in acute myeloid leukemia independent of TP53 mutational status","volume":"31","author":"Hu","year":"2017","journal-title":"Leukemia"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41556-021-00653-6","article-title":"A PRC2-independent function for EZH2 in regulating rRNA 2\u2032-O methylation and IRES-dependent translation","volume":"23","author":"Yi","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Kaito, S., and Iwama, A. (2020). Pathogenic Impacts of Dysregulated Polycomb Repressive Complex Function in Hematological Malignancies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010074"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1038\/bcj.2012.41","article-title":"The expression pattern of small nucleolar and small Cajal body-specific RNAs characterizes distinct molecular subtypes of multiple myeloma","volume":"2","author":"Ronchetti","year":"2012","journal-title":"Blood Cancer J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13402-012-0113-5","article-title":"Expression of small nucleolar RNAs in leukemic cells","volume":"36","author":"Teittinen","year":"2013","journal-title":"Cell Oncol. (Dordr)"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.molcel.2019.06.020","article-title":"Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21","volume":"75","author":"Kim","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm3376","article-title":"New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs","volume":"13","author":"Gibson","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2010.06.017","article-title":"The PARP side of the nucleus: Molecular actions, physiological outcomes, and clinical targets","volume":"39","author":"Krishnakumar","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cell.2018.02.036","article-title":"Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis","volume":"173","author":"Khajuria","year":"2018","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1182\/blood-2009-10-178129","article-title":"Ribosomopathies: Human disorders of ribosome dysfunction","volume":"115","author":"Narla","year":"2010","journal-title":"Blood"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41589-018-0184-3","article-title":"N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation","volume":"15","author":"Ma","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Sergeeva, O., Sergeev, P., Melnikov, P., Prikazchikova, T., Dontsova, O., and Zatsepin, T. (2020). Modification of Adenosine196 by Mettl3 Methyltransferase in the 5\u2019-External Transcribed Spacer of 47S Pre-rRNA Affects rRNA Maturation. Cells, 9.","DOI":"10.3390\/cells9041061"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e49443","DOI":"10.15252\/embr.201949443","article-title":"The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila","volume":"21","author":"Leismann","year":"2020","journal-title":"EMBO Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"108544","DOI":"10.1016\/j.celrep.2020.108544","article-title":"Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth","volume":"33","author":"Rong","year":"2020","journal-title":"Cell Rep."},{"key":"ref_68","first-page":"1657","article-title":"FBW7 in hematological tumors","volume":"19","author":"Zhu","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41556-021-00652-7","article-title":"PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications","volume":"23","author":"Shi","year":"2021","journal-title":"Nat. Cell Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/9\/4755\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:55:50Z","timestamp":1760162150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/9\/4755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,30]]},"references-count":69,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["ijms22094755"],"URL":"https:\/\/doi.org\/10.3390\/ijms22094755","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,30]]}}}