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Copper amine oxidases (CuAOs) oxidize polyamines to aminoaldehydes releasing ammonium and hydrogen peroxide, which participates in the complex network of reactive oxygen species acting as signaling molecules involved in responses to biotic and abiotic stresses. CuAOs have been identified and characterized in different plant species, but the most extensive study on a CuAO gene family has been carried out in Arabidopsis thaliana. Growing attention has been devoted in the last years to the investigation of the CuAO expression pattern during development and in response to an array of stress and stress-related hormones, events in which recent studies have highlighted CuAOs to play a key role by modulation of a multilevel phenotypic plasticity expression. In this review, the attention will be focused on the involvement of different AtCuAOs in the IAA\/JA\/ABA signal transduction pathways which mediate stress-induced phenotypic plasticity events.<\/jats:p>","DOI":"10.3390\/ijms22105136","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T22:46:14Z","timestamp":1620859574000},"page":"5136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Plant Copper Amine Oxidases: Key Players in Hormone Signaling Leading to Stress-Induced Phenotypic Plasticity"],"prefix":"10.3390","volume":"22","author":[{"given":"Ilaria","family":"Fraudentali","sequence":"first","affiliation":[{"name":"Department of Science, University \u201cRoma Tre\u201d, 00146 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato A.","family":"Rodrigues-Pousada","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-1187","authenticated-orcid":false,"given":"Riccardo","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Science, University \u201cRoma Tre\u201d, 00146 Rome, Italy"},{"name":"Interuniversity Consortium National Institute of Biostructures and Biosystems (INBB), 00136 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-4516","authenticated-orcid":false,"given":"Sandip A.","family":"Ghuge","sequence":"additional","affiliation":[{"name":"The Volcani Center, ARO, Institute of Plant Sciences, Bet Dagan 50250, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-8718","authenticated-orcid":false,"given":"Alessandra","family":"Cona","sequence":"additional","affiliation":[{"name":"Department of Science, University \u201cRoma Tre\u201d, 00146 Rome, Italy"},{"name":"Interuniversity Consortium National Institute of Biostructures and Biosystems (INBB), 00136 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-7398-9_1","article-title":"Polyamines in the Context of Metabolic Networks","volume":"1694","author":"Wuddineh","year":"2018","journal-title":"Methods Mol. 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