{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:56:01Z","timestamp":1790085361008,"version":"4.0.1"},"reference-count":314,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In recent decades, researchers around the world have been studying intensively how micro-organisms that are present inside living organisms could affect the main processes of life, namely health and pathological conditions of mind or body. They discovered a relationship between the whole microbial colonization and the initiation and development of different medical disorders. Besides already known probiotics, novel products such as postbiotics and paraprobiotics have been developed in recent years to create new non-viable micro-organisms or bacterial-free extracts, which can provide benefits to the host with additional bioactivity to probiotics, but without the risk of side effects. The best alternatives in the use of probiotics and postbiotics to maintain the health of the intestinal microbiota and to prevent the attachment of pathogens to children and adults are highlighted and discussed as controversies and challenges. Updated knowledge of the molecular and cellular mechanisms involved in the balance between microbiota and immune system for the introspection on the gut\u2013lung\u2013brain axis could reveal the latest benefits and perspectives of applied photobiomics for health. Multiple interconditioning between photobiomodulation (PBM), probiotics, and the human microbiota, their effects on the human body, and their implications for the management of viral infectious diseases is essential. Coupled complex PBM and probiotic interventions can control the microbiome, improve the activity of the immune system, and save the lives of people with immune imbalances. There is an urgent need to seek and develop innovative treatments to successfully interact with the microbiota and the human immune system in the coronavirus crisis. In the near future, photobiomics and metabolomics should be applied innovatively in the SARS-CoV-2 crisis (to study and design new therapies for COVID-19 immediately), to discover how bacteria can help us through adequate energy biostimulation to combat this pandemic, so that we can find the key to the hidden code of communication between RNA viruses, bacteria, and our body.<\/jats:p>","DOI":"10.3390\/ijms22094942","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T11:10:27Z","timestamp":1620299427000},"page":"4942","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8067-5184","authenticated-orcid":false,"given":"Laura","family":"Ailioaie","sequence":"first","affiliation":[{"name":"Department of Medical Physics, Alexandru Ioan Cuza University, 11 Carol I Boulevard, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-0130","authenticated-orcid":false,"given":"Gerhard","family":"Litscher","sequence":"additional","affiliation":[{"name":"Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine, Research Unit for Complementary and Integrative Laser Medicine, and Traditional Chinese Medicine (TCM) Research Center Graz, Medical University of Graz, Auenbruggerplatz 39, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nm.4517","article-title":"Current understanding of the human microbiome","volume":"24","author":"Gilbert","year":"2018","journal-title":"Nat. Med."},{"key":"ref_3","unstructured":"Burge, M. (1988). Mycoparasitism and plant disease control. Fungi in Biological Control Systems, Manchester University Press."},{"key":"ref_4","unstructured":"Dubos, R.J. (1951). Louis Pasteur: Free Lance of Science, Victor Gollancz Ltd.. [1st ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/d41586-019-01654-0","article-title":"Priorities for the next 10 years of human microbiome research","volume":"569","author":"Proctor","year":"2019","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1469-0691.2012.03916.x","article-title":"The microbiome as a human organ","volume":"18","author":"Baquero","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cca.2015.01.003","article-title":"The role of the gut microbiome in the healthy adult status","volume":"451","author":"Salvatore","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_8","unstructured":"(2021, January 18). Microbiome. Definition of Microbiome. Merriam-Webster Dictionary. Available online: https:\/\/www.merriam-webster.com\/dictionary\/microbiome."},{"key":"ref_9","unstructured":"Zimmer, C. (2021, January 18). Our Microbiomes, Ourselves. The New York Times, Available online: https:\/\/carlzimmer.com\/our-microbiomes-ourselves-282\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40168-015-0094-5","article-title":"The vocabulary of microbiome research: A proposal","volume":"3","author":"Marchesi","year":"2015","journal-title":"Microbiome"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s40168-020-00875-0","article-title":"Microbiome definition re-visited: Old concepts and new challenges","volume":"8","author":"Berg","year":"2020","journal-title":"Microbiome"},{"key":"ref_12","unstructured":"Normandin, S., and Wolfe, C. (2009). Varieties of living things: Life at the intersection of lineage and metabolism. Vitalism and the Scientific Image in Post-Enlightenment Life Science, Springer. History, Philosophy and Theory of the Life Sciences."},{"key":"ref_13","first-page":"8","article-title":"\u201cOme Sweet\u201d Omics\u2014A Genealogical Treasury of Words","volume":"15","author":"Lederberg","year":"2001","journal-title":"Scientist"},{"key":"ref_14","unstructured":"(2021, January 18). What\u2019s the Difference between Microbiome and Microbiota?. Available online: https:\/\/atlasbiomed.com\/blog\/whats-the-difference-between-microbiome-and-microbiota\/."},{"key":"ref_15","unstructured":"Ruthsatz, M., Voisin, E., Lima, N., and D\u2019Hondt, K. (2021, January 18). Human Microbiomes in Health and Disease: Strategic Options for Regulatory Science and Healthcare Policy. Regulatory Focus. News Articles. July 2020. Regulatory Affairs Professionals Society. Available online: https:\/\/www.raps.org\/news-and-articles\/news-articles\/2020\/7\/human-microbiomes-in-health-and-disease-strategic."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sender, R., Fuchs, S., and Milo, R. (2016). Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biol., 14.","DOI":"10.1101\/036103"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"\u017b\u00f3\u0142kiewicz, J., Marzec, A., Ruszczy\u0144ski, M., and Feleszko, W. (2020). Postbiotics\u2014A Step Beyond Pre- and Probiotics. Nutrients, 12.","DOI":"10.3390\/nu12082189"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G.A.D., Gasbarrini, A., and Mele, M.C. (2019). What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms, 10.","DOI":"10.3390\/microorganisms7010014"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The Human Intestinal Microbiome in Health and Disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mohammadkhah, A.I., Simpson, E.B., Patterson, S.G., and Ferguson, J.F. (2018). Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease. Children, 5.","DOI":"10.3390\/children5120160"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1089\/chi.2017.0034","article-title":"Investigating Caesarean Section Birth as a Risk Factor for Childhood Overweight","volume":"14","author":"Lavin","year":"2018","journal-title":"Child. Obes."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/gutjnl-2012-303249","article-title":"Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section","volume":"63","author":"Jakobsson","year":"2014","journal-title":"Gut"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1111\/j.1365-2222.2009.03326.x","article-title":"Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses","volume":"39","author":"Tomicic","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e190905","DOI":"10.1001\/jamanetworkopen.2019.0905","article-title":"Association of the Infant Gut Microbiome with Early Childhood Neurodevelopmental Outcomes: An Ancillary Study to the VDAART Randomized Clinical Trial","volume":"2","author":"Sordillo","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/pr.2014.162","article-title":"Gut microbiota of the very-low-birth-weight infant","volume":"77","author":"Unger","year":"2015","journal-title":"Pediatr. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40168-017-0248-8","article-title":"Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: A systematic review and meta-analysis","volume":"5","author":"Pammi","year":"2017","journal-title":"Microbiome"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s42003-021-01689-y","article-title":"Components of a Neanderthal gut microbiome recovered from fecal sediments from El Salt","volume":"4","author":"Rampelli","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.celrep.2018.05.018","article-title":"Infant and Adult Gut Microbiome and Metabolome in Rural Bassa and Urban Settlers from Nigeria","volume":"23","author":"Ayeni","year":"2018","journal-title":"Cell Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1038\/s41467-017-01973-8","article-title":"Meta-Analysis of gut microbiome studies identifies disease-specific and shared responses","volume":"8","author":"Duvallet","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Mariat, D., Firmesse, O., Levenez, F., Guimar\u0103es, V., Sokol, H., Dor\u00e9, J., Corthier, G., and Furet, J.P. (2009). The Firmicutes\/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol., 9.","DOI":"10.1186\/1471-2180-9-123"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.immuni.2017.04.008","article-title":"Homeostatic Immunity and the Microbiota","volume":"46","author":"Belkaid","year":"2017","journal-title":"Immunity"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrmicro2538","article-title":"Mucin dynamics and enteric pathogens","volume":"9","author":"McGuckin","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1757-4749-5-5","article-title":"Intestinal microbiota, probiotics and mental health: From Metchnikoff to modern advances: Part I\u2014Autointoxication revisited","volume":"5","author":"Bested","year":"2013","journal-title":"Gut Pathog."},{"key":"ref_35","first-page":"753","article-title":"Intestinal poisons and arteriosclerosis","volume":"24","author":"Metchnikoff","year":"1910","journal-title":"Ann. Inst. Pasteur"},{"key":"ref_36","first-page":"436","article-title":"Why not live forever?","volume":"53","author":"Metchnikoff","year":"1912","journal-title":"Cosmopolitan"},{"key":"ref_37","unstructured":"Pelton, B. (2021, January 28). Postbiotic Metabolites: The New Frontier in Microbiome Science. Townsend Letter. Available online: https:\/\/www.townsendletter.com\/article\/431-postbiotic-metabolites-the-new-frontier-in-microbiome-science\/."},{"key":"ref_38","first-page":"2311","article-title":"Arteriosclerosis and intestinal poisons","volume":"55","author":"Editors","year":"1910","journal-title":"JAMA"},{"key":"ref_39","unstructured":"Metchnikoff, E. (2004). The Prolongation of Life: Optimistic Studies, Springer. [1st ed.]."},{"key":"ref_40","unstructured":"(2021, January 28). Joint FAO\/WHO Working Group Report on Drafting Guidelines for the Evaluation of Probiotics in Food; London Ontario (CA), 30 April and 1 May 2002. Available online: https:\/\/www.who.int\/foodsafety\/fs_management\/en\/probiotic_guidelines.pdf."},{"key":"ref_41","unstructured":"Food and Agriculture Organization (FAO) of the United Nations (2021, April 19). Food Safety and Quality: Probiotics. Available online: http:\/\/www.fao.org\/food\/food-safety-quality\/a-z-index\/probiotics\/en\/."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"\u017duntar, I., Petric, Z., Bursa\u0107 Kova\u010devi\u0107, D., and Putnik, P. (2020). Safety of Probiotics: Functional Fruit Beverages and Nutraceuticals. Foods, 9.","DOI":"10.3390\/foods9070947"},{"key":"ref_43","unstructured":"(2021, January 28). Illumina Acquires BlueBee to Accelerate Processing, Analysis and Sharing of Next Generation Sequencing Data at Scale. Available online: https:\/\/www.illumina.com\/company\/news-center\/press-releases\/press-release-details.html?newsid=76a97c76-a723-4233-acb3-030736719d80."},{"key":"ref_44","unstructured":"Proctor, L. (2021, January 28). The NIH Human Microbiome Project: Catalyst for an Emerging Field in Biomedical Research, Available online: https:\/\/www.genome.gov\/Pages\/About\/NACHGR\/February2018AgendaDocuments\/HMP_talk_Feb_Council_final_020618.pdf."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6220","DOI":"10.1128\/JB.185.20.6220-6223.2003","article-title":"Metagenomic analyses of an uncultured viral community from human feces","volume":"185","author":"Breitbart","year":"2003","journal-title":"J. Bacteriol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cell.2006.02.017","article-title":"Ecological and evolutionary forces shaping microbial diversity in the human intestine","volume":"124","author":"Ley","year":"2006","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri2710","article-title":"Immune adaptations that maintain homeostasis with the intestinal microbiota","volume":"10","author":"Hooper","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.immuni.2012.04.011","article-title":"Commensal bacteria calibrate the activation threshold of innate antiviral immunity","volume":"37","author":"Abt","year":"2012","journal-title":"Immunity"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/imr.12171","article-title":"T-cell selection and intestinal homeostasis","volume":"259","author":"Ai","year":"2014","journal-title":"Immunol. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.immuni.2018.01.007","article-title":"Human T Cell Development, Localization, and Function throughout Life","volume":"48","author":"Kumar","year":"2018","journal-title":"Immunity"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41423-018-0192-y","article-title":"Tissue-Resident lymphocytes: From adaptive to innate immunity","volume":"16","author":"Sun","year":"2019","journal-title":"Cell Mol. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Booth, J.S., and Toapanta, F.R. (2021). B and T Cell Immunity in Tissues and Across the Ages. Vaccines, 9.","DOI":"10.3390\/vaccines9010024"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/imm.13117","article-title":"Intestinal epithelial cells: At the interface of the microbiota and mucosal immunity","volume":"158","author":"Soderholm","year":"2019","journal-title":"Immunology"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Mahapatro, M., Erkert, L., and Becker, C. (2021). Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut. Cells, 10.","DOI":"10.3390\/cells10010111"},{"key":"ref_56","unstructured":"(2021, January 24). Pan American Health Organization (PAHO): Noncommunicable Disease Prevention and Control. Available online: https:\/\/www.paho.org\/salud-en-las-americas-2017\/?p=1391."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_58","unstructured":"(2021, January 31). 2018 Annual Meeting\u2014International Scientific Association for Probiotics and Prebiotics (ISAPP). Minimum Criteria for Probiotics. Available online: https:\/\/isappscience.org\/2018-annual-meeting\/."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"a010074","DOI":"10.1101\/cshperspect.a010074","article-title":"Probiotics: Properties, examples, and specific applications","volume":"3","author":"Behnsen","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.dld.2017.07.011","article-title":"A consumer\u2019s guide for probiotics: 10 golden rules for correct use","volume":"49","author":"Toscano","year":"2017","journal-title":"Dig. Liver Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12934-017-0851-1","article-title":"Future access and improvement of industrial lactic acid bacteria cultures","volume":"16","author":"Johansen","year":"2017","journal-title":"Microb. Cell Fact."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3389\/fmicb.2020.01662","article-title":"Criteria to Qualify Microorganisms as \u201cProbiotic\u201d in Foods and Dietary Supplements","volume":"11","author":"Binda","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.12688\/f1000research.19043.1","article-title":"Probiotics and prebiotics in clinical tests: An update","volume":"8","year":"2019","journal-title":"F1000Research"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1080\/10408398.2014.918533","article-title":"Adhesion of lactobacilli and their anti-infectivity potential","volume":"57","author":"Yadav","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_65","first-page":"415","article-title":"Gut microbiota, immune system, and bone","volume":"102","author":"Sassi","year":"2017","journal-title":"Calcif. Tissue Int."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1017\/S0029665110001527","article-title":"Role of toll-like receptors in the development of immunotolerance mediated by probiotics","volume":"69","author":"Munoz","year":"2010","journal-title":"Proc. Nutr. Soc."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"19","DOI":"10.29328\/journal.jcn.1001023","article-title":"Anti-Inflammatory probiotic biomarkers in Fermented foods","volume":"3","author":"Ahmed","year":"2019","journal-title":"J. Clin. Nephrol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cytogfr.2020.10.004","article-title":"An evaluation of the effects of probiotics on tumoral necrosis factor (TNF-\u03b1) signaling and gene expression","volume":"57","author":"Vincenzi","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jcv.2014.03.021","article-title":"Specific probiotics and virological findings in symptomatic conscripts attending military service in Finland","volume":"60","author":"Lehtoranta","year":"2014","journal-title":"J. Clin. Virol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12934-020-01426-w","article-title":"Postbiotics-Parabiotics: The new horizons in microbial biotherapy and functional foods","volume":"19","author":"Nataraj","year":"2020","journal-title":"Microb. Cell Fact."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S.J., Berenjian, A., and Ghasemi, Y. (2019). Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications. Foods, 8.","DOI":"10.3390\/foods8030092"},{"key":"ref_72","unstructured":"FAO, and WHO (2021, February 10). Guidelines for the Evaluation of Probiotics in Food, Paris, Available online: http:\/\/www.fda.gov\/ohrms\/dockets\/dockets\/95s0316\/95s-0316-rpt0282-tab-03-ref-19-joint-faowho-vol219.pdf."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Marco, M.L., Sanders, M.E., G\u00e4nzle, M., Arrieta, M.C., Cotter, P.D., De Vuyst, L., Hill, C., Holzapfel, W., Lebeer, S., and Merenstein, D. (2021). Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods. Nat. Rev. Gastroenterol. Hepatol.","DOI":"10.1038\/s41575-020-00390-5"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"109502","DOI":"10.1016\/j.foodres.2020.109502","article-title":"Postbiotics and paraprobiotics: From concepts to applications","volume":"136","author":"Liceaga","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tifs.2018.03.009","article-title":"Postbiotics: An evolving term within the functional foods field","volume":"75","author":"Garcia","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Plaza-D\u00edaz, J., Ruiz-Ojeda, F.J., Vilchez-Padial, L.M., and Gil, A. (2017). Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases. Nutrients, 9.","DOI":"10.3390\/nu9060555"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Varzakas, T., Kandylis, P., Dimitrellou, D., Salamoura, C., Zakynthinos, G., and Proestos, C. (2018). Innovative and fortified food: Probiotics, prebiotics, gmos, and superfood. Preparation and Processing of Religious and Cultural Foods, Elsevier.","DOI":"10.1016\/B978-0-08-101892-7.00006-7"},{"key":"ref_78","unstructured":"(2021, February 08). Sources. Probiotics Have Been with Us for a Long Time. Available online: https:\/\/internationalprobiotics.org\/resources\/sources\/."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4014\/jmb.1911.11019","article-title":"Potential Health-Promoting Benefits of Paraprobiotics, Inactivated Probiotic Cells","volume":"30","author":"Akter","year":"2020","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3389\/fphys.2019.01343","article-title":"Intestinal microbiota-associated metabolites: Crucial factors in the effectiveness of herbal medicines and diet therapies","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1017\/S0007114515000823","article-title":"Oligosaccharides in infant formula: More evidence to validate the role of prebiotics","volume":"113","author":"Vandenplas","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/lam.12740","article-title":"Fermented cereal beverages: From probiotic, prebiotic and synbiotic towards Nanoscience designed healthy drinks","volume":"65","year":"2017","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jib.439","article-title":"Is beer a source of prebiotics?","volume":"123","author":"Kanyer","year":"2017","journal-title":"J. Inst. Brew."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.foodchem.2015.01.139","article-title":"Oligosaccharides of Cabernet Sauvignon, Syrah and Monastrell red wines","volume":"179","author":"Williams","year":"2015","journal-title":"Food Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox4010001","article-title":"Studies on Modulation of Gut Microbiota by Wine Polyphenols: From Isolated Cultures to Omic Approaches","volume":"4","author":"Cueva","year":"2015","journal-title":"Antioxidants"},{"key":"ref_86","unstructured":"Thompson, R. (2021, February 08). Four Popular Types of Probiotics. Available online: https:\/\/www.healthcareglobal.com\/technology-and-ai-3\/four-popular-types-probiotics."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"570344","DOI":"10.3389\/fnut.2020.570344","article-title":"Paraprobiotics and Postbiotics of Probiotic Lactobacilli, Their Positive Effects on the Host and Action Mechanisms: A Review","volume":"7","author":"Teame","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/1574-6941.12186","article-title":"Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro","volume":"87","author":"Scott","year":"2014","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Guarino, M., Altomare, A., Emerenziani, S., Di Rosa, C., Ribolsi, M., Balestrieri, P., Iovino, P., Rocchi, G., and Cicala, M. (2020). Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults. Nutrients, 12.","DOI":"10.3390\/nu12041037"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"16574","DOI":"10.1038\/s41598-019-53242-x","article-title":"Dietary Short-Chain Fatty Acid Intake Improves the Hepatic Metabolic Condition Via Ffar3","volume":"9","author":"Shimizu","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Subedi, L., Venkatesan, R., and Kim, S.Y. (2017). Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK\/NF-\u03baB\/TNF-\u03b1 Signaling. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071423"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.micres.2017.04.001","article-title":"Restoration of cefixime-induced gut microbiota changes by Lactobacillus cocktails and fructooligosaccharides in a mouse model","volume":"200","author":"Shi","year":"2017","journal-title":"Microbiol. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000342079","article-title":"Probiotic mechanisms of action","volume":"61","author":"Gil","year":"2012","journal-title":"Ann. Nutr. Metab."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.5713\/ajas.2012.12110","article-title":"The Bacillus subtilis and Lactic Acid Bacteria Probiotics Influences Intestinal Mucin Gene Expression, Histomorphology and Growth Performance in Broilers","volume":"25","author":"Aliakbarpour","year":"2012","journal-title":"Asian Australas. J. Anim. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1007\/s00253-019-09978-7","article-title":"Adhesion mechanisms mediated by probiotics and prebiotics and their potential impact on human health","volume":"103","author":"Rastall","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Castilho, N.P.A., Colombo, M., Oliveira, L.L., de Todorov, S.D., and Nero, L.A. (2019). Lactobacillus curvatus UFV-NPAC1 and other lactic acid bacteria isolated from calabresa, a fermented meat product, present high bacteriocinogenic activity against Listeria monocytogenes. BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1436-4"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases","volume":"10","author":"Landskron","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Berm\u00fadez-Humar\u00e1n, L.G., Salinas, E., Ortiz, G.G., Ramirez-Jirano, L.J., Morales, J.A., and Bitzer-Quintero, O.K. (2019). From Probiotics to Psychobiotics: Live Beneficial Bacteria Which Act on the Brain-Gut Axis. Nutrients, 11.","DOI":"10.3390\/nu11040890"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."},{"key":"ref_100","first-page":"323","article-title":"Paraprobiotics and postbiotics: Contemporary and promising natural antibiotics alternatives and their applications in the poultry field","volume":"10","year":"2020","journal-title":"Open Vet. J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12263-011-0218-x","article-title":"The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: Proposal of paraprobiotic concept)","volume":"6","author":"Taverniti","year":"2011","journal-title":"Genes Nutr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/jn\/136.12.3069","article-title":"Daily intake of heat-killed Lactobacillus plantarum L-137 augments acquired immunity in healthy adults","volume":"136","author":"Hirose","year":"2006","journal-title":"J. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2016.00096","article-title":"Postbiotic modulation of retinoic acid imprinted mucosal-like dendritic cells by probiotic Lactobacillus reuteri 17938 in vitro","volume":"7","author":"Haileselassie","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Cousin, F., Jouan-Lanhouet, S., Dimanche-Boitrel, M.T., Corcos, L., and Jan, G. (2012). Milk Fermented by Propionibacterium freudenreichii Induces Apoptosis of HGT-1 Human Gastric Cancer Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031892"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Malag\u00f3n-Rojas, J.N., Mantziari, A., Salminen, S., and Szajewska, H. (2020). Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review. Nutrients, 12.","DOI":"10.3390\/nu12020389"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"980","DOI":"10.5551\/jat.4812","article-title":"Kefiran reduces atherosclerosis in rabbits fed a high cholesterol diet","volume":"17","author":"Uchida","year":"2010","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s42255-019-0073-4","article-title":"The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans","volume":"1","author":"Andreux","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/iwj.13451","article-title":"The role of topical probiotics on wound healing: A review of animal and human studies","volume":"17","author":"Knackstedt","year":"2020","journal-title":"Int. Wound J."},{"key":"ref_109","unstructured":"Maftei, M.N. (2021, February 14). Probiotic, Prebiotic and Synbiotic Products in Human Health. Available online: https:\/\/www.intechopen.com\/books\/frontiers-and-new-trends-in-the-science-of-fermented-food-and-beverages\/probiotic-prebiotic-and-synbiotic-products-in-human-health."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13063-017-1885-8","article-title":"The effects of probiotic and synbiotic supplementation on metabolic syndrome indices in adults at risk of type 2 diabetes: Study protocol for a randomized controlled trial","volume":"18","author":"Kassaian","year":"2017","journal-title":"Trials"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Sergeev, I.N., Aljutaily, T., Walton, G., and Huarte, E. (2020). Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity. Nutrients, 12.","DOI":"10.3390\/nu12010222"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.4158\/EP151157.RA","article-title":"Gut microbiota, prebiotics, probiotics, and synbiotics in management of obesity and prediabetes: Review of randomized controlled trials","volume":"22","author":"Barengolts","year":"2016","journal-title":"Endocr. Pract."},{"key":"ref_113","first-page":"872","article-title":"Modulation of the gut microbiota: A focus on treatments for irritable bowel syndrome Postgrad","volume":"129","author":"Harris","year":"2017","journal-title":"Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1398-9995.2010.02416.x","article-title":"Synbiotics prevent asthma-like symptoms in infants with atopic dermatitis","volume":"66","author":"Heymans","year":"2011","journal-title":"Allergy"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Piqu\u00e9, N., Berlanga, M., and Mi\u00f1ana-Galbis, D. (2019). Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102534"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3920\/BM2018.0159","article-title":"Dealing with the remaining controversies of probiotic safety","volume":"10","author":"Claassen","year":"2019","journal-title":"Benef. Microbes"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41575-020-0344-2","article-title":"The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics","volume":"17","author":"Swanson","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_118","unstructured":"UNICEF, WHO, World Bank, and UN-DESA Population Division (2021, February 12). Levels and Trends in Child Mortality Report 2019. Estimates Developed by the UN Inter-Agency Group for Child Mortality Estimation. Available online: https:\/\/www.who.int\/maternal_child_adolescent\/documents\/levels_trends_child_mortality_2019\/en\/."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/5584_2018_313","article-title":"Necrotizing enterocolitis and the preterm infant microbiome","volume":"1125","author":"Baranowski","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S1473-3099(18)30362-1","article-title":"Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: A systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Troeger","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1515\/revneuro-2018-0024","article-title":"Gut dysbiosis, leaky gut, and intestinal epithelial proliferation in neurological disorders: Towards the development of a new therapeutic using amino acids, prebiotics, probiotics, and postbiotics","volume":"30","author":"Maguire","year":"2019","journal-title":"Rev. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.copbio.2013.10.006","article-title":"Rational identification of diet-derived postbiotics for improving intestinal microbiota function","volume":"26","author":"Klemashevich","year":"2014","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3920\/BM2019.0015","article-title":"Postbiotics: Facts and open questions. A position paper on the need for a consensus definition","volume":"10","author":"Collado","year":"2019","journal-title":"Benef. Microbes"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"251","DOI":"10.21307\/pjm-2018-044","article-title":"Are Probiotic Really Safe for Humans?","volume":"67","author":"Tyski","year":"2018","journal-title":"Pol. J. Microbiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ijos.2014.52","article-title":"Probiotics to counteract biofilm-associated infections: Promising and conflicting data","volume":"6","author":"Vuotto","year":"2014","journal-title":"Int. J. Oral Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.vaccine.2011.11.107","article-title":"High dose and low dose Lactobacillus acidophilus exerted differential immune modulating effects on T cell immune responses induced by an oral human rotavirus vaccine in gnotobiotic pigs","volume":"30","author":"Wen","year":"2012","journal-title":"Vaccine"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1016\/j.jaci.2009.07.014","article-title":"Antimicrobial peptides and the skin immune defense system","volume":"124","author":"Schauber","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/QCO.0000000000000269","article-title":"Probiotics for prevention of necrotizing enterocolitis and sepsis in preterm infants","volume":"29","author":"Embleton","year":"2016","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1093\/cid\/civ085","article-title":"Risk and safety of probiotics","volume":"60","author":"Doron","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/MCG.0b013e318279abf0","article-title":"Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis","volume":"47","author":"Vahabnezhad","year":"2013","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s15010-015-0798-2","article-title":"Breakthrough Lactobacillus rhamnosus GG bacteremia associated with probiotic use in an adult patient with severe active ulcerative colitis: Case report and review of the literature","volume":"43","author":"Meini","year":"2015","journal-title":"Infection"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1086\/380455","article-title":"Lactobacillus bacteremia, clinical significance, and patient outcome, with special focus on probiotic L. rhamnosus GG","volume":"38","author":"Salminen","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1086\/342912","article-title":"Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland","volume":"35","author":"Salminen","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/039463201402700120","article-title":"Saccharomyces cerevisiae fungemia, a possible consequence of the treatment of Clostridium difficile colitis with a probioticum","volume":"27","author":"Santino","year":"2014","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Thygesen, J.B., Glerup, H., and Tarp, B. (2012). Saccharomyces boulardii fungemia caused by treatment with a probioticum. BMJ Case Rep., bcr0620114412.","DOI":"10.1136\/bcr.06.2011.4412"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1179\/acb.2004.033","article-title":"Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis","volume":"59","author":"Cherifi","year":"2004","journal-title":"Acta Clin. Belg."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1179\/acb.2004.032","article-title":"Saccharomyces cerevisiae fungemia in a head and neck cancer patient: A case report and review of the literature","volume":"59","author":"Henry","year":"2004","journal-title":"Acta Clin. Belg."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s005200000123","article-title":"Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii","volume":"8","author":"Cesaro","year":"2000","journal-title":"Support. Care Cancer"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s100960050003","article-title":"Possible role of catheters in Saccharomyces boulardii fungemia","volume":"19","author":"Hennequin","year":"2000","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00134-002-1267-9","article-title":"Seven Cases of fungemia with Saccharomyces boulardii in critically ill patients","volume":"28","author":"Lherm","year":"2002","journal-title":"Intensive Care Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1086\/429916","article-title":"Saccharomyces cerevisiae fungemia: An emerging infectious disease","volume":"40","author":"Bouza","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.mycmed.2017.09.003","article-title":"Saccharomyces cerevisiae fungemia after probiotic treatment in an intensive care unit patient","volume":"28","author":"Kara","year":"2018","journal-title":"J. Mycol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.diagmicrobio.2016.12.004","article-title":"Saccharomyces boulardii probiotic-associated fungemia: Questioning the safety of this preventive probiotic\u2019s use","volume":"87","author":"Martin","year":"2017","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/myc.12604","article-title":"Seven cases of Saccharomyces fungaemia related to use of probiotics","volume":"60","author":"Roy","year":"2017","journal-title":"Mycoses"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5578\/mb.6970","article-title":"Probiyotik tedavisinden sonra ya\u015fl\u0131 bir hastada geli\u015fen Saccharomyces cerevisiae fungemisi [Saccharomyces cerevisiae fungemia in an elderly patient following probiotic treatment]","volume":"48","author":"Eren","year":"2014","journal-title":"Mikrobiyol. Bul."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Costa, R.L., Moreira, J., Lorenzo, A., and Lamas, C.C. (2018). Infectious complications following probiotic ingestion: A potentially underestimated problem? A systematic review of reports and case series. BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-018-2394-3"},{"key":"ref_147","first-page":"27","article-title":"Fungemia following probiotic treatment in an elderly patient","volume":"52","author":"Landaburu","year":"2020","journal-title":"Rev. Argent. Microbiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3920\/BM2013.0074","article-title":"Lactobacillus rhamnosus GG suspected infection in a newborn with intrauterine growth restriction","volume":"5","author":"Paprzycka","year":"2014","journal-title":"Benef. Microbes"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1399-3062.2010.00580.x","article-title":"Lactobacillus probiotic use in cardiothoracic transplant recipients: A link to invasive Lactobacillus infection?","volume":"12","author":"Luong","year":"2010","journal-title":"Transpl. Infect. Dis."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Uusitalo, U., Andren Aronsson, C., Liu, X., Kurppa, K., Yang, J., Liu, E., Skidmore, J., Winkler, C., Rewers, M.J., and Hagopian, W.A. (2019). Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk. Nutrients, 11.","DOI":"10.3390\/nu11081790"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"614986","DOI":"10.3389\/fnut.2020.614986","article-title":"Probiotics as a Weapon in the Fight against COVID-19","volume":"7","author":"Stavropoulou","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1128\/AEM.67.9.3873-3881.2001","article-title":"Putative virulence factor expression by clinical and food isolates of Bacillus spp. after growth in reconstituted infant milk formulae","volume":"67","author":"Rowan","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12937-015-0084-2","article-title":"Detection of antibiotic resistance in probiotics of dietary supplements","volume":"14","author":"Wong","year":"2015","journal-title":"Nutr. J."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Aceti, A., Beghetti, I., Maggio, L., Martini, S., Faldella, G., and Corvaglia, L. (2018). Filling the Gaps: Current Research Directions for a Rational Use of Probiotics in Preterm Infants. Nutrients, 10.","DOI":"10.3390\/nu10101472"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"S261","DOI":"10.1016\/S1590-8658(07)60006-1","article-title":"Antibiotic resistance: The pros and cons of probiotics","volume":"38","author":"Courvalin","year":"2006","journal-title":"Dig. Liver Dis."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"908","DOI":"10.3389\/fmicb.2017.00908","article-title":"Assessing the Risk of Probiotic Dietary Supplements in the Context of Antibiotic Resistance","volume":"8","author":"Zheng","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3","DOI":"10.15171\/hpp.2020.02","article-title":"Postbiotics as novel health-promoting ingredients in functional foods","volume":"10","author":"Abbasi","year":"2020","journal-title":"Health Promot. Perspect."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"190128","DOI":"10.1098\/rsob.190128","article-title":"Temporal development of the infant gut microbiome","volume":"9","author":"Moore","year":"2019","journal-title":"Open Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.nut.2012.03.017","article-title":"Which are more important: Prebiotics or probiotics?","volume":"28","author":"Akbarzadeh","year":"2012","journal-title":"Nutrition"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"8553","DOI":"10.1074\/jbc.R116.752899","article-title":"Microbial metabolites in health and disease: Navigating the unknown in search of function","volume":"292","author":"Martinez","year":"2017","journal-title":"J. Biol Chem."},{"key":"ref_161","unstructured":"National Research Council (US) Committee on Metagenomics: Challenges and Functional Applications (2007). The New Science of Metagenomics: Revealing the Secrets of Our Microbial Planet, National Academies Press."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.2174\/1389201021666200516154833","article-title":"Potential Pharmaceutical and Food Applications of Postbiotics: A Review","volume":"21","author":"Rad","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_163","unstructured":"Mayer, E. (2016). The Mind-Gut Connection: How the Mind Communicates with the Gut, Harper Collins Publishers. [1st ed.]. Chapter 2."},{"key":"ref_164","first-page":"1","article-title":"Lactobacillus fermentum ME-3: An anti-microbial and anti-oxidative probiotic","volume":"21","author":"Mikelsaar","year":"2009","journal-title":"Micro Ecol. Health Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1097\/00008469-199703001-00009","article-title":"Intestinal flora and endogenous vitamin synthesis","volume":"6","author":"Hill","year":"1997","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AEM.05576-11","article-title":"Bacteriocin production: A probiotic trait?","volume":"78","author":"Dobson","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00018-010-0571-8","article-title":"Emerging knowledge of regulatory roles of D-amino acids in bacteria","volume":"68","author":"Cava","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1128\/AEM.04272-13","article-title":"H2O2 production in species of the Lactobacillus acidophilus group: A central role for a novel NADH-dependent flavin reductase","volume":"80","author":"Hertzberger","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.copbio.2010.12.004","article-title":"Impact of microbial transformation of food on health\u2014From fermented foods to fermentation in the gastro-intestinal tract","volume":"22","author":"Veiga","year":"2011","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2174\/1381612824666171227221731","article-title":"Antibiotics Associated Disorders and Post-biotics Induced Rescue in Gut Health","volume":"24","author":"Paul","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2672.2004.02473.x","article-title":"Importance of S-layer proteins in probiotic activity of Lactobacillus acidophilus M92","volume":"98","author":"Frece","year":"2005","journal-title":"J. Appl. Microbiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1074\/jbc.M109.082958","article-title":"Cell Surface of Lactococcus lactis Is Covered by a Protective Polysaccharide Pellicle","volume":"285","author":"Vinogradov","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses","volume":"22","author":"Mogensen","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Mantziari, A., Salminen, S., Szajewska, H., and Malag\u00f3n-Rojas, J.N. (2020). Postbiotics against Pathogens Commonly Involved in Pediatric Infectious Diseases. Microorganisms, 8.","DOI":"10.3390\/microorganisms8101510"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"733","DOI":"10.4161\/viru.29948","article-title":"Effector triggered manipulation of host immune response elicited by different pathotypes of Escherichia coli","volume":"5","author":"Jayamani","year":"2014","journal-title":"Virulence"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/intimm\/dxp017","article-title":"The roles of TLRs, RLRs and NLRs in pathogen recognition","volume":"21","author":"Kawai","year":"2009","journal-title":"Int. Immunol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1369\/jhc.6A7101.2006","article-title":"Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response","volume":"55","author":"Kummer","year":"2007","journal-title":"J. Histochem. Cytochem."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/imm.12677","article-title":"Understanding the regulation of pattern recognition receptors in inflammatory diseases\u2014A \u2018Nod\u2019 in the right direction","volume":"150","author":"Feerick","year":"2017","journal-title":"Immunology"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fphar.2017.00278","article-title":"Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases","volume":"8","author":"Fenini","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3389\/fimmu.2017.01075","article-title":"The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome","volume":"8","author":"Petes","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1007\/s00018-015-1931-1","article-title":"Compartmentalizing Intestinal Epithelial Cell Toll-like Receptors for Immune Surveillance","volume":"72","author":"Yu","year":"2015","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/ejcn.2016.77","article-title":"Korean traditional Chungkookjang improves body composition, lipid profiles and atherogenic indices in overweight\/obese subjects: A double-blind, randomized, crossover, placebo-controlled clinical trial","volume":"70","author":"Byun","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"339","DOI":"10.21307\/pjm-2018-041","article-title":"Bacterial Microbiota and Fatty Acids in the Faeces of Overweight and Obese Children","volume":"67","author":"Litwin","year":"2018","journal-title":"Pol. J. Microbiol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nutres.2009.11.004","article-title":"Antidiabetic effects of fermented soybean products on type 2 diabetes","volume":"30","author":"Kwon","year":"2010","journal-title":"Nutr. Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1880-6805-33-2","article-title":"Fermented foods, microbiota, and mental health: Ancient practice meets nutritional psychiatry","volume":"33","author":"Selhub","year":"2014","journal-title":"J. Physiol. Anthropol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.clnu.2014.05.013","article-title":"Supplementation with Aspergillus oryzae-fermented kochujang lowers serum cholesterol in subjects with hyperlipidemia","volume":"34","author":"Lim","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Tu, M.Y., Chen, H.L., Tung, Y.T., Kao, C.C., Hu, F.C., and Chen, C.M. (2015). Short-Term Effects of Kefir-Fermented Milk Consumption on Bone Mineral Density and Bone Metabolism in a Randomized Clinical Trial of Osteoporotic Patients. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144231"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.clnu.2018.02.014","article-title":"Gut microbiota alterations and dietary modulation in childhood malnutrition\u2014The role of short chain fatty acids","volume":"38","author":"Pekmez","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Corsello, G., Carta, M., Marinello, R., Picca, M., De Marco, G., Micillo, M., Ferrara, D., Vigneri, P., Cecere, G., and Ferri, P. (2017). Preventive Effect of Cow\u2019s Milk Fermented with Lactobacillus paracasei CBA L74 on Common Infectious Diseases in Children: A Multicenter Randomized Controlled Trial. Nutrients, 9.","DOI":"10.3390\/nu9070669"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.clnu.2015.12.004","article-title":"Cow\u2019s milk and rice fermented with Lactobacillus paracasei CBA L74 prevent infectious diseases in children: A randomized controlled trial","volume":"36","author":"Nocerino","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/MPG.0b013e3180375594","article-title":"Effectiveness and Safety of Lactobacillus LB in the Treatment of Mild Acute Diarrhea in Children","volume":"44","author":"Caciano","year":"2007","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Gou, W., Fu, Y., Yue, L., Chen, G., Cai, X., Shuai, M., Xu, F., Yi, X., Chen, H., and Zhu, Y. (2020). Gut microbiota may underlie the predisposition of healthy individuals to COVID-19. medRxiv.","DOI":"10.1101\/2020.04.22.20076091"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1021\/acsnano.0c03402","article-title":"Considering the Effects of Microbiome and Diet on SARS-CoV-2 Infection: Nanotechnology Roles","volume":"14","author":"Ward","year":"2020","journal-title":"ACS Nano"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/MPG.0b013e3182333f18","article-title":"Human Milk Probiotic Lactobacillus fermentum CECT5716 Reduces the Incidence of Gastrointestinal and Upper Respiratory Tract Infections in Infants","volume":"54","author":"Maldonado","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1136\/gutjnl-2011-300971","article-title":"Probiotic and postbiotic activity in health and disease: Comparison on a novel polarised ex-vivo organ culture model","volume":"61","author":"Tsilingiri","year":"2012","journal-title":"Gut"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Wegh, C.A.M., Geerlings, S.Y., Knol, J., Roeselers, G., and Belzer, C. (2019). Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194673"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3389\/fcimb.2020.00397","article-title":"The Postbiotic Activity of Lactobacillus paracasei 28.4 against Candida auris","volume":"10","author":"Rossoni","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/j.sempedsurg.2017.11.003","article-title":"Necrotizing enterocolitis: Pathophysiology from a historical context","volume":"27","author":"Hackam","year":"2018","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/5584_2018_314","article-title":"Can Postbiotics Represent a New Strategy for NEC?","volume":"1125","author":"Mosca","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s12602-019-09568-z","article-title":"In Silico Prediction and In Vitro Assessment of Multifunctional Properties of Postbiotics Obtained from Two Probiotic Bacteria","volume":"12","author":"Hall","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Humam, A.M., Loh, T.C., Foo, H.L., Samsudin, A.A., Mustapha, N.M., Zulkifli, I., and Izuddin, W.I. (2019). Effects of Feeding Different Postbiotics Produced by Lactobacillus plantarum on Growth Performance, Carcass Yield, Intestinal Morphology, Gut Microbiota Composition, Immune Status, and Growth Gene Expression in Broilers under Heat Stress. Animals, 9.","DOI":"10.3390\/ani9090644"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.00080-13","article-title":"Anti-Infective activities of Lactobacillus strains in the human intestinal microbiota: From probiotics to gastrointestinal anti-infectious biotherapeutic agents","volume":"27","author":"Servin","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Johnson, C.N., Kogut, M.H., Genovese, K., He, H., Kazemi, S., and Arsenault, R.J. (2019). Administration of a Postbiotic Causes Immunomodulatory Responses in Broiler Gut and Reduces Disease Pathogenesis Following Challenge. Microorganisms, 7.","DOI":"10.3390\/microorganisms7080268"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Blaabjerg, S., Artzi, D.M., and Aabenhus, R. (2017). Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients\u2014A Systematic Review and Meta-Analysis. Antibiotics, 6.","DOI":"10.3390\/antibiotics6040021"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0022-3476(99)70053-3","article-title":"Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children","volume":"135","author":"Vanderhoof","year":"1999","journal-title":"J. Pediatr."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1097\/MCG.0000000000000349","article-title":"Probiotics for Prevention and Treatment of Diarrhea","volume":"49","author":"Guarino","year":"2015","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_207","first-page":"CD004827","article-title":"Probiotics for the prevention of pediatric antibiotic-associated diarrhea","volume":"4","author":"Guo","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_208","first-page":"37","article-title":"Probiotics for antibiotic-associated diarrhea in children","volume":"66","author":"Yan","year":"2020","journal-title":"Can. Fam. Physician"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Hilty, M., Burke, C., Pedro, H., Cardenas, P., Bush, A., Bossley, C., Davies, J., Ervine, A., Poulter, L., and Pachter, L. (2010). Disordered microbial communities in asthmatic airways. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0008578"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.mi.39.100185.001541","article-title":"Measurement of in situ activities of nonphotosynthetic microorganisms in aquatic and terrestrial habitats","volume":"39","author":"Staley","year":"1985","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev-physiol-021115-105238","article-title":"The Microbiome and the Respiratory Tract","volume":"78","author":"Dickson","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12929-019-0554-5","article-title":"Current understanding of the gut microbiota shaping mechanisms","volume":"26","author":"Chang","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1007\/s00018-020-03452-8","article-title":"The lung microbiota: Role in maintaining pulmonary immune homeostasis and its implications in cancer development and therapy","volume":"77","author":"Sommariva","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.4049\/jimmunol.1600279","article-title":"The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease","volume":"196","author":"Dickson","year":"2016","journal-title":"J. Immunol."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Frank, D.N., Feazel, L.M., Bessesen, M.T., Price, C.S., Janoff, E.N., and Pace, N.R. (2010). The human nasal microbiota and Staphylococcus aureus carriage. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010598"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1128\/IAI.72.9.4996-5003.2004","article-title":"Role of antibiotics and fungal microbiota in driving pulmonary allergic responses","volume":"72","author":"Noverr","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.4049\/jimmunol.1502470","article-title":"Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function","volume":"196","author":"Manuzak","year":"2016","journal-title":"J. Immunol."},{"key":"ref_218","unstructured":"GBD Chronic Respiratory Disease Collaborators (2020). Prevalence and attributable health burden of chronic respiratory diseases, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet Respir. Med., 8, 585\u2013596."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-020-02554-1","article-title":"Probiotics in the prophylaxis of COVID-19: Something is better than nothing","volume":"11","author":"Gohil","year":"2021","journal-title":"3 Biotech"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.intimp.2009.04.015","article-title":"Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice","volume":"9","author":"Maeda","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0091-6749(98)70055-7","article-title":"Heat-Killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice","volume":"102","author":"Murosaki","year":"1998","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1271\/bbb.63.373","article-title":"Immunopotentiating activity of nigerooligosaccharides for the T helper 1-like immune response in mice","volume":"63","author":"Murosaki","year":"1999","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s002620050615","article-title":"Antitumor effect of heat-killed Lactobacillus plantarum L-137 through restoration of impaired interleukin-12 production in tumor-bearing mice","volume":"49","author":"Murosaki","year":"2000","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/CDLI.8.3.593-597.2001","article-title":"Effect of intranasal administration of Lactobacillus casei shirota on influenza virus infection of upper respiratory tract in mice","volume":"8","author":"Hori","year":"2001","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s10096-014-2086-y","article-title":"Probiotics in respiratory virus infections","volume":"33","author":"Lehtoranta","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1002\/fsn3.1719","article-title":"Coronavirus Disease (COVID-19) and Immunity Booster Green Foods: A Mini Review","volume":"8","author":"Arshad","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"e12966","DOI":"10.1111\/cmi.12966","article-title":"The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases","volume":"20","author":"Dumas","year":"2018","journal-title":"Cell Microbiol."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Yeoh, Y.K., Zuo, T., Lui, G.C., Zhang, F., Liu, Q., Li, A.Y.L., Chung, A.C.K., Cheung, C.P., Tso, E.Y.K., and Fung, K.S.C. (2021). Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut, 1\u20139.","DOI":"10.1136\/gutjnl-2020-323020"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.3389\/fimmu.2020.02192","article-title":"Probiotics in medicine: A long debate","volume":"11","author":"Stavropoulou","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1007\/s00134-011-2233-1","article-title":"The brain-lung-brain axis","volume":"37","author":"Stevens","year":"2011","journal-title":"Intensive Care Med."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"198018","DOI":"10.1016\/j.virusres.2020.198018","article-title":"Gut microbiota and Covid-19\u2014Possible link and implications","volume":"285","author":"Dhar","year":"2020","journal-title":"Virus Res."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1472-765X.2010.02844.x","article-title":"Intranasal administration of Lactobacillus rhamnosus GG protects mice from H1N1 influenza virus infection by regulating respiratory immune responses","volume":"50","author":"Harata","year":"2010","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"eaaw1347","DOI":"10.1126\/scisignal.aaw1347","article-title":"TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection","volume":"12","author":"Dhaliwal","year":"2019","journal-title":"Sci. Signal."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12026-020-09137-5","article-title":"COVID 19: A clue from innate immunity","volume":"68","author":"Birra","year":"2020","journal-title":"Immunol. Res."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"198103","DOI":"10.1016\/j.virusres.2020.198103","article-title":"Immunological co-ordination between gut and lungs in SARS-CoV-2 infection","volume":"286","author":"Ahlawat","year":"2020","journal-title":"Virus Res."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"102567","DOI":"10.1016\/j.autrev.2020.102567","article-title":"Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions","volume":"19","author":"Jamilloux","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Patra, S., Saxena, S., Sahu, N., Pradhan, B., and Roychowdhury, A. (2021). Systematic Network and Meta-analysis on the Antiviral Mechanisms of Probiotics: A Preventive and Treatment Strategy to Mitigate SARS-CoV-2 Infection. Probiotics Antimicrob. Proteins, 1\u201319.","DOI":"10.21203\/rs.3.rs-99848\/v1"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1073\/pnas.0904055107","article-title":"Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders","volume":"107","author":"Kwon","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fpubh.2020.00186","article-title":"Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic","volume":"8","author":"Baud","year":"2020","journal-title":"Front. Public Health"},{"key":"ref_240","unstructured":"Finsen, N.R. (2021, February 02). Biographical. NobelPrize.org. Nobel Media AB 2021. Tue. 2 February 2021. Available online: https:\/\/www.nobelprize.org\/prizes\/medicine\/1903\/finsen\/biographical\/."},{"key":"ref_241","unstructured":"Bolognia, J.L., Jorizzo, J.L., and Rapini, R.P. (2008). Dermatology (2 Volume Set), Mosby. [2nd ed.]."},{"key":"ref_242","unstructured":"(2021, February 02). The Nobel Prize in Physiology or Medicine 1903. Available online: https:\/\/www.nobelprize.org\/prizes\/medicine\/1903\/summary\/."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/pho.2008.2276","article-title":"Physiologic rhythms responding to low-level electromagnetic and mechanical signals: The Joule equivalence principle","volume":"26","year":"2008","journal-title":"Photomed. Laser Surg."},{"key":"ref_244","unstructured":"(2021, February 02). The Nobel Prize in Physiology or Medicine 2017. Available online: https:\/\/www.nobelprize.org\/prizes\/medicine\/2017\/summary\/."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1113\/expphysiol.2012.071118","article-title":"The rhythms of life: What your body clock means to you!","volume":"99","author":"Foster","year":"2014","journal-title":"Exp. Physiol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1001\/jama.2017.0653","article-title":"Resetting the Circadian Clock Might Boost Metabolic Health","volume":"317","author":"Kuehn","year":"2017","journal-title":"JAMA"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/pho.2018.4445","article-title":"Photobiomodulation in Light of Our Biological Clock\u2019s Inner Workings","volume":"36","year":"2018","journal-title":"Photomed. Laser Surg."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1126\/science.3059497","article-title":"The intrinsic electrophysiological properties of mammalian neurons: Insights into central nervous system function","volume":"242","year":"1988","journal-title":"Science"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/S0140-6736(02)11737-5","article-title":"Effect of sunlight and season on serotonin turnover in the brain","volume":"360","author":"Lambert","year":"2002","journal-title":"Lancet"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/php.12951","article-title":"Non-Mammalian Hosts and Photobiomodulation: Do All Life-forms Respond to Light?","volume":"95","author":"Hamblin","year":"2019","journal-title":"Photochem. Photobiol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1259\/0007-1285-26-305-234","article-title":"Whole body irradiation; radiobiology or medicine?","volume":"26","author":"Mole","year":"1953","journal-title":"Br. J. Radiol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/imr.12573","article-title":"Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and preclinical experiences","volume":"280","author":"Brix","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1056\/NEJMoa1112824","article-title":"Immunologic correlates of the abscopal effect in a patient with melanoma","volume":"366","author":"Postow","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1158\/0008-5472.CAN-14-3511","article-title":"TGF\u03b2 Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity","volume":"75","author":"Diamond","year":"2015","journal-title":"Cancer Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"5994","DOI":"10.1158\/0008-5472.CAN-16-0549","article-title":"Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming","volume":"76","author":"Rodriguez","year":"2016","journal-title":"Cancer Res."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature14292","article-title":"Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer","volume":"520","author":"Rech","year":"2015","journal-title":"Nature"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cell.2016.01.013","article-title":"Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans","volume":"164","author":"Sender","year":"2016","journal-title":"Cell"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome","volume":"312","author":"Gill","year":"2006","journal-title":"Science"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Karakan, T., Ozkul, C., K\u00fcpeli Akkol, E., Bilici, S., Sobarzo-S\u00e1nchez, E., and Capasso, R. (2021). Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders. Nutrients, 13.","DOI":"10.3390\/nu13020389"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1021\/acschemneuro.7b00373","article-title":"Neuromicrobiology: How Microbes Influence the Brain","volume":"9","author":"Meneguetti","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Salehpour, F., and Hamblin, M.R. (2020). Photobiomodulation for Parkinson\u2019s Disease in Animal Models: A Systematic Review. Biomolecules, 10.","DOI":"10.3390\/biom10040610"},{"key":"ref_263","doi-asserted-by":"crossref","unstructured":"Hamblin, M.R., de Sousa, M.V.P., and Agrawal, T. (2016). History of low-level laser (light) therapy. Handbook of Low-Level Laser Therapy, Pan Stanford Publishing. [1st ed.].","DOI":"10.1201\/9781315364827"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/JEN.S33444","article-title":"Neuroprotective Effects against POCD by Photobiomodulation: Evidence from Assembly\/Disassembly of the Cytoskeleton","volume":"10","author":"Liebert","year":"2016","journal-title":"J. Exp. Neurosci."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3934\/biophy.2017.3.337","article-title":"Mechanisms and applications of the anti-inflammatory effects of photobiomodulation","volume":"4","author":"Hamblin","year":"2017","journal-title":"AIMS Biophys."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10103-018-2594-6","article-title":"Photobiomodulation of the microbiome: Implications for metabolic and inflammatory diseases","volume":"34","author":"Bicknell","year":"2019","journal-title":"Lasers Med. Sci."},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Tetel, M.J., de Vries, G.J., Melcangi, R.C., Panzica, G., and O\u2019Mahony, S.M. (2018). Steroids, stress and the gut microbiome-brain axis. J. Neuroendocrinol., 30.","DOI":"10.1111\/jne.12548"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fnins.2015.00500","article-title":"Turning on Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer\u2019s and Parkinson\u2019s Disease","volume":"9","author":"Johnstone","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrneurol.2015.197","article-title":"Pathogenesis of Parkinson disease\u2014The gut-brain axis and environmental factors","volume":"11","author":"Klingelhoefer","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"ref_270","first-page":"681","article-title":"\u201cPhotobiomics\u201d: Can Light, Including Photobiomodulation, Alter the Microbiome?","volume":"37","author":"Liebert","year":"2019","journal-title":"Photobiomodul. Photomed. Laser Surg."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.cell.2020.12.011","article-title":"Infection trains the host for microbiota-enhanced resistance to pathogens","volume":"184","author":"Stacy","year":"2021","journal-title":"Cell"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-020-03116-4","article-title":"Gut-licensed IFN\u03b3+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes","volume":"590","author":"Sanmarco","year":"2021","journal-title":"Nature"},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.3389\/fimmu.2017.01678","article-title":"Protective microbiota: From localized to long-reaching co-immunity","volume":"8","author":"Chiu","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1038\/s41598-020-60015-4","article-title":"Respiratory mycobiome and suggestion of inter-kingdom network during acute pulmonary exacerbation in cystic fibrosis","volume":"10","author":"Soret","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s40168-018-0566-5","article-title":"Neonatal gut and respiratory microbiota: Coordinated development through time and space","volume":"6","author":"Grier","year":"2018","journal-title":"Microbiome"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"e00251-12","DOI":"10.1128\/mBio.00251-12","article-title":"Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: Interaction between intestinal and respiratory tracts and impact of nutritional exposures","volume":"3","author":"Madan","year":"2012","journal-title":"mBio"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s13205-017-0997-x","article-title":"16S rDNA analysis of the effect of fecal microbiota transplantation on pulmonary and intestinal flora","volume":"7","author":"Liu","year":"2017","journal-title":"3 Biotech"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2018.04.022","article-title":"Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism","volume":"48","author":"Trompette","year":"2018","journal-title":"Immunity"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jaci.2017.08.041","article-title":"Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting","volume":"142","author":"Arrieta","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fcimb.2020.00009","article-title":"The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks","volume":"10","author":"Enaud","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"1372494","DOI":"10.1155\/2020\/1372494","article-title":"Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections","volume":"2020","author":"Acosta","year":"2020","journal-title":"J. Immunol. Res."},{"key":"ref_282","unstructured":"Worldometers (2021, February 21). Coronavirus. COVID-19 Coronavirus Pandemic. Available online: https:\/\/www.worldometers.info\/coronavirus\/."},{"key":"ref_283","first-page":"e090139","article-title":"Lung microbiota in the acute respiratory disease: From coronavirus to metabolomics","volume":"9","author":"Fanos","year":"2020","journal-title":"J. Pediatr. Neonatal Individ. Med. (JPNIM)"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2147\/IDR.S258639","article-title":"Role of Monocytes\/Macrophages in Covid-19 Pathogenesis: Implications for Therapy","volume":"13","author":"Salas","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jinf.2020.06.008","article-title":"Interleukin-6 as prognosticator in patients with COVID-19","volume":"81","author":"Grifoni","year":"2020","journal-title":"J. Infect."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1589\/jpts.29.1527","article-title":"Immunomodulatory effects of two different physical therapy modalities in patients with chronic obstructive pulmonary disease","volume":"29","author":"Mehani","year":"2017","journal-title":"J. Phys. Ther. Sci."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fimmu.2020.00827","article-title":"Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)","volume":"11","author":"Diao","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/jbio.201500113","article-title":"Low level laser therapy reduces acute lung inflammation without impairing lung function","volume":"9","author":"Cury","year":"2016","journal-title":"J. Biophotonics"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jphotobiol.2014.03.021","article-title":"Low-level laser therapy reduces acute lung inflammation in a model of pulmonary and extrapulmonary LPS-induced ARDS","volume":"134","author":"Oliveira","year":"2014","journal-title":"J. Photochem. Photobiol. B."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"155312","DOI":"10.1016\/j.cyto.2020.155312","article-title":"Probable positive effects of the photobiomodulation as an adjunctive treatment in COVID-19: A systematic review","volume":"137","author":"Nejatifard","year":"2021","journal-title":"Cytokine"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s10103-019-02728-1","article-title":"In vitro effect of low-level laser therapy on the proliferative, apoptosis modulation, and oxi-inflammatory markers of premature-senescent hydrogen peroxide-induced dermal fibroblasts","volume":"34","author":"Maldaner","year":"2019","journal-title":"Lasers Med. Sci."},{"key":"ref_292","doi-asserted-by":"crossref","unstructured":"Atri, C., Guerfali, F.Z., and Laouini, D. (2018). Role of Human Macrophage Polarization in Inflammation during Infectious Diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061801"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3389\/fonc.2020.01255","article-title":"Review on the Cellular Mechanisms of Low-Level Laser Therapy Use in Oncology","volume":"10","author":"Tam","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_294","first-page":"1","article-title":"The M1\/M2 Pattern and the Oxidative Stress are Modulated by Low-Level Laser in Human Macrophage","volume":"7","author":"Carvalho","year":"2016","journal-title":"J. Clin. Cell Immunol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2004.00204.x","article-title":"Interferons, interferon-like cytokines, and their receptors","volume":"202","author":"Pestka","year":"2004","journal-title":"Immunol. Rev."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"5","author":"Kawai","year":"2011","journal-title":"Immunity"},{"key":"ref_297","doi-asserted-by":"crossref","unstructured":"Baxter, V.K., and Griffin, D.E. (2020). Interferon-Gamma Modulation of the Local T Cell Response to Alphavirus Encephalomyelitis. Viruses, 12.","DOI":"10.3390\/v12010113"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/CMR.14.4.778-809.2001","article-title":"Antiviral actions of interferons","volume":"14","author":"Samuel","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"193.16","DOI":"10.4049\/jimmunol.202.Supp.193.16","article-title":"Photobiomodulation therapy (PBMT) regulates the production of IL-10 and IFN-\u0194 by peripheral blood mononuclear cells (PBMC) and CD4+ T cells isolated from subjects with Multiple Sclerosis (MS)","volume":"202","author":"Tolentino","year":"2019","journal-title":"J. Immunol."},{"key":"ref_300","doi-asserted-by":"crossref","unstructured":"Soheilifar, S., Fathi, H., and Naghdi, N. (2020). Photobiomodulation therapy as a high potential treatment modality for COVID-19. Lasers Med. Sci., 1\u20134.","DOI":"10.1007\/s10103-020-03206-9"},{"key":"ref_301","first-page":"561","article-title":"Low-level laser boosts extracellular matrix cues and enhances acellular lung scaffold recellularization","volume":"56","author":"Santos","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1038\/s41598-019-39602-7","article-title":"Prevention of respiratory syncytial virus infection with probiotic lactic acid bacterium Lactobacillus gasseri SBT2055","volume":"9","author":"Eguchi","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/00016357.2019.1609697","article-title":"Effect of ingesting yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on influenza virus-bound salivary IgA in elderly residents of nursing homes: A randomized controlled trial","volume":"77","author":"Yamamoto","year":"2019","journal-title":"Acta Odontol. Scand."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.3168\/jds.2018-16103","article-title":"Lactobacillus plantarum DR7 improved upper respiratory tract infections via enhancing immune and inflammatory parameters: A randomized, double-blind, placebo-controlled study","volume":"102","author":"Chong","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.synbio.2018.03.001","article-title":"Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate","volume":"3","author":"Zhang","year":"2018","journal-title":"Synth. Syst. Biotechnol."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2147\/CIA.S141518","article-title":"Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: A randomized controlled open-label trial","volume":"12","author":"Pu","year":"2017","journal-title":"Clin. Interv. Aging"},{"key":"ref_307","doi-asserted-by":"crossref","unstructured":"Mohamed, M.S.M., Elshaghabee, F.M.F., Alharbi, S.A., and El-Hussein, A. (2020). The Prospective Beneficial Effects of Red Laser Exposure on Lactocaseibacillus casei Fermentation of Skim Milk. Biology, 9.","DOI":"10.3390\/biology9090256"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"112152","DOI":"10.1016\/j.jphotobiol.2021.112152","article-title":"Gut flora-targeted photobiomodulation therapy improves senile dementia in an A\u00df-induced Alzheimer\u2019s disease animal model","volume":"216","author":"Chen","year":"2021","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"112156","DOI":"10.1016\/j.jphotobiol.2021.112156","article-title":"Gut microbiome-mediated changes in bone metabolism upon infrared light exposure in rats","volume":"217","author":"Lu","year":"2021","journal-title":"J. Photochem. Photobiol. B."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/1348-0421.12600","article-title":"Antiviral properties of blue laser in an in vitro model of HSV-1 infection","volume":"62","author":"Zupin","year":"2018","journal-title":"Microbiol. Immunol."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s10103-019-02868-4","article-title":"Photobiomodulation therapy is able to decrease IL1B gene expression in an in vitro cellular model of hidradenitis suppurativa","volume":"35","author":"Ferri","year":"2020","journal-title":"Lasers Med. Sci."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"e202000496","DOI":"10.1002\/jbio.202000496","article-title":"Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells","volume":"14","author":"Zupin","year":"2021","journal-title":"J. Biophotonics"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2147\/JIR.S301625","article-title":"Evaluation of Adjunctive Photobiomodulation (PBMT) for COVID-19 Pneumonia via Clinical Status and Pulmonary Severity Indices in a Preliminary Trial","volume":"14","author":"Vetrici","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s15009-021-5701-x","article-title":"Anti-viral Photodynamic Therapy in Covid-19 Management: A Novel Approach in Treating Patients in Early Infection Stages","volume":"47","author":"Weber","year":"2021","journal-title":"Akupunkt. Aurikulomed."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/9\/4942\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:57:41Z","timestamp":1760162261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/9\/4942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,6]]},"references-count":314,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["ijms22094942"],"URL":"https:\/\/doi.org\/10.3390\/ijms22094942","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,6]]}}}